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    Edward David Crandall, PhD, MD

    TitleChair and Professor of Medicine
    SchoolKeck School of Medicine of USC
    DepartmentMedicine
    AddressIRD 620
    Off Campus
    Los Angeles California 90089-9520
    Phone+1 323 226 7593
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      Other Positions
      TitleKenneth T. Norris, Jr., Chair in Medicine

      TitleHastings Foundation Professorship in Medicine


      Collapse Overview 
      Collapse Overview
      Dr. Crandall's research is focused on the following topics: markers of alveolar epithelial cell development and differentiation, regulation of pulmonary epithelial cell differentiation, acute and chronic lung injury and the factors that influence recovery, transport properties of pulmonary alveolar epithelium, cell pathophysiology of alveolar epithelium (e.g., lung injury and pathogenesis of alveolar pulmonary edema, and stem cell biology in lung injury.

      Dr. Crandall received his B.Ch.E. from Cooper Union, his M.S. and Ph.D. in chemical engineering from Northwestern University, and his M.D. from the University of Pennsylvania. His training in internal medicine and pulmonary/critical care medicine was undertaken at the Hospital of the University of Pennsylvania.


      Collapse Biography 
      Collapse Awards and Honors
      2005  - PresBest Doctors of America
      National Institutes of Health1987  - 1997MERIT Award
      National Institutes of Health1975  - 1980Research Career Development Award
      University of PennsylvaniaChair of Department of Medicine Scholarship
      U.S. Public Health ServiceSpecial Fellowship
      Royal E. Cabell Fellowship
      National Science FoundationGraduate Fellowship
      Union Carbide Fellowship
      Walter P. Murphy Fellowship
      New York StateRegents Scholarship

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Lax S, Rayes J, Wichaiyo S, Haining EJ, Lowe K, Grygielska B, Laloo R, Flodby P, Borok Z, Crandall E, Thickett D, Watson SP. Platelet CLEC-2 protects against lung injury via effects of its ligand podoplanin on inflammatory alveolar macrophages in the mouse. Am J Physiol Lung Cell Mol Physiol. 2017 Aug 24; ajplung.00023.2017. PMID: 28839100.
        View in: PubMed
      2. Gukasyan HJ, Uchiyama T, Kim KJ, Ehrhardt C, Wu SK, Borok Z, Crandall E, Lee VHL. Oligopeptide Transport in Rat Lung Alveolar Epithelial Cells is Mediated by Pept2. Pharm Res. 2017 Aug 22. PMID: 28831683.
        View in: PubMed
      3. Horng S, Therattil A, Moyon S, Gordon A, Kim K, Argaw AT, Hara Y, Mariani JN, Sawai S, Flodby P, Crandall E, Borok Z, Sofroniew MV, Chapouly C, John GR. Astrocytic tight junctions control inflammatory CNS lesion pathogenesis. J Clin Invest. 2017 Aug 01; 127(8):3136-3151. PMID: 28737509.
        View in: PubMed
      4. Flodby P, Li C, Liu Y, Wang H, Rieger ME, Minoo P, Crandall E, Ann DK, Borok Z, Zhou B. Cell-specific expression of aquaporin-5 (Aqp5) in alveolar epithelium is directed by GATA6/Sp1 via histone acetylation. Sci Rep. 2017 Jun 14; 7(1):3473. PMID: 28615712.
        View in: PubMed
      5. Marconett CN, Zhou B, Sunohara M, Pouldar TM, Wang H, Liu Y, Rieger ME, Tran E, Flodby P, Siegmund KD, Crandall E, Laird-Offringa IA, Borok Z. Cross-Species Transcriptome Profiling Identifies New Alveolar Epithelial Type I Cell-Specific Genes. Am J Respir Cell Mol Biol. 2017 Mar; 56(3):310-321. PMID: 27749084.
        View in: PubMed
      6. Flodby P, Liebler JM, Sunohara M, Castillo DR, McConnell AM, Krishnaveni MS, Banfalvi A, Li M, Stripp B, Zhou B, Crandall E, Minoo P, Borok Z. Region-specific role for Pten in maintenance of epithelial phenotype and integrity. Am J Physiol Lung Cell Mol Physiol. 2017 Jan 01; 312(1):L131-L142. PMID: 27864284.
