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    Denis Evseenko, MD, PhD

    TitleAssociate Professor of Orthopaedic Surgery
    SchoolKeck School of Medicine of USC
    DepartmentOrthopaedic Surgery
    Address1450 Biggy Street
    Health Sciences Campus
    Los Angeles California 90033
    Phone+1 323 442 2422
    vCardDownload vCard

      Collapse Overview 
      Collapse Overview
      Dr. Denis Evseenko is currently an Associate Professor of Orthopaedic Surgery, Stem Cell Research and Regenerative Medicine at USC. Dr Evseenko was trained in both medicine and molecular pharmacology. His research focuses on the development of novel translational stem cell and small molecule-based approaches for prevention of arthritis and restoration of damaged articular cartilage. Dr Evseenko has been involved in translational research for over 10 years and is the author of numerous peer-reviewed research articles, presentations and patents.

      Evseenko Lab Website


      Collapse Biography 
      Collapse Awards and Honors
      Arthritis National Research Foundation2015James Klinenberg Award
      USC2016USC Stevens Technology Advancement Grant
      Wright Foundation2016Wright Foundation Award

      Collapse ORNG Applications 
      Collapse Featured Publications
      Collapse In The News

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Dickinson SC, Sutton CA, Brady K, Salerno A, Katopodi T, Williams RL, West CC, Evseenko D, Wu L, Pang S, Ferro de Godoy R, Goodship AE, Péault B, Blom AW, Kafienah W, Hollander AP. The Wnt5a Receptor, Receptor Tyrosine Kinase-Like Orphan Receptor 2, Is a Predictive Cell Surface Marker of Human Mesenchymal Stem Cells with an Enhanced Capacity for Chondrogenic Differentiation. Stem Cells. 2017 Aug 20. PMID: 28833807.
        View in: PubMed
      2. Flores A, Schell J, Krall AS, Jelinek D, Miranda M, Grigorian M, Braas D, White AC, Zhou JL, Graham NA, Graeber T, Seth P, Evseenko D, Coller HA, Rutter J, Christofk HR, Lowry WE. Lactate dehydrogenase activity drives hair follicle stem cell activation. Nat Cell Biol. 2017 Sep; 19(9):1017-1026. PMID: 28812580.
        View in: PubMed
      3. Franciozi CEDS, Vangsness CT, Tibone JE, Martinez JC, Rodger D, Chou TC, Tai YC, Brant R, Wu L, Abdalla RJ, Han B, Evseenko D, Humayun M. Parylene scaffold for cartilage lesion. Biomed Microdevices. 2017 Jun; 19(2):26. PMID: 28391436.
        View in: PubMed
      4. Eliasberg CD, Dar A, Jensen AR, Murray IR, Hardy WR, Kowalski TJ, Garagozlo CA, Natsuhara KM, Khan AZ, McBride OJ, Cha PI, Kelley BV, Evseenko D, Feeley BT, McAllister DR, Péault B, Petrigliano FA. Perivascular Stem Cells Diminish Muscle Atrophy Following Massive Rotator Cuff Tears in a Small Animal Model. J Bone Joint Surg Am. 2017 Feb 15; 99(4):331-341. PMID: 28196035.
        View in: PubMed
      5. Wu L, Zhang S, Shkhyan R, Lee S, Gullo F, Eliasberg CD, Petrigliano FA, Ba K, Wang J, Lin Y, Evseenko D. Kappa opioid receptor signaling protects cartilage tissue against posttraumatic degeneration. JCI Insight. 2017 Jan 12; 2(1):e88553. PMID: 28097228.
        View in: PubMed
      6. Markolf KL, Evseenko D, Petrigliano F. Right-Left Differences in Knee Extension Stiffness for the Normal Rat Knee: In Vitro Measurements Using a New Testing Apparatus. J Biomech Eng. 2016 Apr; 138(4):044501. PMID: 26863930.
        View in: PubMed
      7. Chin CJ, Cooper AR, Lill GR, Evseenko D, Zhu Y, He CB, Casero D, Pellegrini M, Kohn DB, Crooks GM. Genetic Tagging During Human Mesoderm Differentiation Reveals Tripotent Lateral Plate Mesodermal Progenitors. Stem Cells. 2016 May; 34(5):1239-50. PMID: 26934332.
        View in: PubMed
