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    Florence M Hofman, PhD

    TitleProfessor of Pathology
    SchoolKeck School of Medicine of USC
    DepartmentPathology
    AddressHMR 2011 Zonal Ave
    Health Sciences Campus
    Los Angeles California 90089-9092
    Phone+1 323 442 1153
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      Dr. Hofman's field of expertise is angiogenesis and the blood-brain-barrier in human primary brain tumors and metastatic breast cancer to the brain. Her approach is to functionally characterize the tumor-associated brain endothelial cells because these cells are the target for anti-vascular therapy in cancer. Her laboratory uses both in vitro and in vivo systems to determine the mechanism(s) of chemoresistance. Once it is understood why these cells are resistant to standard of care drugs, they will identify agents which specifically disrupt the tumor vasculature, resulting in eliminating tumor growth.


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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Chen TC, Yu J, Nouri Nigjeh E, Wang W, Myint PT, Zandi E, Hofman F, Schönthal AH. A perillyl alcohol-conjugated analog of 3-bromopyruvate without cellular uptake dependency on monocarboxylate transporter 1 and with activity in 3-BP-resistant tumor cells. Cancer Lett. 2017 Aug 01; 400:161-174. PMID: 28450161.
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      2. Rosa AI, Grade S, Santos SD, Bernardino L, Chen TC, Relvas J, Hofman F, Agasse F. Heterocellular Contacts with Mouse Brain Endothelial Cells Via Laminin and a6ß1 Integrin Sustain Subventricular Zone (SVZ) Stem/Progenitor Cells Properties. Front Cell Neurosci. 2016; 10:284. PMID: 28018177.
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      3. Kushal S, Wang W, Vaikari VP, Kota R, Chen K, Yeh TS, Jhaveri N, Groshen SL, Olenyuk BZ, Chen TC, Hofman F, Shih JC. Monoamine oxidase A (MAO A) inhibitors decrease glioma progression. Oncotarget. 2016 Mar 22; 7(12):13842-53. PMID: 26871599; PMCID: PMC4924682.
      4. Dong H, Zou M, Bhatia A, Jayaprakash P, Hofman F, Ying Q, Chen M, Woodley DT, Li W. Breast Cancer MDA-MB-231 Cells Use Secreted Heat Shock Protein-90alpha (Hsp90a) to Survive a Hostile Hypoxic Environment. Sci Rep. 2016 Feb 05; 6:20605. PMID: 26846992; PMCID: PMC4742873.
      5. Jhaveri N, Agasse F, Armstrong D, Peng L, Commins D, Wang W, Rosenstein-Sisson R, Vaikari VP, Santiago SV, Santos T, Chen L, Schönthal AH, Chen TC, Hofman F. A novel drug conjugate, NEO212, targeting proneural and mesenchymal subtypes of patient-derived glioma cancer stem cells. Cancer Lett. 2016 Feb 28; 371(2):240-50. PMID: 26683773.
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      6. Hu CM, Fang RH, Wang KC, Luk BT, Thamphiwatana S, Dehaini D, Nguyen P, Angsantikul P, Wen CH, Kroll AV, Carpenter C, Ramesh M, Qu V, Patel SH, Zhu J, Shi W, Hofman F, Chen TC, Gao W, Zhang K, Chien S, Zhang L. Nanoparticle biointerfacing by platelet membrane cloaking. Nature. 2015 Oct 01; 526(7571):118-21. PMID: 26374997; PMCID: PMC4871317.
      7. Chen TC, Cho HY, Wang W, Wetzel SJ, Singh A, Nguyen J, Hofman F, Schönthal AH. Chemotherapeutic effect of a novel temozolomide analog on nasopharyngeal carcinoma in vitro and in vivo. J Biomed Sci. 2015 Aug 19; 22:71. PMID: 26282951; PMCID: PMC4539921.
      8. Schijns VE, Pretto C, Devillers L, Pierre D, Hofman F, Chen TC, Mespouille P, Hantos P, Glorieux P, Bota DA, Stathopoulos A. First clinical results of a personalized immunotherapeutic vaccine against recurrent, incompletely resected, treatment-resistant glioblastoma multiforme (GBM) tumors, based on combined allo- and auto-immune tumor reactivity. Vaccine. 2015 May 28; 33(23):2690-6. PMID: 25865468.
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      9. Bota DA, Alexandru-Abrams D, Pretto C, Hofman F, Chen TC, Fu B, Carrillo JA, Schijns VE, Stathopoulos A. Use of ERC-1671 Vaccine in a Patient with Recurrent Glioblastoma Multiforme after Progression during Bevacizumab Therapy: First Published Report. Perm J. 2015; 19(2):41-6. PMID: 25785641; PMCID: PMC4403580.
