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    Rayudu Gopalakrishna, PhD

    TitleAssociate Professor of Integrative Anatomical Sciences
    SchoolKeck School of Medicine of USC
    DepartmentIntegrative Anatomical Sciences
    AddressBMT 306 A 1333 San Pablo Street
    Health Sciences Campus
    Los Angeles California 90089
    Phone+1 323 442 1770
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      Collapse Overview 

      Collapse Biography 
      Collapse Education and Training
      Andhra University, Visakhapatnam, IndiaB.S.09/1973Biology
      Andhra University, Visakhapatnam, IndiaM.S.09/1975Biochemistry
      University of Madras, Chennai, IndiaPh.D.08/1979Biochemistry
      University of Madras, Chennai, IndiaPost-doc12/1981Biochemistry
      National Cancer Institute, NIH, Bethesda, MDPost-doc11/1983Pathophysiology
      Collapse Awards and Honors
      National Cancer Institute, NIH1988  - 1993FIRST Award
      Keck School of Medicine of USC1995Excellence in Teaching Certificate
      Keck School of Medicine of USC1996Outstanding Teaching Award (year II med))
      Keck School of Medicine of USC2000Outstanding Teaching Award (year II med)
      Keck School of Medicine of USC2003Outstanding Teaching Award (year I med)
      Keck School of Medicine of USC2004Outstanding teaching Award (year II med)
      Keck School of Medicine of USC2006Outstanding Teaching Award (Year I med)
      Keck School of Medicine of USC2008Outstanding Teaching Award (Year II med)
      Keck School of Medicine of USC2008Master Teacher
      Alpha Omega Alpha2010Membership
      Keck School of Medicine of USC2011Outstanding Teaching Award (Year I med)
      Keck School of Medicine of USC2014Outstanding Teaching Award (Year I med)
      Keck School of Medicine of USC2014Outstanding Teaching Award (Year II med)

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Fan TK, Gundimeda U, Mack WJ, Gopalakrishna R. Counteraction of Nogo-A and axonal growth inhibitors by green tea polyphenols and other natural products. Neural Regen Res. 2016 Apr; 11(4):545-6. PMID: 27212904.
        View in: PubMed
      2. Gundimeda U, McNeill TH, Barseghian BA, Tzeng WS, Rayudu DV, Cadenas E, Gopalakrishna R. Polyphenols from green tea prevent antineuritogenic action of Nogo-A via 67-kDa laminin receptor and hydrogen peroxide. J Neurochem. 2015 Jan; 132(1):70-84. PMID: 25314656.
        View in: PubMed
      3. Gundimeda U, McNeill TH, Fan TK, Deng R, Rayudu D, Chen Z, Cadenas E, Gopalakrishna R. Green tea catechins potentiate the neuritogenic action of brain-derived neurotrophic factor: Role of 67-kDa laminin receptor and hydrogen peroxide. Biochem Biophys Res Commun. 2014 Feb 28; 445(1):218-24. PMID: 24508265.
        View in: PubMed
      4. Gopalakrishna R, McNeill TH, Elhiani AA, Gundimeda U. Methods for studying oxidative regulation of protein kinase C. Methods Enzymol. 2013; 528:79-98. PMID: 23849860.
        View in: PubMed
      5. Gundimeda U, McNeill TH, Elhiani AA, Schiffman JE, Hinton DR, Gopalakrishna R. Green Tea Polyphenols Precondition against Cell Death Induced by Oxygen-Glucose Deprivation via Stimulation of Laminin Receptor, Generation of Reactive Oxygen Species, and Activation of Protein Kinase C{epsilon}. J Biol Chem. 2012 Oct 5; 287(41):34694-708. PMID: 22879598.
        View in: PubMed
      6. Gundimeda U, McNeill TH, Schiffman JE, Hinton DR, Gopalakrishna R. Green tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: possible role of reactive oxygen species. J Neurosci Res. 2010 Dec; 88(16):3644-55. PMID: 20936703.
        View in: PubMed
      7. Gundimeda U, Schiffman JE, Gottlieb SN, Roth BI, Gopalakrishna R. Negation of the cancer-preventive actions of selenium by over-expression of protein kinase Cepsilon and selenoprotein thioredoxin reductase. Carcinogenesis. 2009 Sep; 30(9):1553-61. PMID: 19578042.
        View in: PubMed
      8. Gundimeda U, Schiffman JE, Chhabra D, Wong J, Wu A, Gopalakrishna R. Locally generated methylseleninic acid induces specific inactivation of protein kinase C isoenzymes: relevance to selenium-induced apoptosis in prostate cancer cells. J Biol Chem. 2008 Dec 12; 283(50):34519-31. PMID: 18922790.
