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    Rick Adam Friedman, MD, PhD

    TitleProfessor of Otolaryngology Head and Neck Surgery
    SchoolKeck School of Medicine of USC
    DepartmentOtolaryngology
    AddressCHP 204M 1540 Alcazar Street
    Health Sciences Campus
    Los Angeles California 90033
    Phone+1 323 442 5790
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      Other Positions
      TitleDivision Director For Otology/Neurotology


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      Dr. Friedman is a world renowned leader in the treatment of acoustic neuromas. He began his career as a fellow at House Clinic and later joined the group as an Associate where he had a busy practice for 15 years. He now serves as Division Director of Otology, Neurotology and Skull Base Surgery in the USC Caruso Department of Otolaryngology-Head and Neck Surgery at Keck Medicine of USC. Additional areas of expertise include, cochlear implants, glomus tumors, otosclerosis, meningiomas, chronic ear disorders and chronic otitis media. He is an NIH funded scientist and his laboratory studies the genetics of common forms of hearing loss. Dr. Friedman belongs to a majority of the societies in his area of specialization, including the American Academy of Otolaryngology-Head and Neck Surgery, the American Otological Society, the Acoustic Neuroma Association, the American Neurotology Society, the North American Skull Base Society, the Triological Society and the NIH/National Institute of Deafness and other Communication Disorders (NIDCD) where he serves as an Ad Hoc Reviewer.


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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Kari E, Schrauwen I, Llaci L, Fisher LM, Go JL, Naymik M, Knowles JA, Huentelman MJ, Friedman R. Compound heterozygous mutations in MASP1 in a deaf child with absent cochlear nerves. Neurol Genet. 2017 Jun; 3(3):e153. PMID: 28534045.
        View in: PubMed
      2. Lavinsky J, Aaron KA, Christian E, Go JL, Hurth K, Giannotta SL, Friedman R. Solitary Plasmacytoma in the Internal Auditory Canal and Cerebellopontine Angle Mimicking Meningioma. Otol Neurotol. 2016 Dec; 37(10):e400-e401. PMID: 26457817.
        View in: PubMed
      3. Lavinsky J, Ge M, Crow AL, Pan C, Wang J, Salehi P, Myint A, Eskin E, Allayee H, Lusis AJ, Friedman R. The Genetic Architecture of Noise-Induced Hearing Loss: Evidence for a Gene-by-Environment Interaction. G3 (Bethesda). 2016 Oct 13; 6(10):3219-3228. PMID: 27520957.
        View in: PubMed
      4. Salehi P, Myint A, Kim YJ, Ge MX, Lavinsky J, Ho MK, Crow AL, Cruz C, Monges-Hernadez M, Wang J, Hartiala J, Zhang LI, Allayee H, Lusis AJ, Ohyama T, Friedman R. Genome-Wide Association Analysis Identifies Dcc as an Essential Factor in the Innervation of the Peripheral Vestibular System in Inbred Mice. J Assoc Res Otolaryngol. 2016 Oct; 17(5):417-31. PMID: 27539716; PMCID: PMC5023540 [Available on 10/01/17].
      5. Myint A, White CH, Ohmen JD, Li X, Wang J, Lavinsky J, Salehi P, Crow AL, Ohyama T, Friedman R. Large-scale phenotyping of noise-induced hearing loss in 100 strains of mice. Hear Res. 2016 Feb; 332:113-120. PMID: 26706709; PMCID: PMC4769955 [Available on 02/01/17].
      6. Hoa M, Friedman R, Fisher LM, Derebery MJ. Prognostic implications of and audiometric evidence for hearing fluctuation in Meniere's disease. Laryngoscope. 2015 Dec; 125 Suppl 12:S1-12. PMID: 26343803.
        View in: PubMed
      7. Crow AL, Ohmen J, Wang J, Lavinsky J, Hartiala J, Li Q, Li X, Salehide P, Eskin E, Pan C, Lusis AJ, Allayee H, Friedman R. The Genetic Architecture of Hearing Impairment in Mice: Evidence for Frequency-Specific Genetic Determinants. G3 (Bethesda). 2015 Sep 04; 5(11):2329-39. PMID: 26342000; PMCID: PMC4632053.
