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    Mahnaz Shahidi, PhD

    TitleProfessor of Ophthalmology and Biomedical Engineering
    SchoolKeck School of Medicine of USC
    DepartmentOphthalmology
    Address1450 San Pablo Street
    Health Sciences Campus
    Los Angeles California 90033-9224
      Other Positions
      TitleVice Chair For Translational Research


       Overview 
       Overview
      The research of Mahnaz Shahidi, PhD, is focused on development and application of prototype optical imaging technologies to study pathophysiology and improve diagnostic evaluation of ocular and systemic diseases. Ongoing research projects include: imaging of retinal oxygen delivery and metabolism in experimental models of retinal diseases, characterization of microvascular hemodynamics in ocular and systemic diseases, identification of image-based biomarkers of diabetic retinopathy, and assessment of retinal neurovascular coupling and oxygen metabolism in diabetic retinopathy, sickle cell retinopathy and glaucoma. Dr. Shahidi's clinical interests include diabetic retinopathy, sickle cell retinopathy, age-related macular degeneration and glaucoma.


       Biography 
       Awards and Honors
      Juvenile Diabetes Foundation1992Fellowship Award
      The Whitaker Foundation1995Award
      Research to Prevent Blindness2009Senior Scientific Investigator Award
      2010Morton F. Goldberg, MD, FACS Professorship
      UIC2012Inventor of the Year Award
      UIC2014Faculty of the Year Award

       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Blair NP, Wanek J, Felder AE, Brewer KC, Joslin CE, Shahidi M. Inner Retinal Oxygen Delivery, Metabolism, and Extraction Fraction in Ins2Akita Diabetic Mice. Invest Ophthalmol Vis Sci. 2016 Nov 01; 57(14):5903-5909..
        View in: PubMed
      2. Felder AE, Wanek J, Blair NP, Joslin CE, Brewer KC, Chau FY, Lim JI, Leiderman YI, Shahidi M. The Effects of Diabetic Retinopathy Stage and Light Flicker on Inner Retinal Oxygen Extraction Fraction. Invest Ophthalmol Vis Sci. 2016 Oct 1; 57(13):5586-5592..
        View in: PubMed
      3. Wanek J, Blair NP, Chau FY, Lim JI, Leiderman YI, Shahidi M. Alterations in Retinal Layer Thickness and Reflectance at Different Stages of Diabetic Retinopathy by En Face Optical Coherence Tomography. Invest Ophthalmol Vis Sci. 2016 Jul 1; 57(9):OCT341-7..
        View in: PubMed
      4. Khansari MM, O'Neill W, Penn R, Chau F, Blair NP, Shahidi M. Automated fine structure image analysis method for discrimination of diabetic retinopathy stage using conjunctival microvasculature images. Biomed Opt Express. 2016 Jul 1; 7(7):2597-606..
        View in: PubMed
      5. Felder AE, Mercurio C, Wanek J, Ansari R, Shahidi M. Automated Real-Time Conjunctival Microvasculature Image Stabilization. IEEE Trans Med Imaging. 2016 Jul; 35(7):1670-5..
        View in: PubMed
      6. Francis AW, Wanek J, Lim JI, Shahidi M. Enface Thickness Mapping and Reflectance Imaging of Retinal Layers in Diabetic Retinopathy. PLoS One. 2015; 10(12):e0145628..
        View in: PubMed
      7. Kord Valeshabad A, Wanek J, Molokie RE, Machado RF, Gordeuk VR, Shahidi M. Conjunctival and pulmonary hemodynamic properties in sickle cell disease subjects with and without pulmonary hypertension. Clin Case Rep. 2015 Dec; 3(12):1038-41..
        View in: PubMed
      8. Blair NP, Wanek J, Teng PY, Shahidi M. The effect of intravitreal vascular endothelial growth factor on inner retinal oxygen delivery and metabolism in rats. Exp Eye Res. 2016 Feb; 143:141-7..
        View in: PubMed
      9. Khansari MM, Wanek J, Felder AE, Camardo N, Shahidi M. Automated Assessment of Hemodynamics in the Conjunctival Microvasculature Network. IEEE Trans Med Imaging. 2016 Feb; 35(2):605-11..
        View in: PubMed
      10. Felder AE, Wanek J, Blair NP, Shahidi M. Inner Retinal Oxygen Extraction Fraction in Response to Light Flicker Stimulation in Humans. Invest Ophthalmol Vis Sci. 2015 Oct 1; 56(11):6633-7.; PMCID: PMC4611954 [Available on 04/01/16].