      8. Wu L, Prins HJ, Leijten J, Helder MN, Evseenko D, Moroni L, van Blitterswijk CA, Lin Y, Karperien M. Chondrocytes Cocultured with Stromal Vascular Fraction of Adipose Tissue Present More Intense Chondrogenic Characteristics Than with Adipose Stem Cells. Tissue Eng Part A. 2016 Feb; 22(3-4):336-48. PMID: 26732248.
        View in: PubMed
      9. Kowalski TJ, Leong NL, Dar A, Wu L, Kabir N, Khan AZ, Eliasberg CD, Pedron A, Karayan A, Lee S, Di Pauli von Treuheim T, Jiacheng J, Wu BM, Evseenko D, McAllister DR, Petrigliano FA. Hypoxic culture conditions induce increased metabolic rate and collagen gene expression in ACL-derived cells. J Orthop Res. 2016 Jun; 34(6):985-94. PMID: 26621359.
        View in: PubMed
      10. Zhang S, Ba K, Wu L, Lee S, Peault B, Petrigliano FA, McAllister DR, Adams JS, Evseenko D, Lin Y. Adventitial Cells and Perictyes Support Chondrogenesis Through Different Mechanisms in 3-Dimensional Cultures With or Without Nanoscaffolds. J Biomed Nanotechnol. 2015 Oct; 11(10):1799-807. PMID: 26502642.
        View in: PubMed
      11. Choi B, Kim S, Fan J, Kowalski T, Petrigliano F, Evseenko D, Lee M. Covalently conjugated transforming growth factor-ß1 in modular chitosan hydrogels for the effective treatment of articular cartilage defects. Biomater Sci. 2015 May; 3(5):742-52. PMID: 26222593.
        View in: PubMed
      12. Kim J, Lin B, Kim S, Choi B, Evseenko D, Lee M. TGF-ß1 conjugated chitosan collagen hydrogels induce chondrogenic differentiation of human synovium-derived stem cells. J Biol Eng. 2015; 9:1. PMID: 25745515; PMCID: PMC4350967.
      13. Wu L, Petrigliano FA, Ba K, Lee S, Bogdanov J, McAllister DR, Adams JS, Rosenthal AK, Van Handel B, Crooks GM, Lin Y, Evseenko D. Lysophosphatidic acid mediates fibrosis in injured joints by regulating collagen type I biosynthesis. Osteoarthritis Cartilage. 2015 Feb; 23(2):308-18. PMID: 25464168; PMCID: PMC4465392.
      14. Choi B, Kim S, Lin B, Li K, Bezouglaia O, Kim J, Evseenko D, Aghaloo T, Lee M. Visible-light-initiated hydrogels preserving cartilage extracellular signaling for inducing chondrogenesis of mesenchymal stem cells. Acta Biomater. 2015 Jan; 12:30-41. PMID: 25462526.
        View in: PubMed
      15. Vadivel K, Ponnuraj SM, Kumar Y, Zaiss AK, Bunce MW, Camire RM, Wu L, Evseenko D, Herschman HR, Bajaj MS, Bajaj SP. Platelets contain tissue factor pathway inhibitor-2 derived from megakaryocytes and inhibits fibrinolysis. J Biol Chem. 2014 Nov 07; 289(45):31647-61. PMID: 25262870; PMCID: PMC4223360.
      16. Richardson W, Wilkinson D, Wu L, Petrigliano F, Dunn B, Evseenko D. Ensemble multivariate analysis to improve identification of articular cartilage disease in noisy Raman spectra. J Biophotonics. 2015 Jul; 8(7):555-66. PMID: 25264131; PMCID: PMC4472573.
      17. Wu L, Bluguermann C, Kyupelyan L, Latour B, Gonzalez S, Shah S, Galic Z, Ge S, Zhu Y, Petrigliano FA, Nsair A, Miriuka SG, Li X, Lyons KM, Crooks GM, McAllister DR, Van Handel B, Adams JS, Evseenko D. Human developmental chondrogenesis as a basis for engineering chondrocytes from pluripotent stem cells. Stem Cell Reports. 2013; 1(6):575-89. PMID: 24371811; PMCID: PMC3871393.
      18. Arshi A, Nakashima Y, Nakano H, Eaimkhong S, Evseenko D, Reed J, Stieg AZ, Gimzewski JK, Nakano A. Rigid microenvironments promote cardiac differentiation of mouse and human embryonic stem cells. Sci Technol Adv Mater. 2013 Aug 01; 14(2). PMID: 24311969.
        View in: PubMed
      19. Wu L, Gonzalez S, Shah S, Kyupelyan L, Petrigliano FA, McAllister DR, Adams JS, Karperien M, Tuan TL, Benya PD, Evseenko D. Extracellular matrix domain formation as an indicator of chondrocyte dedifferentiation and hypertrophy. Tissue Eng Part C Methods. 2014 Feb; 20(2):160-8. PMID: 23758619; PMCID: PMC3910562.
      20. Evseenko D, Latour B, Richardson W, Corselli M, Sahaghian A, Cardinal S, Zhu Y, Chan R, Dunn B, Crooks GM. Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment. PLoS One. 2013; 8(5):e63718. PMID: 23696850; PMCID: PMC3655943.
