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    Rex A. Moats, PhD

    TitleAssociate Professor of Research Pathology and Radiology
    SchoolKeck School of Medicine of USC
    DepartmentPediatrics
    AddressCHL Mail Stop 81
    Off Campus
    Los Angeles California 90089
    Phone+1 323 361 8503
    vCardDownload vCard
      Other Positions
      TitleScientific Director of Small Animal Research


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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Browne AW, Arnesano C, Harutyunyan N, Khuu T, Martinez JC, Pollack HA, Koos DS, Lee TC, Fraser SE, Moats R, Aparicio JG, Cobrinik D. Structural and Functional Characterization of Human Stem-Cell-Derived Retinal Organoids by Live Imaging. Invest Ophthalmol Vis Sci. 2017 Jul 01; 58(9):3311-3318. PMID: 28672397.
        View in: PubMed
      2. Barish ME, Herrmann K, Tang Y, Argalian Herculian S, Metz M, Aramburo S, Tirughana R, Gutova M, Annala A, Moats R, Goldstein L, Rockne RC, Gutierrez J, Brown CE, Ghoda L, Aboody KS. Human Neural Stem Cell Biodistribution and Predicted Tumor Coverage by a Diffusible Therapeutic in a Mouse Glioma Model. Stem Cells Transl Med. 2017 May 08. PMID: 28481046.
        View in: PubMed
      3. Schall KA, Holoyda KA, Isani M, Schlieve C, Salisbury T, Khuu T, Debelius JW, Moats R, Pollack HA, Lien CL, Fowler K, Hou X, Knight R, Grikscheit TC. Intestinal adaptation in proximal and distal segments: Two epithelial responses diverge after intestinal separation. Surgery. 2017 Apr; 161(4):1016-1027. PMID: 28011012.
        View in: PubMed
      4. Gutova M, Goldstein L, Metz M, Hovsepyan A, Tsurkan LG, Tirughana R, Tsaturyan L, Annala AJ, Synold TW, Wan Z, Seeger R, Anderson C, Moats R, Potter PM, Aboody KS. Optimization of a Neural Stem-Cell-Mediated Carboxylesterase/Irinotecan Gene Therapy for Metastatic Neuroblastoma. Mol Ther Oncolytics. 2017 Mar 17; 4:67-76. PMID: 28345025.
        View in: PubMed
      5. Shackleford GM, Shi XH, Swanson KS, Mahdi MY, Gonzalez-Gomez I, Asgharzadeh S, D'Apuzzo M, Erdreich-Epstein A, Moats R. BarTeL, a Genetically Versatile, Bioluminescent and Granule Neuron Precursor-Targeted Mouse Model for Medulloblastoma. PLoS One. 2016; 11(6):e0156907. PMID: 27310018; PMCID: PMC4911170.
      6. Bonne NX, Vitte J, Chareyre F, Karapetyan G, Khankaldyyan V, Tanaka K, Moats R, Giovannini M. An allograft mouse model for the study of hearing loss secondary to vestibular schwannoma growth. J Neurooncol. 2016 Aug; 129(1):47-56. PMID: 27177628.
        View in: PubMed
      7. Sims JD, Hwang JY, Wagner S, Alonso-Valenteen F, Hanson C, Taguiam JM, Polo R, Harutyunyan I, Karapetyan G, Sorasaenee K, Ibrahim A, Marban E, Moats R, Gray HB, Gross Z, Medina-Kauwe LK. A corrole nanobiologic elicits tissue-activated MRI contrast enhancement and tumor-targeted toxicity. J Control Release. 2015 Nov 10; 217:92-101. PMID: 26334483; PMCID: PMC4623877 [Available on 11/10/16].
      8. Buckley S, Shi W, Xu W, Frey MR, Moats R, Pardo A, Selman M, Warburton D. Increased alveolar soluble annexin V promotes lung inflammation and fibrosis. Eur Respir J. 2015 Nov; 46(5):1417-29. PMID: 26160872; PMCID: PMC4767328 [Available on 11/01/16].
      9. Schall KA, Holoyda KA, Grant CN, Levin DE, Torres ER, Maxwell A, Pollack HA, Moats R, Frey MR, Darehzereshki A, Al Alam D, Lien C, Grikscheit TC. Adult zebrafish intestine resection: a novel model of short bowel syndrome, adaptation, and intestinal stem cell regeneration. Am J Physiol Gastrointest Liver Physiol. 2015 Aug 01; 309(3):G135-45. PMID: 26089336; PMCID: PMC4525108.
