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    Kevin Verne Lemley, MD, PhD

    TitleProfessor of Pediatrics (Clinical Scholar)
    SchoolKeck School of Medicine of USC
    DepartmentPediatrics
    AddressCHL Mail Stop 40
    Off Campus
    Los Angeles California 90089
    Phone+1 323 361 2102
    vCardDownload vCard

      Collapse Overview 
      Collapse Overview
      My main research interests are in podocyte pathobiology and stereologic methods. My clinical interests are in diabetic kidney disease, nephrotic syndrome, genetic kidney diseases. My health systems interests are in the use of clinical pathways/protocols, outcomes assessment and quality audit, and lean systems.


      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Burford JL, Gyarmati G, Shirato I, Kriz W, Lemley K, Peti-Peterdi J. Combined use of electron microscopy and intravital imaging captures morphological and functional features of podocyte detachment. Pflugers Arch. 2017 Aug; 469(7-8):965-974. PMID: 28664407.
        View in: PubMed
      2. Kriz W, Lemley K. Potential relevance of shear stress for slit diaphragm and podocyte function. Kidney Int. 2017 Jun; 91(6):1283-1286. PMID: 28501303.
        View in: PubMed
      3. Mariani LH, Martini S, Barisoni L, Canetta PA, Troost JP, Hodgin JB, Palmer M, Rosenberg AZ, Lemley K, Chien HP, Zee J, Smith A, Appel GB, Trachtman H, Hewitt SM, Kretzler M, Bagnasco SM. Interstitial fibrosis scored on whole-slide digital imaging of kidney biopsies is a predictor of outcome in proteinuric glomerulopathies. Nephrol Dial Transplant. 2017 02 27. PMID: 28339906.
        View in: PubMed
      4. Chon AH, de Oliveira GH, Lemley K, Korst LM, Assaf RD, Chmait RH. Fetal Serum ß2-Microglobulin and Postnatal Renal Function in Lower Urinary Tract Obstruction Treated with Vesicoamniotic Shunt. Fetal Diagn Ther. 2017; 42(1):17-27. PMID: 27603215.
        View in: PubMed
      5. Saulnier PJ, Wheelock KM, Howell S, Weil EJ, Tanamas SK, Knowler WC, Lemley K, Mauer M, Yee B, Nelson RG, Beisswenger PJ. Advanced Glycation End Products Predict Loss of Renal Function and Correlate With Lesions of Diabetic Kidney Disease in American Indians With Type 2 Diabetes. Diabetes. 2016 Dec; 65(12):3744-3753. PMID: 27609106.
        View in: PubMed
      6. Lemley K, Faul C, Schramm K, Meyers K, Kaskel F, Dell KM, Gipson DS, Gibson K, Trachtman H. The Effect of a Gluten-Free Diet in Children With Difficult-to-Manage Nephrotic Syndrome. Pediatrics. 2016 Jul; 138(1). PMID: 27338701; PMCID: PMC4983765.
      7. Lemley K, Bagnasco SM, Nast CC, Barisoni L, Conway CM, Hewitt SM, Song PX. Morphometry Predicts Early GFR Change in Primary Proteinuric Glomerulopathies: A Longitudinal Cohort Study Using Generalized Estimating Equations. PLoS One. 2016; 11(6):e0157148. PMID: 27285824; PMCID: PMC4902229.
      8. Lemley K. Glomerular pathology and the progression of chronic kidney disease. Am J Physiol Renal Physiol. 2016 Jun 01; 310(11):F1385-8. PMID: 27122538.
        View in: PubMed
      9. Kriz W, Lemley K. Mechanical challenges to the glomerular filtration barrier: adaptations and pathway to sclerosis. Pediatr Nephrol. 2017 Mar; 32(3):405-417. PMID: 27008645.
