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    Jang-Hyun Youn, PhD

    TitleAssociate Professor of Physiology & Biophysics
    SchoolKeck School of Medicine of USC
    DepartmentPhysiology and Biophysics
    AddressCSC 2250 Alcazar Steet, CSC 214
    Health Sciences Campus
    Los Angeles California 90089
    Phone+1 323 442 3260
    Emailyoun@usc.edu
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. McDonough AA, Youn J. Potassium Homeostasis: The Knowns, the Unknowns, and the Health Benefits. Physiology (Bethesda). 2017 Mar; 32(2):100-111. PMID: 28202621.
        View in: PubMed
      2. Oh YT, Oh HH, Nguyen AK, Choi CS, Youn J. Circulating free fatty acids inhibit food intake in an oleate-specific manner in rats. Physiol Behav. 2016 Sep 18; 167:194-201. PMID: 27654062.
        View in: PubMed
      3. Oh YT, Tran D, Buchanan TA, Selsted ME, Youn J. The theta-defensin RTD-1 improves insulin action and normalizes plasma glucose and FFA levels in diet-induced obese rats. Am J Physiol Endocrinol Metab. 2015 May 19; ajpendo.00131.2015. PMID: 25991648.
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      4. Youn J. Fat sensing and metabolic syndrome. Rev Endocr Metab Disord. 2014 Dec; 15(4):263-75. PMID: 25344446.
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      5. Choi AY, Choi JH, Hwang KY, Jeong YJ, Choe W, Yoon KS, Ha J, Kim SS, Youn J, Yeo EJ, Kang I. Licochalcone A induces apoptosis through endoplasmic reticulum stress via a phospholipase C?1-, Ca(2+)-, and reactive oxygen species-dependent pathway in HepG2 human hepatocellular carcinoma cells. Apoptosis. 2014 Apr; 19(4):682-97. PMID: 24337903.
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      6. Rengarajan S, Lee DH, Oh YT, Delpire E, Youn J, McDonough AA. Increasing plasma [K+] by intravenous potassium infusion reduces NCC phosphorylation and drives kaliuresis and natriuresis. Am J Physiol Renal Physiol. 2014 May; 306(9):F1059-68. PMID: 24598799.
        View in: PubMed
      7. Oh YT, Kim J, Kang I, Youn J. Regulation of hypothalamic-pituitary-adrenal axis by circulating free Fatty acids in male wistar rats: role of individual free Fatty acids. Endocrinology. 2014 Mar; 155(3):923-31. PMID: 24424035.
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      8. McDonough AA, Youn J. Need to quickly excrete K(+)? Turn off NCC. Kidney Int. 2013 May; 83(5):779-82. PMID: 23633048.
        View in: PubMed
      9. Youn J. Gut sensing of potassium intake and its role in potassium homeostasis. Semin Nephrol. 2013 May; 33(3):248-56. PMID: 23953802.
        View in: PubMed
      10. Oh YT, Kim J, Youn J. Role of pituitary in K+ homeostasis: impaired renal responses to altered K+ intake in hypophysectomized rats. Am J Physiol Regul Integr Comp Physiol. 2013 Jun 15; 304(12):R1166-74. PMID: 23594607.
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      11. Oh YT, Oh KS, Kang I, Youn J. A Fall in Plasma Free Fatty Acid (FFA) Level Activates the Hypothalamic-Pituitary-Adrenal Axis Independent of Plasma Glucose: Evidence for Brain Sensing of Circulating FFA. Endocrinology. 2012 Aug; 153(8):3587-92. PMID: 22669895.
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      12. Stefanovski D, Youn J, Rees M, Watanabe RM, Ader M, Ionut V, Jackson AU, Boehnke M, Collins FS, Bergman RN. Estimating hepatic glucokinase activity using a simple model of lactate kinetics. Diabetes Care. 2012 May; 35(5):1015-20. PMID: 22456868.