      21. Corselli M, Chin CJ, Parekh C, Sahaghian A, Wang W, Ge S, Evseenko D, Wang X, Montelatici E, Lazzari L, Crooks GM, Péault B. Perivascular support of human hematopoietic stem/progenitor cells. Blood. 2013 Apr 11; 121(15):2891-901. PMID: 23412095; PMCID: PMC3707421.
      22. Bluguermann C, Wu L, Petrigliano F, McAllister D, Miriuka S, Evseenko D. Novel aspects of parenchymal-mesenchymal interactions: from cell types to molecules and beyond. Cell Biochem Funct. 2013 Jun; 31(4):271-80. PMID: 23315627.
        View in: PubMed
      23. Nsair A, Schenke-Layland K, Van Handel B, Evseenko D, Kahn M, Zhao P, Mendelis J, Heydarkhan S, Awaji O, Vottler M, Geist S, Chyu J, Gago-Lopez N, Crooks GM, Plath K, Goldhaber J, Mikkola HK, MacLellan WR. Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells. PLoS One. 2012; 7(10):e45603. PMID: 23056209; PMCID: PMC3467279.
      24. Chui A, Evseenko D, Brennecke SP, Keelan JA, Kalionis B, Murthi P. Homeobox gene Distal-less 3 (DLX3) is a regulator of villous cytotrophoblast differentiation. Placenta. 2011 Oct; 32(10):745-51. PMID: 21802725.
        View in: PubMed
      25. Dravid G, Zhu Y, Scholes J, Evseenko D, Crooks GM. Dysregulated gene expression during hematopoietic differentiation from human embryonic stem cells. Mol Ther. 2011 Apr; 19(4):768-81. PMID: 21179006; PMCID: PMC3070091.
      26. Evseenko D, Zhu Y, Schenke-Layland K, Kuo J, Latour B, Ge S, Scholes J, Dravid G, Li X, MacLellan WR, Crooks GM. Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells. Proc Natl Acad Sci U S A. 2010 Aug 03; 107(31):13742-7. PMID: 20643952; PMCID: PMC2922221.
      27. Evseenko D, Schenke-Layland K, Dravid G, Zhu Y, Hao QL, Scholes J, Wang XC, Maclellan WR, Crooks GM. Identification of the critical extracellular matrix proteins that promote human embryonic stem cell assembly. Stem Cells Dev. 2009 Jul-Aug; 18(6):919-28. PMID: 19021502.
        View in: PubMed
      28. Evseenko D, Murthi P, Paxton JW, Reid G, Emerald BS, Mohankumar KM, Lobie PE, Brennecke SP, Kalionis B, Keelan JA. The ABC transporter BCRP/ABCG2 is a placental survival factor, and its expression is reduced in idiopathic human fetal growth restriction. FASEB J. 2007 Nov; 21(13):3592-605. PMID: 17595345.
        View in: PubMed
      29. Aye IL, Paxton JW, Evseenko D, Keelan JA. Expression, localisation and activity of ATP binding cassette (ABC) family of drug transporters in human amnion membranes. Placenta. 2007 Aug-Sep; 28(8-9):868-77. PMID: 17482262.
        View in: PubMed
      30. Evseenko D, Paxton JW, Keelan JA. The xenobiotic transporter ABCG2 plays a novel role in differentiation of trophoblast-like BeWo cells. Placenta. 2007 Apr; 28 Suppl A:S116-20. PMID: 17275084.
        View in: PubMed
      31. Evseenko D, Paxton JW, Keelan JA. Independent regulation of apical and basolateral drug transporter expression and function in placental trophoblasts by cytokines, steroids, and growth factors. Drug Metab Dispos. 2007 Apr; 35(4):595-601. PMID: 17237156.
        View in: PubMed
      32. Evseenko D, Paxton JW, Keelan JA. Active transport across the human placenta: impact on drug efficacy and toxicity. Expert Opin Drug Metab Toxicol. 2006 Feb; 2(1):51-69. PMID: 16863468.
        View in: PubMed
      33. Evseenko D, Paxton JW, Keelan JA. ABC drug transporter expression and functional activity in trophoblast-like cell lines and differentiating primary trophoblast. Am J Physiol Regul Integr Comp Physiol. 2006 May; 290(5):R1357-65. PMID: 16322349.
        View in: PubMed
      34. Evseenko D, Tsirel'nikov NI. Role of placenta in the regulation of fetal erythropoiesis. Bull Exp Biol Med. 2001 Nov; 132(5):1055-7. PMID: 11865320.
        View in: PubMed