        View in: PubMed
      7. Agoro R, Piotet-Morin J, Palomo J, Michaudel C, Vigne S, Maillet I, Chenuet P, Guillou N, Le Bérichel J, Kisielow M, Flodby P, Borok Z, Crandall E, Le Bert M, Quesniaux V, Muller M, Di Padova F, Ryffel B, Gabay C, Couturier-Maillard A. IL-1R1-MyD88 axis elicits papain-induced lung inflammation. Eur J Immunol. 2016 Nov; 46(11):2531-2541. PMID: 27569535.
        View in: PubMed
      8. Flodby P, Kim YH, Beard LL, Gao D, Ji Y, Kage H, Liebler JM, Minoo P, Kim KJ, Borok Z, Crandall E. Knockout Mice Reveal a Major Role for Alveolar Epithelial Type I Cells in Alveolar Fluid Clearance. Am J Respir Cell Mol Biol. 2016 Sep; 55(3):395-406. PMID: 27064541; PMCID: PMC5023030 [Available on 09/01/17].
      9. Rieger ME, Zhou B, Solomon N, Sunohara M, Li C, Nguyen C, Liu Y, Pan JH, Minoo P, Crandall E, Brody SL, Kahn M, Borok Z. p300/ß-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC). J Biol Chem. 2016 Mar 18; 291(12):6569-82. PMID: 26833564; PMCID: PMC4813575 [Available on 03/18/17].
      10. Catalán MA, Kondo Y, Peña-Munzenmayer G, Jaramillo Y, Liu F, Choi S, Crandall E, Borok Z, Flodby P, Shull GE, Melvin JE. A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2263-8. PMID: 25646474; PMCID: PMC4343136.
      11. Kage H, Flodby P, Gao D, Kim YH, Marconett CN, DeMaio L, Kim KJ, Crandall E, Borok Z. Claudin 4 knockout mice: normal physiological phenotype with increased susceptibility to lung injury. Am J Physiol Lung Cell Mol Physiol. 2014 Oct 01; 307(7):L524-36. PMID: 25106430; PMCID: PMC4187039.
      12. Li G, Flodby P, Luo J, Kage H, Sipos A, Gao D, Ji Y, Beard LL, Marconett CN, DeMaio L, Kim YH, Kim KJ, Laird-Offringa IA, Minoo P, Liebler JM, Zhou B, Crandall E, Borok Z. Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis. Am J Respir Cell Mol Biol. 2014 Aug; 51(2):210-22. PMID: 24588076; PMCID: PMC4148039.
      13. Liu CC, Tseng YT, Li W, Wu CY, Mayzus I, Rzhetsky A, Sun F, Waterman M, Chen JJ, Chaudhary PM, Loscalzo J, Crandall E, Zhou XJ. DiseaseConnect: a comprehensive web server for mechanism-based disease-disease connections. Nucleic Acids Res. 2014 Jul; 42(Web Server issue):W137-46. PMID: 24895436; PMCID: PMC4086092.
      14. Negoda A, Kim KJ, Crandall E, Worden RM. Polystyrene nanoparticle exposure induces ion-selective pores in lipid bilayers. Biochim Biophys Acta. 2013 Sep; 1828(9):2215-22. PMID: 23747366; PMCID: PMC4659421.
      15. Xia T, Hamilton RF, Bonner JC, Crandall E, Elder A, Fazlollahi F, Girtsman TA, Kim K, Mitra S, Ntim SA, Orr G, Tagmount M, Taylor AJ, Telesca D, Tolic A, Vulpe CD, Walker AJ, Wang X, Witzmann FA, Wu N, Xie Y, Zink JI, Nel A, Holian A. Interlaboratory evaluation of in vitro cytotoxicity and inflammatory responses to engineered nanomaterials: the NIEHS Nano GO Consortium. Environ Health Perspect. 2013 Jun; 121(6):683-90. PMID: 23649538; PMCID: PMC3672931.
      16. Fazlollahi F, Kim YH, Sipos A, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall E. Nanoparticle translocation across mouse alveolar epithelial cell monolayers: species-specific mechanisms. Nanomedicine. 2013 Aug; 9(6):786-94. PMID: 23454523; PMCID: PMC3702651.
      17. Zhou B, Buckley ST, Patel V, Liu Y, Luo J, Krishnaveni MS, Ivan M, DeMaio L, Kim KJ, Ehrhardt C, Crandall E, Borok Z. Troglitazone attenuates TGF-ß1-induced EMT in alveolar epithelial cells via a PPAR?-independent mechanism. PLoS One. 2012; 7(6):e38827. PMID: 22745681; PMCID: PMC3380041.
