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    Eleanora C. Heisterkamp, PhD

    TitleProfessor of Research Pediatrics
    SchoolKeck School of Medicine of USC
    DepartmentPediatrics
    AddressCHL Mail Stop 54
    Off Campus
    Los Angeles California 90089
    Phone+1 323 361 4595
    vCardDownload vCard

      Collapse Overview 
      Collapse Overview
      General areas of research interest:
      -Drug resistance mechanisms in leukemia
      -Role of the microenvironment in protection of cancer cells
      -NK-based anti-cancer therapy
      -Signal transduction
      -Glycobiology

      Research in Progress
      -Carbohydrate-based interactions between leukemia cells and the supporting microenvironment
      -Glycomics for diagnosis and treatment of leukemia
      -NK-mediated cytotoxicity as therapy for leukemias
      -Study of leukemia-stromal adhesion mechanisms
      -Molecular mechanisms of environmentally-mediated drug resistance


      Accomplishments in the area of cancer research in the past include the unraveling of major aspects of the molecular basis of chronic myeloid leukemia (CML) and Ph-chromosome positive acute lymphoblastic leukemia (ALL): during the period of 1981-1984, we identified two genes, BCR and ABL, which become fused as a result of a chromosomal translocation in CML and Ph-positive ALL.


      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Fei F, Joo EJ, Tarighat SS, Schiffer I, Paz H, Fabbri M, Abdel-Azim H, Groffen J, Heisterkamp E. B-cell precursor acute lymphoblastic leukemia and stromal cells communicate through Galectin-3. Oncotarget. 2015 May 10; 6(13):11378-94. PMID: 25869099.
        View in: PubMed
      2. Abdel-Azim H, Heisterkamp E. Potential of autologous NK cell therapy to eradicate leukemia: "Education is [not] the best provision for old age" -Aristotle. Oncoimmunology. 2015 Feb; 4(2):e984549. PMID: 25949882.
        View in: PubMed
      3. Fei F, Lim M, George AA, Kirzner J, Lee D, Seeger R, Groffen J, Abdel-Azim H, Heisterkamp E. Cytotoxicity of CD56-positive lymphocytes against autologous B-cell precursor acute lymphoblastic leukemia cells. Leukemia. 2015 Apr; 29(4):788-97. PMID: 25134458.
        View in: PubMed
      4. Parameswaran R, Lim M, Fei F, Abdel-Azim H, Arutyunyan A, Schiffer I, McLaughlin ME, Gram H, Huet H, Groffen J, Heisterkamp E. Effector-Mediated Eradication of Precursor B Acute Lymphoblastic Leukemia with a Novel Fc-Engineered Monoclonal Antibody Targeting the BAFF-R. Mol Cancer Ther. 2014 Jun; 13(6):1567-77. PMID: 24825858.
        View in: PubMed
      5. Gong D, Fei F, Lim M, Yu M, Groffen J, Heisterkamp E. Abr, a negative regulator of Rac, attenuates cockroach allergen-induced asthma in a mouse model. J Immunol. 2013 Nov 1; 191(9):4514-20. PMID: 24058174.
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      6. Fei F, Abdel-Azim H, Lim M, Arutyunyan A, von Itzstein M, Groffen J, Heisterkamp E. Galectin-3 in pre-B acute lymphoblastic leukemia. Leukemia. 2013 Dec; 27(12):2385-8. PMID: 23760399.
        View in: PubMed
      7. Parameswaran R, Lim M, Arutyunyan A, Abdel-Azim H, Hurtz C, Lau K, Müschen M, Yu RK, von Itzstein M, Heisterkamp E, Groffen J. O-acetylated N-acetylneuraminic acid as a novel target for therapy in human pre-B acute lymphoblastic leukemia. J Exp Med. 2013 Apr 8; 210(4):805-19. PMID: 23478187.
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      8. Pramanik R, Sheng X, Ichihara B, Heisterkamp E, Mittelman SD. Adipose tissue attracts and protects acute lymphoblastic leukemia cells from chemotherapy. Leuk Res. 2013 May; 37(5):503-9. PMID: 23332453.
        View in: PubMed
      9. Hsieh YT, Gang EJ, Geng H, Park E, Huantes S, Chudziak D, Dauber K, Schaefer P, Scharman C, Shimada H, Shojaee S, Klemm L, Parameswaran R, Loh M, Kang ES, Koo HH, Hofmann WK, Andrade J, Crooks GM, Willman CL, Müschen M, Papayannopoulou T, Heisterkamp E, Bönig H, Kim YM. Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy. Blood. 2013 Mar 7; 121(10):1814-8. PMID: 23319569.
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      10. Yu M, Gong D, Lim M, Arutyunyan A, Groffen J, Heisterkamp E. Lack of bcr and abr promotes hypoxia-induced pulmonary hypertension in mice. PLoS One. 2012; 7(11):e49756. PMID: 23152932.
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      11. Arutyunyan A, Stoddart S, Yi SJ, Fei F, Lim M, Groffen P, Feldhahn N, Groffen J, Heisterkamp E. Expression of cassini, a murine gamma-satellite sequence conserved in evolution, is regulated in normal and malignant hematopoietic cells. BMC Genomics. 2012; 13:418. PMID: 22916712.
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      12. Feldhahn N, Arutyunyan A, Stoddart S, Zhang B, Schmidhuber S, Yi SJ, Kim YM, Groffen J, Heisterkamp E. Environment-mediated drug resistance in Bcr/Abl-positive acute lymphoblastic leukemia. Oncoimmunology. 2012 Aug 1; 1(5):618-629. PMID: 22934254.
        View in: PubMed
      13. Park AR, Oh D, Lim SH, Choi J, Moon J, Yu DY, Park SG, Heisterkamp E, Kim E, Myung PK, Lee JR. Regulation of dendritic arborization by BCR Rac1 GTPase-activating protein, a substrate of PTPRT. J Cell Sci. 2012 Oct 1; 125(Pt 19):4518-31. PMID: 22767509.
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      14. Fei F, Lim M, Schmidhuber S, Moll J, Groffen J, Heisterkamp E. Treatment of human pre-B acute lymphoblastic leukemia with the Aurora kinase inhibitor PHA-739358 (Danusertib). Mol Cancer. 2012; 11:42. PMID: 22721004.
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      15. Gong D, Shi W, Yi SJ, Chen H, Groffen J, Heisterkamp E. TGFß signaling plays a critical role in promoting alternative macrophage activation. BMC Immunol. 2012; 13:31. PMID: 22703233.
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      16. Parameswaran R, Yu M, Lyu MA, Lim M, Rosenblum MG, Groffen J, Heisterkamp E. Treatment of acute lymphoblastic leukemia with an rGel/BLyS fusion toxin. Leukemia. 2012 Aug; 26(8):1786-96. PMID: 22373785.
