Pinchas Cohen, MD

Title(s)Dean
SchoolSchool of Gerontology
AddressGER 103
University Park Campus
Los Angeles CA 90089-0191
Phone+1 213 740 1354
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    The University of Southern California and Buck Institute Nathan Shock Center
    NIH P30AG068345Sep 15, 2020 - May 31, 2025
    Role: Co-Principal Investigator
    Metformin-Regulated Mitochondrial Peptides and their Effects on Aging
    NIH R01AG069698Sep 15, 2020 - May 31, 2025
    Role: Principal Investigator
    Ethnic-specific Effects of Mitochondrial DNA Variants and Environmental Factors on Cognitive Functioning and Dementia
    NIH R01AG068405Aug 1, 2020 - Apr 30, 2025
    Role: Principal Investigator
    Ethnic-Specific Mitochondrial DNA Variations that Contribute to Dementia
    NIH R56AG062693Aug 15, 2019 - Jul 31, 2020
    Role: Principal Investigator
    Humanin is an AD resilience factor through its interaction with APOE4
    NIH RF1AG061834Sep 30, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Role of GPR120 and Macrophages in Dietary Omega-3 Fatty Acid Inhibition of Prostate Cancer
    NIH R01CA231219Sep 17, 2018 - Aug 31, 2023
    Role: Co-Principal Investigator
    Dietary Restriction, GH/IGF-1 & Mechanisms of Cellular Protection and Regeneration
    NIH P01AG055369Feb 15, 2018 - Jan 31, 2023
    Role: Co-Principal Investigator
    Plasma Mitochondrial Peptide Assays as Biomarkers of Environmental Toxin Exposure
    NIH R01ES020812Sep 19, 2011 - Jun 30, 2016
    Role: Principal Investigator
    Humanin and Type 2 Diabetes
    NIH R21DK089447Sep 1, 2011 - Aug 31, 2013
    Role: Co-Principal Investigator
    Novel Mitochondrially Encoded Peptides and Their Role in Health and Disease
    NIH R01GM090311Sep 30, 2009 - Mar 31, 2016
    Role: Principal Investigator
    A family of novel mitochondrially-encoded peptides and their role in aging
    NIH R01AG034430Jul 15, 2009 - Jun 30, 2014
    Role: Principal Investigator
    The Role of IGF2 in Fetal Growth Restriction
    NIH R01HD047013Jun 1, 2004 - Mar 31, 2010
    Role: Principal Investigator
    IGF-I: A Nutrition-Regulated Target in Prostate Cancer
    NIH R01CA100938Jun 13, 2003 - May 31, 2008
    Role: Principal Investigator
    Genomic and Non-Genomic Effects of IGFBP-3 on Apoptosis
    NIH R01AG020954Sep 30, 2001 - Aug 31, 2006
    Role: Principal Investigator
    IGF AXIS IN ASTHMA
    NIH R01AI040203Apr 1, 1998 - Mar 31, 2004
    Role: Principal Investigator
    IGF AXIS ABNORMALITIES IN BPH
    NIH R01DK047591Sep 30, 1993 - Aug 31, 2002
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration. Am J Physiol Endocrinol Metab. 2024 Mar 01; 326(3):E207-E214. Kumagai H, Kim SJ, Miller B, Natsume T, Wan J, Kumagai ME, Ramirez R, Lee SH, Sato A, Mehta HH, Yen K, Cohen P. PMID: 38170165.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. A naturally occurring variant of SHLP2 is a protective factor in Parkinson's disease. Mol Psychiatry. 2024 Jan 03. Kim SJ, Miller B, Hartel NG, Ramirez R, Braniff RG, Leelaprachakul N, Huang A, Wang Y, Arpawong TE, Crimmins EM, Wang P, Sun X, Liu C, Levy D, Yen K, Petzinger GM, Graham NA, Jakowec MW, Cohen P. PMID: 38167865.
      View in: PubMed   Mentions:    Fields:    
    3. Effect of omega-3 fatty acid diet on prostate cancer progression and cholesterol efflux in tumor-associated macrophages-dependence on GPR120. Prostate Cancer Prostatic Dis. 2023 Oct 23. Liang P, Henning SM, Grogan T, Elashoff D, Said J, Cohen P, Aronson WJ. PMID: 37872251.
      View in: PubMed   Mentions: 1     Fields:    
    4. Correction: Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE. Mol Psychiatry. 2023 Apr; 28(4):1827. Miller B, Kim SJ, Mehta HH, Cao K, Kumagai H, Thumaty N, Leelaprachakul N, Braniff RG, Jiao H, Vaughan J, Diedrich J, Saghatelian A, Arpawong TE, Crimmins EM, Ertekin-Taner N, Tubi MA, Hare ET, Braskie MN, Décarie-Spain L, Kanoski SE, Grodstein F, Bennett DA, Zhao L, Toga AW, Wan J, Yen K, Cohen P, Alzheimer’s Disease Neuroimaging Initiative. PMID: 36658336.