        View in: PubMed
      9. Gopalakrishna R, Gundimeda U, Schiffman JE, McNeill TH. A direct redox regulation of protein kinase C isoenzymes mediates oxidant-induced neuritogenesis in PC12 cells. J Biol Chem. 2008 May 23; 283(21):14430-44. PMID: 18375950.
        View in: PubMed
      10. Cordey M, Gundimeda U, Gopalakrishna R, Pike CJ. The synthetic estrogen 4-estren-3 alpha,17 beta-diol (estren) induces estrogen-like neuroprotection. Neurobiol Dis. 2005 Jun-Jul; 19(1-2):331-9. PMID: 15837589.
        View in: PubMed
      11. Cordey M, Gundimeda U, Gopalakrishna R, Pike CJ. Estrogen activates protein kinase C in neurons: role in neuroprotection. J Neurochem. 2003 Mar; 84(6):1340-8. PMID: 12614334.
        View in: PubMed
      12. Gopalakrishna R, Gundimeda U. Antioxidant regulation of protein kinase C in cancer prevention. J Nutr. 2002 Dec; 132(12):3819S-3823S. PMID: 12468631.
        View in: PubMed
      13. Gopalakrishna R, Gundimeda U. Protein kinase C as a molecular target for cancer prevention by selenocompounds. Nutr Cancer. 2001; 40(1):55-63. PMID: 11799924.
        View in: PubMed
      14. Gopalakrishna R, Jaken S. Protein kinase C signaling and oxidative stress. Free Radic Biol Med. 2000 May 1; 28(9):1349-61. PMID: 10924854.
        View in: PubMed
      15. Gopalakrishna R, Gundimeda U, Anderson WB, Colburn NH, Slaga TJ. Tumor promoter benzoyl peroxide induces sulfhydryl oxidation in protein kinase C: its reversibility is related to the cellular resistance to peroxide-induced cytotoxicity. Arch Biochem Biophys. 1999 Mar 15; 363(2):246-58. PMID: 10068446.
        View in: PubMed
      16. Gopalakrishna R, Gundimeda U, Fontana JA, Clarke R. Differential distribution of protein phosphatase 2A in human breast carcinoma cell lines and its relation to estrogen receptor status. Cancer Lett. 1999 Mar 1; 136(2):143-51. PMID: 10355743.
        View in: PubMed
      17. Kaul N, Gopalakrishna R, Gundimeda U, Choi J, Forman HJ. Role of protein kinase C in basal and hydrogen peroxide-stimulated NF-kappa B activation in the murine macrophage J774A.1 cell line. Arch Biochem Biophys. 1998 Feb 1; 350(1):79-86. PMID: 9466823.
        View in: PubMed
      18. Gopalakrishna R, Chen ZH, Gundimeda U. Selenocompounds induce a redox modulation of protein kinase C in the cell, compartmentally independent from cytosolic glutathione: its role in inhibition of tumor promotion. Arch Biochem Biophys. 1997 Dec 1; 348(1):37-48. PMID: 9390172.
        View in: PubMed
      19. Gopalakrishna R, Gundimeda U, Chen ZH. Cancer-preventive selenocompounds induce a specific redox modification of cysteine-rich regions in Ca(2+)-dependent isoenzymes of protein kinase C. Arch Biochem Biophys. 1997 Dec 1; 348(1):25-36. PMID: 9390171.
        View in: PubMed
      20. Kimura H, Harris MS, Sakamoto T, Gopalakrishna R, Gundimeda U, Cui JZ, Spee C, Hinton DR, Ryan SJ. Hypericin inhibits choroidal endothelial cell proliferation and cord formation in vitro. Curr Eye Res. 1997 Oct; 16(10):967-72. PMID: 9330847.
        View in: PubMed
      21. Hamilton HB, Hinton DR, Law RE, Gopalakrishna R, Su YZ, Chen ZH, Weiss MH, Couldwell WT. Inhibition of cellular growth and induction of apoptosis in pituitary adenoma cell lines by the protein kinase C inhibitor hypericin: potential therapeutic application. J Neurosurg. 1996 Aug; 85(2):329-34. PMID: 8755764.
        View in: PubMed
      22. Gundimeda U, Chen ZH, Gopalakrishna R. Tamoxifen modulates protein kinase C via oxidative stress in estrogen receptor-negative breast cancer cells. J Biol Chem. 1996 Jun 7; 271(23):13504-14. PMID: 8662863.
        View in: PubMed
      23. Zhang W, Anker L, Law RE, Hinton DR, Gopalakrishna R, Pu Q, Gundimeda U, Weiss MH, Couldwell WT. Enhancement of radiosensitivity in human malignant glioma cells by hypericin in vitro. Clin Cancer Res. 1996 May; 2(5):843-6. PMID: 9816239.