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      13. Kang I, Kim SW, Youn J. Effects of nicotinic acid on gene expression: potential mechanisms and implications for wanted and unwanted effects of the lipid-lowering drug. J Clin Endocrinol Metab. 2011 Oct; 96(10):3048-55. PMID: 21816780.
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      14. Oh KS, Oh YT, Kim SW, Kita T, Kang I, Youn J. Gut sensing of dietary K? intake increases renal K?excretion. Am J Physiol Regul Integr Comp Physiol. 2011 Aug; 301(2):R421-9. PMID: 21543632.
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      15. Oh YT, Oh KS, Choi YM, Jokiaho A, Donovan C, Choi S, Kang I, Youn J. Continuous 24-h nicotinic acid infusion in rats causes FFA rebound and insulin resistance by altering gene expression and basal lipolysis in adipose tissue. Am J Physiol Endocrinol Metab. 2011 Jun; 300(6):E1012-21. PMID: 21386057.
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      16. Rashid MA, Lee S, Tak E, Lee J, Choi TG, Lee JW, Kim JB, Youn J, Kang I, Ha J, Kim SS. Carbonyl reductase 1 protects pancreatic ß-cells against oxidative stress-induced apoptosis in glucotoxicity and glucolipotoxicity. Free Radic Biol Med. 2010 Nov 30; 49(10):1522-33. PMID: 20728534.
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      17. Choi S, Yoon H, Oh KS, Oh YT, Kim YI, Kang I, Youn J. Widespread effects of nicotinic acid on gene expression in insulin-sensitive tissues: implications for unwanted effects of nicotinic acid treatment. Metabolism. 2011 Jan; 60(1):134-44. PMID: 20303128.
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      18. Koh EH, Kim M, Ranjan KC, Kim HS, Park HS, Oh KS, Park IS, Lee WJ, Kim MS, Park JY, Youn J, Lee KU. eNOS plays a major role in adiponectin synthesis in adipocytes. Am J Physiol Endocrinol Metab. 2010 Apr; 298(4):E846-53. PMID: 20124507.
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      19. Won JC, Park JY, Kim YM, Koh EH, Seol S, Jeon BH, Han J, Kim JR, Park TS, Choi CS, Lee WJ, Kim MS, Lee IK, Youn J, Lee KU. Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha overexpression prevents endothelial apoptosis by increasing ATP/ADP translocase activity. Arterioscler Thromb Vasc Biol. 2010 Feb; 30(2):290-7. PMID: 19965780.
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      20. Greenlee M, Wingo CS, McDonough AA, Youn J, Kone BC. Narrative review: evolving concepts in potassium homeostasis and hypokalemia. Ann Intern Med. 2009 May 5; 150(9):619-25. PMID: 19414841.
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      21. Youn J, McDonough AA. Recent advances in understanding integrative control of potassium homeostasis. Annu Rev Physiol. 2009; 71:381-401. PMID: 18759636.
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      22. Zheng D, Perianayagam A, Lee DH, Brannan MD, Yang LE, Tellalian D, Chen P, Lemieux K, Marette A, Youn J, McDonough AA. AMPK activation with AICAR provokes an acute fall in plasma [K+]. Am J Physiol Cell Physiol. 2008 Jan; 294(1):C126-35. PMID: 18003746.
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      23. Koh EH, Park JY, Park HS, Jeon MJ, Ryu JW, Kim M, Kim SY, Kim MS, Kim SW, Park IS, Youn J, Lee KU. Essential role of mitochondrial function in adiponectin synthesis in adipocytes. Diabetes. 2007 Dec; 56(12):2973-81. PMID: 17827403.
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      24. Lee FN, Oh G, McDonough AA, Youn J. Evidence for gut factor in K+ homeostasis. Am J Physiol Renal Physiol. 2007 Aug; 293(2):F541-7. PMID: 17522262.
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      25. Kim YI, Lee FN, Choi WS, Lee S, Youn J. Insulin regulation of skeletal muscle PDK4 mRNA expression is impaired in acute insulin-resistant states. Diabetes. 2006 Aug; 55(8):2311-7. PMID: 16873695.