      View in: PubMed   Mentions:    Fields:    
    5. Novel Insights into Mitochondrial DNA: Mitochondrial Microproteins and mtDNA Variants Modulate Athletic Performance and Age-Related Diseases. Genes (Basel). 2023 01 21; 14(2). Kumagai H, Miller B, Kim SJ, Leelaprachakul N, Kikuchi N, Yen K, Cohen P. PMID: 36833212; PMCID: PMC9956216.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    6. Florida-California Cancer Research, Education and Engagement (CaRE2) Health Equity Center: Structure, Innovations, and Initial Outcomes. Cancer Control. 2023 Jan-Dec; 30:10732748231197878. Reams RR, Odedina FT, Carpten JD, Redda K, Stern MC, Krieger JL, Aparicio J, Hensel B, Askins N, Abreu A, Adams A, Agyare E, Ali J, Allen JM, Aló R, Baezconde-Garbanati L, Brant J, Brown CP, Buxbaum SG, Cohen P, Cozen W, Ezenwa MO, Falzarano S, Fillingim RB, Flores-Rozas H, Fredenburg KM, George T, Han B, Huang Y, Hughes Halbert C, Kiros GE, Lamango NS, Lee JH, Lyon DE, Mitchell DA, Mochona B, Nieva JJ, Offringa IA, Okunieff P, Parker A, Rhie SK, Richey JM, Rogers SC, Salhia B, Schmittgen TD, Segal R, Setiawan VW, Smith U, Su LM, Suther S, Trevino J, Velazquez-Villarreal EI, Webb FJ, Wu AH, Yao Y, Wilkie DJ. PMID: 37703814; PMCID: PMC10501072.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models. Cell Rep. 2022 09 27; 40(13):111417. Rangan P, Lobo F, Parrella E, Rochette N, Morselli M, Stephen TL, Cremonini AL, Tagliafico L, Persia A, Caffa I, Monacelli F, Odetti P, Bonfiglio T, Nencioni A, Pigliautile M, Boccardi V, Mecocci P, Pike CJ, Cohen P, LaDu MJ, Pellegrini M, Xia K, Tran K, Ann B, Chowdhury D, Longo VD. PMID: 36170815; PMCID: PMC9648488.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    8. Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE. Mol Psychiatry. 2023 04; 28(4):1813-1826. Miller B, Kim SJ, Mehta HH, Cao K, Kumagai H, Thumaty N, Leelaprachakul N, Braniff RG, Jiao H, Vaughan J, Diedrich J, Saghatelian A, Arpawong TE, Crimmins EM, Ertekin-Taner N, Tubi MA, Hare ET, Braskie MN, Décarie-Spain L, Kanoski SE, Grodstein F, Bennett DA, Zhao L, Toga AW, Wan J, Yen K, Cohen P, Alzheimer’s Disease Neuroimaging Initiative*. PMID: 36127429; PMCID: PMC10027624.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    9. Racial differences in circulating mitochondria-derived peptides may contribute to prostate cancer health disparities. Prostate. 2022 09; 82(13):1248-1257. Ramirez-Torres A, Reagan AL, Howard LE, Wiggins E, Vidal AC, Wan J, Miller B, Freedland SJ, Cohen P. PMID: 35789022; PMCID: PMC9388542.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    10. Effect of Humanin G (HNG) on inflammation in age-related macular degeneration (AMD). Aging (Albany NY). 2022 05 16; 14(10):4247-4269. Nashine S, Cohen P, Wan J, Kenney MC. PMID: 35576057; PMCID: PMC9186758.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    11. Mitochondria-derived peptides in aging and healthspan. J Clin Invest. 2022 05 02; 132(9). Miller B, Kim SJ, Kumagai H, Yen K, Cohen P. PMID: 35499074; PMCID: PMC9057581.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    12. Bladder cancer cells shift rapidly and spontaneously to cisplatin-resistant oxidative phosphorylation that is trackable in real time. Sci Rep. 2022 04 01; 12(1):5518. Xu T, Junge JA, Delfarah A, Lu YT, Arnesano C, Iqbal M, Delijani K, Hsieh TC, Hodara E, Mehta HH, Cohen P, Graham NA, Fraser SE, Goldkorn A. PMID: 35365706; PMCID: PMC8976067.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    13. Effects of dietary omega-3 fatty acids on orthotopic prostate cancer progression, tumor associated macrophages, angiogenesis and T-cell activation-dependence on GPR120. Prostate Cancer Prostatic Dis. 2022 09; 25(3):539-546. Liang P, Henning SM, Grogan T, Elashoff D, Ye H, Cohen P, Aronson WJ. PMID: 35075215; PMCID: PMC9308823.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    14. The MOTS-c K14Q polymorphism in the mtDNA is associated with muscle fiber composition and muscular performance. Biochim Biophys Acta Gen Subj. 2022 02; 1866(2):130048. Kumagai H, Natsume T, Kim SJ, Tobina T, Miyamoto-Mikami E, Shiose K, Ichinoseki-Sekine N, Kakigi R, Tsuzuki T, Miller B, Yen K, Murakami H, Miyachi M, Zempo H, Dobashi S, Machida S, Kobayashi H, Naito H, Cohen P, Fuku N. PMID: 34728329; PMCID: PMC8741734.
      View in: PubMed   Mentions: 4     Fields:    
    15. Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension. Biochim Biophys Acta Gen Subj. 2022 01; 1866(1):130017. Kim SJ, Devgan A, Miller B, Lee SM, Kumagai H, Wilson KA, Wassef G, Wong R, Mehta HH, Cohen P, Yen K. PMID: 34624450; PMCID: PMC8595716.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    16. Extending human healthspan and longevity: a symposium report. Ann N Y Acad Sci. 2022 01; 1507(1):70-83. DeVito LM, Barzilai N, Cuervo AM, Niedernhofer LJ, Milman S, Levine M, Promislow D, Ferrucci L, Kuchel GA, Mannick J, Justice J, Gonzales MM, Kirkland JL, Cohen P, Campisi J. PMID: 34498278; PMCID: PMC10231756.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    17. Plasma mitochondrial derived peptides MOTS-c and SHLP2 positively associate with android and liver fat in people without diabetes. Biochim Biophys Acta Gen Subj. 2021 11; 1865(11):129991. Sequeira IR, Woodhead JST, Chan A, D'Souza RF, Wan J, Hollingsworth KG, Plank LD, Cohen P, Poppitt SD, Merry TL. PMID: 34419510.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    18. Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors. Sci Rep. 2021 08 19; 11(1):16916. Dieli-Conwright CM, Sami N, Norris MK, Wan J, Kumagai H, Kim SJ, Cohen P. PMID: 34413391; PMCID: PMC8376922.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    19. Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans. J Appl Physiol (1985). 2021 09 01; 131(3):1035-1042. von Walden F, Fernandez-Gonzalo R, Norrbom J, Emanuelsson EB, Figueiredo VC, Gidlund EK, Norrbrand L, Liu C, Sandström P, Hansson B, Wan J, Cohen P, Alkner B. PMID: 34351816.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    20. The IL-27 component EBI-3 and its receptor subunit IL-27Rα are essential for the cytoprotective action of humanin on male germ cells†. Biol Reprod. 2021 03 11; 104(3):717-730. Jia Y, Swerdloff RS, Lue Y, Dai-Ju J, Surampudi P, Cohen P, Wang C. PMID: 33330922; PMCID: PMC8527998.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    21. MOTS-c reduces myostatin and muscle atrophy signaling. Am J Physiol Endocrinol Metab. 2021 04 01; 320(4):E680-E690. Kumagai H, Coelho AR, Wan J, Mehta HH, Yen K, Huang A, Zempo H, Fuku N, Maeda S, Oliveira PJ, Cohen P, Kim SJ. PMID: 33554779; PMCID: PMC8238132.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    22. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2021 01 20; 12(1):470. Reynolds JC, Lai RW, Woodhead JST, Joly JH, Mitchell CJ, Cameron-Smith D, Lu R, Cohen P, Graham NA, Benayoun BA, Merry TL, Lee C. PMID: 33473109; PMCID: PMC7817689.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    23. A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c. Aging (Albany NY). 2021 01 19; 13(2):1692-1717. Zempo H, Kim SJ, Fuku N, Nishida Y, Higaki Y, Wan J, Yen K, Miller B, Vicinanza R, Miyamoto-Mikami E, Kumagai H, Naito H, Xiao J, Mehta HH, Lee C, Hara M, Patel YM, Setiawan VW, Moore TM, Hevener AL, Sutoh Y, Shimizu A, Kojima K, Kinoshita K, Arai Y, Hirose N, Maeda S, Tanaka K, Cohen P. PMID: 33468709; PMCID: PMC7880332.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    24. Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples. Sci Rep. 2021 01 08; 11(1):3. Miller B, Silverstein A, Flores M, Cao K, Kumagai H, Mehta HH, Yen K, Kim SJ, Cohen P. PMID: 33420163; PMCID: PMC7794290.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    25. Nuclear-Encoded lncRNA MALAT1 Epigenetically Controls Metabolic Reprogramming in HCC Cells through the Mitophagy Pathway. Mol Ther Nucleic Acids. 2021 Mar 05; 23:264-276. Zhao Y, Zhou L, Li H, Sun T, Wen X, Li X, Meng Y, Li Y, Liu M, Liu S, Kim SJ, Xiao J, Li L, Zhang S, Li W, Cohen P, Hoffman AR, Hu JF, Cui J. PMID: 33425485; PMCID: PMC7773746.