      10. Golden EB, Cho HY, Hofman F, Louie SG, Schönthal AH, Chen TC. Quinoline-based antimalarial drugs: a novel class of autophagy inhibitors. Neurosurg Focus. 2015 Mar; 38(3):E12. PMID: 25727221.
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      11. Wang W, Sivakumar W, Torres S, Jhaveri N, Vaikari VP, Gong A, Howard A, Golden EB, Louie SG, Schönthal AH, Hofman F, Chen TC. Effects of convection-enhanced delivery of bevacizumab on survival of glioma-bearing animals. Neurosurg Focus. 2015 Mar; 38(3):E8. PMID: 25727230.
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      12. Huang TT, Parab S, Burnett R, Diago O, Ostertag D, Hofman F, Espinoza FL, Martin B, Ibañez CE, Kasahara N, Gruber HE, Pertschuk D, Jolly DJ, Robbins JM. Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model. Hum Gene Ther. 2015 Feb; 26(2):82-93. PMID: 25419577; PMCID: PMC4326030.
      13. Jhaveri N, Chen TC, Hofman F. Tumor vasculature and glioma stem cells: Contributions to glioma progression. Cancer Lett. 2016 Oct 01; 380(2):545-51. PMID: 25527451.
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      14. Chen TC, Cho HY, Wang W, Nguyen J, Jhaveri N, Rosenstein-Sisson R, Hofman F, Schönthal AH. A novel temozolomide analog, NEO212, with enhanced activity against MGMT-positive melanoma in vitro and in vivo. Cancer Lett. 2015 Mar 28; 358(2):144-51. PMID: 25524552.
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      15. Golden EB, Cho HY, Jahanian A, Hofman F, Louie SG, Schönthal AH, Chen TC. Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy. Neurosurg Focus. 2014 Dec; 37(6):E12. PMID: 25434381.
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      16. Santos T, Fang X, Chen MT, Wang W, Ferreira R, Jhaveri N, Gundersen M, Zhou C, Pagnini P, Hofman F, Chen TC. Sequential administration of carbon nanotubes and near-infrared radiation for the treatment of gliomas. Front Oncol. 2014; 4:180. PMID: 25077069; PMCID: PMC4097104.
      17. Cho HY, Wang W, Jhaveri N, Lee DJ, Sharma N, Dubeau L, Schönthal AH, Hofman F, Chen TC. NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas. Mol Cancer Ther. 2014 Aug; 13(8):2004-17. PMID: 24994771.
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      18. Ferreira R, Santos T, Amar A, Gong A, Chen TC, Tahara SM, Giannotta SL, Hofman F. Argonaute-2 promotes miR-18a entry in human brain endothelial cells. J Am Heart Assoc. 2014 May 16; 3(3):e000968. PMID: 24837588; PMCID: PMC4309089.
      19. Chen TC, Cho HY, Wang W, Barath M, Sharma N, Hofman F, Schönthal AH. A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo. Mol Cancer Ther. 2014 May; 13(5):1181-93. PMID: 24623736.
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      20. Peterson A, Bansal A, Hofman F, Chen TC, Zada G. A systematic review of inhaled intranasal therapy for central nervous system neoplasms: an emerging therapeutic option. J Neurooncol. 2014 Feb; 116(3):437-46. PMID: 24398618.
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      21. Hofman F, Taylor CR. Immunohistochemistry. Curr Protoc Immunol. 2013 Nov 18; 103:Unit 21.4.. PMID: 24510546.
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      22. Ferreira R, Santos T, Amar A, Tahara SM, Chen TC, Giannotta SL, Hofman F. MicroRNA-18a improves human cerebral arteriovenous malformation endothelial cell function. Stroke. 2014 Jan; 45(1):293-7. PMID: 24203843.
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      23. Thomas S, Sharma N, Gonzalez R, Pao PW, Hofman F, Chen TC, Louie SG, Pirrung MC, Schönthal AH. Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I. PLoS One. 2013; 8(6):e65695. PMID: 23755268; PMCID: PMC3675020.
      24. Cho HY, Wang W, Jhaveri N, Torres S, Tseng J, Leong MN, Lee DJ, Goldkorn A, Xu T, Petasis NA, Louie SG, Schönthal AH, Hofman F, Chen TC. Perillyl alcohol for the treatment of temozolomide-resistant gliomas. Mol Cancer Ther. 2012 Nov; 11(11):2462-72. PMID: 22933703.
