Lynda Kay McGinnis, PhD

Title(s)Assistant Professor of Research Obstetrics & Gynecology
SchoolKeck School of Medicine of Usc
AddressIRD 2020 Zonal Ave
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 865 3013
ORCID ORCID Icon0000-0001-7910-9655 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Kansas, Kansas City KSPh.D.Physiology of Reproduction
    Iowa State University, Ames IAM.S.Physiology of Reproduction
    Seattle University, Seattle WAB.S.Biology

    Collapse Overview 
    Collapse Overview
    Areas of interest
    • Effects of the microenvironment and chemotherapy treatments on oocyte health and future embryo developmental potential
    • Oocyte maturation and preimplantation embryo development
    • Fertilization and cell signaling

    Oocyte and embryo health are the primary focus of my research. Our previous research lead to the development of KSOMaa (trade name “Global”), a liquid culture media that provides nutritional support for preimplantation embryos growing in vitro and is now used worldwide in clinical embryology labs treating patients for infertility. We work directly with the clinicians and fellows in the Division of Reproductive Endocrinology and Infertility, and the USC Fertility Clinic on studies designed to understand the causes of infertility, reduced oocyte quality, and poor embryo survival. Identifying the underlying causes of these conditions will enable the development of new treatments that will improve pregnancy rates and the birth of healthy children.

    Current research studies ongoing in my laboratory:
    1. “The effects of long-term cancer treatments on reproductive outlook for cancer survivors”: Some cancer survivors must continue taking therapeutic doses of chemotherapy drugs for many years. For young women of reproductive age, there is concern regarding the effects of these treatments on their chances to have children in the future. We are currently studying the ovarian response and oocyte quality following long-term treatments with Gleevec (Imatinib) or Tamoxifen.
    2. “Exosome / microvesicle regulation of oocyte developmental competence”: Extracellular vesicles (exosomes and microvesicles) are tiny (50-200um) vesicles that are released by cells to send messages and signals to neighboring cells. The fluid that surrounds a growing oocyte contains thousands of vesicles carrying messages between cells of the ovary and the growing oocyte. Our research is aimed to determine the function of these vesicles and if they can be used as markers indicating oocyte health or tools to improve fertilization and embryo development.

    Collapse Research 
    Collapse Research Activities and Funding
    Ex vivo whole ovary culture system for screening gonadotoxicity during drug development
    NIH R43HD114386Sep 22, 2023 - Aug 11, 2024
    Role: PI of sub-award
    Description: This phase I project will provide crucial proof-of-principle for future Phase II studies to test the ability of the whole ovary culture system for longer culture period (1 month), collaborate with drug companies to screen drug candidates for their ovotoxicity or ovoprotection potentials, and to examine long-term endocrine and fertility consequences by transplanting chemotherapeutics-treated ovaries back to the host animal. The technology to maintain prolonged live/functional has the added potential for observing follicle maturation and its related studies (basic and clinical research). Successful development of an ex vivo whole ovary culture system will set new industrial standards during drug development because it will allow the use of ovaries from larger mammals (including women) without causing harm and death to the animal, and it will allow evaluation of the whole ovary while mimicking in vivo delivery of toxic chemotherapeutics.
    Androgens Promote Fertilization of Primate Oocytes
    Wisconsin National Primate Research Center Jan 28, 2020 - Dec 30, 2023
    Role: Co-Investigator
    Description: The ultimate goal of this study is to improve human health, through improved treatments for infertility and the development of new, effective contraceptives. The proposed studies are based on novel preliminary data which indicate a critical role for intrafollicular androgens to prepare the oocyte for fertilization, an essential step in overall fertility. If successful, the results of the proposed studies will 1) identify the androgen-dependent structural and functional changes in the oocyte prior to fertilization and 2) determine the cellular target(s) for androgen action. This knowledge may suggest changes to protocols for human in vitro fertilization and/or point to novel targets for contractive development.