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      17. Park E, Gang EJ, Hsieh YT, Schaefer P, Chae S, Klemm L, Huantes S, Loh M, Conway EM, Kang ES, Hoe Koo H, Hofmann WK, Heisterkamp E, Pelus L, Keerthivasan G, Crispino J, Kahn M, Müschen M, Kim YM. Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia. Blood. 2011 Aug 25; 118(8):2191-9. PMID: 21715311.
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      18. Duy C, Hurtz C, Shojaee S, Cerchietti L, Geng H, Swaminathan S, Klemm L, Kweon SM, Nahar R, Braig M, Park E, Kim YM, Hofmann WK, Herzog S, Jumaa H, Koeffler HP, Yu JJ, Heisterkamp E, Graeber TG, Wu H, Ye BH, Melnick A, Müschen M. BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. Nature. 2011 May 19; 473(7347):384-8. PMID: 21593872.
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      19. Parameswaran R, Yu M, Lim M, Groffen J, Heisterkamp E. Combination of drug therapy in acute lymphoblastic leukemia with a CXCR4 antagonist. Leukemia. 2011 Aug; 25(8):1314-23. PMID: 21483439.
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      20. Yu M, Gang EJ, Parameswaran R, Stoddart S, Fei F, Schmidhuber S, Park E, Hsieh YT, Yang AS, Groffen J, Heisterkamp E, Kim YM. AMD3100 sensitizes acute lymphoblastic leukemia cells to chemotherapy in vivo. Blood Cancer J. 2011 Apr; 1(4):e14. PMID: 22829135.
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      21. Chandra HS, Heisterkamp E, Hungerford A, Morrissette JJ, Nowell PC, Rowley JD, Testa JR. Philadelphia Chromosome Symposium: commemoration of the 50th anniversary of the discovery of the Ph chromosome. Cancer Genet. 2011 Apr; 204(4):171-9. PMID: 21536234.
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      22. Yi SJ, Groffen J, Heisterkamp E. Bcr is a substrate for Transglutaminase 2 cross-linking activity. BMC Biochem. 2011; 12:8. PMID: 21310073.
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      23. Fei F, Kweon SM, Haataja L, De Sepulveda P, Groffen J, Heisterkamp E. The Fer tyrosine kinase regulates interactions of Rho GDP-Dissociation Inhibitor a with the small GTPase Rac. BMC Biochem. 2010; 11:48. PMID: 21122136.
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      24. Oh D, Han S, Seo J, Lee JR, Choi J, Groffen J, Kim K, Cho YS, Choi HS, Shin H, Woo J, Won H, Park SK, Kim SY, Jo J, Whitcomb DJ, Cho K, Kim H, Bae YC, Heisterkamp E, Choi SY, Kim E. Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins. J Neurosci. 2010 Oct 20; 30(42):14134-44. PMID: 20962234.
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      25. Yun JP, Behan JW, Heisterkamp E, Butturini A, Klemm L, Ji L, Groffen J, Müschen M, Mittelman SD. Diet-induced obesity accelerates acute lymphoblastic leukemia progression in two murine models. Cancer Prev Res (Phila). 2010 Oct; 3(10):1259-64. PMID: 20823291.
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      26. Li A, Xing Y, Chan B, Heisterkamp E, Groffen J, Borok Z, Minoo P, Li C. Cell type-specific expression of adenomatous polyposis coli in lung development, injury, and repair. Dev Dyn. 2010 Aug; 239(8):2288-97. PMID: 20658693.
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      27. Parameswaran R, Müschen M, Kim YM, Groffen J, Heisterkamp E. A functional receptor for B-cell-activating factor is expressed on human acute lymphoblastic leukemias. Cancer Res. 2010 Jun 1; 70(11):4346-56. PMID: 20460528.
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      28. Fei F, Stoddart S, Groffen J, Heisterkamp E. Activity of the Aurora kinase inhibitor VX-680 against Bcr/Abl-positive acute lymphoblastic leukemias. Mol Cancer Ther. 2010 May; 9(5):1318-27. PMID: 20388735.
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      29. Fei F, Stoddart S, Müschen M, Kim YM, Groffen J, Heisterkamp E. Development of resistance to dasatinib in Bcr/Abl-positive acute lymphoblastic leukemia. Leukemia. 2010 Apr; 24(4):813-20. PMID: 20111071.
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      30. Yi SJ, Groffen J, Heisterkamp E. Transglutaminase 2 regulates the GTPase-activating activity of Bcr. J Biol Chem. 2009 Dec 18; 284(51):35645-51. PMID: 19840940.
        View in: PubMed
      31. Behan JW, Yun JP, Proektor MP, Ehsanipour EA, Arutyunyan A, Moses AS, Avramis VI, Louie SG, Butturini A, Heisterkamp E, Mittelman SD. Adipocytes impair leukemia treatment in mice. Cancer Res. 2009 Oct 1; 69(19):7867-74. PMID: 19773440.
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      32. Klemm L, Duy C, Iacobucci I, Kuchen S, von Levetzow G, Feldhahn N, Henke N, Li Z, Hoffmann TK, Kim YM, Hofmann WK, Jumaa H, Groffen J, Heisterkamp E, Martinelli G, Lieber MR, Casellas R, Müschen M. The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia. Cancer Cell. 2009 Sep 8; 16(3):232-45. PMID: 19732723.
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      33. Cunnick JM, Schmidhuber S, Chen G, Yu M, Yi SJ, Cho YJ, Kaartinen V, Minoo P, Warburton D, Groffen J, Heisterkamp E. Bcr and Abr cooperate in negatively regulating acute inflammatory responses. Mol Cell Biol. 2009 Nov; 29(21):5742-50. PMID: 19703997.
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      34. Trageser D, Iacobucci I, Nahar R, Duy C, von Levetzow G, Klemm L, Park E, Schuh W, Gruber T, Herzog S, Kim YM, Hofmann WK, Li A, Storlazzi CT, Jäck HM, Groffen J, Martinelli G, Heisterkamp E, Jumaa H, Müschen M. Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function. J Exp Med. 2009 Aug 3; 206(8):1739-53. PMID: 19620627.
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      35. Yi SJ, Lee HT, Groffen J, Heisterkamp E. Bcr/Abl P190 interaction with Spa-1, a GTPase activating protein for the small GTPase Rap1. Int J Mol Med. 2008 Oct; 22(4):453-8. PMID: 18813851.
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      36. Heisterkamp E, Groffen J, Warburton D, Sneddon TP. The human gamma-glutamyltransferase gene family. Hum Genet. 2008 May; 123(4):321-32. PMID: 18357469.