        View in: PubMed
        View in: PubMed Central
      11. Kord Valeshabad A, Wanek J, Gaynes B, Saraf SL, Molokie R, Shahidi M. Conjunctival microvascular hemodynamics following vaso-occlusive crisis in sickle cell disease. Clin Hemorheol Microcirc. 2015 Sep 25; 62(4):359-67..
        View in: PubMed
      12. Kord Valeshabad A, Wanek J, Saraf SL, Gaynes BI, Gordeuk VR, Molokie RE, Shahidi M. Changes in Conjunctival Hemodynamics Predict Albuminuria in Sickle Cell Nephropathy. Am J Nephrol. 2015; 41(6):487-93.; NIHMSID: NIHMS708697 [Available on 08/05/16].
        View in: PubMed
      13. Kord Valeshabad A, Francis AW, Setlur V, Chang P, Mieler WF, Shahidi M. Hemorrhagic Retinopathy after Spondylosis Surgery and Seizure. Optom Vis Sci. 2015 Aug; 92(8):e190-3.; NIHMSID: NIHMS691622 [Available on 08/01/16].
        View in: PubMed
      14. Kord Valeshabad A, Mieler WF, Setlur V, Thomas M, Shahidi M. Posterior segment toxicity after gemcitabine and docetaxel chemotherapy. Optom Vis Sci. 2015 May; 92(5):e110-3.; NIHMSID: NIHMS668202 [Available on 05/01/16].
        View in: PubMed
      15. Mohammad F, Ansari R, Wanek J, Francis A, Shahidi M. Feasibility of level-set analysis of enface OCT retinal images in diabetic retinopathy. Biomed Opt Express. 2015 May 1; 6(5):1904-18.; PMCID: PMC4467721.
        View in: PubMed
        View in: PubMed Central
      16. Kord Valeshabad A, Wanek J, Mukarram F, Zelkha R, Testai FD, Shahidi M. Feasibility of assessment of conjunctival microvascular hemodynamics in unilateral ischemic stroke. Microvasc Res. 2015 Jul; 100:4-8.; NIHMSID: NIHMS684587 [Available on 07/01/16].
        View in: PubMed
      17. Kord Valeshabad A, Wanek J, McAnany JJ, Shahidi M. Effects of optical blur reduction on equivalent intrinsic blur. Optom Vis Sci. 2015 Apr; 92(4):494-9.; NIHMSID: NIHMS662379 [Available on 04/01/16].
        View in: PubMed
      18. Lim JI, Zelkha R, Niec M, Setlur V, Shahidi M. Inner and outer retinal thickness mapping of nonproliferative diabetic retinopathy by spectral-domain optical coherence tomography. Ophthalmic Surg Lasers Imaging Retina. 2015 Mar; 46(3):316-20..
        View in: PubMed
      19. Abbasian J, Blair N, Shahidi M, Ying GS, Huang J, Kaufman L, Blair M. Macular optical coherence tomography in patients with unilateral optic nerve hypoplasia. J AAPOS. 2015 Feb; 19(1):57-61..
        View in: PubMed
      20. Kord Valeshabad A, Wanek J, Zelkha R, Lim JI, Camardo N, Gaynes B, Shahidi M. Conjunctival microvascular haemodynamics in sickle cell retinopathy. Acta Ophthalmol. 2015 Jun; 93(4):e275-80.; NIHMSID: NIHMS635099 [Available on 06/01/16].
        View in: PubMed
      21. Mohammad F, Wanek J, Zelkha R, Lim JI, Chen J, Shahidi M. A Method for En Face OCT Imaging of Subretinal Fluid in Age-Related Macular Degeneration. J Ophthalmol. 2014; 2014:720243.; PMCID: PMC4244942.
        View in: PubMed
        View in: PubMed Central
      22. Valeshabad AK, Wanek J, Grant P, Lim JI, Chau FY, Zelkha R, Camardo N, Shahidi M. Wavefront error correction with adaptive optics in diabetic retinopathy. Optom Vis Sci. 2014 Oct; 91(10):1238-43.; NIHMSID: NIHMS577858.
        View in: PubMed
      23. Teng PY, Wanek J, Blair NP, Shahidi M. Response of inner retinal oxygen extraction fraction to light flicker under normoxia and hypoxia in rat. Invest Ophthalmol Vis Sci. 2014 Sep; 55(9):6055-8.; PMCID: PMC4176416.