    Tamoxifen Effects on Reproductive Outlook for Cancer Survivors”
    Wright Foundation Jul 1, 2019 - Dec 30, 2021
    Role: PI
    Description: The goal of this study is to determine the effects of long-term tamoxifen treatments on the ovary and future potential for pregnancy, and potential for effects on offspring conceived after tamoxifen treatments.
    Tyrosine kinas inhibitor effects on reproductive outlook for cancer patients
    American Cancer Society IRG-58-0070-51Jan 1, 2016 - Dec 31, 2018
    Role: PI
    Exosome / microvesicle regulation of oocyte developmental competence
    NIH R21HD082484Dec 15, 2014 - Nov 30, 2017
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Total and bioavailable 25-hydroxyvitamin D is not associated with improved sexual dysfunction following vitamin D supplementation in women with polycystic ovarian syndrome: a pilot study. J Sex Med. 2024 Feb 27; 21(3):240-247. Eickman K, Maxwell R, McGinnis LK, Stanczyk F, Legro R, Lindheim SR. PMID: 38303661; PMCID: PMC10906494.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Anti-Müllerian hormone levels are associated with skeletal maturity in adolescent girls in the Fels Longitudinal Study. Res Sq. 2023 Sep 29. Ford ML, Choh AC, Gonzalez B, Lindheim SR, Stanczyk FZ, McGinnis LK, Czerwinski SA, Lee M. PMID: 37841846; PMCID: PMC10571635.
      View in: PubMed   Mentions:
    3. Consistency of endometrial receptivity array and histologic dating of spatially distinct endometrial samplings: a prospective, blinded study. F S Rep. 2023 Dec; 4(4):375-379. Place TL, Agarwal R, Najafzadeh P, Walia S, McGinnis LK, Kohli P, Felix JC, Paulson RJ. PMID: 38204947; PMCID: PMC10774899.
      View in: PubMed   Mentions:
    4. Effect of trophectoderm biopsy for PGT-A on live birth rate per embryo in good prognosis patients. Arch Gynecol Obstet. 2022 10; 306(4):1321-1327. Awadalla MS, Agarwal R, Ho JR, McGinnis LK, Ahmady A. PMID: 35821525; PMCID: PMC9470687.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Embryo morphology and live birth in the United States. F S Rep. 2022 Jun; 3(2):131-137. Awadalla MS, Ho JR, McGinnis LK, Ahmady A, Cortessis VK, Paulson RJ. PMID: 35789729; PMCID: PMC9250116.
      View in: PubMed   Mentions: 1  
    6. Examining pre-term birth and cesarean section rates in gestational carrier pregnancies. J Assist Reprod Genet. 2021 Oct; 38(10):2707-2712. Smith MB, Mandelbaum RS, McGinnis LK, Paulson RJ. PMID: 34417659; PMCID: PMC8581118.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Developmental potential of immature human oocytes aspirated after controlled ovarian stimulation. J Assist Reprod Genet. 2021 Sep; 38(9):2291-2299. Mandelbaum RS, Awadalla MS, Smith MB, Violette CJ, Klooster BL, Danis RB, McGinnis LK, Ho JR, Bendikson KA, Paulson RJ, Ahmady A. PMID: 34169401; PMCID: PMC8490553.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    8. Effect of age and morphology on sustained implantation rate after euploid blastocyst transfer. Reprod Biomed Online. 2021 Sep; 43(3):395-403. Awadalla MS, Vestal NL, McGinnis LK, Ahmady A, Paulson RJ. PMID: 34332901.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    9. What is the optimal timing of intracytoplasmic sperm injection (ICSI) after EGG retrieval? A randomized controlled trial. J Assist Reprod Genet. 2021 Aug; 38(8):2151-2156. Smith MB, Ho JR, Cortessis V, Chen IJ, Bendikson KA, Paulson RJ, McGinnis LK, Ahmady A. PMID: 34081233; PMCID: PMC8417178.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    10. A validated model for predicting live birth after embryo transfer. Sci Rep. 2021 05 24; 11(1):10800. Awadalla MS, Bendikson KA, Ho JR, McGinnis LK, Ahmady A. PMID: 34031492; PMCID: PMC8144418.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    11. Association of bioavailable inhibin B and oocyte yield in controlled ovarian stimulation. F S Rep. 2021 Jun; 2(2):189-194. Danis RB, Sriprasert I, Ho JR, McGinnis LK, Kumar A, Stanczyk FZ. PMID: 34278353; PMCID: PMC8267401.
