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    Michael E. Harris

    TitleProfessor of The Practice of Health Services Administration and Policy
    SchoolSol Price School of Public Policy
    DepartmentPublic Policy
    AddressRGL 315
    University Park Campus
    Los Angeles California 90089-0626
    Phone+1 213 821 0467
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      Mr. Harris joined the University of Southern California as an adjunct faculty member and is now a Professor of the Practice of Health Services Administration and Policy at the Sol Price School of Public Policy at USC.

      Mr. Harris’s focus center on health care issues related to prevention, wellness, and access to care for all populations. He is well versed in the areas of health care reform and the Affordable Care Act. With over 30 years of experience, he is focused on the development of future healthcare delivery models, healthcare innovation and its impact on quality of care concepts.

      Mr. Harris is also a nationally recognized speaker with over 30 years of healthcare experience in the areas of managed care payer and provider contracting, Independent Physician Associations, Management Service Organizations, medical group operations, and management of ancillary services. As one of the nation’s leading authorities on healthcare reform, he advises numerous healthcare organizations on the impact of reform and delivery system adaptability.

      Prior to becoming a leading healthcare consultant, Mr. Harris served in several executive positions responsible for the operational efficiency and performance of healthcare delivery systems.

      His civic involvement includes:

      Commissioner of Sustainability
      City of Palm Springs
      Clinton Health Initiative
      City of Palm Springs
      Regional Access Project Foundation
      Healthy Eating Active Living Network (HEALNet)
      City of Palm Springs

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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Harris M, York DM, Piccirilli JA, Anderson VE. Kinetic Isotope Effect Analysis of RNA 2'-O-Transphosphorylation. Methods Enzymol. 2017; 596:433-457. PMID: 28911780.
        View in: PubMed
      2. Knappenberger AJ, Grandhi S, Sheth R, Ahmad MF, Viswanathan R, Harris M. Phylogenetic sequence analysis and functional studies reveal compensatory amino acid substitutions in loop 2 of human ribonucleotide reductase. J Biol Chem. 2017 Aug 14. PMID: 28808063.
        View in: PubMed
      3. Niland CN, Anderson DR, Jankowsky E, Harris M. The contribution of the C5 protein subunit of Escherichia coli ribonuclease P to specificity for precursor tRNA is modulated by proximal 5' leader sequences. RNA. 2017 Oct; 23(10):1502-1511. PMID: 28694328.
        View in: PubMed
      4. Jankowsky E, Harris M. Mapping specificity landscapes of RNA-protein interactions by high throughput sequencing. Methods. 2017 Apr 15; 118-119:111-118. PMID: 28263887.
        View in: PubMed
      5. Jain N, Lin HC, Morgan CE, Harris M, Tolbert BS. Rules of RNA specificity of hnRNP A1 revealed by global and quantitative analysis of its affinity distribution. Proc Natl Acad Sci U S A. 2017 Feb 28; 114(9):2206-2211. PMID: 28193894.
        View in: PubMed
      6. Harris M, Anderson VE. Preface. Methods Enzymol. 2017; 596:xv-xviii. PMID: 28911786.
        View in: PubMed
      7. Vijayaraghavan J, Kramp K, Harris M, van den Akker F. Inhibition of soluble guanylyl cyclase by small molecules targeting the catalytic domain. FEBS Lett. 2016 Oct; 590(20):3669-3680. PMID: 27654641.
        View in: PubMed
      8. Knappenberger AJ, Ahmad MF, Viswanathan R, Dealwis CG, Harris M. Nucleoside Analogue Triphosphates Allosterically Regulate Human Ribonucleotide Reductase and Identify Chemical Determinants That Drive Substrate Specificity. Biochemistry. 2016 Oct 18; 55(41):5884-5896. PMID: 27634056.
        View in: PubMed
      9. Lin HC, Zhao J, Niland CN, Tran B, Jankowsky E, Harris M. Analysis of the RNA Binding Specificity Landscape of C5 Protein Reveals Structure and Sequence Preferences that Direct RNase P Specificity. Cell Chem Biol. 2016 Oct 20; 23(10):1271-1281. PMID: 27693057.
        View in: PubMed
      10. Niland CN, Zhao J, Lin HC, Anderson DR, Jankowsky E, Harris M. Determination of the Specificity Landscape for Ribonuclease P Processing of Precursor tRNA 5' Leader Sequences. ACS Chem Biol. 2016 Aug 19; 11(8):2285-92. PMID: 27336323.