        View in: PubMed
      10. Wheelock KM, Jaiswal M, Martin CL, Fufaa GD, Weil EJ, Lemley K, Yee B, Feldman E, Brosius FC, Knowler WC, Nelson RG, Pop-Busui R. Cardiovascular autonomic neuropathy associates with nephropathy lesions in American Indians with type 2 diabetes. J Diabetes Complications. 2016 Jul; 30(5):873-9. PMID: 27041674; PMCID: PMC4912901 [Available on 07/01/17].
      11. Fufaa GD, Weil EJ, Lemley K, Knowler WC, Brosius FC, Yee B, Mauer M, Nelson RG. Structural Predictors of Loss of Renal Function in American Indians with Type 2 Diabetes. Clin J Am Soc Nephrol. 2016 Feb 05; 11(2):254-61. PMID: 26792530; PMCID: PMC4741038 [Available on 02/05/17].
      12. Pavkov ME, Weil EJ, Fufaa GD, Nelson RG, Lemley K, Knowler WC, Niewczas MA, Krolewski AS. Tumor necrosis factor receptors 1 and 2 are associated with early glomerular lesions in type 2 diabetes. Kidney Int. 2016 Jan; 89(1):226-34. PMID: 26398493; PMCID: PMC4805514.
      13. Gipson DS, Troost JP, Lafayette RA, Hladunewich MA, Trachtman H, Gadegbeku CA, Sedor JR, Holzman LB, Moxey-Mims MM, Perumal K, Kaskel FJ, Nelson PJ, Tuttle KR, Bagnasco SM, Hogan MC, Dell KM, Appel GB, Lieske JC, Ilori TO, Sethna CB, Fervenza FC, Hogan SL, Nachman PH, Rosenberg AZ, Greenbaum LA, Meyers KE, Hewitt SM, Choi MJ, Kopp JB, Zhdanova O, Hodgin JB, Johnstone DB, Adler SG, Avila-Casado C, Neu AM, Hingorani SR, Lemley K, Nast CC, Brady TM, Barisoni-Thomas L, Fornoni A, Jennette JC, Cattran DC, Palmer MB, Gibson KL, Reich HN, Mokrzycki MH, Sambandam KK, Zilleruelo GE, Licht C, Sampson MG, Song P, Mariani LH, Kretzler M. Complete Remission in the Nephrotic Syndrome Study Network. Clin J Am Soc Nephrol. 2016 Jan 07; 11(1):81-9. PMID: 26656320; PMCID: PMC4702222 [Available on 01/07/17].
      14. Sampson MG, Robertson CC, Martini S, Mariani LH, Lemley K, Gillies CE, Otto EA, Kopp JB, Randolph A, Vega-Warner V, Eichinger F, Nair V, Gipson DS, Cattran DC, Johnstone DB, O'Toole JF, Bagnasco SM, Song PX, Barisoni L, Troost JP, Kretzler M, Sedor JR. Integrative Genomics Identifies Novel Associations with APOL1 Risk Genotypes in Black NEPTUNE Subjects. J Am Soc Nephrol. 2016 Mar; 27(3):814-23. PMID: 26150607; PMCID: PMC4769193 [Available on 03/01/17].
      15. Nast CC, Lemley K, Hodgin JB, Bagnasco S, Avila-Casado C, Hewitt SM, Barisoni L. Morphology in the Digital Age: Integrating High-Resolution Description of Structural Alterations With Phenotypes and Genotypes. Semin Nephrol. 2015 May; 35(3):266-78. PMID: 26215864; PMCID: PMC4764351.
      16. Lemley K, Mak RH. Nephrotic syndrome: Efficacy of rituximab in challenging nephrotic syndrome. Nat Rev Nephrol. 2015 May; 11(5):257-8. PMID: 25752834.
        View in: PubMed
      17. Uy N, Graf L, Lemley K, Kaskel F. Effects of gluten-free, dairy-free diet on childhood nephrotic syndrome and gut microbiota. Pediatr Res. 2015 Jan; 77(1-2):252-5. PMID: 25310757; PMCID: PMC4827614.