        View in: PubMed
      24. Sippy BD, Hofman FM, Wright AD, Wang JL, Gopalakrishna R, Gundimeda U, He S, Ryan SJ, Hinton DR. Induction of intercellular adhesion molecule-1 by tumor necrosis factor-alpha through the 55-kDa receptor is dependent on protein kinase C in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 1996 Mar; 37(4):597-606. PMID: 8595959.
        View in: PubMed
      25. Couldwell WT, Law RE, Hinton DR, Gopalakrishna R, Yong VW, Weiss MH. Protein kinase C and growth regulation of pituitary adenomas. Acta Neurochir Suppl. 1996; 65:22-6. PMID: 8738488.
        View in: PubMed
      26. Sweetman LL, Zhang NY, Peterson H, Gopalakrishna R, Sevanian A. Effect of linoleic acid hydroperoxide on endothelial cell calcium homeostasis and phospholipid hydrolysis. Arch Biochem Biophys. 1995 Oct 20; 323(1):97-107. PMID: 7487079.
        View in: PubMed
      27. Gopalakrishna R, Chen ZH, Gundimeda U. Modifications of cysteine-rich regions in protein kinase C induced by oxidant tumor promoters and enzyme-specific inhibitors. Methods Enzymol. 1995; 252:132-46. PMID: 7476346.
        View in: PubMed
      28. Gopalakrishna R, Chen ZH, Gundimeda U. Tobacco smoke tumor promoters, catechol and hydroquinone, induce oxidative regulation of protein kinase C and influence invasion and metastasis of lung carcinoma cells. Proc Natl Acad Sci U S A. 1994 Dec 6; 91(25):12233-7. PMID: 7991611.
        View in: PubMed
      29. Sheu SJ, Sakamoto T, Osusky R, Wang HM, Ogden TE, Ryan SJ, Hinton DR, Gopalakrishna R. Transforming growth factor-beta regulates human retinal pigment epithelial cell phagocytosis by influencing a protein kinase C-dependent pathway. Graefes Arch Clin Exp Ophthalmol. 1994 Nov; 232(11):695-701. PMID: 7531168.
        View in: PubMed
      30. Couldwell WT, Gopalakrishna R, Hinton DR, He S, Weiss MH, Law RE, Apuzzo ML, Law RE. Hypericin: a potential antiglioma therapy. Neurosurgery. 1994 Oct; 35(4):705-9; discussion 709-10. PMID: 7808614.
        View in: PubMed
      31. Gopalakrishna R, Chen ZH, Gundimeda U. Nitric oxide and nitric oxide-generating agents induce a reversible inactivation of protein kinase C activity and phorbol ester binding. J Biol Chem. 1993 Dec 25; 268(36):27180-5. PMID: 8262958.
        View in: PubMed
      32. Gopalakrishna R, Gundimeda U, Wilson JC, Chen ZH. Multiwell filtration assay for rapid determination of protein phosphatase activity. Anal Biochem. 1993 Jul; 212(1):296-9. PMID: 8396364.
        View in: PubMed
      33. Gundimeda U, Hara SK, Anderson WB, Gopalakrishna R. Retinoids inhibit the oxidative modification of protein kinase C induced by oxidant tumor promoters. Arch Biochem Biophys. 1993 Jan; 300(1):526-30. PMID: 8424690.
        View in: PubMed
      34. Gopalakrishna R, Chen ZH, Gundimeda U. Nonphorbol tumor promoters okadaic acid and calyculin-A induce membrane translocation of protein kinase C. Biochem Biophys Res Commun. 1992 Dec 15; 189(2):950-7. PMID: 1472068.
        View in: PubMed
      35. Gopalakrishna R, Chen ZH, Gundimeda U. Irreversible oxidative inactivation of protein kinase C by photosensitive inhibitor calphostin C. FEBS Lett. 1992 Dec 14; 314(2):149-54. PMID: 1281116.
        View in: PubMed
      36. Gopalakrishna R, Chen ZH, Gundimeda U, Wilson JC, Anderson WB. Rapid filtration assays for protein kinase C activity and phorbol ester binding using multiwell plates with fitted filtration discs. Anal Biochem. 1992 Oct; 206(1):24-35. PMID: 1456438.
        View in: PubMed
      37. Gopalakrishna R, Anderson WB. Reversible oxidative activation and inactivation of protein kinase C by the mitogen/tumor promoter periodate. Arch Biochem Biophys. 1991 Mar; 285(2):382-7. PMID: 1654774.
        View in: PubMed