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    Henry M. Sucov, PhD

    TitleProfessor of Stem Cell & Regenerative Medicine
    SchoolKeck School of Medicine of USC
    DepartmentCell and Neurobiology
    AddressBCC 511 1425 San Pablo Street
    Health Sciences Campus
    Los Angeles California 90033
    Phone+1 323 442 2563
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      Other Positions
      TitleDirector, MS Program in Stem Cell Biology and Regenerative Medicine

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      Sucov Lab Website

      Henry Sucov has been recognized several times by the American Heart Association for his work in cardiovascular development. He has served on many grant review panels and committees, and is currently a member of the NIH Cardiovascular Development and Differentiation (CDD) study section. In 2007, he was a Visiting Scholar of the Japanese Society for the Promotion of Science.

      His scientific program is historically grounded in cardiovascular development, reflecting a longstanding interest is in processes that account for ventricular chamber morphogenesis, including mechanisms that support cardiomyocyte proliferation, coronary vascularization and mesenchymal progenitor cell differentiation. More recently, he has increasingly gravitated to the connection between embryonic heart development and postnatal heart biology, and in particular how the postnatal post-injury repair and regenerative response of the heart recapitulates processes that occur in normal development. His lab primarily studies these processes in mice using molecular genetic and genomic strategies.

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Patterson M, Barske L, Van Handel B, Rau CD, Gan P, Sharma A, Parikh S, Denholtz M, Huang Y, Yamaguchi Y, Shen H, Allayee H, Crump JG, Force TI, Lien CL, Makita T, Lusis AJ, Kumar SR, Sucov H. Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration. Nat Genet. 2017 Sep; 49(9):1346-1353. PMID: 28783163.
        View in: PubMed
      2. Zhang H, Pu W, Li G, Huang X, He L, Tian X, Liu Q, Zhang L, Wu SM, Sucov H, Zhou B. Endocardium Minimally Contributes to Coronary Endothelium in the Embryonic Ventricular Free Walls. Circ Res. 2016 Jun 10; 118(12):1880-93. PMID: 27056912.
        View in: PubMed
      3. Ma M, Li P, Shen H, Estrada KD, Xu J, Kumar SR, Sucov H. Dysregulated endocardial TGFß signaling and mesenchymal transformation result in heart outflow tract septation failure. Dev Biol. 2016 Jan 01; 409(1):272-6. PMID: 26522286; PMCID: PMC4742370 [Available on 01/01/17].
      4. Harrison MR, Bussmann J, Huang Y, Zhao L, Osorio A, Burns CG, Burns CE, Sucov H, Siekmann AF, Lien CL. Chemokine-guided angiogenesis directs coronary vasculature formation in zebrafish. Dev Cell. 2015 May 26; 33(4):442-54. PMID: 26017769; PMCID: PMC4448080.
      5. Cavallero S, Shen H, Yi C, Lien CL, Kumar SR, Sucov H. CXCL12 Signaling Is Essential for Maturation of the Ventricular Coronary Endothelial Plexus and Establishment of Functional Coronary Circulation. Dev Cell. 2015 May 26; 33(4):469-77. PMID: 26017771; PMCID: PMC4448078.
      6. Yamaguchi Y, Cavallero S, Patterson M, Shen H, Xu J, Kumar SR, Sucov H. Adipogenesis and epicardial adipose tissue: a novel fate of the epicardium induced by mesenchymal transformation and PPAR? activation. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2070-5. PMID: 25646471; PMCID: PMC4343131.
      7. Shen H, Cavallero S, Estrada KD, Sandovici I, Kumar SR, Makita T, Lien CL, Constancia M, Sucov H. Extracardiac control of embryonic cardiomyocyte proliferation and ventricular wall expansion. Cardiovasc Res. 2015 Mar 01; 105(3):271-8. PMID: 25560321; PMCID: PMC4366578.