      18. Kriz W, Lemley K. A potential role for mechanical forces in the detachment of podocytes and the progression of CKD. J Am Soc Nephrol. 2015 Feb; 26(2):258-69. PMID: 25060060; PMCID: PMC4310663.
      19. Da Sacco S, Lemley K, Sedrakyan S, Zanusso I, Petrosyan A, Peti-Peterdi J, Burford J, De Filippo RE, Perin L. A novel source of cultured podocytes. PLoS One. 2013; 8(12):e81812. PMID: 24349133; PMCID: PMC3861313.
      20. Lemley K. LMX1B mutations with nails and kneecaps: a new paradigm? Nephrol Dial Transplant. 2014 Jan; 29(1):9-12. PMID: 24166463.
        View in: PubMed
      21. Lemley K. An unusual case of hypercalcemia in a patient with renal insufficiency. Pediatr Nephrol. 2014 Sep; 29(9):1529-33. PMID: 24037144.
        View in: PubMed
      22. Mammen C, Matsell DG, Lemley K. The importance of clinical pathways and protocols in pediatric nephrology. Pediatr Nephrol. 2014 Oct; 29(10):1903-14. PMID: 23955786.
        View in: PubMed
      23. Lemley K, Bertram JF, Nicholas SB, White K. Estimation of glomerular podocyte number: a selection of valid methods. J Am Soc Nephrol. 2013 Jul; 24(8):1193-202. PMID: 23833256; PMCID: PMC3736716.
      24. Jennifer Weil E, Lemley K, Myers BD, Nelson RG. The authors reply. Kidney Int. 2013 Jun; 83(6):1203. PMID: 23728009; PMCID: PMC3885351.
      25. Weil EJ, Fufaa G, Jones LI, Lovato T, Lemley K, Hanson RL, Knowler WC, Bennett PH, Yee B, Myers BD, Nelson RG. Effect of losartan on prevention and progression of early diabetic nephropathy in American Indians with type 2 diabetes. Diabetes. 2013 Sep; 62(9):3224-31. PMID: 23545707; PMCID: PMC3749332.
      26. Barisoni L, Nast CC, Jennette JC, Hodgin JB, Herzenberg AM, Lemley K, Conway CM, Kopp JB, Kretzler M, Lienczewski C, Avila-Casado C, Bagnasco S, Sethi S, Tomaszewski J, Gasim AH, Hewitt SM. Digital pathology evaluation in the multicenter Nephrotic Syndrome Study Network (NEPTUNE). Clin J Am Soc Nephrol. 2013 Aug; 8(8):1449-59. PMID: 23393107; PMCID: PMC3731905.
      27. Pavkov ME, Knowler WC, Hanson RL, Williams DE, Lemley K, Myers BD, Nelson RG. Comparison of serum cystatin C, serum creatinine, measured GFR, and estimated GFR to assess the risk of kidney failure in American Indians with diabetic nephropathy. Am J Kidney Dis. 2013 Jul; 62(1):33-41. PMID: 23347458; PMCID: PMC3664248.
      28. Gadegbeku CA, Gipson DS, Holzman LB, Ojo AO, Song PX, Barisoni L, Sampson MG, Kopp JB, Lemley K, Nelson PJ, Lienczewski CC, Adler SG, Appel GB, Cattran DC, Choi MJ, Contreras G, Dell KM, Fervenza FC, Gibson KL, Greenbaum LA, Hernandez JD, Hewitt SM, Hingorani SR, Hladunewich M, Hogan MC, Hogan SL, Kaskel FJ, Lieske JC, Meyers KE, Nachman PH, Nast CC, Neu AM, Reich HN, Sedor JR, Sethna CB, Trachtman H, Tuttle KR, Zhdanova O, Zilleruelo GE, Kretzler M. Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach. Kidney Int. 2013 Apr; 83(4):749-56. PMID: 23325076; PMCID: PMC3612359.
      29. Kriz W, Shirato I, Nagata M, LeHir M, Lemley K. The podocyte's response to stress: the enigma of foot process effacement. Am J Physiol Renal Physiol. 2013 Feb 15; 304(4):F333-47. PMID: 23235479.