      8. Lavinsky J, Crow AL, Pan C, Wang J, Aaron KA, Ho MK, Li Q, Salehide P, Myint A, Monges-Hernadez M, Eskin E, Allayee H, Lusis AJ, Friedman R. Correction: Genome-Wide Association Study Identifies Nox3 as a Critical Gene for Susceptibility to Noise-Induced Hearing Loss. PLoS Genet. 2015 Jun; 11(6):e1005293. PMID: 26068505; PMCID: PMC4465750.
      9. Lavinsky J, Crow AL, Pan C, Wang J, Aaron KA, Ho MK, Li Q, Salehide P, Myint A, Monges-Hernadez M, Eskin E, Allayee H, Lusis AJ, Friedman R. Genome-wide association study identifies nox3 as a critical gene for susceptibility to noise-induced hearing loss. PLoS Genet. 2015 Apr; 11(4):e1005094. PMID: 25880434; PMCID: PMC4399881.
      10. Aaron KA, Lavinsky J, Tuchman A, Go JL, Giannotta SL, Friedman R. A case report of two different skull base pathologies causing hearing loss in the same ear: vestibular schwannoma and superior semicircular canal dehiscence. Am J Otolaryngol. 2015 May-Jun; 36(3):488-91. PMID: 25720919.
        View in: PubMed
      11. Fransen E, Bonneux S, Corneveaux JJ, Schrauwen I, Di Berardino F, White CH, Ohmen JD, Van de Heyning P, Ambrosetti U, Huentelman MJ, Van Camp G, Friedman R. Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment. Eur J Hum Genet. 2015 Jan; 23(1):110-5. PMID: 24939585; PMCID: PMC4266741.
      12. Ohmen J, Kang EY, Li X, Joo JW, Hormozdiari F, Zheng QY, Davis RC, Lusis AJ, Eskin E, Friedman R. Genome-wide association study for age-related hearing loss (AHL) in the mouse: a meta-analysis. J Assoc Res Otolaryngol. 2014 Jun; 15(3):335-52. PMID: 24570207; PMCID: PMC4010595.
      13. Fayad JN, Ursick J, Brackmann DE, Friedman R. Total ossiculoplasty: short- and long-term results using a titanium prosthesis with footplate shoe. Otol Neurotol. 2014 Jan; 35(1):108-13. PMID: 24270724.
        View in: PubMed
      14. Ho MK, Li X, Wang J, Ohmen JD, Friedman R. FVB/NJ mice demonstrate a youthful sensitivity to noise-induced hearing loss and provide a useful genetic model for the study of neural hearing loss. Audiol Neurotol Extra. 2014 Jan 01; 4(1):1-11. PMID: 24707282.
        View in: PubMed
      15. Schwartz MS, Kari E, Strickland BM, Berliner K, Brackmann DE, House JW, Friedman R. Evaluation of the increased use of partial resection of large vestibular schwanommas: facial nerve outcomes and recurrence/regrowth rates. Otol Neurotol. 2013 Oct; 34(8):1456-64. PMID: 23928516.
        View in: PubMed
      16. Ohmen JD, White CH, Li X, Wang J, Fisher LM, Zhang H, Derebery MJ, Friedman R. Genetic evidence for an ethnic diversity in the susceptibility to Ménière's disease. Otol Neurotol. 2013 Sep; 34(7):1336-41. PMID: 23598705.
        View in: PubMed
      17. Rizk HG, Lorenz MB, Friedman R. Neuroglial heterotopia of the internal auditory canal. Otol Neurotol. 2013 Apr; 34(3):e22-3. PMID: 23449443.
        View in: PubMed
      18. Goddard JC, Go JL, Friedman R. Imaging case of the month: Fibrous dysplasia causing superior canal dehiscence. Otol Neurotol. 2013 Jan; 34(1):e1-2. PMID: 23187924.
        View in: PubMed
      19. Fisher LM, Derebery MJ, Friedman R. Oral steroid treatment for hearing improvement in Ménière's disease and endolymphatic hydrops. Otol Neurotol. 2012 Dec; 33(9):1685-91. PMID: 23047260.