      View in: PubMed   Mentions: 1  
    12. Influence of Trophectoderm Biopsy Prior to Frozen Blastocyst Transfer on Obstetrical Outcomes. Reprod Sci. 2021 12; 28(12):3459-3465. Awadalla MS, Park KE, Latack KR, McGinnis LK, Ahmady A, Paulson RJ. PMID: 33768514.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    13. Longitudinal antimüllerian hormone and its correlation with pubertal milestones. F S Rep. 2021 Jun; 2(2):238-244. Smith MB, Ho J, Ma L, Lee M, Czerwinski SA, Glenn TL, Cool DR, Gagneux P, Stanczyk FZ, McGinnis LK, Lindheim SR. PMID: 34278360; PMCID: PMC8267383.
      View in: PubMed   Mentions: 4  
    14. A View from the past into our collective future: the oncofertility consortium vision statement. J Assist Reprod Genet. 2021 Jan; 38(1):3-15. Woodruff TK, Ataman-Millhouse L, Acharya KS, Almeida-Santos T, Anazodo A, Anderson RA, Appiah L, Bader J, Becktell K, Brannigan RE, Breech L, Bourlon MT, Bumbuliene Ž, Burns K, Campo-Engelstein L, Campos JR, Centola GM, Chehin MB, Chen D, De Vos M, Duncan FE, El-Damen A, Fair D, Famuyiwa Y, Fechner PY, Fontoura P, Frias O, Gerkowicz SA, Ginsberg J, Gracia CR, Goldman K, Gomez-Lobo V, Hazelrigg B, Hsieh MH, Hoyos LR, Hoyos-Martinez A, Jach R, Jassem J, Javed M, Jayasinghe Y, Jeelani R, Jeruss JS, Kaul-Mahajan N, Keim-Malpass J, Ketterl TG, Khrouf M, Kimelman D, Kusuhara A, Kutteh WH, Laronda MM, Lee JR, Lehmann V, Letourneau JM, McGinnis LK, McMahon E, Meacham LR, Mijangos MFV, Moravek M, Nahata L, Ogweno GM, Orwig KE, Pavone ME, Peccatori FA, Pesce RI, Pulaski H, Quinn G, Quintana R, Quintana T, de Carvalho BR, Ramsey-Goldman R, Reinecke J, Reis FM, Rios J, Rhoton-Vlasak AS, Rodriguez-Wallberg KA, Roeca C, Rotz SJ, Rowell E, Salama M, Saraf AJ, Scarella A, Schafer-Kalkhoff T, Schmidt D, Senapati S, Shah D, Shikanov A, Shnorhavorian M, Skiles JL, Smith JF, Smith K, Sobral F, Stimpert K, Su HI, Sugimoto K, Suzuki N, Thakur M, Victorson D, Viale L, Vitek W, Wallace WH, Wartella EA, Westphal LM, Whiteside S, Wilcox LH, Wyns C, Xiao S, Xu J, Zelinski M. PMID: 33405006; PMCID: PMC7786868.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    15. Klotho: spinning up some new hype for decreased ovarian reserve research? Fertil Steril. 2020 12; 114(6):1174. Place TL, McGinnis LK. PMID: 33041052.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. Transfer the best and biopsy the rest? Blastocyst euploidy rates differ by morphology and day of biopsy. Arch Gynecol Obstet. 2021 01; 303(1):249-258. McDaniel KE, Awadalla MS, McGinnis LK, Ahmady A. PMID: 32808112.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    17. Effect of Age and Morphology on Live Birth Rate After Cleavage Stage Embryo Transfer. Reprod Sci. 2021 01; 28(1):43-51. Awadalla M, Vestal N, McGinnis L, Ahmady A. PMID: 32648121; PMCID: PMC7782445.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    18. Long-term imatinib diminishes ovarian reserve and impacts embryo quality. J Assist Reprod Genet. 2020 Jun; 37(6):1459-1466. Salem W, Ho JR, Woo I, Ingles SA, Chung K, Paulson RJ, McGinnis LK. PMID: 32372302; PMCID: PMC7311628.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    19. Autoimmune Regulator is required in female mice for optimal embryonic development and implantation†. Biol Reprod. 2019 06 01; 100(6):1492-1504. Warren BD, Ahn SH, McGinnis LK, Grzesiak G, Su RW, Fazleabas AT, Christenson LK, Petroff BK, Petroff MG. PMID: 30770532; PMCID: PMC6561863.