        View in: PubMed
      30. Weil EJ, Lemley K, Mason CC, Yee B, Jones LI, Blouch K, Lovato T, Richardson M, Myers BD, Nelson RG. Podocyte detachment and reduced glomerular capillary endothelial fenestration promote kidney disease in type 2 diabetic nephropathy. Kidney Int. 2012 Nov; 82(9):1010-7. PMID: 22718189; PMCID: PMC3472108.
      31. Sedrakyan S, Da Sacco S, Milanesi A, Shiri L, Petrosyan A, Varimezova R, Warburton D, Lemley K, De Filippo RE, Perin L. Injection of amniotic fluid stem cells delays progression of renal fibrosis. J Am Soc Nephrol. 2012 Apr; 23(4):661-73. PMID: 22302195; PMCID: PMC3312511.
      32. Lemley K. Protecting podocytes: how good do we need to be? Kidney Int. 2012 Jan; 81(1):9-11. PMID: 22170527.
        View in: PubMed
      33. Pavkov ME, Knowler WC, Lemley K, Mason CC, Myers BD, Nelson RG. Early renal function decline in type 2 diabetes. Clin J Am Soc Nephrol. 2012 Jan; 7(1):78-84. PMID: 22076874; PMCID: PMC3265342.
      34. Weil EJ, Lemley K, Yee B, Lovato T, Richardson M, Myers BD, Nelson RG. Podocyte detachment in type 2 diabetic nephropathy. Am J Nephrol. 2011; 33 Suppl 1:21-4. PMID: 21659731; PMCID: PMC3121550.
      35. Lemley K. Pediatrics: Extracellular volume in children with chronic kidney disease. Nat Rev Nephrol. 2011 May 24; 7(7):366-8. PMID: 21610678.
        View in: PubMed
      36. Lemley K. When to initiate ACEI/ARB therapy in patients with type 1 and 2 diabetes. Pediatr Nephrol. 2010 Oct; 25(10):2021-34. PMID: 20352458.
        View in: PubMed
      37. Perin L, Sedrakyan S, Giuliani S, Da Sacco S, Carraro G, Shiri L, Lemley K, Rosol M, Wu S, Atala A, Warburton D, De Filippo RE. Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis. PLoS One. 2010 Feb 24; 5(2):e9357. PMID: 20195358; PMCID: PMC2827539.
      38. Lemley K. Pediatrics: how 'minimal' are the adult consequences of childhood MCNS? Nat Rev Nephrol. 2010 Feb; 6(2):70-1. PMID: 20111047.
        View in: PubMed
      39. Lemley K. Pediatric nephrology: Estimating GFR in children: Schwartz redux. Nat Rev Nephrol. 2009 Jun; 5(6):310-1. PMID: 19474825.
        View in: PubMed
      40. Sanchez-Niño MD, Sanz AB, Ihalmo P, Lassila M, Holthofer H, Mezzano S, Aros C, Groop PH, Saleem MA, Mathieson PW, Langham R, Kretzler M, Nair V, Lemley K, Nelson RG, Mervaala E, Mattinzoli D, Rastaldi MP, Ruiz-Ortega M, Martin-Ventura JL, Egido J, Ortiz A. The MIF receptor CD74 in diabetic podocyte injury. J Am Soc Nephrol. 2009 Feb; 20(2):353-62. PMID: 18842989; PMCID: PMC2637042.
      41. Lemley K. Yet more ways to skin a cat: nephrin mutations outside the neonatal period. J Am Soc Nephrol. 2008 Oct; 19(10):1837-8. PMID: 18753252.
        View in: PubMed
      42. Lemley K. Kidney disease in nail-patella syndrome. Pediatr Nephrol. 2009 Dec; 24(12):2345-54. PMID: 18535845; PMCID: PMC2770138.