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      26. Chen P, Guzman JP, Leong PK, Yang LE, Perianayagam A, Babilonia E, Ho JS, Youn J, Wang WH, McDonough AA. Modest dietary K+ restriction provokes insulin resistance of cellular K+ uptake and phosphorylation of renal outer medulla K+ channel without fall in plasma K+ concentration. Am J Physiol Cell Physiol. 2006 May; 290(5):C1355-63. PMID: 16354756.
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      27. Lee WJ, Lee IK, Kim HS, Kim YM, Koh EH, Won JC, Han SM, Kim MS, Jo I, Oh GT, Park IS, Youn J, Park SW, Lee KU, Park JY. Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinase. Arterioscler Thromb Vasc Biol. 2005 Dec; 25(12):2488-94. PMID: 16224049.
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      28. McDonough AA, Youn J. Role of muscle in regulating extracellular [K+]. Semin Nephrol. 2005 Sep; 25(5):335-42. PMID: 16139689.
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      29. Song KH, Lee WJ, Koh JM, Kim HS, Youn JY, Park HS, Koh EH, Kim MS, Youn J, Lee KU, Park JY. alpha-Lipoic acid prevents diabetes mellitus in diabetes-prone obese rats. Biochem Biophys Res Commun. 2005 Jan 7; 326(1):197-202. PMID: 15567171.
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      30. Rhee MS, Perianayagam A, Chen P, Youn J, McDonough AA. Dexamethasone treatment causes resistance to insulin-stimulated cellular potassium uptake in the rat. Am J Physiol Cell Physiol. 2004 Nov; 287(5):C1229-37. PMID: 15213056.
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      31. Kim MS, Park JY, Namkoong C, Jang PG, Ryu JW, Song HS, Yun JY, Namgoong IS, Ha J, Park IS, Lee IK, Viollet B, Youn J, Lee HK, Lee KU. Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med. 2004 Jul; 10(7):727-33. PMID: 15195087.
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      32. Lee FN, Zhang L, Zheng D, Choi WS, Youn J. Insulin suppresses PDK-4 expression in skeletal muscle independently of plasma FFA. Am J Physiol Endocrinol Metab. 2004 Jul; 287(1):E69-74. PMID: 15026305.
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      33. Koh EH, Kim MS, Park JY, Kim HS, Youn JY, Park HS, Youn J, Lee KU. Peroxisome proliferator-activated receptor (PPAR)-alpha activation prevents diabetes in OLETF rats: comparison with PPAR-gamma activation. Diabetes. 2003 Sep; 52(9):2331-7. PMID: 12941773.
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      34. Choi CS, Kim YB, Lee FN, Zabolotny JM, Kahn BB, Youn J. Lactate induces insulin resistance in skeletal muscle by suppressing glycolysis and impairing insulin signaling. Am J Physiol Endocrinol Metab. 2002 Aug; 283(2):E233-40. PMID: 12110527.
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      35. McDonough AA, Thompson CB, Youn J. Skeletal muscle regulates extracellular potassium. Am J Physiol Renal Physiol. 2002 Jun; 282(6):F967-74. PMID: 11997312.
        View in: PubMed
      36. Choi CS, Lee FN, McDonough AA, Youn J. Independent regulation of in vivo insulin action on glucose versus K(+) uptake by dietary fat and K(+) content. Diabetes. 2002 Apr; 51(4):915-20. PMID: 11916907.
        View in: PubMed
      37. Choi CS, Lee FN, Youn J. Free fatty acids induce peripheral insulin resistance without increasing muscle hexosamine pathway product levels in rats. Diabetes. 2001 Feb; 50(2):418-24. PMID: 11272156.
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      38. Choi CS, Thompson CB, Leong PK, McDonough AA, Youn J. Short-term K(+) deprivation provokes insulin resistance of cellular K(+) uptake revealed with the K(+) clamp. Am J Physiol Renal Physiol. 2001 Jan; 280(1):F95-F102. PMID: 11133519.