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    20. Imatinib treatments have long-term impact on placentation and embryo survival. Sci Rep. 2019 02 22; 9(1):2535. Salem W, Li K, Krapp C, Ingles SA, Bartolomei MS, Chung K, Paulson RJ, Nowak RA, McGinnis LK. PMID: 30796277; PMCID: PMC6385245.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    21. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018; 7(1):1535750. Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, Ayre DC, Bach JM, Bachurski D, Baharvand H, Balaj L, Baldacchino S, Bauer NN, Baxter AA, Bebawy M, Beckham C, Bedina Zavec A, Benmoussa A, Berardi AC, Bergese P, Bielska E, Blenkiron C, Bobis-Wozowicz S, Boilard E, Boireau W, Bongiovanni A, Borràs FE, Bosch S, Boulanger CM, Breakefield X, Breglio AM, Brennan MÁ, Brigstock DR, Brisson A, Broekman ML, Bromberg JF, Bryl-Górecka P, Buch S, Buck AH, Burger D, Busatto S, Buschmann D, Bussolati B, Buzás EI, Byrd JB, Camussi G, Carter DR, Caruso S, Chamley LW, Chang YT, Chen C, Chen S, Cheng L, Chin AR, Clayton A, Clerici SP, Cocks A, Cocucci E, Coffey RJ, Cordeiro-da-Silva A, Couch Y, Coumans FA, Coyle B, Crescitelli R, Criado MF, D'Souza-Schorey C, Das S, Datta Chaudhuri A, de Candia P, De Santana EF, De Wever O, Del Portillo HA, Demaret T, Deville S, Devitt A, Dhondt B, Di Vizio D, Dieterich LC, Dolo V, Dominguez Rubio AP, Dominici M, Dourado MR, Driedonks TA, Duarte FV, Duncan HM, Eichenberger RM, Ekström K, El Andaloussi S, Elie-Caille C, Erdbrügger U, Falcón-Pérez JM, Fatima F, Fish JE, Flores-Bellver M, Försönits A, Frelet-Barrand A, Fricke F, Fuhrmann G, Gabrielsson S, Gámez-Valero A, Gardiner C, Gärtner K, Gaudin R, Gho YS, Giebel B, Gilbert C, Gimona M, Giusti I, Goberdhan DC, Görgens A, Gorski SM, Greening DW, Gross JC, Gualerzi A, Gupta GN, Gustafson D, Handberg A, Haraszti RA, Harrison P, Hegyesi H, Hendrix A, Hill AF, Hochberg FH, Hoffmann KF, Holder B, Holthofer H, Hosseinkhani B, Hu G, Huang Y, Huber V, Hunt S, Ibrahim AG, Ikezu T, Inal JM, Isin M, Ivanova A, Jackson HK, Jacobsen S, Jay SM, Jayachandran M, Jenster G, Jiang L, Johnson SM, Jones JC, Jong A, Jovanovic-Talisman T, Jung S, Kalluri R, Kano SI, Kaur S, Kawamura Y, Keller ET, Khamari D, Khomyakova E, Khvorova A, Kierulf P, Kim KP, Kislinger T, Klingeborn M, Klinke DJ, Kornek M, Kosanovic MM, Kovács ÁF, Krämer-Albers EM, Krasemann S, Krause M, Kurochkin IV, Kusuma GD, Kuypers S, Laitinen S, Langevin SM, Languino LR, Lannigan J, Lässer C, Laurent LC, Lavieu G, Lázaro-Ibáñez E, Le Lay S, Lee MS, Lee YXF, Lemos DS, Lenassi M, Leszczynska A, Li IT, Liao K, Libregts SF, Ligeti E, Lim R, Lim SK, Line A, Linnemannstöns K, Llorente A, Lombard CA, Lorenowicz MJ, Lörincz ÁM, Lötvall J, Lovett J, Lowry MC, Loyer X, Lu Q, Lukomska B, Lunavat TR, Maas SL, Malhi H, Marcilla A, Mariani J, Mariscal J, Martens-Uzunova ES, Martin-Jaular L, Martinez MC, Martins VR, Mathieu M, Mathivanan S, Maugeri M, McGinnis LK, McVey MJ, Meckes DG, Meehan KL, Mertens I, Minciacchi VR, Möller A, Møller Jørgensen M, Morales-Kastresana A, Morhayim J, Mullier F, Muraca M, Musante L, Mussack V, Muth DC, Myburgh KH, Najrana T, Nawaz M, Nazarenko I, Nejsum P, Neri C, Neri T, Nieuwland R, Nimrichter L, Nolan JP, Nolte-'t Hoen EN, Noren Hooten N, O'Driscoll L, O'Grady T, O'Loghlen A, Ochiya T, Olivier M, Ortiz A, Ortiz LA, Osteikoetxea X, Østergaard O, Ostrowski M, Park J, Pegtel DM, Peinado H, Perut F, Pfaffl MW, Phinney DG, Pieters