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    David R. Hinton, MD

    TitleProfessor of Pathology
    SchoolKeck School of Medicine of USC
    DepartmentPathology
    AddressNRT 1450 Biggy Street
    Off Campus
    Los Angeles California 90089-9092
    Phone+1 310 415 6093
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      Other Positions
      TitleGavin S. Herbert Professorship in Vision Research

      TitleAssociate Dean For Vision Science

      TitleVice Chair of Pathology

      TitleDirector, Dean's Research Scholars Program

      TitleExam Committee Facilitator


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      Dr Hinton investigates the pathogenesis of blinding retinal diseases including age related macular degeneration (AMD) and proliferative vitreoretinopathy(PVR). In particular, he is interested in how alterations in the retinal microenvironment can promote the development of intraocular fibrosis, proliferative membranes and neovascular choroidal responses. His work has established the central role of the retinal pigment epithelial (RPE) cell in these disorders, and has demonstrated novel mechanisms for growth factor activation of the RPE with resulting alterations in migration, proliferation and gene expression. He has developed and validated several in vitro and in vivo models of PVR and choroidal neovascularization and has used these models to elucidate basic mechanisms of disease and to evaluate novel therapeutic approaches to the disorders. He is especially interested in therapeutic approaches involving manipulation of growth factor receptors and their intracellular signaling pathways. He has now extended this work into investigating genetic polymorphisms that result in susceptibility to these disorders in human populations. Most recently, Dr Hinton’s lab has been evaluating endogenous neuroprotectants (eg pigment epithelial derived factor) and chaperones (alpha B crystallin) for their therapeutic potential. He has also developed methods for differentiating RPE cells from human embryonic stem cells and is evaluating these cells for their potential for cellular therapy for patients with AMD. In a collaborative Program Project with investigators at the Cleveland Clinic, Dr Hinton investigates the immunopathogenesis of demyelinating diseases of the brain and spinal cord in animal models.