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      25. Sharma N, Thomas S, Golden EB, Hofman F, Chen TC, Petasis NA, Schönthal AH, Louie SG. Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent. Cancer Lett. 2012 Dec 30; 326(2):143-54. PMID: 22863539.
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      26. Thomas S, Sharma N, Golden EB, Cho H, Agarwal P, Gaffney KJ, Petasis NA, Chen TC, Hofman F, Louie SG, Schönthal AH. Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors. Cancer Lett. 2012 Dec 01; 325(1):63-71. PMID: 22664238.
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      27. Stathopoulos A, Pretto C, Devillers L, Pierre D, Hofman F, Kruse C, Jadus M, Chen TC, Schijns VE. Development of immune memory to glial brain tumors after tumor regression induced by immunotherapeutic Toll-like receptor 7/8 activation. Oncoimmunology. 2012 May 01; 1(3):298-305. PMID: 22737605.
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      28. Stathopoulos A, Pretto C, Devillers L, Pierre D, Hofman F, Epstein AL, Farghadani H, Kruse CA, Jadus MR, Chen TC, Schijns VE. Exploring the Therapeutic Efficacy of Glioma Vaccines Based on Allo- and Syngeneic Antigens and Distinct Immunological Costimulation Activators. J Clin Cell Immunol. 2012; Suppl 5:004. PMID: 24955288.
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      29. Jhaveri N, Cho H, Torres S, Wang W, Schönthal AH, Petasis NA, Louie SG, Hofman F, Chen TC. Noscapine inhibits tumor growth in TMZ-resistant gliomas. Cancer Lett. 2011 Dec 22; 312(2):245-52. PMID: 21925789.
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      30. Stapleton CJ, Armstrong DL, Zidovetzki R, Liu CY, Giannotta SL, Hofman F. Thrombospondin-1 modulates the angiogenic phenotype of human cerebral arteriovenous malformation endothelial cells. Neurosurgery. 2011 May; 68(5):1342-53; discussion 1353. PMID: 21307796.
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      31. Dong D, Stapleton C, Luo B, Xiong S, Ye W, Zhang Y, Jhaveri N, Zhu G, Ye R, Liu Z, Bruhn KW, Craft N, Groshen S, Hofman F, Lee AS. A critical role for GRP78/BiP in the tumor microenvironment for neovascularization during tumor growth and metastasis. Cancer Res. 2011 Apr 15; 71(8):2848-57. PMID: 21467168; PMCID: PMC3078191.
      32. Chen TC, Wang W, Golden EB, Thomas S, Sivakumar W, Hofman F, Louie SG, Schönthal AH. Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models. Cancer Lett. 2011 Mar 28; 302(2):100-8. PMID: 21257259.
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      33. Schönthal AH, Chen TC, Hofman F, Louie SG, Petasis NA. Preclinical development of novel anti-glioma drugs targeting the endoplasmic reticulum stress response. Curr Pharm Des. 2011; 17(23):2428-38. PMID: 21827419.
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      34. Hofman F, Stathopoulos A, Kruse CA, Chen TC, Schijns VE. Immunotherapy of malignant gliomas using autologous and allogeneic tissue cells. Anticancer Agents Med Chem. 2010 Jul; 10(6):462-70. PMID: 20879986; PMCID: PMC3999913.
      35. Wang W, Ghandi A, Liebes L, Louie SG, Hofman F, Schönthal AH, Chen TC. Effective conversion of irinotecan to SN-38 after intratumoral drug delivery to an intracranial murine glioma model in vivo. Laboratory investigation. J Neurosurg. 2011 Mar; 114(3):689-94. PMID: 20415520.
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      36. Virrey JJ, Liu Z, Cho HY, Kardosh A, Golden EB, Louie SG, Gaffney KJ, Petasis NA, Schönthal AH, Chen TC, Hofman F. Antiangiogenic activities of 2,5-dimethyl-celecoxib on the tumor vasculature. Mol Cancer Ther. 2010 Mar; 9(3):631-41. PMID: 20197398.
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      37. Virrey JJ, Golden EB, Sivakumar W, Wang W, Pen L, Schönthal AH, Hofman F, Chen TC. Glioma-associated endothelial cells are chemoresistant to temozolomide. J Neurooncol. 2009 Oct; 95(1):13-22. PMID: 19381445.
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      38. Cho HY, Thomas S, Golden EB, Gaffney KJ, Hofman F, Chen TC, Louie SG, Petasis NA, Schönthal AH. Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress. Cancer Lett. 2009 Sep 08; 282(1):87-97. PMID: 19345476.
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      39. Zandian M, Belisle R, Mott KR, Nusinowitz S, Hofman F, Ghiasi H. Optic neuritis in different strains of mice by a recombinant HSV-1 expressing murine interleukin-2. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3275-82. PMID: 19234357.
