Junxiang Wan, MD, PhD

Title(s)Research Assistant Professor of Gerontology
SchoolSchool of Gerontology
AddressGER B1B
University Park Campus
Los Angeles CA 90089-0191
Phone+1 213 740 1398
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    Dr. Wan has extensive training in molecular biology, cell biology and immunology. She is an expert in the field of novel assay development, and has extensive experience in academic research work. Dr. Wan mastered novel ELISA assays for the entire murine IGF/IGFBP system and for human and murine humanin and have done lots of IGFs, IGFBPs and humanin assays with the other collaborators, and developed new assays for mitochondria small peptides (MDPs). She has directed core facilities at UCLA and USC, focusing on translation of assays and novel assay development.
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration. Am J Physiol Endocrinol Metab. 2024 Mar 01; 326(3):E207-E214. Kumagai H, Kim SJ, Miller B, Natsume T, Wan J, Kumagai ME, Ramirez R, Lee SH, Sato A, Mehta HH, Yen K, Cohen P. PMID: 38170165.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Correction: Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE. Mol Psychiatry. 2023 Apr; 28(4):1827. Miller B, Kim SJ, Mehta HH, Cao K, Kumagai H, Thumaty N, Leelaprachakul N, Braniff RG, Jiao H, Vaughan J, Diedrich J, Saghatelian A, Arpawong TE, Crimmins EM, Ertekin-Taner N, Tubi MA, Hare ET, Braskie MN, Décarie-Spain L, Kanoski SE, Grodstein F, Bennett DA, Zhao L, Toga AW, Wan J, Yen K, Cohen P, Alzheimer’s Disease Neuroimaging Initiative. PMID: 36658336.
      View in: PubMed   Mentions:    Fields:    
    3. Modulating heart rate oscillation affects plasma amyloid beta and tau levels in younger and older adults. Sci Rep. 2023 03 09; 13(1):3967. Min J, Rouanet J, Martini AC, Nashiro K, Yoo HJ, Porat S, Cho C, Wan J, Cole SW, Head E, Nation DA, Thayer JF, Mather M. PMID: 36894565; PMCID: PMC9998394.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    4. Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE. Mol Psychiatry. 2023 04; 28(4):1813-1826. Miller B, Kim SJ, Mehta HH, Cao K, Kumagai H, Thumaty N, Leelaprachakul N, Braniff RG, Jiao H, Vaughan J, Diedrich J, Saghatelian A, Arpawong TE, Crimmins EM, Ertekin-Taner N, Tubi MA, Hare ET, Braskie MN, Décarie-Spain L, Kanoski SE, Grodstein F, Bennett DA, Zhao L, Toga AW, Wan J, Yen K, Cohen P, Alzheimer’s Disease Neuroimaging Initiative*. PMID: 36127429; PMCID: PMC10027624.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    5. MOTS-c reduces myostatin and muscle atrophy signaling. Am J Physiol Endocrinol Metab. 2021 04 01; 320(4):E680-E690. Kumagai H, Coelho AR, Wan J, Mehta HH, Yen K, Huang A, Zempo H, Fuku N, Maeda S, Oliveira PJ, Cohen P, Kim SJ. PMID: 33554779; PMCID: PMC8238132.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    6. The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan. Aging (Albany NY). 2020 06 23; 12(12):11185-11199. Yen K, Mehta HH, Kim SJ, Lue Y, Hoang J, Guerrero N, Port J, Bi Q, Navarrete G, Brandhorst S, Lewis KN, Wan J, Swerdloff R, Mattison JA, Buffenstein R, Breton CV, Wang C, Longo V, Atzmon G, Wallace D, Barzilai N, Cohen P. PMID: 32575074; PMCID: PMC7343442.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    7. Assay Development and Measurement of the Aging Biomarker Humanin. Methods Mol Biol. 2020; 2144:201-209. Miller B, Wan J. PMID: 32410037.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity. Physiol Rep. 2019 07; 7(13):e14171. Kim SJ, Miller B, Mehta HH, Xiao J, Wan J, Arpawong TE, Yen K, Cohen P. PMID: 31293078; PMCID: PMC6640593.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    9. Effects of air pollution on mitochondrial function, mitochondrial DNA methylation, and mitochondrial peptide expression. Mitochondrion. 