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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Koronyo Y, Biggs D, Barron E, Boyer DS, Pearlman JA, Au WJ, Kile SJ, Blanco A, Fuchs DT, Ashfaq A, Frautschy S, Cole GM, Miller CA, Hinton D, Verdooner SR, Black KL, Koronyo-Hamaoui M. Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer's disease. JCI Insight. 2017 Aug 17; 2(16). PMID: 28814675.
        View in: PubMed
      2. Minasyan L, Sreekumar PG, Hinton D, Kannan R. Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells. Oxid Med Cell Longev. 2017; 2017:1675230. PMID: 28814984.
        View in: PubMed
      3. Sreekumar PG, Hinton D, Kannan R. Endoplasmic reticulum-mitochondrial crosstalk: a novel role for the mitochondrial peptide humanin. Neural Regen Res. 2017 Jan; 12(1):35-38. PMID: 28250736.
        View in: PubMed
      4. Huang AS, Saraswathy S, Dastiridou A, Begian A, Legaspi H, Mohindroo C, Tan JC, Francis BA, Caprioli J, Hinton D, Weinreb RN. Aqueous Angiography with Fluorescein and Indocyanine Green in Bovine Eyes. Transl Vis Sci Technol. 2016 Nov; 5(6):5. PMID: 27847692.
        View in: PubMed
      5. Matsunaga D, Sreekumar PG, Ishikawa K, Terasaki H, Barron E, Cohen P, Kannan R, Hinton D. Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione. PLoS One. 2016; 11(10):e0165150. PMID: 27783653.
        View in: PubMed
      6. Savarin C, Bergmann CC, Hinton D, Stohlman SA. Differential Regulation of Self-reactive CD4+ T Cells in Cervical Lymph Nodes and Central Nervous System during Viral Encephalomyelitis. Front Immunol. 2016; 7:370. PMID: 27708643.
        View in: PubMed
      7. Koss MJ, Falabella P, Stefanini FR, Pfister M, Thomas BB, Kashani AH, Brant R, Zhu D, Clegg DO, Hinton D, Humayun MS. Subretinal implantation of a monolayer of human embryonic stem cell-derived retinal pigment epithelium: a feasibility and safety study in Yucatán minipigs. Graefes Arch Clin Exp Ophthalmol. 2016 Aug; 254(8):1553-65. PMID: 27335025.
        View in: PubMed
      8. Planchart A, Mattingly CJ, Allen D, Ceger P, Casey W, Hinton D, Kanungo J, Kullman SW, Tal T, Bondesson M, Burgess SM, Sullivan C, Kim C, Behl M, Padilla S, Reif DM, Tanguay RL, Hamm J. Advancing toxicology research using in vivo high throughput toxicology with small fish models. ALTEX. 2016; 33(4):435-452. PMID: 27328013.
        View in: PubMed
      9. Thomas BB, Zhu D, Zhang L, Thomas PB, Hu Y, Nazari H, Stefanini F, Falabella P, Clegg DO, Hinton D, Humayun MS. Survival and Functionality of hESC-Derived Retinal Pigment Epithelium Cells Cultured as a Monolayer on Polymer Substrates Transplanted in RCS Rats. Invest Ophthalmol Vis Sci. 2016 May 01; 57(6):2877-87. PMID: 27233037.
        View in: PubMed
      10. Brant Fernandes RA, Koss MJ, Falabella P, Stefanini FR, Maia M, Diniz B, Ribeiro R, Hu Y, Hinton D, Clegg DO, Chader G, Humayun MS. An Innovative Surgical Technique for Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Pigmented Epithelium in Yucatan Mini Pigs: Preliminary Results. Ophthalmic Surg Lasers Imaging Retina. 2016 Apr 01; 47(4):342-51. PMID: 27065374.
        View in: PubMed
      11. Kochounian H, Zhang Z, Spee C, Hinton D, Fong HK. Targeting of exon VI-skipping human RGR-opsin to the plasma membrane of pigment epithelium and co-localization with terminal complement complex C5b-9. Mol Vis. 2016; 22:213-23. PMID: 27011730; PMCID: PMC4783578.
      12. Sreekumar PG, Ishikawa K, Spee C, Mehta HH, Wan J, Yen K, Cohen P, Kannan R, Hinton D. The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction. Invest Ophthalmol Vis Sci. 2016 Mar; 57(3):1238-53. PMID: 26990160; PMCID: PMC4811181.
      13. Valentin-Torres A, Savarin C, Hinton D, Phares TW, Bergmann CC, Stohlman SA. Sustained TNF production by central nervous system infiltrating macrophages promotes progressive autoimmune encephalomyelitis. J Neuroinflammation. 2016 Feb 22; 13:46. PMID: 26906225; PMCID: PMC4763407.
      14. Ishikawa K, Sreekumar PG, Spee C, Nazari H, Zhu D, Kannan R, Hinton D. aB-Crystallin Regulates Subretinal Fibrosis by Modulation of Epithelial-Mesenchymal Transition. Am J Pathol. 2016 Apr; 186(4):859-73. PMID: 26878210; PMCID: PMC4822331 [Available on 04/01/17].