        View in: PubMed
        View in: PubMed Central
      24. Moss HE, Treadwell G, Wanek J, DeLeon S, Shahidi M. Retinal vessel diameter assessment in papilledema by semi-automated analysis of SLO images: feasibility and reliability. Invest Ophthalmol Vis Sci. 2014 Apr; 55(4):2049-54.; PMCID: PMC3979275.
        View in: PubMed
        View in: PubMed Central
      25. Mezu-Ndubuisi OJ, Wanek J, Chau FY, Teng PY, Blair NP, Reddy NM, Raj JU, Reddy SP, Shahidi M. Correspondence of retinal thinning and vasculopathy in mice with oxygen-induced retinopathy. Exp Eye Res. 2014 May; 122:119-22.; NIHMSID: NIHMS582434.
        View in: PubMed
      26. Wanek J, Teng PY, Blair NP, Shahidi M. Inner retinal oxygen delivery and metabolism in streptozotocin diabetic rats. Invest Ophthalmol Vis Sci. 2014 Mar; 55(3):1588-93.; PMCID: PMC3954275.
        View in: PubMed
        View in: PubMed Central
      27. McAnany JJ, Wanek J, Zelkha R, Lim JI, Chau F, Shahidi M. Neural constraints on visual acuity in proliferative diabetic retinopathy. Optom Vis Sci. 2014 Feb; 91(2):194-9.; NIHMSID: NIHMS543475.
        View in: PubMed
      28. Mezu-Ndubuisi OJ, Teng PY, Wanek J, Blair NP, Chau FY, Reddy NM, Raj JU, Reddy SP, Shahidi M. In vivo retinal vascular oxygen tension imaging and fluorescein angiography in the mouse model of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2013; 54(10):6968-72.; PMCID: PMC3808101.
        View in: PubMed
        View in: PubMed Central
      29. Wanek J, Teng PY, Blair NP, Shahidi M. Inner retinal oxygen delivery and metabolism under normoxia and hypoxia in rat. Invest Ophthalmol Vis Sci. 2013 Jul; 54(7):5012-9.; PMCID: PMC3723378.
        View in: PubMed
        View in: PubMed Central
      30. Wanek J, Gaynes B, Lim JI, Molokie R, Shahidi M. Human bulbar conjunctival hemodynamics in hemoglobin SS and SC disease. Am J Hematol. 2013 Aug; 88(8):661-4.; NIHMSID: NIHMS586718.
        View in: PubMed
      31. Yildirim I, Ansari R, Samil Yetik I, Shahidi M. Direct regularized estimation of retinal vascular oxygen tension based on an experimental model. Ann Biomed Eng. 2013 Nov; 41(11):2285-95.; NIHMSID: NIHMS586313.
        View in: PubMed
      32. Teng PY, Wanek J, Blair NP, Shahidi M. Inner retinal oxygen extraction fraction in rat. Invest Ophthalmol Vis Sci. 2013 Jan; 54(1):647-51.; PMCID: PMC3558991.
        View in: PubMed
        View in: PubMed Central
      33. Gaynes B, Teng PY, Wanek J, Shahidi M. Feasibility of conjunctival hemodynamic measurements in rabbits: reproducibility, validity, and response to acute hypotension. Microcirculation. 2012 Aug; 19(6):521-9.; NIHMSID: NIHMS465113.
        View in: PubMed
      34. McAnany JJ, Alexander KR, Lim JI, Shahidi M. Object frequency characteristics of visual acuity. Invest Ophthalmol Vis Sci. 2011 Dec; 52(13):9534-8.; PMCID: PMC3341120.
        View in: PubMed
        View in: PubMed Central
      35. Teng PY, Blair NP, Wanek J, Shahidi M. Oxygen tension and gradient measurements in the retinal microvasculature of rats. Graefes Arch Clin Exp Ophthalmol. 2012 Mar; 250(3):361-7.; NIHMSID: NIHMS344617.
        View in: PubMed
      36. Wanek J, Blair NP, Shahidi M. Outer retinal oxygen consumption of rat by phosphorescence lifetime imaging. Curr Eye Res. 2012 Feb; 37(2):132-7.; NIHMSID: NIHMS481994.
        View in: PubMed
      37. Wanek J, Teng PY, Albers J, Blair NP, Shahidi M. Inner retinal metabolic rate of oxygen by oxygen tension and blood flow imaging in rat. Biomed Opt Express. 2011 Sep 1; 2(9):2562-8.; PMCID: PMC3184865.
        View in: PubMed
        View in: PubMed Central
      38. Wanek J, Zelkha R, Lim JI, Shahidi M. Feasibility of a method for en face imaging of photoreceptor cell integrity. Am J Ophthalmol. 2011 Nov; 152(5):807-14.e1.; NIHMSID: NIHMS312119.