      18. Zhou B, Liu Y, Kahn M, Ann DK, Han A, Wang H, Nguyen C, Flodby P, Zhong Q, Krishnaveni MS, Liebler JM, Minoo P, Crandall E, Borok Z. Interactions between ß-catenin and transforming growth factor-ß signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP). J Biol Chem. 2012 Mar 02; 287(10):7026-38. PMID: 22241478; PMCID: PMC3293544.
      19. DeMaio L, Buckley ST, Krishnaveni MS, Flodby P, Dubourd M, Banfalvi A, Xing Y, Ehrhardt C, Minoo P, Zhou B, Crandall E, Borok Z. Ligand-independent transforming growth factor-ß type I receptor signalling mediates type I collagen-induced epithelial-mesenchymal transition. J Pathol. 2012 Mar; 226(4):633-44. PMID: 21984393; PMCID: PMC4012689.
      20. Fazlollahi F, Sipos A, Kim YH, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall E. Translocation of PEGylated quantum dots across rat alveolar epithelial cell monolayers. Int J Nanomedicine. 2011; 6:2849-57. PMID: 22131830; PMCID: PMC3224711.
      21. Yacobi NR, Fazllolahi F, Kim YH, Sipos A, Borok Z, Kim KJ, Crandall E. Nanomaterial interactions with and trafficking across the lung alveolar epithelial barrier: implications for health effects of air-pollution particles. Air Qual Atmos Health. 2011 Mar 01; 4(1):65-78. PMID: 25568662.
        View in: PubMed
      22. Fazlollahi F, Angelow S, Yacobi NR, Marchelletta R, Yu AS, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall E. Polystyrene nanoparticle trafficking across MDCK-II. Nanomedicine. 2011 Oct; 7(5):588-94. PMID: 21310266; PMCID: PMC3130091.
      23. Zhong Q, Zhou B, Ann DK, Minoo P, Liu Y, Banfalvi A, Krishnaveni MS, Dubourd M, Demaio L, Willis BC, Kim KJ, duBois RM, Crandall E, Beers MF, Borok Z. Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: effects of misfolded surfactant protein. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):498-509. PMID: 21169555; PMCID: PMC3175581.
      24. Kim YH, Fazlollahi F, Kennedy IM, Yacobi NR, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall E. Alveolar epithelial cell injury due to zinc oxide nanoparticle exposure. Am J Respir Crit Care Med. 2010 Dec 01; 182(11):1398-409. PMID: 20639441; PMCID: PMC3029930.
      25. Borok Z, Crandall E. More life for a "terminal" cell. Am J Physiol Lung Cell Mol Physiol. 2009 Dec; 297(6):L1042-4. PMID: 19837848; PMCID: PMC2793181.
      26. Flodby P, Borok Z, Banfalvi A, Zhou B, Gao D, Minoo P, Ann DK, Morrisey EE, Crandall E. Directed expression of Cre in alveolar epithelial type 1 cells. Am J Respir Cell Mol Biol. 2010 Aug; 43(2):173-8. PMID: 19767448; PMCID: PMC2937230.
      27. Yacobi NR, Malmstadt N, Fazlollahi F, DeMaio L, Marchelletta R, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall E. Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles. Am J Respir Cell Mol Biol. 2010 May; 42(5):604-14. PMID: 19574531; PMCID: PMC2874446.
      28. Demaio L, Tseng W, Balverde Z, Alvarez JR, Kim KJ, Kelley DG, Senior RM, Crandall E, Borok Z. Characterization of mouse alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L1051-8. PMID: 19329539; PMCID: PMC2692796.
      29. Patel LN, Wang J, Kim KJ, Borok Z, Crandall E, Shen WC. Conjugation with cationic cell-penetrating peptide increases pulmonary absorption of insulin. Mol Pharm. 2009 Mar-Apr; 6(2):492-503. PMID: 19228019; PMCID: PMC2798810.
      30. Zhou B, Francis TA, Yang H, Tseng W, Zhong Q, Frenkel B, Morrisey EE, Ann DK, Minoo P, Crandall E, Borok Z. GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1. Am J Physiol Cell Physiol. 2008 Nov; 295(5):C1141-50. PMID: 18768929; PMCID: PMC2584994.
      31. Patel LN, Uchiyama T, Kim KJ, Borok Z, Crandall E, Shen WC, Lee VH. Molecular and functional expression of multidrug resistance-associated protein-1 in primary cultured rat alveolar epithelial cells. J Pharm Sci. 2008 Jun; 97(6):2340-9. PMID: 17854063.