      8. Cambier L, Plate M, Sucov H, Pashmforoush M. Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3. Development. 2014 Aug; 141(15):2959-71. PMID: 25053429; PMCID: PMC4197672.
      9. Engelhard C, Sarsfield S, Merte J, Wang Q, Li P, Beppu H, Kolodkin AL, Sucov H, Ginty DD. MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons. Elife. 2013 Sep 17; 2:e01160. PMID: 24052814; PMCID: PMC3776557.
      10. Huang Y, Harrison MR, Osorio A, Kim J, Baugh A, Duan C, Sucov H, Lien CL. Igf Signaling is Required for Cardiomyocyte Proliferation during Zebrafish Heart Development and Regeneration. PLoS One. 2013; 8(6):e67266. PMID: 23840646; PMCID: PMC3694143.
      11. Zhou J, Pashmforoush M, Sucov H. Endothelial neuropilin disruption in mice causes DiGeorge syndrome-like malformations via mechanisms distinct to those caused by loss of Tbx1. PLoS One. 2012; 7(3):e32429. PMID: 22396765; PMCID: PMC3292556.
      12. Li P, Pashmforoush M, Sucov H. Mesodermal retinoic acid signaling regulates endothelial cell coalescence in caudal pharyngeal arch artery vasculogenesis. Dev Biol. 2012 Jan 01; 361(1):116-24. PMID: 22040871; PMCID: PMC3235035.
      13. Li P, Cavallero S, Gu Y, Chen TH, Hughes J, Hassan AB, Brüning JC, Pashmforoush M, Sucov H. IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development. Development. 2011 May; 138(9):1795-805. PMID: 21429986; PMCID: PMC3074453.
      14. Snead ML, Zhu DH, Lei Y, Luo W, Bringas PO, Sucov H, Rauth RJ, Paine ML, White SN. A simplified genetic design for mammalian enamel. Biomaterials. 2011 Apr; 32(12):3151-7. PMID: 21295848; PMCID: PMC3045652.
      15. Brade T, Kumar S, Cunningham TJ, Chatzi C, Zhao X, Cavallero S, Li P, Sucov H, Ruiz-Lozano P, Duester G. Retinoic acid stimulates myocardial expansion by induction of hepatic erythropoietin which activates epicardial Igf2. Development. 2011 Jan; 138(1):139-48. PMID: 21138976; PMCID: PMC2998168.
      16. Li P, Pashmforoush M, Sucov H. Retinoic acid regulates differentiation of the secondary heart field and TGFbeta-mediated outflow tract septation. Dev Cell. 2010 Mar 16; 18(3):480-5. PMID: 20230754; PMCID: PMC2841063.
      17. Nolting J, Daniel C, Reuter S, Stuelten C, Li P, Sucov H, Kim BG, Letterio JJ, Kretschmer K, Kim HJ, von Boehmer H. Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines. J Exp Med. 2009 Sep 28; 206(10):2131-9. PMID: 19737861; PMCID: PMC2757891.
      18. Sucov H, Gu Y, Thomas S, Li P, Pashmforoush M. Epicardial control of myocardial proliferation and morphogenesis. Pediatr Cardiol. 2009 Jul; 30(5):617-25. PMID: 19277768.
        View in: PubMed
      19. Asahina K, Tsai SY, Li P, Ishii M, Maxson RE, Sucov H, Tsukamoto H. Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development. Hepatology. 2009 Mar; 49(3):998-1011. PMID: 19085956; PMCID: PMC2673117.
      20. Choudhary B, Zhou J, Li P, Thomas S, Kaartinen V, Sucov H. Absence of TGFbeta signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm. Genesis. 2009 Feb; 47(2):115-21. PMID: 19165826.
        View in: PubMed
      21. Chen YH, Ishii M, Sucov H, Maxson RE. Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium. BMC Dev Biol. 2008 Jul 30; 8:75. PMID: 18667074; PMCID: PMC2518925.
      22. Makita T, Sucov H, Gariepy CE, Yanagisawa M, Ginty DD. Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons. Nature. 2008 Apr 10; 452(7188):759-63. PMID: 18401410; PMCID: PMC2713667.
      23. Kang J, Gu Y, Li P, Johnson BL, Sucov H, Thomas PS. PDGF-A as an epicardial mitogen during heart development. Dev Dyn. 2008 Mar; 237(3):692-701. PMID: 18297729.
        View in: PubMed
      24. Kameda Y, Nishimaki T, Chisaka O, Iseki S, Sucov H. Expression of the epithelial marker E-cadherin by thyroid C cells and their precursors during murine development. J Histochem Cytochem. 2007 Oct; 55(10):1075-88. PMID: 17595340.