        View in: PubMed
      20. Gázquez I, Moreno A, Requena T, Ohmen J, Santos-Perez S, Aran I, Soto-Varela A, Pérez-Garrigues H, López-Nevot A, Batuecas A, Friedman R, López-Nevot MA, López-Escamez JA. Functional variants of MIF, INFG and TFNA genes are not associated with disease susceptibility or hearing loss progression in patients with Ménière's disease. Eur Arch Otorhinolaryngol. 2013 Mar; 270(4):1521-9. PMID: 23179933.
        View in: PubMed
      21. Friedman R, Hoa M, Brackmann DE. Surgical management of endolymphatic sac tumors. J Neurol Surg B Skull Base. 2013 Feb; 74(1):12-9. PMID: 24436884; PMCID: PMC3699165.
      22. Newman DL, Fisher LM, Ohmen J, Parody R, Fong CT, Frisina ST, Mapes F, Eddins DA, Robert Frisina D, Frisina RD, Friedman R. GRM7 variants associated with age-related hearing loss based on auditory perception. Hear Res. 2012 Dec; 294(1-2):125-32. PMID: 23102807; PMCID: PMC3705704.
      23. Kari E, Friedman R. Hearing preservation: microsurgery. Curr Opin Otolaryngol Head Neck Surg. 2012 Oct; 20(5):358-66. PMID: 22929113.
        View in: PubMed
      24. Ghazalpour A, Rau CD, Farber CR, Bennett BJ, Orozco LD, van Nas A, Pan C, Allayee H, Beaven SW, Civelek M, Davis RC, Drake TA, Friedman R, Furlotte N, Hui ST, Jentsch JD, Kostem E, Kang HM, Kang EY, Joo JW, Korshunov VA, Laughlin RE, Martin LJ, Ohmen JD, Parks BW, Pellegrini M, Reue K, Smith DJ, Tetradis S, Wang J, Wang Y, Weiss JN, Kirchgessner T, Gargalovic PS, Eskin E, Lusis AJ, LeBoeuf RC. Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mamm Genome. 2012 Oct; 23(9-10):680-92. PMID: 22892838; PMCID: PMC3586763.
      25. Friedman R, Goddard JC, Wilkinson EP, Schwartz MS, Slattery WH, Fayad JN, Brackmann DE. Hearing preservation with the middle cranial fossa approach for neurofibromatosis type 2. Otol Neurotol. 2011 Dec; 32(9):1530-7. PMID: 21986931.
        View in: PubMed
      26. Friedman R, Berliner KI, Bassim M, Ursick J, Slattery WH, Schwartz MS, Brackmann DE. A paradigm shift in salvage surgery for radiated vestibular schwannoma. Otol Neurotol. 2011 Oct; 32(8):1322-8. PMID: 21897324.
        View in: PubMed
      27. Wilkinson EP, Hoa M, Slattery WH, Fayad JN, Friedman R, Schwartz MS, Brackmann DE. Evolution in the management of facial nerve schwannoma. Laryngoscope. 2011 Oct; 121(10):2065-74. PMID: 21898431.
        View in: PubMed
      28. Slattery WH, Hoa M, Bonne N, Friedman R, Schwartz MS, Fisher LM, Brackmann DE. Middle fossa decompression for hearing preservation: a review of institutional results and indications. Otol Neurotol. 2011 Aug; 32(6):1017-24. PMID: 21725256.
        View in: PubMed
      29. Goddard JC, Schwartz MS, Friedman R. Fundal fluid as a predictor of hearing preservation in the middle cranial fossa approach for vestibular schwannoma. Otol Neurotol. 2010 Sep; 31(7):1128-34. PMID: 20657334.
        View in: PubMed
      30. Bassim MK, Berliner KI, Fisher LM, Brackmann DE, Friedman R. Radiation therapy for the treatment of vestibular schwannoma: a critical evaluation of the state of the literature. Otol Neurotol. 2010 Jun; 31(4):567-73. PMID: 20300044.
        View in: PubMed
      31. White CH, Ohmen JD, Sheth S, Zebboudj AF, McHugh RK, Hoffman LF, Lusis AJ, Davis RC, Friedman R. Genome-wide screening for genetic loci associated with noise-induced hearing loss. Mamm Genome. 2009 Apr; 20(4):207-13. PMID: 19337678; PMCID: PMC2823581.