        View in: PubMed
      32. Liebler JM, Lutzko C, Banfalvi A, Senadheera D, Aghamohammadi N, Crandall E, Borok Z. Retention of human bone marrow-derived cells in murine lungs following bleomycin-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2008 Aug; 295(2):L285-92. PMID: 18515407; PMCID: PMC2519849.
      33. Zhou B, Ann DK, Flodby P, Minoo P, Liebler JM, Crandall E, Borok Z. Rat aquaporin-5 4.3-kb 5'-flanking region differentially regulates expression in salivary gland and lung in vivo. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C111-20. PMID: 18448628; PMCID: PMC2493550.
      34. Yacobi NR, Demaio L, Xie J, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall E. Polystyrene nanoparticle trafficking across alveolar epithelium. Nanomedicine. 2008 Jun; 4(2):139-45. PMID: 18375191.
        View in: PubMed
      35. Uchiyama T, Fujita T, Gukasyan HJ, Kim KJ, Borok Z, Crandall E, Lee VH. Functional characterization and cloning of amino acid transporter B(0,+) (ATB(0,+)) in primary cultured rat pneumocytes. J Cell Physiol. 2008 Mar; 214(3):645-54. PMID: 17960566.
        View in: PubMed
      36. Bahhady R, Kim KJ, Borok Z, Crandall E, Shen WC. Characterization of protein factor(s) in rat bronchoalveolar lavage fluid that enhance insulin transport via transcytosis across primary rat alveolar epithelial cell monolayers. Eur J Pharm Biopharm. 2008 Aug; 69(3):808-16. PMID: 18406118; PMCID: PMC3638983.
      37. Zhou B, Zhong Q, Minoo P, Li C, Ann DK, Frenkel B, Morrisey EE, Crandall E, Borok Z. Foxp2 inhibits Nkx2.1-mediated transcription of SP-C via interactions with the Nkx2.1 homeodomain. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):750-8. PMID: 18239190; PMCID: PMC2396252.
      38. Bates SR, Tao JQ, Yu KJ, Borok Z, Crandall E, Collins HL, Rothblat GH. Expression and biological activity of ABCA1 in alveolar epithelial cells. Am J Respir Cell Mol Biol. 2008 Mar; 38(3):283-92. PMID: 17884990; PMCID: PMC2258448.
      39. Qiao R, Yan W, Clavijo C, Mehrian-Shai R, Zhong Q, Kim KJ, Ann D, Crandall E, Borok Z. Effects of KGF on alveolar epithelial cell transdifferentiation are mediated by JNK signaling. Am J Respir Cell Mol Biol. 2008 Feb; 38(2):239-46. PMID: 17872496; PMCID: PMC2214671.
      40. Yacobi NR, Phuleria HC, Demaio L, Liang CH, Peng CA, Sioutas C, Borok Z, Kim KJ, Crandall E. Nanoparticle effects on rat alveolar epithelial cell monolayer barrier properties. Toxicol In Vitro. 2007 Dec; 21(8):1373-81. PMID: 17555923; PMCID: PMC3855017.
      41. Bahhady R, Kim KJ, Borok Z, Crandall E, Shen WC. Enhancement of insulin transport across primary rat alveolar epithelial cell monolayers by endogenous cellular factor(s). Pharm Res. 2007 Sep; 24(9):1713-9. PMID: 17443400.
        View in: PubMed
      42. Flodby P, Zhou B, Ann DK, Kim KJ, Minoo P, Crandall E, Borok Z. Conserved elements within first intron of aquaporin-5 (Aqp5) function as transcriptional enhancers. Biochem Biophys Res Commun. 2007 Apr 27; 356(1):26-31. PMID: 17339032; PMCID: PMC2366028.
      43. Zhou B, Ann DK, Li X, Kim KJ, Lin H, Minoo P, Crandall E, Borok Z. Hypertonic induction of aquaporin-5: novel role of hypoxia-inducible factor-1alpha. Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1280-90. PMID: 17108010.
        View in: PubMed
      44. Nguyen HV, Chen JL, Zhong J, Kim KJ, Crandall E, Borok Z, Chen Y, Ann DK. SUMOylation attenuates sensitivity toward hypoxia- or desferroxamine-induced injury by modulating adaptive responses in salivary epithelial cells. Am J Pathol. 2006 May; 168(5):1452-63. PMID: 16651613; PMCID: PMC1606580.