BC, Pink RC, Pisetsky DS, Pogge von Strandmann E, Polakovicova I, Poon IK, Powell BH, Prada I, Pulliam L, Quesenberry P, Radeghieri A, Raffai RL, Raimondo S, Rak J, Ramirez MI, Raposo G, Rayyan MS, Regev-Rudzki N, Ricklefs FL, Robbins PD, Roberts DD, Rodrigues SC, Rohde E, Rome S, Rouschop KM, Rughetti A, Russell AE, Saá P, Sahoo S, Salas-Huenuleo E, Sánchez C, Saugstad JA, Saul MJ, Schiffelers RM, Schneider R, Schøyen TH, Scott A, Shahaj E, Sharma S, Shatnyeva O, Shekari F, Shelke GV, Shetty AK, Shiba K, Siljander PR, Silva AM, Skowronek A, Snyder OL, Soares RP, Sódar BW, Soekmadji C, Sotillo J, Stahl PD, Stoorvogel W, Stott SL, Strasser EF, Swift S, Tahara H, Tewari M, Timms K, Tiwari S, Tixeira R, et al. PMID: 30637094; PMCID: PMC6322352.
      View in: PubMed   Mentions: 4392     Fields:    
    22. Micro-RNAs involved in cellular proliferation have altered expression profiles in granulosa of young women with diminished ovarian reserve. J Assist Reprod Genet. 2018 Oct; 35(10):1777-1786. Woo I, Christenson LK, Gunewardena S, Ingles SA, Thomas S, Ahmady A, Chung K, Bendikson K, Paulson R, McGinnis LK. PMID: 29987422; PMCID: PMC6150892.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    23. Pushing the limits of detection: investigation of cell-free DNA for aneuploidy screening in embryos. Fertil Steril. 2018 08; 110(3):467-475.e2. Ho JR, Arrach N, Rhodes-Long K, Ahmady A, Ingles S, Chung K, Bendikson KA, Paulson RJ, McGinnis LK. PMID: 29960707.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCTClinical Trials
    24. Blastulation timing is associated with differential mitochondrial content in euploid embryos. J Assist Reprod Genet. 2018 Apr; 35(4):711-720. Ho JR, Arrach N, Rhodes-Long K, Salem W, McGinnis LK, Chung K, Bendikson KA, Paulson RJ, Ahmady A. PMID: 29353449; PMCID: PMC5949106.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    25. Perinatal outcomes after natural conception versus in vitro fertilization (IVF) in gestational surrogates: a model to evaluate IVF treatment versus maternal effects. Fertil Steril. 2017 12; 108(6):993-998. Woo I, Hindoyan R, Landay M, Ho J, Ingles SA, McGinnis LK, Paulson RJ, Chung K. PMID: 29202976.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    26. Stage-specific follicular extracellular vesicle uptake and regulation of bovine granulosa cell proliferation. Biol Reprod. 2017 Oct 01; 97(4):644-655. Hung WT, Navakanitworakul R, Khan T, Zhang P, Davis JS, McGinnis LK, Christenson LK. PMID: 29025042; PMCID: PMC6248580.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    27. The role of angiogenic markers in adverse perinatal outcomes: fresh versus frozen embryo transfers. J Assist Reprod Genet. 2017 Dec; 34(12):1639-1643. Woo I, Chan Y, Sriprasert I, Louie K, Ingles S, Stanczyk F, McGinnis LK, Chung K. PMID: 28871422; PMCID: PMC5714817.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    28. Sperm-oocyte contact induces outside-in signaling via PYK2 activation. Dev Biol. 2017 08 01; 428(1):52-62. Wang H, Luo J, Carlton C, McGinnis LK, Kinsey WH. PMID: 28527703; PMCID: PMC5539980.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    29. Extracellular Vesicles from Bovine Follicular Fluid Support Cumulus Expansion. Biol Reprod. 2015 Nov; 93(5):117. Hung WT, Hong X, Christenson LK, McGinnis LK. PMID: 26423123; PMCID: PMC4712005.