        View in: PubMed
      39. McAnany JJ, Shahidi M, Applegate RA, Zelkha R, Alexander KR. Contributions of optical and non-optical blur to variation in visual acuity. Optom Vis Sci. 2011 Jun; 88(6):716-23.; NIHMSID: NIHMS279957.
        View in: PubMed
      40. Hoang QV, Chau FY, Shahidi M, Lim JI. Central macular splaying and outer retinal thinning in asymptomatic sickle cell patients by spectral-domain optical coherence tomography. Am J Ophthalmol. 2011 Jun; 151(6):990-994.e1.; NIHMSID: NIHMS484246.
        View in: PubMed
      41. Hoang QV, Chau FY, Shahidi M, Miller MT, Blair MP. Macular thinning associated with unilateral optic nerve hypoplasia. Ophthalmic Surg Lasers Imaging. 2011; 42 Online:e6-9.; NIHMSID: NIHMS481569.
        View in: PubMed
      42. Loduca AL, Zhang C, Zelkha R, Shahidi M. Thickness mapping of retinal layers by spectral-domain optical coherence tomography. Am J Ophthalmol. 2010 Dec; 150(6):849-55.; NIHMSID: NIHMS247678.
        View in: PubMed
      43. Shahidi M, Wanek J, Blair NP, Little DM, Wu T. Retinal tissue oxygen tension imaging in the rat. Invest Ophthalmol Vis Sci. 2010 Sep; 51(9):4766-70.; PMCID: PMC2941162.
        View in: PubMed
        View in: PubMed Central
      44. Blair MP, Gupta M, Blair NP, Shahidi M. Association between retinal thickness and retinal pigment epithelium elevation in age-related macular degeneration. Ophthalmic Surg Lasers Imaging. 2010 Mar-Apr; 41(2):175-81..
        View in: PubMed
      45. Pasadhika S, Fishman GA, Stone EM, Lindeman M, Zelkha R, Lopez I, Koenekoop RK, Shahidi M. Differential macular morphology in patients with RPE65-, CEP290-, GUCY2D-, and AIPL1-related Leber congenital amaurosis. Invest Ophthalmol Vis Sci. 2010 May; 51(5):2608-14.; PMCID: PMC2868490.
        View in: PubMed
        View in: PubMed Central
      46. Blair NP, Wanek JM, Mori M, Shahidi M. Abnormal retinal vascular oxygen tension response to light flicker in diabetic rats. Invest Ophthalmol Vis Sci. 2009 Nov; 50(11):5444-8.; NIHMSID: NIHMS206016.
        View in: PubMed
      47. Yildirim I, Ansari R, Wanek J, Yetik IS, Shahidi M. Regularized estimation of retinal vascular oxygen tension from phosphorescence images. IEEE Trans Biomed Eng. 2009 Aug; 56(8):1989-95.; NIHMSID: NIHMS206125.
        View in: PubMed
      48. Yang YR, Wanek J, Shahidi M. Representing the retinal line spread shape with mathematical functions. J Zhejiang Univ Sci B. 2008 Dec; 9(12):996-1002.; PMCID: PMC2596293.
        View in: PubMed
        View in: PubMed Central
      49. Blair NP, Shahidi M, Lai WW, Zelkha R. Correlation between microaneurysms and retinal thickness in diabetic macular edema. Retina. 2008 Oct; 28(8):1097-103..
        View in: PubMed
      50. Shahidi M, Wanek J, Blair NP, Mori M. Three-dimensional mapping of chorioretinal vascular oxygen tension in the rat. Invest Ophthalmol Vis Sci. 2009 Feb; 50(2):820-5.; NIHMSID: NIHMS95748.
        View in: PubMed
      51. Bagci AM, Shahidi M, Ansari R, Blair M, Blair NP, Zelkha R. Thickness profiles of retinal layers by optical coherence tomography image segmentation. Am J Ophthalmol. 2008 Nov; 146(5):679-87.; NIHMSID: NIHMS76762.
        View in: PubMed
      52. Wanek JM, Mori M, Shahidi M. Effect of aberrations and scatter on image resolution assessed by adaptive optics retinal section imaging. J Opt Soc Am A Opt Image Sci Vis. 2007 May; 24(5):1296-304.; NIHMSID: NIHMS182381.
        View in: PubMed
      53. Apushkin MA, Fishman GA, Alexander KR, Shahidi M. Retinal thickness and visual thresholds measured in patients with retinitis pigmentosa. Retina. 2007 Mar; 27(3):349-57..