      View in: PubMed   Mentions: 45  
    26. Mito-Omics and immune function: Applying novel mitochondrial omic techniques to the context of the aging immune system. Transl Med Aging. 2020; 4:132-140. Silverstein AR, Flores MK, Miller B, Kim SJ, Yen K, Mehta HH, Cohen P. PMID: 32844137; PMCID: PMC7441040.
      View in: PubMed   Mentions:
    27. The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan. Aging (Albany NY). 2020 06 23; 12(12):11185-11199. Yen K, Mehta HH, Kim SJ, Lue Y, Hoang J, Guerrero N, Port J, Bi Q, Navarrete G, Brandhorst S, Lewis KN, Wan J, Swerdloff R, Mattison JA, Buffenstein R, Breton CV, Wang C, Longo V, Atzmon G, Wallace D, Barzilai N, Cohen P. PMID: 32575074; PMCID: PMC7343442.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    28. A Mitochondrial Genome-Wide Association Study of Cataract in a Latino Population. Transl Vis Sci Technol. 2020 05; 9(6):25. Miller B, Torres M, Jiang X, McKean-Cowdin R, Nousome D, Kim SJ, Mehta HH, Yen K, Cohen P, Varma R. PMID: 32821522; PMCID: PMC7408807.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    29. Peptides derived from small mitochondrial open reading frames: Genomic, biological, and therapeutic implications. Exp Cell Res. 2020 08 15; 393(2):112056. Miller B, Kim SJ, Kumagai H, Mehta HH, Xiang W, Liu J, Yen K, Cohen P. PMID: 32387288; PMCID: PMC7778388.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    30. High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men. J Appl Physiol (1985). 2020 05 01; 128(5):1346-1354. Woodhead JST, D'Souza RF, Hedges CP, Wan J, Berridge MV, Cameron-Smith D, Cohen P, Hickey AJR, Mitchell CJ, Merry TL. PMID: 32271093; PMCID: PMC7717117.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    31. Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition. Aging (Albany NY). 2020 03 17; 12(6):5244-5258. D'Souza RF, Woodhead JST, Hedges CP, Zeng N, Wan J, Kumagai H, Lee C, Cohen P, Cameron-Smith D, Mitchell CJ, Merry TL. PMID: 32182209; PMCID: PMC7138593.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    32. Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective. Horm Res Paediatr. 2019; 92(1):1-14. Collett-Solberg PF, Ambler G, Backeljauw PF, Bidlingmaier M, Biller BMK, Boguszewski MCS, Cheung PT, Choong CSY, Cohen LE, Cohen P, Dauber A, Deal CL, Gong C, Hasegawa Y, Hoffman AR, Hofman PL, Horikawa R, Jorge AAL, Juul A, Kamenický P, Khadilkar V, Kopchick JJ, Kriström B, Lopes MLA, Luo X, Miller BS, Misra M, Netchine I, Radovick S, Ranke MB, Rogol AD, Rosenfeld RG, Saenger P, Wit JM, Woelfle J. PMID: 31514194; PMCID: PMC6979443.