      15. Saraswathy S, Tan JC, Yu F, Francis BA, Hinton D, Weinreb RN, Huang AS. Aqueous Angiography: Real-Time and Physiologic Aqueous Humor Outflow Imaging. PLoS One. 2016; 11(1):e0147176. PMID: 26807586; PMCID: PMC4725949.
      16. Ishikawa K, He S, Terasaki H, Nazari H, Zhang H, Spee C, Kannan R, Hinton D. Resveratrol inhibits epithelial-mesenchymal transition of retinal pigment epithelium and development of proliferative vitreoretinopathy. Sci Rep. 2015 Nov 10; 5:16386. PMID: 26552368; PMCID: PMC4639835.
      17. He S, Barron E, Ishikawa K, Nazari Khanamiri H, Spee C, Zhou P, Kase S, Wang Z, Dustin LD, Hinton D. Inhibition of DNA Methylation and Methyl-CpG-Binding Protein 2 Suppresses RPE Transdifferentiation: Relevance to Proliferative Vitreoretinopathy. Invest Ophthalmol Vis Sci. 2015 Aug; 56(9):5579-89. PMID: 26305530; PMCID: PMC4553933.
      18. Zhang H, He S, Spee C, Ishikawa K, Hinton D. SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by Resveratrol and its relevance to choroidal neovascularization. Cytokine. 2015 Dec; 76(2):549-52. PMID: 26174951; PMCID: PMC4605850 [Available on 12/01/16].
      19. Butchi N, Kapil P, Puntambekar S, Stohlman SA, Hinton D, Bergmann CC. Myd88 Initiates Early Innate Immune Responses and Promotes CD4 T Cells during Coronavirus Encephalomyelitis. J Virol. 2015 Sep; 89(18):9299-312. PMID: 26136579; PMCID: PMC4542380.
      20. Puntambekar SS, Hinton D, Yin X, Savarin C, Bergmann CC, Trapp BD, Stohlman SA. Interleukin-10 is a critical regulator of white matter lesion containment following viral induced demyelination. Glia. 2015 Jun 30. PMID: 26132901.
        View in: PubMed
      21. Nazari H, Zhang L, Zhu D, Chader GJ, Falabella P, Stefanini F, Rowland T, Clegg DO, Kashani AH, Hinton D, Humayun MS. Stem cell based therapies for age-related macular degeneration: The promises and the challenges. Prog Retin Eye Res. 2015 Sep; 48:1-39. PMID: 26113213.
        View in: PubMed
      22. Kannan R, Sreekumar PG, Hinton D. Alpha crystallins in the retinal pigment epithelium and implications for the pathogenesis and treatment of age-related macular degeneration. Biochim Biophys Acta. 2016 Jan; 1860(1 Pt B):258-68. PMID: 26026469; PMCID: PMC4662643 [Available on 01/01/17].
      23. Savarin C, Hinton D, Valentin-Torres A, Chen Z, Trapp BD, Bergmann CC, Stohlman SA. Astrocyte response to IFN-? limits IL-6-mediated microglia activation and progressive autoimmune encephalomyelitis. J Neuroinflammation. 2015 Apr 22; 12:79. PMID: 25896970; PMCID: PMC4410573.
      24. Chan N, He S, Spee CK, Ishikawa K, Hinton D. Attenuation of choroidal neovascularization by histone deacetylase inhibitor. PLoS One. 2015; 10(3):e0120587. PMID: 25807249; PMCID: PMC4373846.
      25. Ishikawa K, Kannan R, Hinton D. Molecular mechanisms of subretinal fibrosis in age-related macular degeneration. Exp Eye Res. 2016 Jan; 142:19-25. PMID: 25773985.
        View in: PubMed
      26. Hwang M, Phares TW, Hinton D, Stohlman SA, Bergmann CC, Min B. Distinct CD4 T-cell effects on primary versus recall CD8 T-cell responses during viral encephalomyelitis. Immunology. 2015 Mar; 144(3):374-386. PMID: 25187405.
        View in: PubMed
      27. Hirsch L, Nazari H, Sreekumar PG, Kannan R, Dustin L, Zhu D, Barron E, Hinton D. TGF-ß2 secretion from RPE decreases with polarization and becomes apically oriented. Cytokine. 2015 Feb; 71(2):394-6. PMID: 25496702; PMCID: PMC4297550.
      28. Kannan R, Hinton D. Sodium iodate induced retinal degeneration: new insights from an old model. Neural Regen Res. 2014 Dec 01; 9(23):2044-5. PMID: 25657718; PMCID: PMC4316465.
      29. Hirano Y, Yasuma T, Mizutani T, Fowler BJ, Tarallo V, Yasuma R, Kim Y, Bastos-Carvalho A, Kerur N, Gelfand BD, Bogdanovich S, He S, Zhang X, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Nagai H, Haro I, Núñez G, Ambati BK, Hinton D, Ambati J. IL-18 is not therapeutic for neovascular age-related macular degeneration. Nat Med. 2014 Dec; 20(12):1372-5. PMID: 25473914; PMCID: PMC4275546.