      10. Li Y, Trivedi V, Truong TV, Koos DS, Lansford R, Chuong CM, Warburton D, Moats R, Fraser SE. Dynamic imaging of the growth plate cartilage reveals multiple contributors to skeletal morphogenesis. Nat Commun. 2015 Apr 13; 6:6798. PMID: 25865282; PMCID: PMC4403347.
      11. Gao F, Thompson JR, Petsios E, Erkenbrack E, Moats R, Bottjer DJ, Davidson EH. Juvenile skeletogenesis in anciently diverged sea urchin clades. Dev Biol. 2015 Apr 01; 400(1):148-58. PMID: 25641694.
        View in: PubMed
      12. Morshed RA, Gutova M, Juliano J, Barish ME, Hawkins-Daarud A, Oganesyan D, Vazgen K, Yang T, Annala A, Ahmed AU, Aboody KS, Swanson KR, Moats R, Lesniak MS. Analysis of glioblastoma tumor coverage by oncolytic virus-loaded neural stem cells using MRI-based tracking and histological reconstruction. Cancer Gene Ther. 2015 Jan; 22(1):55-61. PMID: 25525033; PMCID: PMC4293243.
      13. Hu H, Li D, Liu S, Wang M, Moats R, Conti PS, Li Z. Integrin a2ß1 targeted GdVO4:Eu ultrathin nanosheet for multimodal PET/MR imaging. Biomaterials. 2014 Oct; 35(30):8649-58. PMID: 25043573.
        View in: PubMed
      14. Blumenfeld CM, Sadtler BF, Fernandez GE, Dara L, Nguyen C, Alonso-Valenteen F, Medina-Kauwe L, Moats R, Lewis NS, Grubbs RH, Gray HB, Sorasaenee K. Cellular uptake and cytotoxicity of a near-IR fluorescent corrole-TiO2 nanoconjugate. J Inorg Biochem. 2014 Nov; 140:39-44. PMID: 25061689; PMCID: PMC4998051.
      15. Gutova M, Frank JA, D'Apuzzo M, Khankaldyyan V, Gilchrist MM, Annala AJ, Metz MZ, Abramyants Y, Herrmann KA, Ghoda LY, Najbauer J, Brown CE, Blanchard MS, Lesniak MS, Kim SU, Barish ME, Aboody KS, Moats R. Magnetic resonance imaging tracking of ferumoxytol-labeled human neural stem cells: studies leading to clinical use. Stem Cells Transl Med. 2013 Oct; 2(10):766-75. PMID: 24014682; PMCID: PMC3785261.
      16. Akhtari M, Pope W, Mathern G, Moats R, Frew A, Mandelkern M. Functionalized magnetonanoparticles in visualization of intracranial tumors on MRI. Mol Imaging Biol. 2013 Jun; 15(3):299-306. PMID: 23184607.
        View in: PubMed
      17. Aboody KS, Najbauer J, Metz MZ, D'Apuzzo M, Gutova M, Annala AJ, Synold TW, Couture LA, Blanchard S, Moats R, Garcia E, Aramburo S, Valenzuela VV, Frank RT, Barish ME, Brown CE, Kim SU, Badie B, Portnow J. Neural stem cell-mediated enzyme/prodrug therapy for glioma: preclinical studies. Sci Transl Med. 2013 May 08; 5(184):184ra59. PMID: 23658244; PMCID: PMC3864887.
      18. Blumenfeld CM, Grubbs RH, Moats R, Gray HB, Sorasaenee K. Decorating metal oxide surfaces with fluorescent chlorosulfonated corroles. Inorg Chem. 2013 May 06; 52(9):4774-6. PMID: 23611256.
        View in: PubMed
      19. Akhtari M, Bragin A, Moats R, Frew A, Mandelkern M. Imaging brain neuronal activity using functionalized magnetonanoparticles and MRI. Brain Topogr. 2012 Oct; 25(4):374-88. PMID: 22622772.
        View in: PubMed
      20. Gutova M, Shackleford GM, Khankaldyyan V, Herrmann KA, Shi XH, Mittelholtz K, Abramyants Y, Blanchard MS, Kim SU, Annala AJ, Najbauer J, Synold TW, D'Apuzzo M, Barish ME, Moats R, Aboody KS. Neural stem cell-mediated CE/CPT-11 enzyme/prodrug therapy in transgenic mouse model of intracerebellar medulloblastoma. Gene Ther. 2013 Feb; 20(2):143-50. PMID: 22402322; PMCID: PMC4149468.
      21. Xu J, Erdreich-Epstein A, Gonzalez-Gomez I, Melendez EY, Smbatyan G, Moats R, Rosol M, Biegel JA, Reynolds CP. Novel cell lines established from pediatric brain tumors. J Neurooncol. 2012 Apr; 107(2):269-80. PMID: 22120608; PMCID: PMC3379550.