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      37. Kweon SM, Cho YJ, Minoo P, Groffen J, Heisterkamp E. Activity of the Bcr GTPase-activating domain is regulated through direct protein/protein interaction with the Rho guanine nucleotide dissociation inhibitor. J Biol Chem. 2008 Feb 8; 283(6):3023-30. PMID: 18070886.
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      38. Kaur P, Feldhahn N, Zhang B, Trageser D, Müschen M, Pertz V, Groffen J, Heisterkamp E. Nilotinib treatment in mouse models of P190 Bcr/Abl lymphoblastic leukemia. Mol Cancer. 2007; 6:67. PMID: 17958915.
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      39. Ding W, Shi W, Bellusci S, Groffen J, Heisterkamp E, Minoo P, Warburton D. Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF-beta1 signaling and EGF as well as FGF receptor tyrosine kinase-ERK pathways in mesenchymal cells. J Cell Physiol. 2007 Sep; 212(3):796-806. PMID: 17516543.
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      40. Zhang B, Groffen J, Heisterkamp E. Increased resistance to a farnesyltransferase inhibitor by N-cadherin expression in Bcr/Abl-P190 lymphoblastic leukemia cells. Leukemia. 2007 Jun; 21(6):1189-97. PMID: 17392819.
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      41. Zhu NL, Li C, Huang HH, Sebald M, Londhe VA, Heisterkamp E, Warburton D, Bellusci S, Minoo P. TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells. Gene. 2007 May 15; 393(1-2):70-80. PMID: 17350185.
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      42. Cho YJ, Cunnick JM, Yi SJ, Kaartinen V, Groffen J, Heisterkamp E. Abr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages. Mol Cell Biol. 2007 Feb; 27(3):899-911. PMID: 17116687.
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      43. Mishra S, Pertz V, Zhang B, Kaur P, Shimada H, Groffen J, Kazimierczuk Z, Pinna LA, Heisterkamp E. Treatment of P190 Bcr/Abl lymphoblastic leukemia cells with inhibitors of the serine/threonine kinase CK2. Leukemia. 2007 Jan; 21(1):178-80. PMID: 17082777.
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      44. Mishra S, Zhang B, Cunnick JM, Heisterkamp E, Groffen J. Resistance to imatinib of bcr/abl p190 lymphoblastic leukemia cells. Cancer Res. 2006 May 15; 66(10):5387-93. PMID: 16707466.
        View in: PubMed
      45. Cunnick J, Kaur P, Cho Y, Groffen J, Heisterkamp E. Use of bone marrow-derived macrophages to model murine innate immune responses. J Immunol Methods. 2006 Apr 20; 311(1-2):96-105. PMID: 16563426.
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      46. Cho YJ, Hemmeryckx B, Groffen J, Heisterkamp E. Interaction of Bcr/Abl with C3G, an exchange factor for the small GTPase Rap1, through the adapter protein Crkl. Biochem Biophys Res Commun. 2005 Aug 12; 333(4):1276-83. PMID: 15982636.
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      47. Cho YJ, Zhang B, Kaartinen V, Haataja L, de Curtis I, Groffen J, Heisterkamp E. Generation of rac3 null mutant mice: role of Rac3 in Bcr/Abl-caused lymphoblastic leukemia. Mol Cell Biol. 2005 Jul; 25(13):5777-85. PMID: 15964830.
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      48. Zhang B, Groffen J, Heisterkamp E. Resistance to farnesyltransferase inhibitors in Bcr/Abl-positive lymphoblastic leukemia by increased expression of a novel ABC transporter homolog ATP11a. Blood. 2005 Aug 15; 106(4):1355-61. PMID: 15860663.
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      49. Curtis C, Hemmeryckx B, Haataja L, Senadheera D, Groffen J, Heisterkamp E. Scambio, a novel guanine nucleotide exchange factor for Rho. Mol Cancer. 2004 Apr 23; 3:10. PMID: 15107133.
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      50. Mishra S, Zhang B, Groffen J, Heisterkamp E. A farnesyltransferase inhibitor increases survival of mice with very advanced stage acute lymphoblastic leukemia/lymphoma caused by P190 Bcr/Abl. Leukemia. 2004 Jan; 18(1):23-8. PMID: 14603339.
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      51. Mishra S, Reichert A, Cunnick J, Senadheera D, Hemmeryckx B, Heisterkamp E, Groffen J. Protein kinase CKIIalpha interacts with the Bcr moiety of Bcr/Abl and mediates proliferation of Bcr/Abl-expressing cells. Oncogene. 2003 Nov 13; 22(51):8255-62. PMID: 14614449.
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      52. Piedra J, Miravet S, Castaño J, Pálmer HG, Heisterkamp E, García de Herreros A, Duñach M. p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction. Mol Cell Biol. 2003 Apr; 23(7):2287-97. PMID: 12640114.
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      53. Leung K, Nagy A, Gonzalez-Gomez I, Groffen J, Heisterkamp E, Kaartinen V. Targeted expression of activated Rac3 in mammary epithelium leads to defective postlactational involution and benign mammary gland lesions. Cells Tissues Organs. 2003; 175(2):72-83. PMID: 14605486.
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      54. Heisterkamp E, Groffen J. Philadelphia-positive leukemia: a personal perspective. Oncogene. 2002 Dec 9; 21(56):8536-40. PMID: 12476299.
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      55. Kaartinen V, Haataja L, Nagy A, Heisterkamp E, Groffen J. TGFbeta3-induced activation of RhoA/Rho-kinase pathway is necessary but not sufficient for epithelio-mesenchymal transdifferentiation: implications for palatogenesis. Int J Mol Med. 2002 Jun; 9(6):563-70. PMID: 12011971.
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      56. Hemmeryckx B, Reichert A, Watanabe M, Kaartinen V, de Jong R, Pattengale PK, Groffen J, Heisterkamp E. BCR/ABL P190 transgenic mice develop leukemia in the absence of Crkl. Oncogene. 2002 May 9; 21(20):3225-31. PMID: 12082638.
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      57. De Langhe S, Haataja L, Senadheera D, Groffen J, Heisterkamp E. Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain. Int J Mol Med. 2002 May; 9(5):451-9. PMID: 11956649.
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      58. Kaartinen V, Nagy A, Gonzalez-Gomez I, Groffen J, Heisterkamp E. Vestibular dysgenesis in mice lacking Abr and Bcr Cdc42/RacGAPs. Dev Dyn. 2002 Apr; 223(4):517-25. PMID: 11921339.
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      59. Haataja L, Kaartinen V, Groffen J, Heisterkamp E. The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading. J Biol Chem. 2002 Mar 8; 277(10):8321-8. PMID: 11756406.
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      60. Kaartinen V, Gonzalez-Gomez I, Voncken JW, Haataja L, Faure E, Nagy A, Groffen J, Heisterkamp E. Abnormal function of astroglia lacking Abr and Bcr RacGAPs. Development. 2001 Nov; 128(21):4217-27. PMID: 11684658.