2019 05; 46:22-29. Breton CV, Song AY, Xiao J, Kim SJ, Mehta HH, Wan J, Yen K, Sioutas C, Lurmann F, Xue S, Morgan TE, Zhang J, Cohen P. PMID: 30980914; PMCID: PMC6506186.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    10. Comparing the Utility of Mitochondrial and Nuclear DNA to Adjust for Genetic Ancestry in Association Studies. Cells. 2019 04 03; 8(4). Miller B, Arpawong TE, Jiao H, Kim SJ, Yen K, Mehta HH, Wan J, Carpten JC, Cohen P. PMID: 30987182; PMCID: PMC6523867.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    11. GRSF1 is an age-related regulator of senescence. Sci Rep. 2019 04 03; 9(1):5546. Kim SJ, Chun M, Wan J, Lee C, Yen K, Cohen P. PMID: 30944385; PMCID: PMC6447602.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    12. Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans. Sci Rep. 2018 09 21; 8(1):14212. Yen K, Wan J, Mehta HH, Miller B, Christensen A, Levine ME, Salomon MP, Brandhorst S, Xiao J, Kim SJ, Navarrete G, Campo D, Harry GJ, Longo V, Pike CJ, Mack WJ, Hodis HN, Crimmins EM, Cohen P. PMID: 30242290; PMCID: PMC6154958.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    13. Mitochondrial peptides modulate mitochondrial function during cellular senescence. Aging (Albany NY). 2018 Jun 10; 10(6):1239-1256. Kim SJ, Mehta HH, Wan J, Kuehnemann C, Chen J, Hu JF, Hoffman AR, Cohen P. PMID: 29886458; PMCID: PMC6046248.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    14. Low circulating levels of the mitochondrial-peptide hormone SHLP2: novel biomarker for prostate cancer risk. Oncotarget. 2017 Nov 07; 8(55):94900-94909. Xiao J, Howard L, Wan J, Wiggins E, Vidal A, Cohen P, Freedland SJ. PMID: 29212276; PMCID: PMC5706922.
      View in: PubMed   Mentions: 21     Fields:    
    15. Mitochondrially derived peptides as novel regulators of metabolism. J Physiol. 2017 11 01; 595(21):6613-6621. Kim SJ, Xiao J, Wan J, Cohen P, Yen K. PMID: 28574175; PMCID: PMC5663826.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    16. The Potent Humanin Analogue (HNG) Protects Germ Cells and Leucocytes While Enhancing Chemotherapy-Induced Suppression of Cancer Metastases in Male Mice. Endocrinology. 2015 Dec; 156(12):4511-21. Lue Y, Swerdloff R, Wan J, Xiao J, French S, Atienza V, Canela V, Bruhn KW, Stone B, Jia Y, Cohen P, Wang C. PMID: 26384090; PMCID: PMC4655208.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    17. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015 Mar 03; 21(3):443-54. Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P. PMID: 25738459; PMCID: PMC4350682.
      View in: PubMed   Mentions: 256     Fields:    Translation:HumansAnimalsCells
    18. IGF-I regulates the age-dependent signaling peptide humanin. Aging Cell. 2014 Oct; 13(5):958-61. Lee C, Wan J, Miyazaki B, Fang Y, Guevara-Aguirre J, Yen K, Longo V, Bartke A, Cohen P. PMID: 25040290; PMCID: PMC4172517.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimals
    19. Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab. 2014 Mar 04; 19(3):407-17. Levine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, Longo VD. PMID: 24606898; PMCID: PMC3988204.
      View in: PubMed   Mentions: 368     Fields:    Translation:HumansAnimalsCells
    20. Pharmacokinetics and tissue distribution of humanin and its analogues in male rodents. Endocrinology. 2013 Oct; 154(10):3739-44. Chin YP, Keni J, Wan J, Mehta H, Anene F, Jia Y, Lue YH, Swerdloff R, Cobb LJ, Wang C, Cohen P. PMID: 23836030; PMCID: PMC3776863.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    21. Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model. Aging Cell. 2013 Apr; 12(2):257-68. Parrella E, Maxim T, Maialetti F, Zhang L, Wan J, Wei M, Cohen P, Fontana L, Longo VD. PMID: 23362919; PMCID: PMC3982836.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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