      22. Tang Y, Sharma P, Nelson MD, Simerly R, Moats R. Automatic abdominal fat assessment in obese mice using a segmental shape model. J Magn Reson Imaging. 2011 Oct; 34(4):866-73. PMID: 21769982.
        View in: PubMed
      23. Tang Y, Lee S, Nelson MD, Richard S, Moats R. Adipose segmentation in small animals at 7T: a preliminary study. BMC Genomics. 2010 Dec 01; 11 Suppl 3:S9. PMID: 21143791; PMCID: PMC2999354.
      24. Thu MS, Najbauer J, Kendall SE, Harutyunyan I, Sangalang N, Gutova M, Metz MZ, Garcia E, Frank RT, Kim SU, Moats R, Aboody KS. Iron labeling and pre-clinical MRI visualization of therapeutic human neural stem cells in a murine glioma model. PLoS One. 2009 Sep 29; 4(9):e7218. PMID: 19787043; PMCID: PMC2746284.
      25. Lu SC, Ramani K, Ou X, Lin M, Yu V, Ko K, Park R, Bottiglieri T, Tsukamoto H, Kanel G, French SW, Mato JM, Moats R, Grant E. S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model. Hepatology. 2009 Aug; 50(2):462-71. PMID: 19444874; PMCID: PMC2754739.
      26. Tang Y, Jackson H, Lee S, Nelson M, Moats R. Shape-aided kidney extraction in MR urography. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:5781-4. PMID: 19963658.
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      27. Wen X, Zou Y, Luo W, Goldberg M, Moats R, Conti PS, Snead ML, Paine ML. Biglycan overexpression on tooth enamel formation in transgenic mice. Anat Rec (Hoboken). 2008 Oct; 291(10):1246-53. PMID: 18727043; PMCID: PMC2562349.
      28. Lee W, Karapetyan G, Moats R, Yamashita DD, Moon HB, Ferguson DJ, Yen S. Corticotomy-/osteotomy-assisted tooth movement microCTs differ. J Dent Res. 2008 Sep; 87(9):861-7. PMID: 18719214.
        View in: PubMed
      29. Wood JC, Aguilar M, Otto-Duessel M, Nick H, Nelson MD, Moats R. Influence of iron chelation on R1 and R2 calibration curves in gerbil liver and heart. Magn Reson Med. 2008 Jul; 60(1):82-9. PMID: 18581418; PMCID: PMC2525452.
      30. Akhtari M, Bragin A, Cohen M, Moats R, Brenker F, Lynch MD, Vinters HV, Engel J. Functionalized magnetonanoparticles for MRI diagnosis and localization in epilepsy. Epilepsia. 2008 Aug; 49(8):1419-30. PMID: 18479391; PMCID: PMC2685186.
      31. Otto-Duessel M, Aguilar M, Moats R, Wood JC. Antioxidant-mediated effects in a gerbil model of iron overload. Acta Haematol. 2007; 118(4):193-9. PMID: 17940334; PMCID: PMC2892915.
      32. Peng H, Sohara Y, Moats R, Nelson MD, Groshen SG, Ye W, Reynolds CP, DeClerck YA. The activity of zoledronic Acid on neuroblastoma bone metastasis involves inhibition of osteoclasts and tumor cell survival and proliferation. Cancer Res. 2007 Oct 01; 67(19):9346-55. PMID: 17909043.
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      33. Liao CP, Zhong C, Saribekyan G, Bading J, Park R, Conti PS, Moats R, Berns A, Shi W, Zhou Z, Nikitin AY, Roy-Burman P. Mouse models of prostate adenocarcinoma with the capacity to monitor spontaneous carcinogenesis by bioluminescence or fluorescence. Cancer Res. 2007 Aug 01; 67(15):7525-33. PMID: 17671224.
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      34. Otto-Duessel M, Aguilar M, Nick H, Moats R, Wood JC. Comparison of twice-daily vs once-daily deferasirox dosing in a gerbil model of iron cardiomyopathy. Exp Hematol. 2007 Jul; 35(7):1069-73. PMID: 17588475; PMCID: PMC2892931.
      35. Wood JC, Otto-Duessel M, Gonzalez I, Aguilar MI, Shimada H, Nick H, Nelson M, Moats R. Deferasirox and deferiprone remove cardiac iron in the iron-overloaded gerbil. Transl Res. 2006 Nov; 148(5):272-80. PMID: 17145573; PMCID: PMC2896322.