      43. Lemley K. Diabetes and chronic kidney disease: lessons from the Pima Indians. Pediatr Nephrol. 2008 Nov; 23(11):1933-40. PMID: 18320236.
        View in: PubMed
      44. Lemley K, Lafayette RA, Derby G, Blouch KL, Anderson L, Efron B, Myers BD. Prediction of early progression in recently diagnosed IgA nephropathy. Nephrol Dial Transplant. 2008 Jan; 23(1):213-22. PMID: 17890749.
        View in: PubMed
      45. Lemley K. An introduction to biomarkers: applications to chronic kidney disease. Pediatr Nephrol. 2007 Nov; 22(11):1849-59. PMID: 17394023.
        View in: PubMed
      46. Lemley K. Neonatal nephrotic presentation of a child with heterozygous NPHS1 mutation. Pediatr Nephrol. 2006 Jun; 21(6):864-6. PMID: 16703378.
        View in: PubMed
      47. Lemley K. Can theophylline prevent the development of renal dysfunction in neonates with severe asphyxia? Nat Clin Pract Nephrol. 2006 Apr; 2(4):196-7. PMID: 16932425.
        View in: PubMed
      48. Lemley K, Boothroyd DB, Blouch KL, Nelson RG, Jones LI, Olshen RA, Myers BD. Modeling GFR trajectories in diabetic nephropathy. Am J Physiol Renal Physiol. 2005 Oct; 289(4):F863-70. PMID: 15900022.
        View in: PubMed
      49. Lemley K. Proteinuria or peptiduria: where's the beef? J Lab Clin Med. 2005 May; 145(5):228-30. PMID: 15902093.
        View in: PubMed
      50. Higgins JP, Wang L, Kambham N, Montgomery K, Mason V, Vogelmann SU, Lemley K, Brown PO, Brooks JD, van de Rijn M. Gene expression in the normal adult human kidney assessed by complementary DNA microarray. Mol Biol Cell. 2004 Feb; 15(2):649-56. PMID: 14657249; PMCID: PMC329285.
      51. Hoang K, Tan JC, Derby G, Blouch KL, Masek M, Ma I, Lemley K, Myers BD. Determinants of glomerular hypofiltration in aging humans. Kidney Int. 2003 Oct; 64(4):1417-24. PMID: 12969161.
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      52. Hogg RJ, Furth S, Lemley K, Portman R, Schwartz GJ, Coresh J, Balk E, Lau J, Levin A, Kausz AT, Eknoyan G, Levey AS. National Kidney Foundation's Kidney Disease Outcomes Quality Initiative clinical practice guidelines for chronic kidney disease in children and adolescents: evaluation, classification, and stratification. Pediatrics. 2003 Jun; 111(6 Pt 1):1416-21. PMID: 12777562.
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      53. Lynch SK, Lemley K, Polak MJ. The effect of dopamine on glomerular filtration rate in normotensive, oliguric premature neonates. Pediatr Nephrol. 2003 Jul; 18(7):649-52. PMID: 12750981.
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      54. Vogelmann SU, Nelson WJ, Myers BD, Lemley K. Urinary excretion of viable podocytes in health and renal disease. Am J Physiol Renal Physiol. 2003 Jul; 285(1):F40-8. PMID: 12631553; PMCID: PMC3368602.
      55. Lemley K. A basis for accelerated progression of diabetic nephropathy in Pima Indians. Kidney Int Suppl. 2003 Feb; (83):S38-42. PMID: 12864873.
        View in: PubMed
      56. Nagata M, Tomari S, Kanemoto K, Usui J, Lemley K. Podocytes, parietal cells, and glomerular pathology: the role of cell cycle proteins. Pediatr Nephrol. 2003 Jan; 18(1):3-8. PMID: 12488982.
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      57. Lemley K, Lafayette RA, Safai M, Derby G, Blouch K, Squarer A, Myers BD. Podocytopenia and disease severity in IgA nephropathy. Kidney Int. 2002 Apr; 61(4):1475-85. PMID: 11918755.
        View in: PubMed