      32. Hilgert N, Monahan K, Kurima K, Li C, Friedman R, Griffith AJ, Van Camp G. Amino acid 572 in TMC1: hot spot or critical functional residue for dominant mutations causing hearing impairment. J Hum Genet. 2009 Mar; 54(3):188-90. PMID: 19180119; PMCID: PMC3431155.
      33. Friedman R, Van Laer L, Huentelman MJ, Sheth SS, Van Eyken E, Corneveaux JJ, Tembe WD, Halperin RF, Thorburn AQ, Thys S, Bonneux S, Fransen E, Huyghe J, Pyykkö I, Cremers CW, Kremer H, Dhooge I, Stephens D, Orzan E, Pfister M, Bille M, Parving A, Sorri M, Van de Heyning PH, Makmura L, Ohmen JD, Linthicum FH, Fayad JN, Pearson JV, Craig DW, Stephan DA, Van Camp G. GRM7 variants confer susceptibility to age-related hearing impairment. Hum Mol Genet. 2009 Feb 15; 18(4):785-96. PMID: 19047183; PMCID: PMC2638831.
      34. Niu H, Li X, Makmura L, Friedman R. Mapping of genetic modifiers of Eya1 ( bor/bor ) in CAST/EiJ and BALB/cJ that suppress cochlear aplasia and associated deafness. Mamm Genome. 2008 Sep; 19(9):634-9. PMID: 18836772.
        View in: PubMed
      35. Wilkinson EP, Friedman R. Acute suppurative otitis media. Ear Nose Throat J. 2008 May; 87(5):250. PMID: 18572776.
        View in: PubMed
      36. Wilkinson EP, Liu GC, Friedman R. Correction of progressive hearing loss in superior canal dehiscence syndrome. Laryngoscope. 2008 Jan; 118(1):10-3. PMID: 18090259.
        View in: PubMed
      37. Kutz JW, Friedman R. Congenital middle ear cholesteatoma. Ear Nose Throat J. 2007 Nov; 86(11):654. PMID: 18225618.
        View in: PubMed
      38. Friedman R, Cullen RD, Ulis J, Brackmann DE. Management of cerebrospinal fluid leaks after acoustic tumor removal. Neurosurgery. 2007 Sep; 61(3 Suppl):35-9; discussion 39-40. PMID: 17876231.
        View in: PubMed
      39. Kutz JW, Verma S, Tan HT, Lo WW, Slattery WH, Friedman R. Surgical management of skull base chondroblastoma. Laryngoscope. 2007 May; 117(5):848-53. PMID: 17473681.
        View in: PubMed
      40. Slattery WH, Fisher LM, Hitselberger W, Friedman R, Brackmann DE. Hearing preservation surgery for neurofibromatosis Type 2-related vestibular schwannoma in pediatric patients. J Neurosurg. 2007 Apr; 106(4 Suppl):255-60. PMID: 17465357.
        View in: PubMed
      41. Starkweather A, Friedman R. Effect of ciprodex on graft healing in tympanoplasty. Adv Ther. 2007 Mar-Apr; 24(2):427-35. PMID: 17565934.
        View in: PubMed
      42. Doherty JK, Friedman R. Controversies in building a management algorithm for vestibular schwannomas. Curr Opin Otolaryngol Head Neck Surg. 2006 Oct; 14(5):305-13. PMID: 16974142.
        View in: PubMed
      43. McHugh RK, Friedman R. Genetics of hearing loss: Allelism and modifier genes produce a phenotypic continuum. Anat Rec A Discov Mol Cell Evol Biol. 2006 Apr; 288(4):370-81. PMID: 16550584.
        View in: PubMed
      44. Niu H, Makmura L, Shen T, Sheth SS, Blair K, Friedman R. Identification of two major loci that suppress hearing loss and cochlear dysmorphogenesis in Eya1bor/bor mice. Genomics. 2006 Sep; 88(3):302-8. PMID: 16488112.