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    30. MicroRNA in Ovarian Biology and Disease. Cold Spring Harb Perspect Med. 2015 May 18; 5(9):a022962. McGinnis LK, Luense LJ, Christenson LK. PMID: 25986593; PMCID: PMC4561398.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    31. Role of focal adhesion kinase in oocyte-follicle communication. Mol Reprod Dev. 2015 Feb; 82(2):90-102. McGinnis LK, Kinsey WH. PMID: 25536210; PMCID: PMC4324459.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    32. Ovarian autoimmune disease: clinical concepts and animal models. Cell Mol Immunol. 2014 Nov; 11(6):510-21. Warren BD, Kinsey WK, McGinnis LK, Christenson LK, Jasti S, Stevens AM, Petroff BK, Petroff MG. PMID: 25327908; PMCID: PMC4220844.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    33. Post-ovulatory aging of oocytes disrupts kinase signaling pathways and lysosome biogenesis. Mol Reprod Dev. 2014 Oct; 81(10):928-45. McGinnis LK, Pelech S, Kinsey WH. PMID: 25242074; PMCID: PMC4211271.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    34. PTK2b function during fertilization of the mouse oocyte. Biochem Biophys Res Commun. 2014 Aug 01; 450(3):1212-7. Luo J, McGinnis LK, Carlton C, Beggs HE, Kinsey WH. PMID: 24667605; PMCID: PMC4133292.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    35. A catalyst for change in reproductive science: John D. Biggers as a mentor’s mentor. J Assist Reprod Genet. 2013 Aug; 30(8):979-94. Albertini DF, McGinnis LK. PMID: 24077825; PMCID: PMC3790115.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    36. Protein tyrosine kinase signaling in the mouse oocyte cortex during sperm-egg interactions and anaphase resumption. Mol Reprod Dev. 2013 Apr; 80(4):260-72. McGinnis LK, Luo J, Kinsey WH. PMID: 23401167; PMCID: PMC3891396.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    37. Signaling modalities during oogenesis in mammals. Curr Top Dev Biol. 2013; 102:227-42. McGinnis LK, Limback SD, Albertini DF. PMID: 23287035.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    38. The autoimmune regulator prevents premature reproductive senescence in female mice. Biol Reprod. 2012 Apr; 86(4):110. Jasti S, Warren BD, McGinnis LK, Kinsey WH, Petroff BK, Petroff MG. PMID: 22219212; PMCID: PMC3338656.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    39. Protein tyrosine kinase signaling during oocyte maturation and fertilization. Mol Reprod Dev. 2011 Oct-Nov; 78(10-11):831-45. McGinnis LK, Carroll DJ, Kinsey WH. PMID: 21681843; PMCID: PMC3186829.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    40. Fer tyrosine kinase is required for germinal vesicle breakdown and meiosis-I in mouse oocytes. Mol Reprod Dev. 2011 Jan; 78(1):33-47. McGinnis LK, Hong X, Christenson LK, Kinsey WH. PMID: 21268181; PMCID: PMC3918464.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    41. Mammalian oocytes are targets for prostaglandin E2 (PGE2) action. Reprod Biol Endocrinol. 2010 Nov 01; 8:131. Duffy DM, McGinnis LK, Vandevoort CA, Christenson LK. PMID: 21040553; PMCID: PMC2988801.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    42. Dynamics of protein phosphorylation during meiotic maturation. J Assist Reprod Genet. 2010 Apr; 27(4):169-82. McGinnis LK, Albertini DF. PMID: 20174967; PMCID: PMC2854990.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    43. Role of Fyn kinase in oocyte developmental potential. Reprod Fertil Dev. 2010; 22(6):966-76. Luo J, McGinnis LK, Kinsey WH. PMID: 20591331; PMCID: PMC3933928.