        View in: PubMed
      11. Niland CN, Jankowsky E, Harris M. Optimization of high-throughput sequencing kinetics for determining enzymatic rate constants of thousands of RNA substrates. Anal Biochem. 2016 Oct 01; 510:1-10. PMID: 27296633; PMCID: PMC4980219 [Available on 10/01/17].
      12. Misko TA, Wijerathna SR, Radivoyevitch T, Berdis AJ, Ahmad MF, Harris M, Dealwis CG. Inhibition of yeast ribonucleotide reductase by Sml1 depends on the allosteric state of the enzyme. FEBS Lett. 2016 Jun; 590(12):1704-12. PMID: 27155231; PMCID: PMC4925217 [Available on 06/01/17].
      13. Mullins MR, Rajavel M, Hernandez-Sanchez W, de la Fuente M, Biendarra SM, Harris M, Taylor DJ. POT1-TPP1 Binding and Unfolding of Telomere DNA Discriminates against Structural Polymorphism. J Mol Biol. 2016 Jul 03; 428(13):2695-708. PMID: 27173378; PMCID: PMC4905795 [Available on 07/03/17].
      14. Zhang S, Gu H, Chen H, Strong E, Ollie EW, Kellerman D, Liang D, Miyagi M, Anderson VE, Piccirilli JA, York DM, Harris M. Isotope effect analyses provide evidence for an altered transition state for RNA 2'-O-transphosphorylation catalyzed by Zn(2+). Chem Commun (Camb). 2016 Mar 25; 52(24):4462-5. PMID: 26859380; PMCID: PMC4916458.
      15. Lee TS, Radak BK, Harris M, York DM. A Two-Metal-Ion-Mediated Conformational Switching Pathway for HDV Ribozyme Activation. ACS Catal. 2016; 6(3):1853-1869. PMID: 27774349.
        View in: PubMed
      16. Ahmad MF, Huff SE, Pink J, Alam I, Zhang A, Perry K, Harris M, Misko T, Porwal SK, Oleinick NL, Miyagi M, Viswanathan R, Dealwis CG. Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators. J Med Chem. 2015 Dec 24; 58(24):9498-509. PMID: 26488902; PMCID: PMC4751996.
      17. Harris M. Theme and Variation in tRNA 5' End Processing Enzymes: Comparative Analysis of Protein versus Ribonucleoprotein RNase P. J Mol Biol. 2016 Jan 16; 428(1):5-9. PMID: 26655024.
        View in: PubMed
      18. Jankowsky E, Harris M. Specificity and nonspecificity in RNA-protein interactions. Nat Rev Mol Cell Biol. 2015 Sep; 16(9):533-44. PMID: 26285679; PMCID: PMC4744649.
      19. Koo SC, Lu J, Li NS, Leung E, Das SR, Harris M, Piccirilli JA. Transition State Features in the Hepatitis Delta Virus Ribozyme Reaction Revealed by Atomic Perturbations. J Am Chem Soc. 2015 Jul 22; 137(28):8973-82. PMID: 26125657; PMCID: PMC4758122.
      20. Radak BK, Lee TS, Harris M, York DM. Assessment of metal-assisted nucleophile activation in the hepatitis delta virus ribozyme from molecular simulation and 3D-RISM. RNA. 2015 Sep; 21(9):1566-77. PMID: 26170378; PMCID: PMC4536318.
      21. Mojica MF, Mahler SG, Bethel CR, Taracila MA, Kosmopoulou M, Papp-Wallace KM, Llarrull LI, Wilson BM, Marshall SH, Wallace CJ, Villegas MV, Harris M, Vila AJ, Spencer J, Bonomo RA. Exploring the Role of Residue 228 in Substrate and Inhibitor Recognition by VIM Metallo-ß-lactamases. Biochemistry. 2015 May 26; 54(20):3183-96. PMID: 25915520; PMCID: PMC4700511.
      22. Kellerman DL, Simmons KS, Pedraza M, Piccirilli JA, York DM, Harris M. Determination of hepatitis delta virus ribozyme N(-1) nucleobase and functional group specificity using internal competition kinetics. Anal Biochem. 2015 Aug 15; 483:12-20. PMID: 25937290; PMCID: PMC4461535.