        View in: PubMed
      54. Shahidi M, Mori M, Zelkha R. A method for three-dimensional imaging of the retina in human eyes. Ophthalmic Surg Lasers Imaging. 2007 Jan-Feb; 38(1):35-42..
        View in: PubMed
      55. Shakoor A, Blair NP, Mori M, Shahidi M. Chorioretinal vascular oxygen tension changes in response to light flicker. Invest Ophthalmol Vis Sci. 2006 Nov; 47(11):4962-5.; NIHMSID: NIHMS206017.
        View in: PubMed
      56. Badlani V, Shahidi M, Shakoor A, Edward DP, Zelkha R, Wilensky J. Nerve fiber layer thickness in glaucoma patients with asymmetric hemifield visual field loss. J Glaucoma. 2006 Aug; 15(4):275-80..
        View in: PubMed
      57. Shahidi M, Shakoor A, Blair NP, Mori M, Shonat RD. A method for chorioretinal oxygen tension measurement. Curr Eye Res. 2006 Apr; 31(4):357-66.; NIHMSID: NIHMS207471.
        View in: PubMed
      58. Shahidi M, Yang Y, Rajagopalan AS, Alexander KR, Zelkha R, Fishman GA. A method for differentiating ocular higher-order aberrations from light scatter applied to retinitis pigmentosa. Optom Vis Sci. 2005 Nov; 82(11):976-80..
        View in: PubMed
      59. Shakoor A, Shahidi M, Blair NP, Mori M. Noninvasive assessment of chorioretinal oxygenation changes in experimental carotid occlusion. Curr Eye Res. 2005 Sep; 30(9):763-71..
        View in: PubMed
      60. Shakoor A, Blair NP, Shahidi M. Imaging retinal depression sign in sickle cell anemia using optical coherence tomography and the retinal thickness analyzer. Arch Ophthalmol. 2005 Sep; 123(9):1278-9..
        View in: PubMed
      61. Rajagopalan AS, Shahidi M, Alexander KR, Fishman GA, Zelkha R. Higher-order wavefront aberrations in retinitis pigmentosa. Optom Vis Sci. 2005 Jul; 82(7):623-8..
        View in: PubMed
      62. Shahidi M, Wang Z, Zelkha R. Quantitative thickness measurement of retinal layers imaged by optical coherence tomography. Am J Ophthalmol. 2005 Jun; 139(6):1056-61..
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      63. Shahidi M, Yang Y. Measurements of ocular aberrations and light scatter in healthy subjects. Optom Vis Sci. 2004 Nov; 81(11):853-7..
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      64. Joslin CE, Wu SM, McMahon TT, Shahidi M. Is "whole eye" wavefront analysis helpful to corneal refractive therapy? Eye Contact Lens. 2004 Oct; 30(4):186-8; discussion 205-6..
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      65. Shahidi M, Blair NP, Mori M, Zelkha R. Optical section retinal imaging and wavefront sensing in diabetes. Optom Vis Sci. 2004 Oct; 81(10):778-84..
        View in: PubMed
      66. Shahidi M, Blair NP, Mori M, Zelkha R. Feasibility of noninvasive imaging of chorioretinal oxygenation. Ophthalmic Surg Lasers Imaging. 2004 Sep-Oct; 35(5):415-22..
        View in: PubMed
      67. Szlyk JP, Mahler CL, Seiple W, Vajaranant TS, Blair NP, Shahidi M. Relationship of retinal structural and clinical vision parameters to driving performance of diabetic retinopathy patients. J Rehabil Res Dev. 2004 May; 41(3A):347-58..
        View in: PubMed
      68. Joslin CE, Wu SM, McMahon TT, Shahidi M. Higher-order wavefront aberrations in corneal refractive therapy. Optom Vis Sci. 2003 Dec; 80(12):805-11..
        View in: PubMed
      69. Lai WW, Shahidi M, Mori M, Pulido JS. Chorioretinal topography and histopathology in laser-induced choroidal neovascularization. Ophthalmic Surg Lasers Imaging. 2003 Jan-Feb; 34(1):38-43..
        View in: PubMed
      70. Nishiwaki H, Shahidi M, Vitale S, Alexander J, Asran S, Mori M, Blair NP, Zeimer R. Relation between retinal thickening and clinically visible fundus pathologies in mild nonproliferative diabetic retinopathy. Ophthalmic Surg Lasers. 2002 Mar-Apr; 33(2):127-34..
        View in: PubMed
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