      36. Sodir NM, Chen X, Park R, Nickel AE, Conti PS, Moats R, Bading JR, Shibata D, Laird PW. Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice. Cancer Res. 2006 Sep 01; 66(17):8430-8. PMID: 16951153.
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      37. Mouchess ML, Sohara Y, Nelson MD, DeCLerck YA, Moats R. Multimodal imaging analysis of tumor progression and bone resorption in a murine cancer model. J Comput Assist Tomogr. 2006 May-Jun; 30(3):525-34. PMID: 16778634.
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      38. Chen X, Park R, Khankaldyyan V, Gonzales-Gomez I, Tohme M, Moats R, Bading JR, Laug WE, Conti PS. Longitudinal microPET imaging of brain tumor growth with F-18-labeled RGD peptide. Mol Imaging Biol. 2006 Jan-Feb; 8(1):9-15. PMID: 16315003.
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      39. Chaudhari AJ, Darvas F, Bading JR, Moats R, Conti PS, Smith DJ, Cherry SR, Leahy RM. Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging. Phys Med Biol. 2005 Dec 07; 50(23):5421-41. PMID: 16306643.
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      40. Møller LB, Paulsen M, Koch R, Moats R, Guldberg P, Güttler F. Inter-individual variation in brain phenylalanine concentration in patients with PKU is not caused by genetic variation in the 4F2hc/LAT1 complex. Mol Genet Metab. 2005 Dec; 86 Suppl 1:S119-23. PMID: 16176881.
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      41. Wood JC, Otto-Duessel M, Aguilar M, Nick H, Nelson MD, Coates TD, Pollack H, Moats R. Cardiac iron determines cardiac T2*, T2, and T1 in the gerbil model of iron cardiomyopathy. Circulation. 2005 Jul 26; 112(4):535-43. PMID: 16027257; PMCID: PMC2896311.
      42. Kobayashi H, Carbonaro D, Pepper K, Petersen D, Ge S, Jackson H, Shimada H, Moats R, Kohn DB. Neonatal gene therapy of MPS I mice by intravenous injection of a lentiviral vector. Mol Ther. 2005 May; 11(5):776-89. PMID: 15851016.
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      43. Wood JC, Enriquez C, Ghugre N, Otto-Duessel M, Aguilar M, Nelson MD, Moats R, Coates TD. Physiology and pathophysiology of iron cardiomyopathy in thalassemia. Ann N Y Acad Sci. 2005; 1054:386-95. PMID: 16339687; PMCID: PMC2892916.
      44. Reynolds CP, Sun BC, DeClerck YA, Moats R. Assessing growth and response to therapy in murine tumor models. Methods Mol Med. 2005; 111:335-50. PMID: 15911989.
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      45. Chen X, Conti PS, Moats R. In vivo near-infrared fluorescence imaging of integrin alphavbeta3 in brain tumor xenografts. Cancer Res. 2004 Nov 01; 64(21):8009-14. PMID: 15520209.
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      46. Chen X, Park R, Shahinian AH, Tohme M, Khankaldyyan V, Bozorgzadeh MH, Bading JR, Moats R, Laug WE, Conti PS. 18F-labeled RGD peptide: initial evaluation for imaging brain tumor angiogenesis. Nucl Med Biol. 2004 Feb; 31(2):179-89. PMID: 15013483.
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      47. Brumm VL, Azen C, Moats R, Stern AM, Broomand C, Nelson MD, Koch R. Neuropsychological outcome of subjects participating in the PKU adult collaborative study: a preliminary review. J Inherit Metab Dis. 2004; 27(5):549-66. PMID: 15669671.
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      48. Moats R, Moseley KD, Koch R, Nelson M. Brain phenylalanine concentrations in phenylketonuria: research and treatment of adults. Pediatrics. 2003 Dec; 112(6 Pt 2):1575-9. PMID: 14654668.
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      49. Moats R, Velan-Mullan S, Jacobs R, Gonzalez-Gomez I, Dubowitz DJ, Taga T, Khankaldyyan V, Schultz L, Fraser S, Nelson MD, Laug WE. Micro-MRI at 11.7 T of a murine brain tumor model using delayed contrast enhancement. Mol Imaging. 2003 Jul; 2(3):150-8. PMID: 14649058.
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      50. Koch R, Moseley KD, Yano S, Nelson M, Moats R. Large neutral amino acid therapy and phenylketonuria: a promising approach to treatment. Mol Genet Metab. 2003 Jun; 79(2):110-3. PMID: 12809641.
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      51. Burgos JS, Rosol M, Moats R, Khankaldyyan V, Kohn DB, Nelson MD, Laug WE. Time course of bioluminescent signal in orthotopic and heterotopic brain tumors in nude mice. Biotechniques. 2003 Jun; 34(6):1184-8. PMID: 12813886.