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      39. Kim CH, Youn J, Park JY, Hong SK, Park KS, Park SW, Suh KI, Lee KU. Effects of high-fat diet and exercise training on intracellular glucose metabolism in rats. Am J Physiol Endocrinol Metab. 2000 Jun; 278(6):E977-84. PMID: 10826998.
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      40. Kim JK, Choi CS, Youn J. Acute effect of growth hormone to induce peripheral insulin resistance is independent of FFA and insulin levels in rats. Am J Physiol. 1999 Oct; 277(4 Pt 1):E742-9. PMID: 10516135.
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      41. Thompson CB, Choi C, Youn J, McDonough AA. Temporal responses of oxidative vs. glycolytic skeletal muscles to K+ deprivation: Na+ pumps and cell cations. Am J Physiol. 1999 Jun; 276(6 Pt 1):C1411-9. PMID: 10362605.
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      42. Wi JK, Kim JK, Youn J. Reduced glucose clearance as the major determinant of postabsorptive hyperglycemia in diabetic rats. Am J Physiol. 1998 Feb; 274(2 Pt 1):E257-64. PMID: 9486156.
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      43. Kim JK, Youn J. Prolonged suppression of glucose metabolism causes insulin resistance in rat skeletal muscle. Am J Physiol. 1997 Feb; 272(2 Pt 1):E288-96. PMID: 9124337.
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      44. Ozel B, Youngren JF, Kim JK, Goldfine ID, Sung CK, Youn J. The development of insulin resistance with high fat feeding in rats does not involve either decreased insulin receptor tyrosine kinase activity or membrane glycoprotein PC-1. Biochem Mol Med. 1996 Dec; 59(2):174-81. PMID: 8986641.
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      45. Steil GM, Richey J, Kim JK, Wi JK, Rebrin K, Bergman RN, Youn J. Extracellular glucose distribution is not altered by insulin: analysis of plasma and interstitial L-glucose kinetics. Am J Physiol. 1996 Nov; 271(5 Pt 1):E855-64. PMID: 8944672.
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      46. Wi JK, Kim JK, Youn J. Mechanisms of postabsorptive hyperglycemia in streptozotocin diabetic rats. Am J Physiol. 1996 May; 270(5 Pt 1):E752-8. PMID: 8967462.
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      47. Kim JK, Wi JK, Youn J. Metabolic impairment precedes insulin resistance in skeletal muscle during high-fat feeding in rats. Diabetes. 1996 May; 45(5):651-8. PMID: 8621018.
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      48. Kim JK, Wi JK, Youn J. Plasma free fatty acids decrease insulin-stimulated skeletal muscle glucose uptake by suppressing glycolysis in conscious rats. Diabetes. 1996 Apr; 45(4):446-53. PMID: 8603766.
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      49. Youn J, Kim JK, Steil GM. Assessment of extracellular glucose distribution and glucose transport activity in conscious rats. Am J Physiol. 1995 Apr; 268(4 Pt 1):E712-21. PMID: 7733271.
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      50. Youn J, Gulve EA, Henriksen EJ, Holloszy JO. Interactions between effects of W-7, insulin, and hypoxia on glucose transport in skeletal muscle. Am J Physiol. 1994 Oct; 267(4 Pt 2):R888-94. PMID: 7943429.
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      51. Youn J, Kim JK, Buchanan TA. Time courses of changes in hepatic and skeletal muscle insulin action and GLUT4 protein in skeletal muscle after STZ injection. Diabetes. 1994 Apr; 43(4):564-71. PMID: 8138062.
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      52. Youn J, Buchanan TA. Fasting does not impair insulin-stimulated glucose uptake but alters intracellular glucose metabolism in conscious rats. Diabetes. 1993 May; 42(5):757-63. PMID: 8482433.
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      53. Gulve EA, Henriksen EJ, Rodnick KJ, Youn J, Holloszy JO. Glucose transporters and glucose transport in skeletal muscles of 1- to 25-mo-old rats. Am J Physiol. 1993 Mar; 264(3 Pt 1):E319-27. PMID: 8460679.