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      40. Jabbour MN, Elder JB, Samuelson CG, Khashabi S, Hofman F, Giannotta SL, Liu CY. Aberrant angiogenic characteristics of human brain arteriovenous malformation endothelial cells. Neurosurgery. 2009 Jan; 64(1):139-46; discussion 146-8. PMID: 19145162.
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      41. Virrey JJ, Dong D, Stiles C, Patterson JB, Pen L, Ni M, Schönthal AH, Chen TC, Hofman F, Lee AS. Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells. Mol Cancer Res. 2008 Aug; 6(8):1268-75. PMID: 18708359; PMCID: PMC2593417.
      42. Virrey JJ, Guan S, Li W, Schönthal AH, Chen TC, Hofman F. Increased survivin expression confers chemoresistance to tumor-associated endothelial cells. Am J Pathol. 2008 Aug; 173(2):575-85. PMID: 18599610; PMCID: PMC2475793.
      43. Schönthal AH, Chen TC, Hofman F, Louie SG, Petasis NA. Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs. Expert Opin Investig Drugs. 2008 Feb; 17(2):197-208. PMID: 18230053.
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      44. Kardosh A, Golden EB, Pyrko P, Uddin J, Hofman F, Chen TC, Louie SG, Petasis NA, Schönthal AH. Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib. Cancer Res. 2008 Feb 01; 68(3):843-51. PMID: 18245486.
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      45. Dong D, Ni M, Li J, Xiong S, Ye W, Virrey JJ, Mao C, Ye R, Wang M, Pen L, Dubeau L, Groshen S, Hofman F, Lee AS. Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development. Cancer Res. 2008 Jan 15; 68(2):498-505. PMID: 18199545.
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      46. Pyrko P, Schönthal AH, Hofman F, Chen TC, Lee AS. The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas. Cancer Res. 2007 Oct 15; 67(20):9809-16. PMID: 17942911.
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      47. Kardosh A, Soriano N, Pyrko P, Liu YT, Jabbour M, Hofman F, Schönthal AH. Reduced survivin expression and tumor cell survival during chronic hypoxia and further cytotoxic enhancement by the cyclooxygenase-2 inhibitor celecoxib. J Biomed Sci. 2007 Sep; 14(5):647-62. PMID: 17440835.
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      48. Chen HC, Hofman F, Kung JT, Lin YD, Wu-Hsieh BA. Both virus and tumor necrosis factor alpha are critical for endothelium damage in a mouse model of dengue virus-induced hemorrhage. J Virol. 2007 Jun; 81(11):5518-26. PMID: 17360740; PMCID: PMC1900309.
      49. Gupta V, Su YS, Samuelson CG, Liebes LF, Chamberlain MC, Hofman F, Schönthal AH, Chen TC. Irinotecan: a potential new chemotherapeutic agent for atypical or malignant meningiomas. J Neurosurg. 2007 Mar; 106(3):455-62. PMID: 17367069.
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      50. Dietlin TA, Hofman F, Lund BT, Gilmore W, Stohlman SA, van der Veen RC. Mycobacteria-induced Gr-1+ subsets from distinct myeloid lineages have opposite effects on T cell expansion. J Leukoc Biol. 2007 May; 81(5):1205-12. PMID: 17307863.
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      51. Charalambous C, Virrey J, Kardosh A, Jabbour MN, Qazi-Abdullah L, Pen L, Zidovetzki R, Schönthal AH, Chen TC, Hofman F. Glioma-associated endothelial cells show evidence of replicative senescence. Exp Cell Res. 2007 Apr 01; 313(6):1192-202. PMID: 17291495.
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      52. Pyrko P, Soriano N, Kardosh A, Liu YT, Uddin J, Petasis NA, Hofman F, Chen CS, Chen TC, Schönthal AH. Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo. Mol Cancer. 2006 May 18; 5:19. PMID: 16707021; PMCID: PMC1479836.
      53. Gupta V, Wang W, Sosnowski BA, Hofman F, Chen TC. Fibroblast growth factor-2-retargeted adenoviral vector for selective transduction of primary glioblastoma multiforme endothelial cells. Neurosurg Focus. 2006 Apr 15; 20(4):E26. PMID: 16709032.
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      54. Gupta V, Su YS, Wang W, Kardosh A, Liebes LF, Hofman F, Schönthal AH, Chen TC. Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin. Neurosurg Focus. 2006 Apr 15; 20(4):E20. PMID: 16709026.