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      52. Koch R, Moseley KD, Moats R, Yano S, Matalon R, Guttler F. Danger of high-protein dietary supplements to persons with hyperphenylalaninaemia. J Inherit Metab Dis. 2003; 26(4):339-42. PMID: 12971421.
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      53. Zhang X, Kuroda S, Carpenter D, Nishimura I, Soo C, Moats R, Iida K, Wisner E, Hu FY, Miao S, Beanes S, Dang C, Vastardis H, Longaker M, Tanizawa K, Kanayama N, Saito N, Ting K. Craniosynostosis in transgenic mice overexpressing Nell-1. J Clin Invest. 2002 Sep; 110(6):861-70. PMID: 12235118; PMCID: PMC151127.
      54. Koch R, Moats R, Guttler F, Guldberg P, Nelson M. Blood-brain phenylalanine relationships in persons with phenylketonuria. Pediatrics. 2000 Nov; 106(5):1093-6. PMID: 11061780.
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      55. Dubowitz DJ, Tyszka JM, Sewry CA, Moats R, Scadeng M, Dubowitz V. High resolution magnetic resonance imaging of the brain in the dy/dy mouse with merosin-deficient congenital muscular dystrophy. Neuromuscul Disord. 2000 Jun; 10(4-5):292-8. PMID: 10838257.
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      56. Louie AY, Hüber MM, Ahrens ET, Rothbächer U, Moats R, Jacobs RE, Fraser SE, Meade TJ. In vivo visualization of gene expression using magnetic resonance imaging. Nat Biotechnol. 2000 Mar; 18(3):321-5. PMID: 10700150.
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      57. Moats R, Koch R, Moseley K, Guldberg P, Guttler F, Boles RG, Nelson MD. Brain phenylalanine concentration in the management of adults with phenylketonuria. J Inherit Metab Dis. 2000 Feb; 23(1):7-14. PMID: 10682303.
        View in: PubMed
      58. Moats R, Ma LQ, Wajed R, Sugiura Y, Lazaryev A, Tyszka M, Jacobs R, Fraser S, Nelson MD, DeClerck YA. Magnetic resonance imaging for the evaluation of a novel metastatic orthotopic model of human neuroblastoma in immunodeficient mice. Clin Exp Metastasis. 2000; 18(6):455-61. PMID: 11592302.
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      59. Hoang TQ, Bluml S, Dubowitz DJ, Moats R, Kopyov O, Jacques D, Ross BD. Quantitative proton-decoupled 31P MRS and 1H MRS in the evaluation of Huntington's and Parkinson's diseases. Neurology. 1998 Apr; 50(4):1033-40. PMID: 9566391.
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      60. Moats R, Shonk T. Evaluation of automated MR spectroscopy: application in Alzheimer disease. AJNR Am J Neuroradiol. 1995 Oct; 16(9):1779-82. PMID: 8693974.
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      61. Moats R, Watson L, Shonk T, Tokuyama S, Braslau D, Eto R, Mandigo JC, Ross BD. Added value of automated clinical proton MR spectroscopy of the brain. J Comput Assist Tomogr. 1995 May-Jun; 19(3):480-91. PMID: 7790562.
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      62. Shonk TK, Moats R, Gifford P, Michaelis T, Mandigo JC, Izumi J, Ross BD. Probable Alzheimer disease: diagnosis with proton MR spectroscopy. Radiology. 1995 Apr; 195(1):65-72. PMID: 7892497.
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      63. Ross BD, Jacobson S, Villamil F, Korula J, Kreis R, Ernst T, Shonk T, Moats R. Subclinical hepatic encephalopathy: proton MR spectroscopic abnormalities. Radiology. 1994 Nov; 193(2):457-63. PMID: 7972763.
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      64. Moats R, Ernst T, Shonk TK, Ross BD. Abnormal cerebral metabolite concentrations in patients with probable Alzheimer disease. Magn Reson Med. 1994 Jul; 32(1):110-5. PMID: 8084225.
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      65. Webb PG, Sailasuta N, Kohler SJ, Raidy T, Moats R, Hurd RE. Automated single-voxel proton MRS: technical development and multisite verification. Magn Reson Med. 1994 Apr; 31(4):365-73. PMID: 8208111.
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      66. Moats R, Lien YH, Filippi D, Ross BD. Decrease in cerebral inositols in rats and humans. Biochem J. 1993 Oct 01; 295 ( Pt 1):15-8. PMID: 8216210; PMCID: PMC1134813.
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