      45. Willis BC, Liebler JM, Luby-Phelps K, Nicholson AG, Crandall E, du Bois RM, Borok Z. Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis. Am J Pathol. 2005 May; 166(5):1321-32. PMID: 15855634; PMCID: PMC1606388.
      46. Bourke S, Mason HS, Borok Z, Kim KJ, Crandall E, Kemp PJ. Development of a lung slice preparation for recording ion channel activity in alveolar epithelial type I cells. Respir Res. 2005 Apr 27; 6:40. PMID: 15857506; PMCID: PMC1131928.
      47. Chen SP, Zhou B, Willis BC, Sandoval AJ, Liebler JM, Kim KJ, Ann DK, Crandall E, Borok Z. Effects of transdifferentiation and EGF on claudin isoform expression in alveolar epithelial cells. J Appl Physiol (1985). 2005 Jan; 98(1):322-8. PMID: 15361518.
        View in: PubMed
      48. Kim KJ, Borok Z, Ehrhardt C, Willis BC, Lehr CM, Crandall E. Estimation of paracellular conductance of primary rat alveolar epithelial cell monolayers. J Appl Physiol (1985). 2005 Jan; 98(1):138-43. PMID: 15273240.
        View in: PubMed
      49. Liebler JM, Borok Z, Li X, Zhou B, Sandoval AJ, Kim KJ, Crandall E. Alveolar epithelial type I cells express beta2-adrenergic receptors and G-protein receptor kinase 2. J Histochem Cytochem. 2004 Jun; 52(6):759-67. PMID: 15150284.
        View in: PubMed
      50. Kim KJ, Fandy TE, Lee VH, Ann DK, Borok Z, Crandall E. Net absorption of IgG via FcRn-mediated transcytosis across rat alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol. 2004 Sep; 287(3):L616-22. PMID: 15169676.
        View in: PubMed
      51. Qiao R, Zhou B, Harboe-Schmidt E, Kasahara N, Kim KJ, Liebler JM, Crandall E, Borok Z. Subunit-specific coordinate upregulation of sodium pump activity in alveolar epithelial cells by lentivirus-mediated gene transfer. Hum Gene Ther. 2004 May; 15(5):457-68. PMID: 15144576.
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      52. Kelley MA, Angus D, Chalfin DB, Crandall E, Ingbar D, Johanson W, Medina J, Sessler CN, Vender JS. The critical care crisis in the United States: a report from the profession. Chest. 2004 Apr; 125(4):1514-7. PMID: 15078767.
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      53. Widera A, Kim KJ, Crandall E, Shen WC. Transcytosis of GCSF-transferrin across rat alveolar epithelial cell monolayers. Pharm Res. 2003 Aug; 20(8):1231-8. PMID: 12948021.
        View in: PubMed
      54. Willis BC, Kim KJ, Li X, Liebler J, Crandall E, Borok Z. Modulation of ion conductance and active transport by TGF-beta 1 in alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol. 2003 Dec; 285(6):L1192-200. PMID: 12730080.
        View in: PubMed
      55. Qiao R, Zhou B, Liebler JM, Li X, Crandall E, Borok Z. Identification of three genes of known function expressed by alveolar epithelial type I cells. Am J Respir Cell Mol Biol. 2003 Jul; 29(1):98-105. PMID: 12600825.
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      56. Kim KJ, Matsukawa Y, Yamahara H, Kalra VK, Lee VH, Crandall E. Absorption of intact albumin across rat alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol. 2003 Mar; 284(3):L458-65. PMID: 12573985.
        View in: PubMed
      57. Crandall E, Effros RM. Historical perspectives on lung edema clearance. J Appl Physiol (1985). 2002 Oct; 93(4):1527-32. PMID: 12235055.
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      58. Borok Z, Liebler JM, Lubman RL, Foster MJ, Zhou B, Li X, Zabski SM, Kim KJ, Crandall E. Na transport proteins are expressed by rat alveolar epithelial type I cells. Am J Physiol Lung Cell Mol Physiol. 2002 Apr; 282(4):L599-608. PMID: 11880284.
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      59. Mairbäurl H, Mayer K, Kim KJ, Borok Z, Bärtsch P, Crandall E. Hypoxia decreases active Na transport across primary rat alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol. 2002 Apr; 282(4):L659-65. PMID: 11880290.
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      60. Joseph D, Tirmizi O, Zhang XL, Crandall E, Lubman RL. Polarity of alveolar epithelial cell acid-base permeability. Am J Physiol Lung Cell Mol Physiol. 2002 Apr; 282(4):L675-83. PMID: 11880292.
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