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      61. Senadheera D, Haataja L, Groffen J, Heisterkamp E. The small GTPase Rac interacts with ubiquitination complex proteins Cullin-1 and CDC23. Int J Mol Med. 2001 Aug; 8(2):127-33. PMID: 11445862.
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      62. Blavier L, Lazaryev A, Groffen J, Heisterkamp E, DeClerck YA, Kaartinen V. TGF-beta3-induced palatogenesis requires matrix metalloproteinases. Mol Biol Cell. 2001 May; 12(5):1457-66. PMID: 11359935.
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      63. Heisterkamp E, Voncken JW, Senadheera D, Hemmeryckx B, Gonzalez-Gomez I, Reichert A, Pattengale PK, Groffen J. The Bcr N-terminal oligomerization domain contributes to the full oncogenicity of P190 Bcr/Abl in transgenic mice. Int J Mol Med. 2001 Apr; 7(4):351-7. PMID: 11254872.
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      64. Reichert A, Heisterkamp E, Daley GQ, Groffen J. Treatment of Bcr/Abl-positive acute lymphoblastic leukemia in P190 transgenic mice with the farnesyl transferase inhibitor SCH66336. Blood. 2001 Mar 1; 97(5):1399-403. PMID: 11222386.
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      65. Hemmeryckx B, van Wijk A, Reichert A, Kaartinen V, de Jong R, Pattengale PK, Gonzalez-Gomez I, Groffen J, Heisterkamp E. Crkl enhances leukemogenesis in BCR/ABL P190 transgenic mice. Cancer Res. 2001 Feb 15; 61(4):1398-405. PMID: 11245441.
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      66. Heisterkamp E, Voncken JW, Senadheera D, Gonzalez-Gomez I, Reichert A, Haataja L, Reinikainen A, Pattengale PK, Groffen J. Reduced oncogenicity of p190 Bcr/Abl F-actin-binding domain mutants. Blood. 2000 Sep 15; 96(6):2226-32. PMID: 10979970.
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      67. Salloukh HF, Vowles I, Heisterkamp E, Groffen J, Laneuville P. Early events in leukemogenesis in P190Bcr-abl transgenic mice. Oncogene. 2000 Sep 7; 19(38):4362-74. PMID: 10980612.
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      68. Nguyen TT, Mohrbacher AF, Tsai YC, Groffen J, Heisterkamp E, Nichols PW, Yu MC, Lübbert M, Jones PA. Quantitative measure of c-abl and p15 methylation in chronic myelogenous leukemia: biological implications. Blood. 2000 May 1; 95(9):2990-2. PMID: 10779450.
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      69. Faure E, Heisterkamp E, Groffen J, Kaartinen V. Differential expression of TGF-beta isoforms during postlactational mammary gland involution. Cell Tissue Res. 2000 Apr; 300(1):89-95. PMID: 10805078.
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      70. Dunder U, Kaartinen V, Valtonen P, Väänänen E, Kosma VM, Heisterkamp E, Groffen J, Mononen I. Enzyme replacement therapy in a mouse model of aspartylglycosaminuria. FASEB J. 2000 Feb; 14(2):361-7. PMID: 10657992.
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      71. Morris CM, Haataja L, McDonald M, Gough S, Markie D, Groffen J, Heisterkamp E. The small GTPase RAC3 gene is located within chromosome band 17q25.3 outside and telomeric of a region commonly deleted in breast and ovarian tumours. Cytogenet Cell Genet. 2000; 89(1-2):18-23. PMID: 10894930.
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      72. Shi W, Heisterkamp E, Groffen J, Zhao J, Warburton D, Kaartinen V. TGF-beta3-null mutation does not abrogate fetal lung maturation in vivo by glucocorticoids. Am J Physiol. 1999 Dec; 277(6 Pt 1):L1205-13. PMID: 10600892.
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      73. Groffen J, de Jong R, Haataja L, Kaartinen V, Heisterkamp E. Phosphorylation substrates and altered signalling in leukemias caused by BCR/ABL. Leukemia. 1999 Apr; 13 Suppl 1:S81-2. PMID: 10232372.
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      74. de Jong R, van Wijk A, Heisterkamp E, Groffen J. C3G is tyrosine-phosphorylated after integrin-mediated cell adhesion in normal but not in Bcr/Abl expressing cells. Oncogene. 1998 Nov 26; 17(21):2805-10. PMID: 9840945.
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      75. Kyono WT, de Jong R, Park RK, Liu Y, Heisterkamp E, Groffen J, Durden DL. Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI). J Immunol. 1998 Nov 15; 161(10):5555-63. PMID: 9820532.
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      76. Voncken JW, Baram TZ, Gonzales-Gomez I, Van Schaick H, Shih JC, Chen K, Groffen J, Heisterkamp E. Abnormal stress response and increased fighting behavior in mice lacking the bcr gene product. Int J Mol Med. 1998 Nov; 2(5):577-83. PMID: 9858655.
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      77. Gonzalez-Gomez I, Mononen I, Heisterkamp E, Groffen J, Kaartinen V. Progressive neurodegeneration in aspartylglycosaminuria mice. Am J Pathol. 1998 Oct; 153(4):1293-300. PMID: 9777961.
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      78. Rosato R, Veltmaat JM, Groffen J, Heisterkamp E. Involvement of the tyrosine kinase fer in cell adhesion. Mol Cell Biol. 1998 Oct; 18(10):5762-70. PMID: 9742093.
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      79. Shanske AL, Grunwald H, Cook P, Heisterkamp E, Groffen J. Philadelphia-negative chronic myelogenous leukemia in a patient with a unique complex translocation: 46,XY,t(9;12;15)(q34;12;q21). Leuk Res. 1998 Jul; 22(7):645-8. PMID: 9680116.
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      80. Kaartinen V, Mononen I, Gonzalez-Gomez I, Noronkoski T, Heisterkamp E, Groffen J. Phenotypic characterization of mice with targeted disruption of glycosylasparaginase gene: a mouse model for aspartylglycosaminuria. J Inherit Metab Dis. 1998 Jun; 21(3):207-9. PMID: 9686358.
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      81. Voncken JW, Kaartinen V, Groffen J, Heisterkamp E. Bcr/Abl associated leukemogenesis in bcr null mutant mice. Oncogene. 1998 Apr 16; 16(15):2029-32. PMID: 9591787.
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      82. Haataja L, Groffen J, Heisterkamp E. Identification of a novel Rac3-interacting protein C1D. Int J Mol Med. 1998 Apr; 1(4):665-70. PMID: 9852280.