      23. Harris M, Piccirilli JA, York DM. Integration of kinetic isotope effect analyses to elucidate ribonuclease mechanism. Biochim Biophys Acta. 2015 Nov; 1854(11):1801-8. PMID: 25936517; PMCID: PMC4604014 [Available on 11/01/16].
      24. Chen H, Piccirilli JA, Harris M, York DM. Effect of Zn2+ binding and enzyme active site on the transition state for RNA 2'-O-transphosphorylation interpreted through kinetic isotope effects. Biochim Biophys Acta. 2015 Nov; 1854(11):1795-800. PMID: 25812974; PMCID: PMC4743498.
      25. Dissanayake T, Swails JM, Harris M, Roitberg AE, York DM. Interpretation of pH-activity profiles for acid-base catalysis from molecular simulations. Biochemistry. 2015 Feb 17; 54(6):1307-13. PMID: 25615525; PMCID: PMC4441796.
      26. Porwal SK, Furia E, Harris M, Viswanathan R, Devireddy L. Synthetic, potentiometric and spectroscopic studies of chelation between Fe(III) and 2,5-DHBA supports salicylate-mode of siderophore binding interactions. J Inorg Biochem. 2015 Apr; 145:1-10. PMID: 25589161.
        View in: PubMed
      27. Chen H, Giese TJ, Huang M, Wong KY, Harris M, York DM. Mechanistic insights into RNA transphosphorylation from kinetic isotope effects and linear free energy relationships of model reactions. Chemistry. 2014 Oct 27; 20(44):14336-43. PMID: 25223953; PMCID: PMC4432475.
      28. Lin HC, Yandek LE, Gjermeni I, Harris M. Determination of relative rate constants for in vitro RNA processing reactions by internal competition. Anal Biochem. 2014 Dec 15; 467:54-61. PMID: 25173512; PMCID: PMC4252809.
      29. Kellerman DL, York DM, Piccirilli JA, Harris M. Altered (transition) states: mechanisms of solution and enzyme catalyzed RNA 2'-O-transphosphorylation. Curr Opin Chem Biol. 2014 Aug; 21:96-102. PMID: 25023967; PMCID: PMC4149925.
      30. Merrick WC, Harris M. Control not at initiation? Bah, humbug! EMBO J. 2014 Jan 07; 33(1):3-4. PMID: 24363142; PMCID: PMC3990677.
      31. Guenther UP, Yandek LE, Niland CN, Campbell FE, Anderson D, Anderson VE, Harris M, Jankowsky E. Hidden specificity in an apparently nonspecific RNA-binding protein. Nature. 2013 Oct 17; 502(7471):385-8. PMID: 24056935; PMCID: PMC3800043.
      32. Gu H, Zhang S, Wong KY, Radak BK, Dissanayake T, Kellerman DL, Dai Q, Miyagi M, Anderson VE, York DM, Piccirilli JA, Harris M. Experimental and computational analysis of the transition state for ribonuclease A-catalyzed RNA 2'-O-transphosphorylation. Proc Natl Acad Sci U S A. 2013 Aug 06; 110(32):13002-7. PMID: 23878223; PMCID: PMC3740856.
      33. Corriveau M, Mullins MR, Baus D, Harris M, Taylor DJ. Coordinated interactions of multiple POT1-TPP1 proteins with telomere DNA. J Biol Chem. 2013 Jun 07; 288(23):16361-70. PMID: 23616058; PMCID: PMC3675573.
      34. Yandek LE, Lin HC, Harris M. Alternative substrate kinetics of Escherichia coli ribonuclease P: determination of relative rate constants by internal competition. J Biol Chem. 2013 Mar 22; 288(12):8342-54. PMID: 23362254; PMCID: PMC3605652.
      35. Radak BK, Harris M, York DM. Molecular simulations of RNA 2'-O-transesterification reaction models in solution. J Phys Chem B. 2013 Jan 10; 117(1):94-103. PMID: 23214417; PMCID: PMC3574632.
      36. Papp-Wallace KM, Senkfor B, Gatta J, Chai W, Taracila MA, Shanmugasundaram V, Han S, Zaniewski RP, Lacey BM, Tomaras AP, Skalweit MJ, Harris M, Rice LB, Buynak JD, Bonomo RA. Early insights into the interactions of different ß-lactam antibiotics and ß-lactamase inhibitors against soluble forms of Acinetobacter baumannii PBP1a and Acinetobacter sp. PBP3. Antimicrob Agents Chemother. 2012 Nov; 56(11):5687-92. PMID: 22908165; PMCID: PMC3486531.