      View in: PubMed   Mentions: 89     Fields:    Translation:Humans
    33. Effect of dietary omega-3 fatty acids on castrate-resistant prostate cancer and tumor-associated macrophages. Prostate Cancer Prostatic Dis. 2020 03; 23(1):127-135. Liang P, Henning SM, Guan J, Grogan T, Elashoff D, Cohen P, Aronson WJ. PMID: 31439889; PMCID: PMC7031053.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    34. The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity. Physiol Rep. 2019 07; 7(13):e14171. Kim SJ, Miller B, Mehta HH, Xiao J, Wan J, Arpawong TE, Yen K, Cohen P. PMID: 31293078; PMCID: PMC6640593.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    35. Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment. Metabolomics. 2019 06 06; 15(6):88. Mehta HH, Xiao J, Ramirez R, Miller B, Kim SJ, Cohen P, Yen K. PMID: 31172328; PMCID: PMC6554247.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    36. Effects of air pollution on mitochondrial function, mitochondrial DNA methylation, and mitochondrial peptide expression. Mitochondrion. 2019 05; 46:22-29. Breton CV, Song AY, Xiao J, Kim SJ, Mehta HH, Wan J, Yen K, Sioutas C, Lurmann F, Xue S, Morgan TE, Zhang J, Cohen P. PMID: 30980914; PMCID: PMC6506186.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    37. Comparing the Utility of Mitochondrial and Nuclear DNA to Adjust for Genetic Ancestry in Association Studies. Cells. 2019 04 03; 8(4). Miller B, Arpawong TE, Jiao H, Kim SJ, Yen K, Mehta HH, Wan J, Carpten JC, Cohen P. PMID: 30987182; PMCID: PMC6523867.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    38. GRSF1 is an age-related regulator of senescence. Sci Rep. 2019 04 03; 9(1):5546. Kim SJ, Chun M, Wan J, Lee C, Yen K, Cohen P. PMID: 30944385; PMCID: PMC6447602.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    39. MOTS-c: an equal opportunity insulin sensitizer. J Mol Med (Berl). 2019 04; 97(4):487-490. Kim SJ, Miller B, Kumagai H, Yen K, Cohen P. PMID: 30788534; PMCID: PMC6462348.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    40. Humanin is a novel regulator of Hedgehog signaling and prevents glucocorticoid-induced bone growth impairment. FASEB J. 2019 04; 33(4):4962-4974. Zaman F, Zhao Y, Celvin B, Mehta HH, Wan J, Chrysis D, Ohlsson C, Fadeel B, Cohen P, Sävendahl L. PMID: 30657335; PMCID: PMC6988867.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    41. Role of Host GPR120 in Mediating Dietary Omega-3 Fatty Acid Inhibition of Prostate Cancer. J Natl Cancer Inst. 2019 01 01; 111(1):52-59. Liang P, Henning SM, Guan J, Grogan T, Elashoff D, Olefsky JM, Cohen P, Aronson WJ. PMID: 30202902; PMCID: PMC6335116.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    42. Growth hormone therapy in children; research and practice - A review. Growth Horm IGF Res. 2019 02; 44:20-32. Collett-Solberg PF, Jorge AAL, Boguszewski MCS, Miller BS, Choong CSY, Cohen P, Hoffman AR, Luo X, Radovick S, Saenger P. PMID: 30605792.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    43. Mitochondrial biology and prostate cancer ethnic disparity. Carcinogenesis. 2018 12 13; 39(11):1311-1319. Xiao J, Cohen P, Stern MC, Odedina F, Carpten J, Reams R. PMID: 30304372; PMCID: PMC6292412.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    44. Characterizing the protective effects of SHLP2, a mitochondrial-derived peptide, in macular degeneration. Sci Rep. 2018 10 11; 8(1):15175. Nashine S, Cohen P, Nesburn AB, Kuppermann BD, Kenney MC. PMID: 30310092; PMCID: PMC6182005.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    45. Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans. Sci Rep. 2018 09 21; 8(1):14212. Yen K, Wan J, Mehta HH, Miller B, Christensen A, Levine ME, Salomon MP, Brandhorst S, Xiao J, Kim SJ, Navarrete G, Campo D, Harry GJ, Longo V, Pike CJ, Mack WJ, Hodis HN, Crimmins EM, Cohen P. PMID: 30242290; PMCID: PMC6154958.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    46. Chronic treatment with the mitochondrial peptide humanin prevents age-related myocardial fibrosis in mice. Am J Physiol Heart Circ Physiol. 2018 11 01; 315(5):H1127-H1136. Qin Q, Mehta H, Yen K, Navarrete G, Brandhorst S, Wan J, Delrio S, Zhang X, Lerman LO, Cohen P, Lerman A. PMID: 30004252; PMCID: PMC6415743.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    47. Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice. Nat Commun. 2018 06 19; 9(1):2394. Mao K, Quipildor GF, Tabrizian T, Novaj A, Guan F, Walters RO, Delahaye F, Hubbard GB, Ikeno Y, Ejima K, Li P, Allison DB, Salimi-Moosavi H, Beltran PJ, Cohen P, Barzilai N, Huffman DM. PMID: 29921922; PMCID: PMC6008442.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    48. Mitochondrial peptides modulate mitochondrial function during cellular senescence. Aging (Albany NY). 2018 Jun 10; 10(6):1239-1256. Kim SJ, Mehta HH, Wan J, Kuehnemann C, Chen J, Hu JF, Hoffman AR, Cohen P. PMID: 29886458; PMCID: PMC6046248.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    49. The Oxygen Paradox, the French Paradox, and age-related diseases. Geroscience. 2017 12; 39(5-6):499-550. Davies JMS, Cillard J, Friguet B, Cadenas E, Cadet J, Cayce R, Fishmann A, Liao D, Bulteau AL, Derbré F, Rébillard A, Burstein S, Hirsch E, Kloner RA, Jakowec M, Petzinger G, Sauce D, Sennlaub F, Limon I, Ursini F, Maiorino M, Economides C, Pike CJ, Cohen P, Salvayre AN, Halliday MR, Lundquist AJ, Jakowec NA, Mechta-Grigoriou F, Mericskay M, Mariani J, Li Z, Huang D, Grant E, Forman HJ, Finch CE, Sun PY, Pomatto LCD, Agbulut O, Warburton D, Neri C, Rouis M, Cillard P, Capeau J, Rosenbaum J, Davies KJA. PMID: 29270905; PMCID: PMC5745211.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    50. Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction. Int J Cardiol. 2018 03 01; 254:23-27. Qin Q, Delrio S, Wan J, Jay Widmer R, Cohen P, Lerman LO, Lerman A. PMID: 29242099.
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    51. Phase II prospective randomized trial of weight loss prior to radical prostatectomy. Prostate Cancer Prostatic Dis. 2018 06; 21(2):212-220. Henning SM, Galet C, Gollapudi K, Byrd JB, Liang P, Li Z, Grogan T, Elashoff D, Magyar CE, Said J, Cohen P, Aronson WJ. PMID: 29203893; PMCID: PMC5986584.
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    52. Subcellular Fractionation for ERK Activation Upon Mitochondrial-derived Peptide Treatment. J Vis Exp. 2017 09 25; (127). Kim SJ, Xiao J, Cohen P, Yen K. PMID: 28994791; PMCID: PMC5752322.
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    53. Low circulating levels of the mitochondrial-peptide hormone SHLP2: novel biomarker for prostate cancer risk. Oncotarget. 2017 Nov 07; 8(55):94900-94909. Xiao J, Howard L, Wan J, Wiggins E, Vidal A, Cohen P, Freedland SJ. PMID: 29212276; PMCID: PMC5706922.
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    54. The Mitochondrial-Derived Peptides, HumaninS14G and Small Humanin-like Peptide 2, Exhibit Chaperone-like Activity. Sci Rep. 2017 08 10; 7(1):7802. Okada AK, Teranishi K, Lobo F, Isas JM, Xiao J, Yen K, Cohen P, Langen R. PMID: 28798389; PMCID: PMC5552803.
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    55. Feeling misguided: a comment on the US guidelines on growth hormone and insulin-like growth factor-I treatment in children and adolescents. Curr Opin Pediatr. 2017 08; 29(4):472-474. Saenger P, Cohen P. PMID: 28604412.