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      83. de Jong R, van Wijk A, Haataja L, Heisterkamp E, Groffen J. BCR/ABL-induced leukemogenesis causes phosphorylation of Hef1 and its association with Crkl. J Biol Chem. 1997 Dec 19; 272(51):32649-55. PMID: 9405482.
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      84. Haataja L, Groffen J, Heisterkamp E. Characterization of RAC3, a novel member of the Rho family. J Biol Chem. 1997 Aug 15; 272(33):20384-8. PMID: 9252344.
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      85. Kaartinen V, Cui XM, Heisterkamp E, Groffen J, Shuler CF. Transforming growth factor-beta3 regulates transdifferentiation of medial edge epithelium during palatal fusion and associated degradation of the basement membrane. Dev Dyn. 1997 Jul; 209(3):255-60. PMID: 9215640.
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      86. Groffen J, Heisterkamp E. The chimeric BCR-ABL gene. Baillieres Clin Haematol. 1997 Jun; 10(2):187-201. PMID: 9376659.
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      87. Chai Y, Sasano Y, Bringas P, Mayo M, Kaartinen V, Heisterkamp E, Groffen J, Slavkin H, Shuler C. Characterization of the fate of midline epithelial cells during the fusion of mandibular prominences in vivo. Dev Dyn. 1997 Apr; 208(4):526-35. PMID: 9097024.
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      88. de Jong R, ten Hoeve J, Heisterkamp E, Groffen J. Tyrosine 207 in CRKL is the BCR/ABL phosphorylation site. Oncogene. 1997 Feb 6; 14(5):507-13. PMID: 9053848.
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      89. Haataja L, Raffel C, Ledbetter DH, Tanigami A, Petersen D, Heisterkamp E, Groffen J. Deletion within the D17S34 locus in a primitive neuroectodermal tumor. Cancer Res. 1997 Jan 1; 57(1):32-4. PMID: 8988035.
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      90. Kaartinen V, Mononen I, Voncken JW, Noronkoski T, Gonzalez-Gomez I, Heisterkamp E, Groffen J. A mouse model for the human lysosomal disease aspartylglycosaminuria. Nat Med. 1996 Dec; 2(12):1375-8. PMID: 8946839.
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      91. Liu J, Wu Y, Ma GZ, Lu D, Haataja L, Heisterkamp E, Groffen J, Arlinghaus RB. Inhibition of Bcr serine kinase by tyrosine phosphorylation. Mol Cell Biol. 1996 Mar; 16(3):998-1005. PMID: 8622703.
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      92. Voncken JW, Kaartinen V, Pattengale PK, Germeraad WT, Groffen J, Heisterkamp E. BCR/ABL P210 and P190 cause distinct leukemia in transgenic mice. Blood. 1995 Dec 15; 86(12):4603-11. PMID: 8541551.
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      93. Salgia R, Uemura N, Okuda K, Li JL, Pisick E, Sattler M, de Jong R, Druker B, Heisterkamp E, Chen LB. CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells. J Biol Chem. 1995 Dec 8; 270(49):29145-50. PMID: 7493940.
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      94. Kaartinen V, Voncken JW, Shuler C, Warburton D, Bu D, Heisterkamp E, Groffen J. Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction. Nat Genet. 1995 Dec; 11(4):415-21. PMID: 7493022.
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      95. Chuang TH, Xu X, Kaartinen V, Heisterkamp E, Groffen J, Bokoch GM. Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family. Proc Natl Acad Sci U S A. 1995 Oct 24; 92(22):10282-6. PMID: 7479768.
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      96. de Jong R, Haataja L, Voncken JW, Heisterkamp E, Groffen J. Tyrosine phosphorylation of murine Crkl. Oncogene. 1995 Oct 19; 11(8):1469-74. PMID: 7478571.
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      97. Heisterkamp E, Mulder MP, Langeveld A, ten Hoeve J, Wang Z, Roe BA, Groffen J. Localization of the human mitochondrial citrate transporter protein gene to chromosome 22Q11 in the DiGeorge syndrome critical region. Genomics. 1995 Sep 20; 29(2):451-6. PMID: 8666394.
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      98. de Jong R, ten Hoeve J, Heisterkamp E, Groffen J. Crkl is complexed with tyrosine-phosphorylated Cbl in Ph-positive leukemia. J Biol Chem. 1995 Sep 15; 270(37):21468-71. PMID: 7545163.
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      99. Chissoe SL, Bodenteich A, Wang YF, Wang YP, Burian D, Clifton SW, Crabtree J, Freeman A, Iyer K, Jian L. Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation. Genomics. 1995 May 1; 27(1):67-82. PMID: 7665185.
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      100. Fioretos T, Heisterkamp E, Groffen J. Standpoint on imprinting of BCR and ABL. Leukemia. 1995 Apr; 9(4):743-4. PMID: 7723414.
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      101. Voncken JW, van Schaick H, Kaartinen V, Deemer K, Coates T, Landing B, Pattengale P, Dorseuil O, Bokoch GM, Groffen J. Increased neutrophil respiratory burst in bcr-null mutants. Cell. 1995 Mar 10; 80(5):719-28. PMID: 7889565.
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      102. Morris C, Benjes S, Haataja L, Ledbetter DH, Heisterkamp E, Groffen J. Spatial organization of ABR and CRK genes on human chromosome band 17p13.3. Oncogene. 1995 Mar 2; 10(5):1009-11. PMID: 7898918.
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      103. Mononen I, Heisterkamp E, Dunder U, Romppanen EL, Noronkoski T, Kuronen I, Groffen J. Recombinant glycosylasparaginase and in vitro correction of aspartylglycosaminuria. FASEB J. 1995 Mar; 9(5):428-33. PMID: 7896015.
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      104. Fioretos T, Voncken JW, Baram TZ, Kamme F, Groffen J, Heisterkamp E. Regional localization and developmental expression of the BCR gene in rodent brain. Cell Mol Biol Res. 1995; 41(2):97-102. PMID: 8581068.
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      105. ten Hoeve J, Arlinghaus RB, Guo JQ, Heisterkamp E, Groffen J. Tyrosine phosphorylation of CRKL in Philadelphia+ leukemia. Blood. 1994 Sep 15; 84(6):1731-6. PMID: 7521685.
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      106. Christoffersen CT, Bornfeldt KE, Rotella CM, Gonzales N, Vissing H, Shymko RM, ten Hoeve J, Groffen J, Heisterkamp E, De Meyts P. Negative cooperativity in the insulin-like growth factor-I receptor and a chimeric IGF-I/insulin receptor. Endocrinology. 1994 Jul; 135(1):472-5. PMID: 8013387.
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      107. Haataja L, Fioretos T, Voncken J, Groffen J, Heisterkamp E. IFN-alpha treatment of p190 bcr abl transgenic mice. Int J Oncol. 1994 Jul; 5(1):47-9. PMID: 21559556.