        View in: PubMed
      45. Friedman R, Brackmann DE, Hitselberger WE, Schwartz MS, Iqbal Z, Berliner KI. Surgical salvage after failed irradiation for vestibular schwannoma. Laryngoscope. 2005 Oct; 115(10):1827-32. PMID: 16222204.
        View in: PubMed
      46. Slattery WH, Fisher LM, Iqbal Z, Friedman R, Liu N. Intratympanic steroid injection for treatment of idiopathic sudden hearing loss. Otolaryngol Head Neck Surg. 2005 Aug; 133(2):251-9. PMID: 16087024.
        View in: PubMed
      47. Cunningham CD, Friedman R, Brackmann DE, Hitselberger WE, Lin HW. Neurotologic skull base surgery in pediatric patients. Otol Neurotol. 2005 Mar; 26(2):231-6. PMID: 15793410.
        View in: PubMed
      48. Friedman R, Makmura L, Biesiada E, Wang X, Keithley EM. Eya1 acts upstream of Tbx1, Neurogenin 1, NeuroD and the neurotrophins BDNF and NT-3 during inner ear development. Mech Dev. 2005 May; 122(5):625-34. PMID: 15817220.
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      49. Zhang Y, Knosp BM, Maconochie M, Friedman R, Smith RJ. A comparative study of Eya1 and Eya4 protein function and its implication in branchio-oto-renal syndrome and DFNA10. J Assoc Res Otolaryngol. 2004 Sep; 5(3):295-304. PMID: 15492887; PMCID: PMC2504552.
      50. Shen T, Friedman R, Brackmann DE, Slattery WH, Hitselberger WE, Schwartz MS, Fisher L. The evolution of surgical approaches for posterior fossa meningiomas. Otol Neurotol. 2004 May; 25(3):394-7. PMID: 15129123.
        View in: PubMed
      51. Roland PS, Stewart MG, Hannley M, Friedman R, Manolidis S, Matz G, Rybak L, Weber P, Owens F. Consensus panel on role of potentially ototoxic antibiotics for topical middle ear use: Introduction, methodology, and recommendations. Otolaryngol Head Neck Surg. 2004 Mar; 130(3 Suppl):S51-6. PMID: 15054363.
        View in: PubMed
      52. Roland PS, Rybak L, Hannley M, Matz G, Stewart MG, Manolidis S, Friedman R, Weber P, Owens F. Animal ototoxicity of topical antibiotics and the relevance to clinical treatment of human subjects. Otolaryngol Head Neck Surg. 2004 Mar; 130(3 Suppl):S57-78. PMID: 15054364.
        View in: PubMed
      53. Matz G, Rybak L, Roland PS, Hannley M, Friedman R, Manolidis S, Stewart MG, Weber P, Owens F. Ototoxicity of ototopical antibiotic drops in humans. Otolaryngol Head Neck Surg. 2004 Mar; 130(3 Suppl):S79-82. PMID: 15054365.
        View in: PubMed
      54. Li X, Fischel-Ghodsian N, Schwartz F, Yan Q, Friedman R, Guan MX. Biochemical characterization of the mitochondrial tRNASer(UCN) T7511C mutation associated with nonsyndromic deafness. Nucleic Acids Res. 2004; 32(3):867-77. PMID: 14960712; PMCID: PMC373379.
      55. Friedman R, Kesser B, Brackmann DE, Fisher LM, Slattery WH, Hitselberger WE. Long-term hearing preservation after middle fossa removal of vestibular schwannoma. Otolaryngol Head Neck Surg. 2003 Dec; 129(6):660-5. PMID: 14663432.
        View in: PubMed
      56. Floyd JA, Gold DA, Concepcion D, Poon TH, Wang X, Keithley E, Chen D, Ward EJ, Chinn SB, Friedman R, Yu HT, Moriwaki K, Shiroishi T, Hamilton BA. A natural allele of Nxf1 suppresses retrovirus insertional mutations. Nat Genet. 2003 Nov; 35(3):221-8. PMID: 14517553; PMCID: PMC2756099.
      57. Li XC, Friedman R. Nonsyndromic hereditary hearing loss. Otolaryngol Clin North Am. 2002 Apr; 35(2):275-85. PMID: 12391618.
        View in: PubMed