        View in: PubMed
      25. Chen YH, Ishii M, Sun J, Sucov H, Maxson RE. Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract. Dev Biol. 2007 Aug 15; 308(2):421-37. PMID: 17601530.
        View in: PubMed
      26. Wang J, Nagy A, Larsson J, Dudas M, Sucov H, Kaartinen V. Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects. BMC Dev Biol. 2006 Nov 01; 6:51. PMID: 17078885; PMCID: PMC1635039.
      27. Choudhary B, Ito Y, Makita T, Sasaki T, Chai Y, Sucov H. Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGFbeta receptor (Tgfbr2) mutant mice. Dev Biol. 2006 Jan 15; 289(2):420-9. PMID: 16332365.
        View in: PubMed
      28. Ishii M, Han J, Yen HY, Sucov H, Chai Y, Maxson RE. Combined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crest. Development. 2005 Nov; 132(22):4937-50. PMID: 16221730.
        View in: PubMed
      29. Makita T, Duncan SA, Sucov H. Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation. Dev Biol. 2005 Apr 01; 280(1):59-72. PMID: 15766748.
        View in: PubMed
      30. Kang JO, Sucov H. Convergent proliferative response and divergent morphogenic pathways induced by epicardial and endocardial signaling in fetal heart development. Mech Dev. 2005 Jan; 122(1):57-65. PMID: 15582777.
        View in: PubMed
      31. Kertesz N, Wu J, Chen TH, Sucov H, Wu H. The role of erythropoietin in regulating angiogenesis. Dev Biol. 2004 Dec 01; 276(1):101-10. PMID: 15531367.
        View in: PubMed
      32. Ishii M, Merrill AE, Chan YS, Gitelman I, Rice DP, Sucov H, Maxson RE. Msx2 and Twist cooperatively control the development of the neural crest-derived skeletogenic mesenchyme of the murine skull vault. Development. 2003 Dec; 130(24):6131-42. PMID: 14597577.
        View in: PubMed
      33. Han J, Ito Y, Yeo JY, Sucov H, Maas R, Chai Y. Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19(INK4d) expression during odontogenesis. Dev Biol. 2003 Sep 01; 261(1):183-96. PMID: 12941628.
        View in: PubMed
      34. Chen T, Chang TC, Kang JO, Choudhary B, Makita T, Tran CM, Burch JB, Eid H, Sucov H. Epicardial induction of fetal cardiomyocyte proliferation via a retinoic acid-inducible trophic factor. Dev Biol. 2002 Oct 01; 250(1):198-207. PMID: 12297106.
        View in: PubMed
      35. Jiang X, Choudhary B, Merki E, Chien KR, Maxson RE, Sucov H. Normal fate and altered function of the cardiac neural crest cell lineage in retinoic acid receptor mutant embryos. Mech Dev. 2002 Sep; 117(1-2):115-22. PMID: 12204252.
        View in: PubMed
      36. Huang J, Powell WC, Khodavirdi AC, Wu J, Makita T, Cardiff RD, Cohen MB, Sucov H, Roy-Burman P. Prostatic intraepithelial neoplasia in mice with conditional disruption of the retinoid X receptor alpha allele in the prostate epithelium. Cancer Res. 2002 Aug 15; 62(16):4812-9. PMID: 12183441.
        View in: PubMed
      37. Brewer S, Jiang X, Donaldson S, Williams T, Sucov H. Requirement for AP-2alpha in cardiac outflow tract morphogenesis. Mech Dev. 2002 Jan; 110(1-2):139-49. PMID: 11744375.
        View in: PubMed
      38. Kwang SJ, Brugger SM, Lazik A, Merrill AE, Wu LY, Liu YH, Ishii M, Sangiorgi FO, Rauchman M, Sucov H, Maas RL, Maxson RE. Msx2 is an immediate downstream effector of Pax3 in the development of the murine cardiac neural crest. Development. 2002 Jan; 129(2):527-38. PMID: 11807043.
        View in: PubMed
      39. Jiang X, Iseki S, Maxson RE, Sucov H, Morriss-Kay GM. Tissue origins and interactions in the mammalian skull vault. Dev Biol. 2002 Jan 01; 241(1):106-16. PMID: 11784098.
        View in: PubMed
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