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    44. Fyn kinase activity is required for normal organization and functional polarity of the mouse oocyte cortex. Mol Reprod Dev. 2009 Sep; 76(9):819-31. Luo J, McGinnis LK, Kinsey WH. PMID: 19363790; PMCID: PMC4001720.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    45. Further optimization of mouse spermatozoa evaporative drying techniques. Cryobiology. 2009 Aug; 59(1):113-5. Elmoazzen HY, Lee GY, Li MW, McGinnis LK, Lloyd KC, Toner M, Biggers JD. PMID: 19375415; PMCID: PMC2722843.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    46. Multiple mechanisms of germ cell loss in the perinatal mouse ovary. Reproduction. 2009 Apr; 137(4):709-20. Rodrigues P, Limback D, McGinnis LK, Plancha CE, Albertini DF. PMID: 19176312.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    47. Functions of Fyn kinase in the completion of meiosis in mouse oocytes. Dev Biol. 2009 Mar 15; 327(2):280-7. McGinnis LK, Kinsey WH, Albertini DF. PMID: 19118543; PMCID: PMC2649971.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    48. Dicer1 is essential for female fertility and normal development of the female reproductive system. Endocrinology. 2008 Dec; 149(12):6207-12. Hong X, Luense LJ, McGinnis LK, Nothnick WB, Christenson LK. PMID: 18703631; PMCID: PMC2613048.
      View in: PubMed   Mentions: 106     Fields:    Translation:Animals
    49. Oogenesis: Prospects and challenges for the future. J Cell Physiol. 2008 Aug; 216(2):355-65. Rodrigues P, Limback D, McGinnis LK, Plancha CE, Albertini DF. PMID: 18452183.
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    50. Long-term storage of mouse spermatozoa after evaporative drying. Reproduction. 2007 May; 133(5):919-29. Li MW, Biggers JD, Elmoazzen HY, Toner M, McGinnis L, Lloyd KC. PMID: 17616722.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    51. Localized activation of Src-family protein kinases in the mouse egg. Dev Biol. 2007 Jun 01; 306(1):241-54. McGinnis LK, Albertini DF, Kinsey WH. PMID: 17449027; PMCID: PMC2694733.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    52. One-step versus two-step culture of mouse preimplantation embryos: is there a difference? Hum Reprod. 2005 Dec; 20(12):3376-84. Biggers JD, McGinnis LK, Lawitts JA. PMID: 16123096.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    53. Mouse sperm desiccated and stored in trehalose medium without freezing. Biol Reprod. 2005 Oct; 73(4):627-33. McGinnis LK, Zhu L, Lawitts JA, Bhowmick S, Toner M, Biggers JD. PMID: 15930320.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    54. Mouse embryo development following IVF in media containing either L-glutamine or glycyl-L-glutamine. Hum Reprod. 2005 May; 20(5):1364-71. Summers MC, McGinnis LK, Lawitts JA, Biggers JD. PMID: 15705624.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    55. Enhanced effect of glycyl-L-glutamine on mouse preimplantation embryos in vitro. Reprod Biomed Online. 2004 Jul; 9(1):59-69. Biggers JD, McGinnis LK, Lawitts JA. PMID: 15257821.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    56. Discrepancies between the effects of glutamine in cultures of preimplantation mouse embryos. Reprod Biomed Online. 2004 Jul; 9(1):70-3. Biggers JD, McGinnis LK, Summers MC. PMID: 15257823.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    57. Intracytoplasmic sperm injection (ICSI) enables rescue of valuable mutant mouse strains. Comp Med. 2003 Jun; 53(3):265-9. Li MW, McGinnis L, Zhu L, Lawitts J, Biggers J, Lloyd KC. PMID: 12868571.