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      108. ten Hoeve J, Kaartinen V, Fioretos T, Haataja L, Voncken JW, Heisterkamp E, Groffen J. Cellular interactions of CRKL, and SH2-SH3 adaptor protein. Cancer Res. 1994 May 15; 54(10):2563-7. PMID: 8168080.
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      109. Courtay C, Heisterkamp E, Siest G, Groffen J. Expression of multiple gamma-glutamyltransferase genes in man. Biochem J. 1994 Feb 1; 297 ( Pt 3):503-8. PMID: 7906515.
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      110. ten Hoeve J, Morris C, Poustka A, Groffen J, Heisterkamp E. Isolation of NotI sites from chromosome 22q11. Genomics. 1993 Dec; 18(3):588-97. PMID: 7905853.
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      111. Fioretos T, Heisterkamp E, Groffen J, Benjes S, Morris C. CRK proto-oncogene maps to human chromosome band 17p13. Oncogene. 1993 Oct; 8(10):2853-5. PMID: 8378094.
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      112. ten Hoeve J, Morris C, Heisterkamp E, Groffen J. Isolation and chromosomal localization of CRKL, a human crk-like gene. Oncogene. 1993 Sep; 8(9):2469-74. PMID: 8361759.
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      113. Heisterkamp E, Kaartinen V, van Soest S, Bokoch GM, Groffen J. Human ABR encodes a protein with GAPrac activity and homology to the DBL nucleotide exchange factor domain. J Biol Chem. 1993 Aug 15; 268(23):16903-6. PMID: 8349582.
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      114. Lu D, Liu J, Campbell M, Guo JQ, Heisterkamp E, Groffen J, Canaani E, Arlinghaus R. Tyrosine phosphorylation of P160 BCR by P210 BCR-ABL. Blood. 1993 Aug 15; 82(4):1257-63. PMID: 8353288.
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      115. Reynolds CH, Willson MG, Groffen J, Heisterkamp E, Peakman TC, Page MJ. Comparison of baculovirus-expressed c-Abl and BCR/ABL protein tyrosine kinases. Biochim Biophys Acta. 1993 Apr 30; 1181(2):122-30. PMID: 8481400.
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      116. Morris C, Courtay C, Geurts van Kessel A, ten Hoeve J, Heisterkamp E, Groffen J. Localization of a gamma-glutamyl-transferase-related gene family on chromosome 22. Hum Genet. 1993 Mar; 91(1):31-6. PMID: 8095916.
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      117. Groffen J, Voncken JW, Kaartinen V, Morris C, Heisterkamp E. Ph-positive leukemia: a transgenic mouse model. Leuk Lymphoma. 1993; 11 Suppl 1:19-24. PMID: 8251894.
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      118. Voncken JW, Griffiths S, Greaves MF, Pattengale PK, Heisterkamp E, Groffen J. Restricted oncogenicity of BCR/ABL p190 in transgenic mice. Cancer Res. 1992 Aug 15; 52(16):4534-9. PMID: 1643646.
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      119. Griffiths SD, Healy LE, Ford AM, Bennett CA, Voncken JW, Heisterkamp E, Groffen J, Greaves MF. Clonal characteristics of acute lymphoblastic cells derived from BCR/ABL p190 transgenic mice. Oncogene. 1992 Jul; 7(7):1391-9. PMID: 1377812.
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      120. Rajpert-De Meyts E, Shi M, Chang M, Robison TW, Groffen J, Heisterkamp E, Forman HJ. Transfection with gamma-glutamyl transpeptidase enhances recovery from glutathione depletion using extracellular glutathione. Toxicol Appl Pharmacol. 1992 May; 114(1):56-62. PMID: 1350117.
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      121. Mononen I, Heisterkamp E, Kaartinen V, Mononen T, Williams JC, Groffen J. Aspartylglycosaminuria in a non-Finnish patient caused by a donor splice mutation in the glycoasparaginase gene. J Biol Chem. 1992 Feb 15; 267(5):3196-9. PMID: 1737774.
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      122. Voncken JW, Morris C, Pattengale P, Dennert G, Kikly C, Groffen J, Heisterkamp E. Clonal development and karyotype evolution during leukemogenesis of BCR/ABL transgenic mice. Blood. 1992 Feb 15; 79(4):1029-36. PMID: 1737087.
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      123. Morris C, Heisterkamp E, Groffen J, Williams JC, Mononen I. Chromosomal localization of the human glycoasparaginase gene to 4q32-q33. Hum Genet. 1992 Jan; 88(3):295-7. PMID: 1733831.
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      124. Groffen J, Voncken JW, van Schaick H, Heisterkamp E. Animal models for chronic myeloid leukemia and acute lymphoblastic leukemia. Leukemia. 1992; 6 Suppl 1:44-6. PMID: 1548935.
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      125. Heisterkamp E, Jenster G, Kioussis D, Pattengale PK, Groffen J. Human bcr-abl gene has a lethal effect on embryogenesis. Transgenic Res. 1991 Dec; 1(1):45-53. PMID: 1726940.
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      126. Morris CM, Heisterkamp E, Groffen J, Fitzgerald PH. Entire ABL gene is joined with 5'-BCR in some patients with Philadelphia-positive leukemia. Blood. 1991 Aug 15; 78(4):1078-84. PMID: 1868241.
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      127. Heisterkamp E, Rajpert-De Meyts E, Uribe L, Forman HJ, Groffen J. Identification of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase. Proc Natl Acad Sci U S A. 1991 Jul 15; 88(14):6303-7. PMID: 1676842.
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      128. Morris C, Kennedy M, Heisterkamp E, Columbano-Green L, Romeril K, Groffen J, Fitzgerald P. A complex chromosome rearrangement forms the BCR-ABL fusion gene in leukemic cells with a normal karyotype. Genes Chromosomes Cancer. 1991 Jul; 3(4):263-71. PMID: 1958592.
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      129. Morris CM, Hao QL, Heisterkamp E, Fitzgerald PH, Groffen J. Localization of the TRK proto-oncogene to human chromosome bands 1q23-1q24. Oncogene. 1991 Jun; 6(6):1093-5. PMID: 1829807.
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      130. Mononen I, Heisterkamp E, Kaartinen V, Williams JC, Yates JR, Griffin PR, Hood LE, Groffen J. Aspartylglycosaminuria in the Finnish population: identification of two point mutations in the heavy chain of glycoasparaginase. Proc Natl Acad Sci U S A. 1991 Apr 1; 88(7):2941-5. PMID: 2011603.
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      131. Laneuville P, Heisterkamp E, Groffen J. Expression of the chronic myelogenous leukemia-associated p210bcr/abl oncoprotein in a murine IL-3 dependent myeloid cell line. Oncogene. 1991 Feb; 6(2):275-82. PMID: 1705688.