      37. Levitt PS, Papp-Wallace KM, Taracila MA, Hujer AM, Winkler ML, Smith KM, Xu Y, Harris M, Bonomo RA. Exploring the role of a conserved class A residue in the O-Loop of KPC-2 ß-lactamase: a mechanism for ceftazidime hydrolysis. J Biol Chem. 2012 Sep 14; 287(38):31783-93. PMID: 22843686; PMCID: PMC3442512.
      38. Wong KY, Gu H, Zhang S, Piccirilli JA, Harris M, York DM. Characterization of the reaction path and transition states for RNA transphosphorylation models from theory and experiment. Angew Chem Int Ed Engl. 2012 Jan 16; 51(3):647-51. PMID: 22076983; PMCID: PMC3448066.
      39. Lee TS, Giambasu G, Harris M, York DM. Characterization of the Structure and Dynamics of the HDV Ribozyme at Different Stages Along the Reaction Path. J Phys Chem Lett. 2011 Oct 20; 2(20):2538-2543. PMID: 22200005.
        View in: PubMed
      40. Christian EL, Anderson VE, Harris M. Deconvolution of Raman spectroscopic signals for electrostatic, H-bonding, and inner-sphere interactions between ions and dimethyl phosphate in solution. J Inorg Biochem. 2011 Apr; 105(4):538-47. PMID: 21334281; PMCID: PMC3268073.
      41. Harris M, Dai Q, Gu H, Kellerman DL, Piccirilli JA, Anderson VE. Kinetic isotope effects for RNA cleavage by 2'-O- transphosphorylation: nucleophilic activation by specific base. J Am Chem Soc. 2010 Aug 25; 132(33):11613-21. PMID: 20669950; PMCID: PMC2946848.
      42. Christian EL, Anderson VE, Carey PR, Harris M. A quantitative Raman spectroscopic signal for metal-phosphodiester interactions in solution. Biochemistry. 2010 Apr 06; 49(13):2869-79. PMID: 20180599; PMCID: PMC3246276.
      43. Koutmou KS, Zahler NH, Kurz JC, Campbell FE, Harris M, Fierke CA. Protein-precursor tRNA contact leads to sequence-specific recognition of 5' leaders by bacterial ribonuclease P. J Mol Biol. 2010 Feb 12; 396(1):195-208. PMID: 19932118; PMCID: PMC2829246.
      44. Sun L, Campbell FE, Yandek LE, Harris M. Binding of C5 protein to P RNA enhances the rate constant for catalysis for P RNA processing of pre-tRNAs lacking a consensus (+ 1)/C(+ 72) pair. J Mol Biol. 2010 Feb 05; 395(5):1019-37. PMID: 19917291; PMCID: PMC3410724.
      45. Harris M, Christian EL. RNA crosslinking methods. Methods Enzymol. 2009; 468:127-46. PMID: 20946768; PMCID: PMC3246272.
      46. Harris M, Cassano AG. Experimental analyses of the chemical dynamics of ribozyme catalysis. Curr Opin Chem Biol. 2008 Dec; 12(6):626-39. PMID: 18952193; PMCID: PMC2770263.
      47. Schroeder LA, Gries TJ, Saecker RM, Record MT, Harris M, DeHaseth PL. Evidence for a tyrosine-adenine stacking interaction and for a short-lived open intermediate subsequent to initial binding of Escherichia coli RNA polymerase to promoter DNA. J Mol Biol. 2009 Jan 16; 385(2):339-49. PMID: 18976666; PMCID: PMC2677906.
      48. Dai Q, Frederiksen JK, Anderson VE, Harris M, Piccirilli JA. Efficient synthesis of [2'-18O]uridine and its incorporation into oligonucleotides: a new tool for mechanistic study of nucleotidyl transfer reactions by isotope effect analysis. J Org Chem. 2008 Jan 04; 73(1):309-11. PMID: 18052189.
        View in: PubMed
      49. Sun L, Harris M. Evidence that binding of C5 protein to P RNA enhances ribozyme catalysis by influencing active site metal ion affinity. RNA. 2007 Sep; 13(9):1505-15. PMID: 17652407; PMCID: PMC1950769.
      50. Cassano AG, Wang B, Anderson DR, Previs S, Harris M, Anderson VE. Inaccuracies in selected ion monitoring determination of isotope ratios obviated by profile acquisition: nucleotide 18O/16O measurements. Anal Biochem. 2007 Aug 01; 367(1):28-39. PMID: 17560863; PMCID: PMC2045637.