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      55. Charalambous C, Chen TC, Hofman F. Characteristics of tumor-associated endothelial cells derived from glioblastoma multiforme. Neurosurg Focus. 2006 Apr 15; 20(4):E22. PMID: 16709028.
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      56. Milan J, Charalambous C, Elhag R, Chen TC, Li W, Guan S, Hofman F, Zidovetzki R. Multiple signaling pathways are involved in endothelin-1-induced brain endothelial cell migration. Am J Physiol Cell Physiol. 2006 Jul; 291(1):C155-64. PMID: 16452160.
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      57. Charalambous C, Pen LB, Su YS, Milan J, Chen TC, Hofman F. Interleukin-8 differentially regulates migration of tumor-associated and normal human brain endothelial cells. Cancer Res. 2005 Nov 15; 65(22):10347-54. PMID: 16288024.
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      58. Kardosh A, Soriano N, Liu YT, Uddin J, Petasis NA, Hofman F, Chen TC, Schönthal AH. Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2 inhibitory analog of celecoxib. Blood. 2005 Dec 15; 106(13):4330-8. PMID: 16123214.
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      59. Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, Brooks AI, Kanagala S, Rubio A, Sagare A, Liu D, Li F, Armstrong D, Gasiewicz T, Zidovetzki R, Song X, Hofman F, Zlokovic BV. Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nat Med. 2005 Sep; 11(9):959-65. PMID: 16116430.
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      60. Kardosh A, Wang W, Uddin J, Petasis NA, Hofman F, Chen TC, Schönthal AH. Dimethyl-celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory function, potently mimics the anti-tumor effects of celecoxib on Burkitt's lymphoma in vitro and in vivo. Cancer Biol Ther. 2005 May; 4(5):571-82. PMID: 15846081.
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      61. Osorio Y, La Point SF, Nusinowitz S, Hofman F, Ghiasi H. CD8+-dependent CNS demyelination following ocular infection of mice with a recombinant HSV-1 expressing murine IL-2. Exp Neurol. 2005 May; 193(1):1-18. PMID: 15817260.
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      62. Charalambous C, Hofman F, Chen TC. Functional and phenotypic differences between glioblastoma multiforme-derived and normal human brain endothelial cells. J Neurosurg. 2005 Apr; 102(4):699-705. PMID: 15871513.
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      63. van der Veen RC, Dietlin TA, Karapetian A, Holland SM, Hofman F. Extra-cellular superoxide promotes T cell expansion through inactivation of nitric oxide. J Neuroimmunol. 2004 Aug; 153(1-2):183-9. PMID: 15265676.
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      64. Osorio Y, Cai S, Hofman F, Brown DJ, Ghiasi H. Involvement of CD8+ T-cells in exacerbation of corneal scarring in mice. Curr Eye Res. 2004 Aug-Sep; 29(2-3):145-51. PMID: 15512961.
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      65. van der Veen RC, Dietlin TA, Hofman F. Tissue expression of inducible nitric oxide synthase requires IFN-gamma production by infiltrating splenic T cells: more evidence for immunosuppression by nitric oxide. J Neuroimmunol. 2003 Dec; 145(1-2):86-90. PMID: 14644034.
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      66. Wu Z, Hofman F, Zlokovic BV. A simple method for isolation and characterization of mouse brain microvascular endothelial cells. J Neurosci Methods. 2003 Nov 30; 130(1):53-63. PMID: 14583404.
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      67. Deane R, Du Yan S, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J, Zhu H, Ghiso J, Frangione B, Stern A, Schmidt AM, Armstrong DL, Arnold B, Liliensiek B, Nawroth P, Hofman F, Kindy M, Stern D, Zlokovic B. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med. 2003 Jul; 9(7):907-13. PMID: 12808450.
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      68. Giri R, Selvaraj S, Miller CA, Hofman F, Yan SD, Stern D, Zlokovic BV, Kalra VK. Effect of endothelial cell polarity on beta-amyloid-induced migration of monocytes across normal and AD endothelium. Am J Physiol Cell Physiol. 2002 Sep; 283(3):C895-904. PMID: 12176746.
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      69. Hofman F. Immunohistochemistry. Curr Protoc Immunol. 2002 Aug; Chapter 21:Unit 21.4. PMID: 18432882.
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      70. Chen TC, Wadsten P, Su S, Rawlinson N, Hofman F, Hill CK, Schönthal AH. The type IV phosphodiesterase inhibitor rolipram induces expression of the cell cycle inhibitors p21(Cip1) and p27(Kip1), resulting in growth inhibition, increased differentiation, and subsequent apoptosis of malignant A-172 glioma cells. Cancer Biol Ther. 2002 May-Jun; 1(3):268-76. PMID: 12432276.
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