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    Marcel E Nimni, PhD

    TitleProfessor of Surgery
    SchoolKeck School of Medicine of USC
    DepartmentSurgery
    AddressEDM 191
    Health Sciences Campus
    Los Angeles California 90089-9560
    Phone+1 323 224 5067
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      Collapse Overview
      Dr. Nimni is a Professor of Surgery, Biochemistry & Molecular Biology and Biomedical Engineering, and Director of Tissue Engineering Laboratories at the Keck School of Medicine of USC. His major areas of research activities include: Biochemistry of collagen: molecular structure, biosynthesis, mechanisms of crosslinking in soft tissues, bone and cartilage; interactions between connective tissues constituents, biochemical changes in degenerative diseases. Cell culture. Hydrophobic interactions involved in the self-assembly of macromolecules. Biochemistry of vascular tissues. Trans-dermal drug delivery. Mechanism of bone formation and dystrophic calcification. Osteogenesis: decline of osteoprogenitor cells with age. Collagen derived bioprosthesis. Growth factors (TGF-B, BMP’s and others). Bone and cartilage repair. Sulfur amino acids and glutathione: relationship to tissue repair.


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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Hoang BX, Shaw DG, Han B, Fang JY, Nimni M. Acidosis and Formaldehyde Secretion as a Possible Pathway of Cancer Pain and Options for Improved Cancer Pain Control. J Pain Palliat Care Pharmacother. 2015 Sep; 29(3):276-80. PMID: 26368037.
        View in: PubMed
      2. Hoang BX, Han B, Shaw DG, Nimni M. Zinc as a possible preventive and therapeutic agent in pancreatic, prostate, and breast cancer. Eur J Cancer Prev. 2015 Aug 27. PMID: 26317381.
        View in: PubMed
      3. Tan S, Fang JY, Yang Z, Nimni M, Han B. The synergetic effect of hydrogel stiffness and growth factor on osteogenic differentiation. Biomaterials. 2014 Jul; 35(20):5294-306. PMID: 24703716.
        View in: PubMed
      4. Han B, Yang Z, Fang JY, Kuwahara K, Nimni M, Thanasukarn J, Tayag C. The effects of heparin binding proteins in platelet releasate on bone formation. Tissue Eng Part A. 2014 Apr; 20(7-8):1263-70. PMID: 24295446.
        View in: PubMed
      5. Fang J, Yang Z, Tan S, Tayag C, Nimni M, Urata M, Han B. Injectable gel graft for bone defect repair. Regen Med. 2014 Jan; 9(1):41-51. PMID: 24351005.
        View in: PubMed
      6. Tian M, Yang Z, Kuwahara K, Nimni M, Wan C, Han B. Delivery of demineralized bone matrix powder using a thermogelling chitosan carrier. Acta Biomater. 2012 Feb; 8(2):753-62. PMID: 22079781.
        View in: PubMed
      7. Montes LF, Nimni M. Topical griseofulvin in dermatophytoses. Skinmed. 2011 Mar-Apr; 9(2):134-5. PMID: 21548526.
        View in: PubMed
      8. Kuwahara K, Yang Z, Slack GC, Nimni M, Han B. Cell delivery using an injectable and adhesive transglutaminase-gelatin gel. Tissue Eng Part C Methods. 2010 Aug; 16(4):609-18. PMID: 19757996.
        View in: PubMed
      9. Han B, Woodell-May J, Ponticiello M, Yang Z, Nimni M. The effect of thrombin activation of platelet-rich plasma on demineralized bone matrix osteoinductivity. J Bone Joint Surg Am. 2009 Jun; 91(6):1459-70. PMID: 19487525.
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      10. Yeh TT, Wen ZH, Lee HS, Lee CH, Yang Z, Jean YH, Wu SS, Nimni M, Han B. Intra-articular injection of collagenase induced experimental osteoarthritis of the lumbar facet joint in rats. Eur Spine J. 2008 May; 17(5):734-42. PMID: 18224353.
        View in: PubMed
      11. Han B, Yang Z, Nimni M. Effects of gamma irradiation on osteoinduction associated with demineralized bone matrix. J Orthop Res. 2008 Jan; 26(1):75-82. PMID: 17724732.
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      12. Nimni M, Han B, Cordoba F. Are we getting enough sulfur in our diet? Nutr Metab (Lond). 2007; 4:24. PMID: 17986345.
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      13. Kim S, Nimni M, Yang Z, Han B. Chitosan/gelatin-based films crosslinked by proanthocyanidin. J Biomed Mater Res B Appl Biomater. 2005 Nov; 75(2):442-50. PMID: 16047322.
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      14. Han B, Yang Z, Nimni M. Effects of moisture and temperature on the osteoinductivity of demineralized bone matrix. J Orthop Res. 2005 Jul; 23(4):855-61. PMID: 16023000.
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      15. Han B, Nimni M. Transdermal delivery of amino acids and antioxidants enhance collagen synthesis: in vivo and in vitro studies. Connect Tissue Res. 2005; 46(4-5):251-7. PMID: 16546829.
        View in: PubMed
      16. Han B, Tang B, Nimni M. Quantitative and sensitive in vitro assay for osteoinductive activity of demineralized bone matrix. J Orthop Res. 2003 Jul; 21(4):648-54. PMID: 12798064.
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      17. Han B, Jaurequi J, Tang BW, Nimni M. Proanthocyanidin: a natural crosslinking reagent for stabilizing collagen matrices. J Biomed Mater Res A. 2003 Apr 1; 65(1):118-24. PMID: 12635161.
        View in: PubMed
      18. Han B, Tang B, Nimni M. Combined effects of phosphatidylcholine and demineralized bone matrix on bone induction. Connect Tissue Res. 2003; 44(3-4):160-6. PMID: 14504036.
        View in: PubMed
      19. Han B, Perelman N, Tang B, Hall F, Shors EC, Nimni M. Collagen-targeted BMP3 fusion proteins arrayed on collagen matrices or porous ceramics impregnated with Type I collagen enhance osteogenesis in a rat cranial defect model. J Orthop Res. 2002 Jul; 20(4):747-55. PMID: 12168663.
        View in: PubMed
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