Joseph G Hacia, PhD
|Title||Associate Professor of Biochemistry & Molecular Medicine|
|School||Keck School of Medicine of USC|
|Department||Biochemistry and Molecular Biology|
|Address||CSC 261 2250 Alcazar Street|
Health Sciences Campus
Los Angeles California 90089
|Phone||+1 323 442 3030|
|Title||Vice Chair For Medical Education|
Joe Hacia, an Associate Professor of Biochemistry and Molecular Biology, is a medical geneticist who obtained his undergraduate training at Rutgers University and graduate training at the California Institute of Technology. Prior to joining the USC faculty, he obtained his post-doctoral training at the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH).
The Hacia laboratory focuses on developing therapies for genetic disorders caused by impaired peroxisome assembly, structure, and function. His group focuses on peroxisome biogenesis disorders (PBDs), which include Zellweger spectrum disorder (PBD-ZSD) and rhizomelic chondrodysplasia punctata (RCDP). Affected children frequently show progressive loss of vision and hearing, brain and liver dysfunction, craniofacial dysmorphism, and enamel defects. They also have interest in therapeutic development for the related peroxisomal disorder X-linked adrenoleukodystrophy (X-ALD), including the childhood cerebral ALD (CCALD) form of disease that results in inflammatory demyelination and adult onset adrenomyeloneuropathy (AMN) that affects spinal cord function and leads to loss of lower limb functions.
The Hacia laboratory is involved in high-content screening of large chemical libraries as well as retinal gene therapy and cell transplantation therapy projects. As part of these efforts, they developed patient-specific induced pluripotent stem cells (iPSCs) as cell culture models of peroxisomal disorders. By working closely with the physician-scientists and patient advocacy groups, the Global Foundation for Peroxisomal Disorders (GFPD) (http://www.thegfpd.org/) and RhizoKids International (http://www.rhizokids.com/), they seek to translate their research into improved treatments in the near future.
The Hacia laboratory has also used comparative genomics and lipidomics approaches to uncover evidence that peroxisomal metabolism has been strongly influenced by primate diets. They wish to use the knowledge gained from these projects to benefit the health of captive non-human primates and people with peroxisomal disorders.
Research Interests: medical genetics, molecular therapeutics
Diseases Models: cultured fibroblasts, induced pluripotent stem cells, genetically engineered mice
Consortia: Global Foundation for Peroxisomal Disorders and RhizoKids International
||1995||Howard Hughes Medical Institute Predoctoral Fellow|
|2000||American Society of Human Genetics (ASHG) Postdoctoral Translational Research Award|
|2002||V Foundation Scholar|
||2010||Editorial Board of Genome Research|
||2013||Member of NIH Comparative Genomics Study Section|
|2008||Editorial Board Nucleic Acids Research|
|2010||Chaired Session at ASHG meeting on Early Diagnosis and Treatment of CNS-based Metabolic Disorders|
|2010||Editorial Board BMC Genomics|
|2010||Member, Scientific Advisory Board of the Global Foundation for Peroxisomal Disorders|
|2012||External Reviewer, Institute of Medicine Review of California Institute for Regenerative Medicine|
|2013||Year 1 USC Medical Teaching Award|
|2014||Chaired Session at ASHG meeting on Targeted Drug Therapies for Progressive Genetic Disorders|
|2015||Year 2 USC Medical Teaching Award|
|2015||Member of X-linked Adrenoleukodystrophy (ALD) Connect Workgroup on Therapy Review|
|2015||Member of Chemical Gene & Cell Therapy Committee of the American Society of Gene & Cell Therapy|
|2016||Editorial Board BMC Medical Genomics|
|2016||Year 1 USC Medical Teaching Award|
|2016||Year 1 Outstanding Course Award for USC Medical Teaching|
|2016||Master Teacher of the Keck School of Medicine of USC|
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