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    56. Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage. Cell Death Dis. 2017 07 20; 8(7):e2951. Nashine S, Cohen P, Chwa M, Lu S, Nesburn AB, Kuppermann BD, Kenney MC. PMID: 28726777; PMCID: PMC5550888.
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    57. Mitochondrially derived peptides as novel regulators of metabolism. J Physiol. 2017 11 01; 595(21):6613-6621. Kim SJ, Xiao J, Wan J, Cohen P, Yen K. PMID: 28574175; PMCID: PMC5663826.
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    58. The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature. Sci Adv. 2017 06; 3(6):e1602025. Ben-Avraham D, Govindaraju DR, Budagov T, Fradin D, Durda P, Liu B, Ott S, Gutman D, Sharvit L, Kaplan R, Bougnères P, Reiner A, Shuldiner AR, Cohen P, Barzilai N, Atzmon G. PMID: 28630896; PMCID: PMC5473676.
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    59. Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production. Cell Metab. 2017 Jun 06; 25(6):1320-1333.e5. Hine C, Kim HJ, Zhu Y, Harputlugil E, Longchamp A, Matos MS, Ramadoss P, Bauerle K, Brace L, Asara JM, Ozaki CK, Cheng SY, Singha S, Ahn KH, Kimmelman A, Fisher FM, Pissios P, Withers DJ, Selman C, Wang R, Yen K, Longo VD, Cohen P, Bartke A, Kopchick JJ, Miller R, Hollenberg AN, Mitchell JR. PMID: 28591635; PMCID: PMC5722247.
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    60. Mitochondrial DNA Hypomethylation Is a Biomarker Associated with Induced Senescence in Human Fetal Heart Mesenchymal Stem Cells. Stem Cells Int. 2017; 2017:1764549. Yu D, Du Z, Pian L, Li T, Wen X, Li W, Kim SJ, Xiao J, Cohen P, Cui J, Hoffman AR, Hu JF. PMID: 28484495; PMCID: PMC5397648.
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    61. Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes. Cell. 2017 02 23; 168(5):775-788.e12. Cheng CW, Villani V, Buono R, Wei M, Kumar S, Yilmaz OH, Cohen P, Sneddon JB, Perin L, Longo VD. PMID: 28235195; PMCID: PMC5357144.
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    62. Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Sci Transl Med. 2017 02 15; 9(377). Wei M, Brandhorst S, Shelehchi M, Mirzaei H, Cheng CW, Budniak J, Groshen S, Mack WJ, Guen E, Di Biase S, Cohen P, Morgan TE, Dorff T, Hong K, Michalsen A, Laviano A, Longo VD. PMID: 28202779; PMCID: PMC6816332.
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    63. Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice. Sci Rep. 2017 02 01; 7:40919. Lee AS, Brandhorst S, Rangel DF, Navarrete G, Cohen P, Longo VD, Chen J, Groshen S, Morgan TE, Dubeau L. PMID: 28145503; PMCID: PMC5286507.
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    64. Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione. PLoS One. 2016; 11(10):e0165150. Matsunaga D, Sreekumar PG, Ishikawa K, Terasaki H, Barron E, Cohen P, Kannan R, Hinton DR. PMID: 27783653; PMCID: PMC5081188.
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    65. Lower circulating insulin-like growth factor-I is associated with better cognition in females with exceptional longevity without compromise to muscle mass and function. Aging (Albany NY). 2016 10 14; 8(10):2414-2424. Perice L, Barzilai N, Verghese J, Weiss EF, Holtzer R, Cohen P, Milman S. PMID: 27744417; PMCID: PMC5115897.
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    66. The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus. Oncotarget. 2016 Jul 26; 7(30):46899-46912. Kim SJ, Guerrero N, Wassef G, Xiao J, Mehta HH, Cohen P, Yen K. PMID: 27384491; PMCID: PMC5216912.
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    67. Effect of Dietary Omega-3 Fatty Acids on Tumor-Associated Macrophages and Prostate Cancer Progression. Prostate. 2016 10; 76(14):1293-302. Liang P, Henning SM, Schokrpur S, Wu L, Doan N, Said J, Grogan T, Elashoff D, Cohen P, Aronson WJ. PMID: 27338236; PMCID: PMC5081258.
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    68. Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. Cell Metab. 2016 06 14; 23(6):1093-1112. Mitchell SJ, Madrigal-Matute J, Scheibye-Knudsen M, Fang E, Aon M, González-Reyes JA, Cortassa S, Kaushik S, Gonzalez-Freire M, Patel B, Wahl D, Ali A, Calvo-Rubio M, Burón MI, Guiterrez V, Ward TM, Palacios HH, Cai H, Frederick DW, Hine C, Broeskamp F, Habering L, Dawson J, Beasley TM, Wan J, Ikeno Y, Hubbard G, Becker KG, Zhang Y, Bohr VA, Longo DL, Navas P, Ferrucci L, Sinclair DA, Cohen P, Egan JM, Mitchell JR, Baur JA, Allison DB, Anson RM, Villalba JM, Madeo F, Cuervo AM, Pearson KJ, Ingram DK, Bernier M, de Cabo R. PMID: 27304509; PMCID: PMC4911707.
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    69. Safety and feasibility of fasting in combination with platinum-based chemotherapy. BMC Cancer. 2016 06 10; 16:360. Dorff TB, Groshen S, Garcia A, Shah M, Tsao-Wei D, Pham H, Cheng CW, Brandhorst S, Cohen P, Wei M, Longo V, Quinn DI. PMID: 27282289; PMCID: PMC4901417.
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    70. MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radic Biol Med. 2016 11; 100:182-187. Lee C, Kim KH, Cohen P. PMID: 27216708; PMCID: PMC5116416.
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    71. Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers. Aging (Albany NY). 2016 04; 8(4):796-809. Cobb LJ, Lee C, Xiao J, Yen K, Wong RG, Nakamura HK, Mehta HH, Gao Q, Ashur C, Huffman DM, Wan J, Muzumdar R, Barzilai N, Cohen P. PMID: 27070352; PMCID: PMC4925829.
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    72. Growth Hormone Research Society perspective on the development of long-acting growth hormone preparations. Eur J Endocrinol. 2016 Jun; 174(6):C1-8. Christiansen JS, Backeljauw PF, Bidlingmaier M, Biller BM, Boguszewski MC, Casanueva FF, Chanson P, Chatelain P, Choong CS, Clemmons DR, Cohen LE, Cohen P, Frystyk J, Grimberg A, Hasegawa Y, Haymond MW, Ho K, Hoffman AR, Holly JM, Horikawa R, Höybye C, Jorgensen JO, Johannsson G, Juul A, Katznelson L, Kopchick JJ, Lee KO, Lee KW, Luo X, Melmed S, Miller BS, Misra M, Popovic V, Rosenfeld RG, Ross J, Ross RJ, Saenger P, Strasburger CJ, Thorner MO, Werner H, Yuen K. PMID: 27009113; PMCID: PMC5081743.
