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    Nuria Maria Pastor-Soler, MD, PhD

    TitleAssociate Professor of Medicine
    SchoolKeck School of Medicine of USC
    AddressIRD 2020 Zonal Ave
    Off Campus
    Los Angeles California 90033
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      Other Positions
      TitleAssistant Dean For Research Mentoring

      Collapse Overview 
      Collapse Overview
      Dr. Pastor-Soler's research interests include regulation acid-base homeostasis by the kidney and the study of the vacuolar proton ATPase (V-ATPase) in the kidney and the male reproductive tract. Other research projects in her laboratory study the regulation of sodium transport in the collecting duct by bicarbonate-regulated sAC, and renal salt transport regulation by WNK kinases, to name a few. She is currently studying the molecular and cellular mechanisms by which metabolic pathways in the kidney are affected by acidosis, a known predictor of CKD progression. She is also studying renal cell carcinomas with the aim to confirm a novel biomarker that could be used clinically to assess the presence and severity of this disease.

      Dr. Pastor-Soler earned her medical degree from Jefferson Medical College. She then went on to complete her PhD in Biochemistry and Molecular Biology at Jefferson. Dr. Pastor-Soler completed her Nephrology Fellowship at the Brigham and Women's/Massachusetts General Hospital program. She is currently Associate Professor of Medicine in the Division of Nephrology and Hypertension and Assistant Dean for Research Mentoring at Keck School of Medicine of USC. She is also the Director of the Required Scholarly Project Program.

      Collapse Biography 
      Collapse Awards and Honors
      Armand Hammer United World College1984 - 1986Full Scholarship
      1985 - 1986Abigail Van Buren Scholarship
      Bryn Mawr College1986 - 1989Full Scholarship
      Haverford College1988Pew Summer Research Foundation Fellowship
      Dorothy Nepper Marshall Teacher Apprenticeship1988 - 1989Scholar
      Thomas Jefferson University1989 - 1996Gibbon Scholar
      P. and E. Brown Foerderer Foundation1990 - 1991Fellowship
      American Society of Nephrology2005Fellow
      Massachusetts General Hospital2005Claflin Distinguished Scholar Award
      American Society of Nephrology2009Carl W. Gottschalk Research Scholar Grant
      American Physiological Society2009Renal Section, New Investigator Award
      American Physiological Society2011Career Enhancement Award
      American Society for Clinical Investigation2012Member
      Telluride Epithelial Physiology Workshop2012Research Recognition Award
      American Physiological Society2012Renal Section, Young Investigator Award
      Department of Medicine, University of Pittsburgh2012 - 2014Junior Scholar Award
      Council for the Kidney in Cardiovascular Disease, American Heart Association2014 - 2016Elected to Vice-Chair
      Women in Nephrology2016President
      Council for the Kidney in Cardiovascular Disease, American Heart Association2016Chair

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Emlet DR, Pastor-Soler N, Marciszyn A, Wen X, Gomez H, Humphries WH, Morrisroe S, Volpe JK, Kellum JA. Insulin-Like Growth Factor Binding Protein 7 and Tissue Inhibitor of Metalloproteinases-2: Differential Expression and Secretion in Human Kidney Tubule Cells. Am J Physiol Renal Physiol. 2016 Dec 21; ajprenal.00271.2016. PMID: 28003188.
        View in: PubMed
      2. Mo D, Costa SA, Ihrke G, Youker RT, Pastor-Soler N, Hughey RP, Weisz OA. Sialylation of N-linked glycans mediates apical delivery of endolyn in MDCK cells via a galectin-9-dependent mechanism. Mol Biol Cell. 2012 Sep; 23(18):3636-46. PMID: 22855528.
        View in: PubMed
      3. Rondanino C, Poland PA, Kinlough CL, Li H, Rbaibi Y, Myerburg MM, Al-bataineh MM, Kashlan OB, Pastor-Soler N, Hallows KR, Weisz OA, Apodaca G, Hughey RP. Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells. Am J Physiol Renal Physiol. 2011 Sep; 301(3):F622-33. PMID: 21677144.
        View in: PubMed
      4. Estilo G, Liu W, Pastor-Soler N, Mitchell P, Carattino MD, Kleyman TR, Satlin LM. Effect of aldosterone on BK channel expression in mammalian cortical collecting duct. Am J Physiol Renal Physiol. 2008 Sep; 295(3):F780-8. PMID: 18579708.
        View in: PubMed
      5. Pietrement C, Da Silva N, Silberstein C, James M, Marsolais M, Van Hoek A, Brown D, Pastor-Soler N, Ameen N, Laprade R, Ramesh V, Breton S. Role of NHERF1, cystic fibrosis transmembrane conductance regulator, and cAMP in the regulation of aquaporin 9. J Biol Chem. 2008 Feb 1; 283(5):2986-96. PMID: 18055461.
        View in: PubMed
      6. Pastor-Soler N, PiƩtrement C, Breton S. Role of acid/base transporters in the male reproductive tract and potential consequences of their malfunction. Physiology (Bethesda). 2005 Dec; 20:417-28. PMID: 16287991.
        View in: PubMed
      7. Bouley R, Pastor-Soler N, Cohen O, McLaughlin M, Breton S, Brown D. Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra). Am J Physiol Renal Physiol. 2005 Jun; 288(6):F1103-12. PMID: 15644488.
        View in: PubMed
      8. Beaulieu V, Da Silva N, Pastor-Soler N, Brown CR, Smith PJ, Brown D, Breton S. Modulation of the actin cytoskeleton via gelsolin regulates vacuolar H+-ATPase recycling. J Biol Chem. 2005 Mar 4; 280(9):8452-63. PMID: 15591047.
        View in: PubMed
      9. Silberstein C, Bouley R, Huang Y, Fang P, Pastor-Soler N, Brown D, Van Hoek AN. Membrane organization and function of M1 and M23 isoforms of aquaporin-4 in epithelial cells. Am J Physiol Renal Physiol. 2004 Sep; 287(3):F501-11. PMID: 15149973.
        View in: PubMed
      10. Pastor-Soler N, Beaulieu V, Litvin TN, Da Silva N, Chen Y, Brown D, Buck J, Levin LR, Breton S. Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling. J Biol Chem. 2003 Dec 5; 278(49):49523-9. PMID: 14512417.
        View in: PubMed
      11. van Balkom BW, van Raak M, Breton S, Pastor-Soler N, Bouley R, van der Sluijs P, Brown D, Deen PM. Hypertonicity is involved in redirecting the aquaporin-2 water channel into the basolateral, instead of the apical, plasma membrane of renal epithelial cells. J Biol Chem. 2003 Jan 10; 278(2):1101-7. PMID: 12374804.
        View in: PubMed
      12. Fisher JS, Pastor-Soler N, Sharpe RM, Breton S. Modulation of the onset of postnatal development of H(+)-ATPase-rich cells by steroid hormones in rat epididymis. Biol Reprod. 2002 Oct; 67(4):1106-14. PMID: 12297525.
        View in: PubMed
      13. Pastor-Soler N, Isnard-Bagnis C, Herak-Kramberger C, Sabolic I, Van Hoek A, Brown D, Breton S. Expression of aquaporin 9 in the adult rat epididymal epithelium is modulated by androgens. Biol Reprod. 2002 Jun; 66(6):1716-22. PMID: 12021052.
        View in: PubMed
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