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      132. Hao QL, Ferris DK, White G, Heisterkamp E, Groffen J. Nuclear and cytoplasmic location of the FER tyrosine kinase. Mol Cell Biol. 1991 Feb; 11(2):1180-3. PMID: 1990274.
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      133. Heisterkamp E, Groffen J. Molecular insights into the Philadelphia translocation. Hematol Pathol. 1991; 5(1):1-10. PMID: 2050600.
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      134. Zhu QS, Heisterkamp E, Groffen J. Unique organization of the human BCR gene promoter. Nucleic Acids Res. 1990 Dec 11; 18(23):7119-25. PMID: 2263470.
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      135. Morris CM, Heisterkamp E, Kennedy MA, Fitzgerald PH, Groffen J. Ph-negative chronic myeloid leukemia: molecular analysis of ABL insertion into M-BCR on chromosome 22. Blood. 1990 Nov 1; 76(9):1812-8. PMID: 2171702.
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      136. DiSilvestre D, Morris C, Heisterkamp E, Groffen J. A second hypervariable RFLP within the ABR gene. Nucleic Acids Res. 1990 Oct 11; 18(19):5925. PMID: 1977148.
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      137. DiSilvestre D, Morris C, Heisterkamp E, Groffen J. A hypervariable RFLP within the ABR gene. Nucleic Acids Res. 1990 Oct 11; 18(19):5924. PMID: 1977147.
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      138. Justice MJ, Siracusa LD, Gilbert DJ, Heisterkamp E, Groffen J, Chada K, Silan CM, Copeland NG, Jenkins NA. A genetic linkage map of mouse chromosome 10: localization of eighteen molecular markers using a single interspecific backcross. Genetics. 1990 Aug; 125(4):855-66. PMID: 1975791.
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      139. Zhu QS, Heisterkamp E, Groffen J. Characterization of the human ABL promoter regions. Oncogene. 1990 Jun; 5(6):885-91. PMID: 2163052.
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      140. Heisterkamp E, Morris C, Sender L, Knoppel E, Uribe L, Cui MY, Groffen J. Rearrangement of the human ABL oncogene in a glioblastoma. Cancer Res. 1990 Jun 1; 50(11):3429-34. PMID: 2334939.
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      141. Heisterkamp E, Jenster G, ten Hoeve J, Zovich D, Pattengale PK, Groffen J. Acute leukaemia in bcr/abl transgenic mice. Nature. 1990 Mar 15; 344(6263):251-3. PMID: 2179728.
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      142. Morris C, Heisterkamp E, Hao QL, Testa JR, Groffen J. The human tyrosine kinase gene (FER) maps to chromosome 5 and is deleted in myeloid leukemias with a del(5q). Cytogenet Cell Genet. 1990; 53(4):196-200. PMID: 2209086.
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      143. Pawson T, Letwin K, Lee T, Hao QL, Heisterkamp E, Groffen J. The FER gene is evolutionarily conserved and encodes a widely expressed member of the FPS/FES protein-tyrosine kinase family. Mol Cell Biol. 1989 Dec; 9(12):5722-5. PMID: 2685575.
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      144. Heisterkamp E, Morris C, Groffen J. ABR, an active BCR-related gene. Nucleic Acids Res. 1989 Nov 11; 17(21):8821-31. PMID: 2587217.
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      145. Hao QL, Heisterkamp E, Groffen J. Isolation and sequence analysis of a novel human tyrosine kinase gene. Mol Cell Biol. 1989 Apr; 9(4):1587-93. PMID: 2725517.
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      146. Heisterkamp E, Jenkins R, Thibodeau S, Testa JR, Weinberg K, Groffen J. The bcr gene in Philadelphia chromosome positive acute lymphoblastic leukemia. Blood. 1989 Apr; 73(5):1307-11. PMID: 2930839.
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      147. van der Feltz MJ, Shivji MK, Allen PB, Heisterkamp E, Groffen J, Wiedemann LM. Nucleotide sequence of both reciprocal translocation junction regions in a patient with Ph positive acute lymphoblastic leukaemia, with a breakpoint within the first intron of the BCR gene. Nucleic Acids Res. 1989 Jan 11; 17(1):1-10. PMID: 2911461.
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      148. Groffen J, Hermans A, Grosveld G, Heisterkamp E. Molecular analysis of chromosome breakpoints. Prog Nucleic Acid Res Mol Biol. 1989; 36:281-300. PMID: 2660191.
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      149. Groffen J, Heisterkamp E. Philadelphia chromosome translocation. Crit Rev Oncog. 1989; 1(1):53-64. PMID: 2488124.
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      150. Rajpert-De Meyts E, Heisterkamp E, Groffen J. Cloning and nucleotide sequence of human gamma-glutamyl transpeptidase. Proc Natl Acad Sci U S A. 1988 Dec; 85(23):8840-4. PMID: 2904146.
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      151. Heisterkamp E, Knoppel E, Groffen J. The first BCR gene intron contains breakpoints in Philadelphia chromosome positive leukemia. Nucleic Acids Res. 1988 Nov 11; 16(21):10069-81. PMID: 3194194.
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      152. Heisterkamp E, Groffen J. Duplication of the bcr and gamma-glutamyl transpeptidase genes. Nucleic Acids Res. 1988 Aug 25; 16(16):8045-56. PMID: 2901712.
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      153. Groffen J, Heisterkamp E. The BCR/ABL hybrid gene. Baillieres Clin Haematol. 1987 Dec; 1(4):983-99. PMID: 3332859.
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      154. de Klein A, Bartram CR, Hagemeijer A, Heisterkamp E, Stam K, Groffen J, Grosveld G. The c-abl oncogene in chronic myelogenous leukemia. Haematologica. 1987 Nov-Dec; 72(6 Suppl):19-22. PMID: 3127291.
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      155. Hermans A, Heisterkamp E, von Linden M, van Baal S, Meijer D, van der Plas D, Wiedemann LM, Groffen J, Bootsma D, Grosveld G. Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia. Cell. 1987 Oct 9; 51(1):33-40. PMID: 2820585.
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      156. Stam K, Heisterkamp E, Reynolds FH, Groffen J. Evidence that the phl gene encodes a 160,000-dalton phosphoprotein with associated kinase activity. Mol Cell Biol. 1987 May; 7(5):1955-60. PMID: 3299055.
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      157. Chan LC, Karhi KK, Rayter SI, Heisterkamp E, Eridani S, Powles R, Lawler SD, Groffen J, Foulkes JG, Greaves MF, Wiedemann LM. A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia. Nature. 1987 Feb 12-18; 325(6105):635-7. PMID: 3027581.