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    73. The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction. Invest Ophthalmol Vis Sci. 2016 Mar; 57(3):1238-53. Sreekumar PG, Ishikawa K, Spee C, Mehta HH, Wan J, Yen K, Cohen P, Kannan R, Hinton DR. PMID: 26990160; PMCID: PMC4811181.
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    74. Central insulin-like growth factor-1 (IGF-1) restores whole-body insulin action in a model of age-related insulin resistance and IGF-1 decline. Aging Cell. 2016 Feb; 15(1):181-6. Huffman DM, Farias Quipildor G, Mao K, Zhang X, Wan J, Apontes P, Cohen P, Barzilai N. PMID: 26534869; PMCID: PMC4717281.
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    75. The Potent Humanin Analogue (HNG) Protects Germ Cells and Leucocytes While Enhancing Chemotherapy-Induced Suppression of Cancer Metastases in Male Mice. Endocrinology. 2015 Dec; 156(12):4511-21. Lue Y, Swerdloff R, Wan J, Xiao J, French S, Atienza V, Canela V, Bruhn KW, Stone B, Jia Y, Cohen P, Wang C. PMID: 26384090; PMCID: PMC4655208.
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    76. Status of long-acting-growth hormone preparations--2015. Growth Horm IGF Res. 2015 Oct; 25(5):201-6. Høybye C, Cohen P, Hoffman AR, Ross R, Biller BM, Christiansen JS, Growth Hormone Research Society. PMID: 26187188.
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    77. Rat Humanin is encoded and translated in mitochondria and is localized to the mitochondrial compartment where it regulates ROS production. Mol Cell Endocrinol. 2015 Sep 15; 413:96-100. Paharkova V, Alvarez G, Nakamura H, Cohen P, Lee KW. PMID: 26116236.
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    78. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab. 2015 Jul 07; 22(1):86-99. Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo VD. PMID: 26094889; PMCID: PMC4509734.
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    79. The effects of humanin and its analogues on male germ cell apoptosis induced by chemotherapeutic drugs. Apoptosis. 2015 Apr; 20(4):551-61. Jia Y, Ohanyan A, Lue YH, Swerdloff RS, Liu PY, Cohen P, Wang C. PMID: 25666707; PMCID: PMC4351164.
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    80. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015 Mar 03; 21(3):443-54. Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P. PMID: 25738459; PMCID: PMC4350682.
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    81. The effect of sex on humanin levels in healthy adults and patients with uncomplicated type 1 diabetes mellitus. Can J Physiol Pharmacol. 2015 Apr; 93(4):239-43. Lytvyn Y, Wan J, Lai V, Cohen P, Cherney DZ. PMID: 25615723.
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    82. IGF-I regulates the age-dependent signaling peptide humanin. Aging Cell. 2014 Oct; 13(5):958-61. Lee C, Wan J, Miyazaki B, Fang Y, Guevara-Aguirre J, Yen K, Longo V, Bartke A, Cohen P. PMID: 25040290; PMCID: PMC4172517.
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    83. IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in mice. J Endocrinol. 2014 Apr; 221(1):145-55. Moody G, Beltran PJ, Mitchell P, Cajulis E, Chung YA, Hwang D, Kendall R, Radinsky R, Cohen P, Calzone FJ. PMID: 24492468; PMCID: PMC4160154.
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    84. Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity. Aging Cell. 2014 Aug; 13(4):769-71. Milman S, Atzmon G, Huffman DM, Wan J, Crandall JP, Cohen P, Barzilai N. PMID: 24618355; PMCID: PMC4116456.
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    85. Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab. 2014 Mar 04; 19(3):407-17. Levine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, Longo VD. PMID: 24606898; PMCID: PMC3988204.
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    86. New role for the mitochondrial peptide humanin: protective agent against chemotherapy-induced side effects. J Natl Cancer Inst. 2014 Mar; 106(3):dju006. Cohen P. PMID: 24586106; PMCID: PMC3982780.
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    87. Dose-sparing and safety-enhancing effects of an IGF-I-based dosing regimen in short children treated with growth hormone in a 2-year randomized controlled trial: therapeutic and pharmacoeconomic considerations. Clin Endocrinol (Oxf). 2014 Jul; 81(1):71-6. Cohen P, Weng W, Rogol AD, Rosenfeld RG, Kappelgaard AM, Germak J. PMID: 24428305; PMCID: PMC4160145.
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    88. Pharmacokinetics and tissue distribution of humanin and its analogues in male rodents. Endocrinology. 2013 Oct; 154(10):3739-44. Chin YP, Keni J, Wan J, Mehta H, Anene F, Jia Y, Lue YH, Swerdloff R, Cobb LJ, Wang C, Cohen P. PMID: 23836030; PMCID: PMC3776863.
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    89. Effects of calorie restriction and IGF-1 receptor blockade on the progression of 22Rv1 prostate cancer xenografts. Int J Mol Sci. 2013 Jul 03; 14(7):13782-95. Galet C, Gray A, Said JW, Castor B, Wan J, Beltran PJ, Calzone FJ, Elashoff D, Cohen P, Aronson WJ. PMID: 23823800; PMCID: PMC3742217.
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    90. Prepubertal children with growth hormone deficiency treated for four years with growth hormone experience dose-dependent increase in height, but not in the rate of puberty initiation. Horm Res Paediatr. 2013; 80(1):28-37. Rogol AD, Cohen P, Weng W, Kappelgaard AM, Germak JA. PMID: 23816571.
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    91. Response of the insulin-like growth factor (IGF) system to IGF-IR inhibition and androgen deprivation in a neoadjuvant prostate cancer trial: effects of obesity and androgen deprivation. J Clin Endocrinol Metab. 2013 May; 98(5):E820-8. Dean JP, Sprenger CC, Wan J, Haugk K, Ellis WJ, Lin DW, Corman JM, Dalkin BL, Mostaghel E, Nelson PS, Cohen P, Montgomery B, Plymate SR. PMID: 23533230; PMCID: PMC4430583.