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      54. Ren JM, Youn J, Gulve EA, Henriksen EJ, Holloszy JO. Effects of alkaline pH on the stimulation of glucose transport in rat skeletal muscle. Biochim Biophys Acta. 1993 Feb 9; 1145(2):199-204. PMID: 8431452.
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      55. Slentz CA, Gulve EA, Rodnick KJ, Henriksen EJ, Youn J, Holloszy JO. Glucose transporters and maximal transport are increased in endurance-trained rat soleus. J Appl Physiol. 1992 Aug; 73(2):486-92. PMID: 1399970.
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      56. Buchanan TA, Youn J, Campese VM, Sipos GF. Enhanced glucose tolerance in spontaneously hypertensive rats. Pancreatic beta-cell hyperfunction with normal insulin sensitivity. Diabetes. 1992 Jul; 41(7):872-8. PMID: 1612202.
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      57. Youn J, Bergman RN. Conversion of oral glucose to lactate in dogs. Primary site and relative contribution to blood lactate. Diabetes. 1991 Jun; 40(6):738-47. PMID: 2040389.
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      58. Youn J, Gulve EA, Holloszy JO. Calcium stimulates glucose transport in skeletal muscle by a pathway independent of contraction. Am J Physiol. 1991 Mar; 260(3 Pt 1):C555-61. PMID: 2003578.
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      59. Gulve EA, Cartee GD, Youn J, Holloszy JO. Prolonged incubation of skeletal muscle increases system A amino acid transport. Am J Physiol. 1991 Jan; 260(1 Pt 1):C88-95. PMID: 1987782.
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      60. Youn J, Bergman RN. Enhancement of hepatic glycogen by gluconeogenic precursors: substrate flux or metabolic control? Am J Physiol. 1990 Jun; 258(6 Pt 1):E899-906. PMID: 2193531.
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      61. Bergman RN, Hope ID, Yang YJ, Watanabe RM, Meador MA, Youn J, Ader M. Assessment of insulin sensitivity in vivo: a critical review. Diabetes Metab Rev. 1989 Aug; 5(5):411-29. PMID: 2667927.
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      62. Youn J, Ader M, Bergman RN. Glucose phosphorylation is not rate limiting for accumulation of glycogen from glucose in perfused livers from fasted rats. J Biol Chem. 1989 Jan 5; 264(1):168-72. PMID: 2642472.
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      63. Cane P, Haun CK, Evered J, Youn J, Bergman RN. Response to deep hypoglycemia does not involve glucoreceptors in carotid perfused tissue. Am J Physiol. 1988 Nov; 255(5 Pt 1):E680-7. PMID: 2847539.
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      64. Antwi D, Youn J, Shargill NS, Lesikar DD, Kaslow HR. Regulation of glycogen synthase in muscle and adipose tissue during fasting and refeeding. Am J Physiol. 1988 Jun; 254(6 Pt 1):E720-5. PMID: 3132046.
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      65. Yang YJ, Youn J, Bergman RN. Modified protocols improve insulin sensitivity estimation using the minimal model. Am J Physiol. 1987 Dec; 253(6 Pt 1):E595-602. PMID: 2892414.
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      66. Youn J, Bergman RN. Patterns of glycogen turnover in liver characterized by computer modeling. Am J Physiol. 1987 Oct; 253(4 Pt 1):E360-9. PMID: 3661699.
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      67. Youn J, Kaslow HR, Bergman RN. Fructose effect to suppress hepatic glycogen degradation. J Biol Chem. 1987 Aug 25; 262(24):11470-7. PMID: 3114246.
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      68. Youn J, Youn MS, Bergman RN. Synergism of glucose and fructose in net glycogen synthesis in perfused rat livers. J Biol Chem. 1986 Dec 5; 261(34):15960-9. PMID: 3023336.
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      69. Youn J, Kim HC, Lee HK, Min BG. Computed insulin profiles for normalization of glycemia in diabetic patients. Bull Math Biol. 1983; 45(5):739-48. PMID: 6360264.
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