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      158. Bartram CR, Böhlke JV, Adolph S, Hameister H, Ganser A, Anger B, Heisterkamp E, Groffen J. Deletion of c-fms sequences in the 5q- syndrome. Leukemia. 1987 Feb; 1(2):146-9. PMID: 3312836.
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      159. Grosveld G, Hermans A, De Klein A, Bootsma D, Heisterkamp E, Groffen J. The role of the Philadelphia translocation in chronic myelocytic leukemia. Ann N Y Acad Sci. 1987; 511:262-9. PMID: 3125778.
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      160. De Klein A, Hagemeijer A, Bartram CR, Houwen R, Hoefsloot L, Carbonell F, Chan L, Barnett M, Greaves M, Kleihauer E. bcr rearrangement and translocation of the c-abl oncogene in Philadelphia positive acute lymphoblastic leukemia. Blood. 1986 Dec; 68(6):1369-75. PMID: 3465378.
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      161. de Klein A, van Agthoven T, Groffen C, Heisterkamp E, Groffen J, Grosveld G. Molecular analysis of both translocation products of a Philadelphia-positive CML patient. Nucleic Acids Res. 1986 Sep 11; 14(17):7071-82. PMID: 3463934.
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      162. Grosveld G, Verwoerd T, van Agthoven T, de Klein A, Ramachandran KL, Heisterkamp E, Stam K, Groffen J. The chronic myelocytic cell line K562 contains a breakpoint in bcr and produces a chimeric bcr/c-abl transcript. Mol Cell Biol. 1986 Feb; 6(2):607-16. PMID: 3023859.
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      163. Stam K, Heisterkamp E, Grosveld G, de Klein A, Verma RS, Coleman M, Dosik H, Groffen J. Evidence of a new chimeric bcr/c-abl mRNA in patients with chronic myelocytic leukemia and the Philadelphia chromosome. N Engl J Med. 1985 Dec 5; 313(23):1429-33. PMID: 3864009.
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      164. Heisterkamp E, Stam K, Groffen J, de Klein A, Grosveld G. Structural organization of the bcr gene and its role in the Ph' translocation. Nature. 1985 Jun 27-Jul 3; 315(6022):758-61. PMID: 2989703.
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      165. Bartram CR, Kleihauer E, de Klein A, Grosveld G, Teyssier JR, Heisterkamp E, Groffen J. C-abl and bcr are rearranged in a Ph1-negative CML patient. EMBO J. 1985 Mar; 4(3):683-6. PMID: 3859408.
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      166. Groffen J, Stephenson JR, Heisterkamp E, Bartram C, de Klein A, Grosveld G. The human c-abl oncogene in the Philadelphia translocation. J Cell Physiol Suppl. 1984; 3:179-91. PMID: 6589229.
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      167. Groffen J, Stephenson JR, Heisterkamp E, de Klein A, Bartram CR, Grosveld G. Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell. 1984 Jan; 36(1):93-9. PMID: 6319012.
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      168. Bartram CR, de Klein A, Hagemeijer A, Grosveld G, Heisterkamp E, Groffen J. Localization of the human c-sis oncogene in Ph1-positive and Ph1-negative chronic myelocytic leukemia by in situ hybridization. Blood. 1984 Jan; 63(1):223-5. PMID: 6336312.
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      169. Heisterkamp E, Stephenson JR, Groffen J, Hansen PF, de Klein A, Bartram CR, Grosveld G. Localization of the c-ab1 oncogene adjacent to a translocation break point in chronic myelocytic leukaemia. Nature. 1983 Nov 17-23; 306(5940):239-42. PMID: 6316147.
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      170. Bartram CR, de Klein A, Hagemeijer A, van Agthoven T, Geurts van Kessel A, Bootsma D, Grosveld G, Ferguson-Smith MA, Davies T, Stone M. Translocation of c-ab1 oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia. Nature. 1983 Nov 17-23; 306(5940):277-80. PMID: 6580527.
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      171. Groffen J, Heisterkamp E, Spurr N, Dana S, Wasmuth JJ, Stephenson JR. Chromosomal localization of the human c-fms oncogene. Nucleic Acids Res. 1983 Sep 24; 11(18):6331-9. PMID: 6684766.
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      172. Sheer D, Hiorns LR, Stanley KF, Goodfellow PN, Swallow DM, Povey S, Heisterkamp E, Groffen J, Stephenson JR, Solomon E. Genetic analysis of the 15;17 chromosome translocation associated with acute promyelocytic leukemia. Proc Natl Acad Sci U S A. 1983 Aug; 80(16):5007-11. PMID: 6576373.
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      173. Groffen J, Heisterkamp E, Stephenson JR, van Kessel AG, de Klein A, Grosveld G, Bootsma D. c-sis is translocated from chromosome 22 to chromosome 9 in chronic myelocytic leukemia. J Exp Med. 1983 Jul 1; 158(1):9-15. PMID: 6306134.
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      174. Groffen J, Heisterkamp E, Reynolds FH, Stephenson JR. Homology between phosphotyrosine acceptor site of human c-abl and viral oncogene products. Nature. 1983 Jul 14-20; 304(5922):167-9. PMID: 6191223.
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      175. Heisterkamp E, Groffen J, Stephenson JR. Isolation of v-fms and its human cellular homolog. Virology. 1983 Apr 15; 126(1):248-58. PMID: 6302985.
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      176. Groffen J, Heisterkamp E, Blennerhassett G, Stephenson JR. Regulation of viral and cellular oncogene expression by cytosine methylation. Virology. 1983 Apr 15; 126(1):213-27. PMID: 6302983.
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      177. Groffen J, Heisterkamp E, Shibuya M, Hanafusa H, Stephenson JR. Transforming genes of avian (v-fps) and mammalian (v-fes) retroviruses correspond to a common cellular locus. Virology. 1983 Mar; 125(2):480-6. PMID: 6301150.
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      178. Heisterkamp E, Groffen J, Stephenson JR. The human v-abl cellular homologue. J Mol Appl Genet. 1983; 2(1):57-68. PMID: 6302194.
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      179. de Klein A, van Kessel AG, Grosveld G, Bartram CR, Hagemeijer A, Bootsma D, Spurr NK, Heisterkamp E, Groffen J, Stephenson JR. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. Nature. 1982 Dec 23; 300(5894):765-7. PMID: 6960256.
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      180. Heisterkamp E, Groffen J, Stephenson JR, Spurr NK, Goodfellow PN, Solomon E, Carritt B, Bodmer WF. Chromosomal localization of human cellular homologues of two viral oncogenes. Nature. 1982 Oct 21; 299(5885):747-9. PMID: 7121606.
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      181. Groffen J, Heisterkamp E, Grosveld F, Van de Ven W, Stephenson JR. Isolation of human oncogene sequences (v-fes homolog) from a cosmid library. Science. 1982 Jun 4; 216(4550):1136-8. PMID: 6281890.
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