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    92. Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model. Aging Cell. 2013 Apr; 12(2):257-68. Parrella E, Maxim T, Maialetti F, Zhang L, Wan J, Wei M, Cohen P, Fontana L, Longo VD. PMID: 23362919; PMCID: PMC3982836.
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    93. Efficacy of IGF-based growth hormone (GH) dosing in nonGH-deficient (nonGHD) short stature children with low IGF-I is not related to basal IGF-I levels. Clin Endocrinol (Oxf). 2013 Mar; 78(3):405-14. Cohen P, Rogol AD, Weng W, Kappelgaard AM, Rosenfeld RG, Germak J, American Norditropin Study Group. PMID: 22924571.
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    94. Humanin: a harbinger of mitochondrial-derived peptides? Trends Endocrinol Metab. 2013 May; 24(5):222-8. Lee C, Yen K, Cohen P. PMID: 23402768; PMCID: PMC3641182.
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    95. The emerging role of the mitochondrial-derived peptide humanin in stress resistance. J Mol Endocrinol. 2013 Feb; 50(1):R11-9. Yen K, Lee C, Mehta H, Cohen P. PMID: 23239898; PMCID: PMC3705736.
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    96. Resveratrol worsens survival in SCID mice with prostate cancer xenografts in a cell-line specific manner, through paradoxical effects on oncogenic pathways. Prostate. 2013 May; 73(7):754-62. Klink JC, Tewari AK, Masko EM, Antonelli J, Febbo PG, Cohen P, Dewhirst MW, Pizzo SV, Freedland SJ. PMID: 23192356; PMCID: PMC3628095.
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    97. Growth hormone receptor (GHR) exon 3 polymorphism status detection by dual-enzyme-linked immunosorbent assay (ELISA). J Clin Endocrinol Metab. 2013 Jan; 98(1):E77-81. Wan J, Atzmon G, Hwang D, Barzlai N, Kratzsch J, Cohen P. PMID: 23162096; PMCID: PMC3537082.
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    98. IGFBP-3 nuclear localization predicts human prostate cancer recurrence. Horm Cancer. 2013 Feb; 4(1):12-23. Seligson DB, Yu H, Tze S, Said J, Pantuck AJ, Cohen P, Lee KW. PMID: 23011725; PMCID: PMC3541441.
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    99. Humanin prevents intra-renal microvascular remodeling and inflammation in hypercholesterolemic ApoE deficient mice. Life Sci. 2012 Sep 04; 91(5-6):199-206. Zhang X, Urbieta-Caceres VH, Eirin A, Bell CC, Crane JA, Tang H, Jordan KL, Oh YK, Zhu XY, Korsmo MJ, Bachar AR, Cohen P, Lerman A, Lerman LO. PMID: 22820173; PMCID: PMC3703734.
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    100. How useful are serum IGF-I measurements for managing GH replacement therapy in adults and children? Pituitary. 2012 Jun; 15(2):126-34. Pawlikowska-Haddal A, Cohen P, Cook DM. PMID: 21909971.
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    101. Effect of a low-fat diet combined with IGF-1 receptor blockade on 22Rv1 prostate cancer xenografts. Mol Cancer Ther. 2012 Jul; 11(7):1539-46. Konijeti R, Koyama S, Gray A, Barnard RJ, Said JW, Castor B, Elashoff D, Wan J, Beltran PJ, Calzone FJ, Cohen P, Galet C, Aronson WJ. PMID: 22562985; PMCID: PMC3392522.
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    102. Humanin, a cytoprotective peptide, is expressed in carotid atherosclerotic [corrected] plaques in humans. PLoS One. 2012; 7(2):e31065. Zacharias DG, Kim SG, Massat AE, Bachar AR, Oh YK, Herrmann J, Rodriguez-Porcel M, Cohen P, Lerman LO, Lerman A. PMID: 22328926; PMCID: PMC3273477.
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    103. Long-term surveillance of growth hormone therapy. J Clin Endocrinol Metab. 2012 Jan; 97(1):68-72. Rosenfeld RG, Cohen P, Robison LL, Bercu BB, Clayton P, Hoffman AR, Radovick S, Saenger P, Savage MO, Wit JM. PMID: 22174422.
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    104. Phase II prospective randomized trial of a low-fat diet with fish oil supplementation in men undergoing radical prostatectomy. Cancer Prev Res (Phila). 2011 Dec; 4(12):2062-71. Aronson WJ, Kobayashi N, Barnard RJ, Henning S, Huang M, Jardack PM, Liu B, Gray A, Wan J, Konijeti R, Freedland SJ, Castor B, Heber D, Elashoff D, Said J, Cohen P, Galet C. PMID: 22027686; PMCID: PMC3232341.
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    105. Global Igfbp1 deletion does not affect prostate cancer development in a c-Myc transgenic mouse model. J Endocrinol. 2011 Dec; 211(3):297-304. Gray A, Aronson WJ, Barnard RJ, Mehta H, Wan J, Said J, Cohen P, Galet C. PMID: 21903863; PMCID: PMC3271951.
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    106. Insulin-like growth factor (IGF)-I and IGF-II contribute differentially to the phenotype of pregnancy associated plasma protein-A knock-out mice. Growth Horm IGF Res. 2011 Oct; 21(5):243-7. Mason EJ, Grell JA, Wan J, Cohen P, Conover CA. PMID: 21802327; PMCID: PMC3171618.
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    107. Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice. Atherosclerosis. 2011 Nov; 219(1):65-73. Oh YK, Bachar AR, Zacharias DG, Kim SG, Wan J, Cobb LJ, Lerman LO, Cohen P, Lerman A. PMID: 21763658; PMCID: PMC3885346.
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    108. IGFBP-3 is a metastasis suppression gene in prostate cancer. Cancer Res. 2011 Aug 01; 71(15):5154-63. Mehta HH, Gao Q, Galet C, Paharkova V, Wan J, Said J, Sohn JJ, Lawson G, Cohen P, Cobb LJ, Lee KW. PMID: 21697285; PMCID: PMC3148406.
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    109. Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med. 2011 Feb 16; 3(70):70ra13. Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD. PMID: 21325617; PMCID: PMC3357623.
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    118. Opposing roles of insulin-like growth factor binding protein 3 and humanin in the regulation of testicular germ cell apoptosis. Endocrinology. 2010 Jan; 151(1):350-7. Lue Y, Swerdloff R, Liu Q, Mehta H, Hikim AS, Lee KW, Jia Y, Hwang D, Cobb LJ, Cohen P, Wang C. PMID: 19952275.