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    58. Desiccation tolerance of spermatozoa dried at ambient temperature: production of fetal mice. Biol Reprod. 2003 May; 68(5):1779-86. Bhowmick S, Zhu L, McGinnis L, Lawitts J, Nath BD, Toner M, Biggers J. PMID: 12606475.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    59. Evidence that glucose is not always an inhibitor of mouse preimplantation development in vitro. Hum Reprod. 2001 Jan; 16(1):153-163. Biggers JD, McGinnis LK. PMID: 11139555.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    60. IVF of mouse ova in a simplex optimized medium supplemented with amino acids. Hum Reprod. 2000 Aug; 15(8):1791-801. Summers MC, McGinnis LK, Lawitts JA, Raffin M, Biggers JD. PMID: 10920105.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    61. Amino acids and preimplantation development of the mouse in protein-free potassium simplex optimized medium. Biol Reprod. 2000 Jul; 63(1):281-93. Biggers JD, McGinnis LK, Raffin M. PMID: 10859270.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    62. Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality. Mol Cell Biol. 1999 Oct; 19(10):7237-44. Donohoe ME, Zhang X, McGinnis L, Biggers J, Li E, Shi Y. PMID: 10490658; PMCID: PMC84716.
      View in: PubMed   Mentions: 153     Fields:    Translation:Animals
    63. Coordinate action of Wt1 and a modifier gene supports embryonic survival in the oviduct. Mol Reprod Dev. 1999 Apr; 52(4):366-75. Kreidberg JA, Natoli TA, McGinnis L, Donovan M, Biggers JD, Amstutz A. PMID: 10092116.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    64. Polyvinyl alcohol and amino acids as substitutes for bovine serum albumin in culture media for mouse preimplantation embryos. Hum Reprod Update. 1997 Mar-Apr; 3(2):125-35. Biggers JD, Summers MC, McGinnis LK. PMID: 9286737.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    65. Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature. 1996 Dec 05; 384(6608):470-4. Sicinski P, Donaher JL, Geng Y, Parker SB, Gardner H, Park MY, Robker RL, Richards JS, McGinnis LK, Biggers JD, Eppig JJ, Bronson RT, Elledge SJ, Weinberg RA. PMID: 8945475.
      View in: PubMed   Mentions: 213     Fields:    Translation:HumansAnimalsCells
    66. Chromatin organization, meiotic status and meiotic competence acquisition in mouse oocytes from cultured ovarian follicles. J Reprod Fertil. 1995 Jul; 104(2):277-84. Johnson LD, Albertini DF, McGinnis LK, Biggers JD. PMID: 7473419.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    67. Investigations into the control of litter size in swine: I. Comparative studies on in vitro development of Meishan and Yorkshire preimplantation embryos. J Anim Sci. 1993 Jun; 71(6):1561-5. Youngs CR, Ford SP, McGinnis LK, Anderson LH. PMID: 8325817.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    68. In vitro development of ovine embryos in CZB medium. Theriogenology. 1992 Mar; 37(3):559-69. McGinnis LK, Youngs CR. PMID: 16727058.
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    69. Failure of embryo transfer to transmit BLV in a dairy herd. Vet Rec. 1990 Nov 03; 127(18):456. DiGiacomo RF, McGinnis LK, Studer E, Evermann JF. PMID: 2177290.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
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