      51. Sun L, Campbell FE, Zahler NH, Harris M. Evidence that substrate-specific effects of C5 protein lead to uniformity in binding and catalysis by RNase P. EMBO J. 2006 Sep 06; 25(17):3998-4007. PMID: 16932744; PMCID: PMC1560353.
      52. Anderson VE, Ruszczycky MW, Harris M. Activation of oxygen nucleophiles in enzyme catalysis. Chem Rev. 2006 Aug; 106(8):3236-51. PMID: 16895326.
        View in: PubMed
      53. Christian EL, Smith KM, Perera N, Harris M. The P4 metal binding site in RNase P RNA affects active site metal affinity through substrate positioning. RNA. 2006 Aug; 12(8):1463-7. PMID: 16822954; PMCID: PMC1524898.
      54. Guo X, Campbell FE, Sun L, Christian EL, Anderson VE, Harris M. RNA-dependent folding and stabilization of C5 protein during assembly of the E. coli RNase P holoenzyme. J Mol Biol. 2006 Jun 30; 360(1):190-203. PMID: 16750220.
        View in: PubMed
      55. Zahler NH, Sun L, Christian EL, Harris M. The pre-tRNA nucleotide base and 2'-hydroxyl at N(-1) contribute to fidelity in tRNA processing by RNase P. J Mol Biol. 2005 Feb 04; 345(5):969-85. PMID: 15644198.
        View in: PubMed
      56. Cassano AG, Anderson VE, Harris M. Analysis of solvent nucleophile isotope effects: evidence for concerted mechanisms and nucleophilic activation by metal coordination in nonenzymatic and ribozyme-catalyzed phosphodiester hydrolysis. Biochemistry. 2004 Aug 17; 43(32):10547-59. PMID: 15301552.
        View in: PubMed
      57. Cassano AG, Anderson VE, Harris M. Understanding the transition states of phosphodiester bond cleavage: insights from heavy atom isotope effects. Biopolymers. 2004 Jan; 73(1):110-29. PMID: 14691944.
        View in: PubMed
      58. Zahler NH, Christian EL, Harris M. Recognition of the 5' leader of pre-tRNA substrates by the active site of ribonuclease P. RNA. 2003 Jun; 9(6):734-45. PMID: 12756331; PMCID: PMC1370440.
      59. Harris M, Christian EL. Recent insights into the structure and function of the ribonucleoprotein enzyme ribonuclease P. Curr Opin Struct Biol. 2003 Jun; 13(3):325-33. PMID: 12831883.
        View in: PubMed
      60. Kaye NM, Zahler NH, Christian EL, Harris M. Conservation of helical structure contributes to functional metal ion interactions in the catalytic domain of ribonuclease P RNA. J Mol Biol. 2002 Nov 29; 324(3):429-42. PMID: 12445779.
        View in: PubMed
      61. Christian EL, Zahler NH, Kaye NM, Harris M. Analysis of substrate recognition by the ribonucleoprotein endonuclease RNase P. Methods. 2002 Nov; 28(3):307-22. PMID: 12431435.
        View in: PubMed
      62. Cassano AG, Anderson VE, Harris M. Evidence for direct attack by hydroxide in phosphodiester hydrolysis. J Am Chem Soc. 2002 Sep 18; 124(37):10964-5. PMID: 12224928.
        View in: PubMed
      63. Christian EL, Kaye NM, Harris M. Evidence for a polynuclear metal ion binding site in the catalytic domain of ribonuclease P RNA. EMBO J. 2002 May 01; 21(9):2253-62. PMID: 11980722; PMCID: PMC125996.
      64. Kaye NM, Christian EL, Harris M. NAIM and site-specific functional group modification analysis of RNase P RNA: magnesium dependent structure within the conserved P1-P4 multihelix junction contributes to catalysis. Biochemistry. 2002 Apr 09; 41(14):4533-45. PMID: 11926814.
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      65. Campbell FE, Cassano AG, Anderson VE, Harris M. Pre-steady-state and stopped-flow fluorescence analysis of Escherichia coli ribonuclease III: insights into mechanism and conformational changes associated with binding and catalysis. J Mol Biol. 2002 Mar 15; 317(1):21-40. PMID: 11916377.
        View in: PubMed