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    122. Humanin: a novel central regulator of peripheral insulin action. PLoS One. 2009 Jul 22; 4(7):e6334. Muzumdar RH, Huffman DM, Atzmon G, Buettner C, Cobb LJ, Fishman S, Budagov T, Cui L, Einstein FH, Poduval A, Hwang D, Barzilai N, Cohen P. PMID: 19623253; PMCID: PMC2709436.
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    125. Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. J Biol Chem. 2009 Jul 24; 284(30):19937-44. Fan Y, Menon RK, Cohen P, Hwang D, Clemens T, DiGirolamo DJ, Kopchick JJ, Le Roith D, Trucco M, Sperling MA. PMID: 19460757; PMCID: PMC2740419.
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    138. Quantitative ontogeny of murine insulin-like growth factor (IGF)-I, IGF-binding protein-3 and the IGF-related acid-labile subunit. Growth Horm IGF Res. 2008 Feb; 18(1):65-74. Hwang DL, Lee PD, Cohen P. PMID: 17719253; PMCID: PMC2276237.
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    139. Treatment perspectives in idiopathic short stature with a focus on IGF-I deficiency. Pediatr Endocrinol Rev. 2007 May; 4 Suppl 2:252-71. Rosenthal S, Cohen P, Clayton P, Backeljauw P, Bang P, Ten S. PMID: 17581497.
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    140. Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3. Carcinogenesis. 2007 Aug; 28(8):1653-8. Lee KW, Cobb LJ, Paharkova-Vatchkova V, Liu B, Milbrandt J, Cohen P. PMID: 17434920.
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    143. Growth hormone therapy improves bone mineral density in children with cerebral palsy: a preliminary pilot study. J Clin Endocrinol Metab. 2007 Mar; 92(3):932-7. Ali O, Shim M, Fowler E, Greenberg M, Perkins D, Oppenheim W, Cohen P. PMID: 17179200.
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    147. Insulin-like growth factor binding protein 3 as an anticancer molecule in Ewing's sarcoma. Int J Cancer. 2006 Sep 01; 119(5):1039-46. Benini S, Zuntini M, Manara MC, Cohen P, Nicoletti G, Nanni P, Oh Y, Picci P, Scotlandi K. PMID: 16570284.
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    148. Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2. Clin Cancer Res. 2006 Aug 01; 12(15):4662-70. Kobayashi N, Barnard RJ, Henning SM, Elashoff D, Reddy ST, Cohen P, Leung P, Hong-Gonzalez J, Freedland SJ, Said J, Gui D, Seeram NP, Popoviciu LM, Bagga D, Heber D, Glaspy JA, Aronson WJ. PMID: 16899616; PMCID: PMC3410648.
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    151. The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone. J Endocrinol. 2006 May; 189(2):289-99. Yakar S, Bouxsein ML, Canalis E, Sun H, Glatt V, Gundberg C, Cohen P, Hwang D, Boisclair Y, Leroith D, Rosen CJ. PMID: 16648296.
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    155. Identification of insulin-like growth factor binding protein-3 as a farnesyl transferase inhibitor SCH66336-induced negative regulator of angiogenesis in head and neck squamous cell carcinoma. Clin Cancer Res. 2006 Jan 15; 12(2):653-61. Oh SH, Kim WY, Kim JH, Younes MN, El-Naggar AK, Myers JN, Kies M, Cohen P, Khuri F, Hong WK, Lee HY. PMID: 16428512.
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    157. Control of aging and longevity by IGF-I signaling. Exp Gerontol. 2005 Nov; 40(11):867-72. Yang J, Anzo M, Cohen P. PMID: 16154307.
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    161. Pharmacodynamic considerations with recombinant human insulin-like growth factor-I in children. Horm Res. 2005; 63(5):220-7. Ferry RJ, Cohen P, Levitt Katz LE. PMID: 15886488; PMCID: PMC3102299.
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    166. EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. Mol Cell Biol. 2004 Aug; 24(16):7275-83. Prieur A, Tirode F, Cohen P, Delattre O. PMID: 15282325; PMCID: PMC479730.
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    169. Insulin-like growth factor binding protein-3 antagonizes the effects of retinoids in myeloid leukemia cells. Blood. 2004 Jul 01; 104(1):237-42. Ikezoe T, Tanosaki S, Krug U, Liu B, Cohen P, Taguchi H, Koeffler HP. PMID: 15026318.
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    170. Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4531-6. Licinio J, Caglayan S, Ozata M, Yildiz BO, de Miranda PB, O'Kirwan F, Whitby R, Liang L, Cohen P, Bhasin S, Krauss RM, Veldhuis JD, Wagner AJ, DePaoli AM, McCann SM, Wong ML. PMID: 15070752; PMCID: PMC384781.
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    181. Type Ialpha collagen is an IGFBP-3 binding protein. Growth Horm IGF Res. 2003 Apr-Jun; 13(2-3):89-97. Liu B, Weinzimer SA, Gibson TB, Mascarenhas D, Cohen P. PMID: 12735930.
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    182. Rapid insulin-like growth factor (IGF)-independent effects of IGF binding protein-3 on endothelial cell survival. J Clin Endocrinol Metab. 2003 Feb; 88(2):900-7. Franklin SL, Ferry RJ, Cohen P. PMID: 12574231; PMCID: PMC3314536.
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    183. Insulin-like growth factors and their binding proteins in children born small for gestational age: implication for growth hormone therapy. Horm Res. 2003; 60 Suppl 3:115-23. Ali O, Cohen P. PMID: 14671408.
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    184. Effect of diet and exercise on serum insulin, IGF-I, and IGFBP-1 levels and growth of LNCaP cells in vitro (United States). Cancer Causes Control. 2002 Dec; 13(10):929-35. Ngo TH, Barnard RJ, Tymchuk CN, Cohen P, Aronson WJ. PMID: 12588089.
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    185. Diagnosis and management of growth hormone deficiency in childhood and adolescence--part 2: growth hormone treatment in growth hormone deficient children. Growth Horm IGF Res. 2002 Oct; 12(5):323-41. Tanaka T, Cohen P, Clayton PE, Laron Z, Hintz RL, Sizonenko PC. PMID: 12213187.
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    186. Effects of dose and gender on the growth and growth factor response to GH in GH-deficient children: implications for efficacy and safety. J Clin Endocrinol Metab. 2002 Jan; 87(1):90-8. Cohen P, Bright GM, Rogol AD, Kappelgaard AM, Rosenfeld RG, American Norditropin Clinical Trials Group. PMID: 11788629.
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