      30. Fowler BJ, Gelfand BD, Kim Y, Kerur N, Tarallo V, Hirano Y, Amarnath S, Fowler DH, Radwan M, Young MT, Pittman K, Kubes P, Agarwal HK, Parang K, Hinton D, Bastos-Carvalho A, Li S, Yasuma T, Mizutani T, Yasuma R, Wright C, Ambati J. Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity. Science. 2014 Nov 21; 346(6212):1000-3. PMID: 25414314; PMCID: PMC4274127.
      31. Hsiung J, Zhu D, Hinton D. Polarized human embryonic stem cell-derived retinal pigment epithelial cell monolayers have higher resistance to oxidative stress-induced cell death than nonpolarized cultures. Stem Cells Transl Med. 2015 Jan; 4(1):10-20. PMID: 25411476; PMCID: PMC4275015.
      32. Sur A, Kesaraju S, Prentice H, Ayyanathan K, Baronas-Lowell D, Zhu D, Hinton D, Blanks J, Weissbach H. Pharmacological protection of retinal pigmented epithelial cells by sulindac involves PPAR-a. Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47):16754-9. PMID: 25385631; PMCID: PMC4250171.
      33. Kim Y, Tarallo V, Kerur N, Yasuma T, Gelfand BD, Bastos-Carvalho A, Hirano Y, Yasuma R, Mizutani T, Fowler BJ, Li S, Kaneko H, Bogdanovich S, Ambati BK, Hinton D, Hauswirth WW, Hakem R, Wright C, Ambati J. DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration. Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45):16082-7. PMID: 25349431; PMCID: PMC4234570.
      34. de Aquino MT, Kapil P, Hinton D, Phares TW, Puntambekar SS, Savarin C, Bergmann CC, Stohlman SA. IL-27 limits central nervous system viral clearance by promoting IL-10 and enhances demyelination. J Immunol. 2014 Jul 01; 193(1):285-94. PMID: 24890725; PMCID: PMC4067872.
      35. Zhou P, Kannan R, Spee C, Sreekumar PG, Dou G, Hinton D. Protection of retina by aB crystallin in sodium iodate induced retinal degeneration. PLoS One. 2014; 9(5):e98275. PMID: 24874187; PMCID: PMC4038555.
      36. Sonoda S, Nagineni CN, Kitamura M, Spee C, Kannan R, Hinton D. Ceramide inhibits connective tissue growth factor expression by human retinal pigment epithelial cells. Cytokine. 2014 Aug; 68(2):137-40. PMID: 24758915; PMCID: PMC4051296.
      37. Kapil P, Stohlman SA, Hinton D, Bergmann CC. PKR mediated regulation of inflammation and IL-10 during viral encephalomyelitis. J Neuroimmunol. 2014 May 15; 270(1-2):1-12. PMID: 24642385; PMCID: PMC4019976.
      38. Savarin C, Bergmann CC, Hinton D, Stohlman SA. MMP-independent role of TIMP-1 at the blood brain barrier during viral encephalomyelitis. ASN Neuro. 2013 Nov 26; 5(5):e00127. PMID: 24156369; PMCID: PMC3840398.
      39. Kerur N, Hirano Y, Tarallo V, Fowler BJ, Bastos-Carvalho A, Yasuma T, Yasuma R, Kim Y, Hinton D, Kirschning CJ, Gelfand BD, Ambati J. TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy. Invest Ophthalmol Vis Sci. 2013 Nov 11; 54(12):7395-401. PMID: 24114535; PMCID: PMC3825570.
      40. Butchi NB, Hinton D, Stohlman SA, Kapil P, Fensterl V, Sen GC, Bergmann CC. Ifit2 deficiency results in uncontrolled neurotropic coronavirus replication and enhanced encephalitis via impaired alpha/beta interferon induction in macrophages. J Virol. 2014 Jan; 88(2):1051-64. PMID: 24198415; PMCID: PMC3911674.
      41. de Aquino MT, Puntambekar SS, Savarin C, Bergmann CC, Phares TW, Hinton D, Stohlman SA. Role of CD25(+) CD4(+) T cells in acute and persistent coronavirus infection of the central nervous system. Virology. 2013 Dec; 447(1-2):112-20. PMID: 24210105; PMCID: PMC3906923.
      42. Phares TW, DiSano KD, Hinton D, Hwang M, Zajac AJ, Stohlman SA, Bergmann CC. IL-21 optimizes T cell and humoral responses in the central nervous system during viral encephalitis. J Neuroimmunol. 2013 Oct 15; 263(1-2):43-54. PMID: 23992866; PMCID: PMC3796038.
      43. Diniz B, Thomas P, Thomas B, Ribeiro R, Hu Y, Brant R, Ahuja A, Zhu D, Liu L, Koss M, Maia M, Chader G, Hinton D, Humayun MS. Subretinal implantation of retinal pigment epithelial cells derived from human embryonic stem cells: improved survival when implanted as a monolayer. Invest Ophthalmol Vis Sci. 2013 Jul 26; 54(7):5087-96. PMID: 23833067; PMCID: PMC3726243.
      44. Ribeiro RM, Oregon A, Diniz B, Fernandes RB, Koss MJ, Charafeddin W, Hu Y, Thomas P, Thomas BB, Maia M, Chader GJ, Hinton D, Humayun MS. In vivo detection of hESC-RPE cells via confocal near-infrared fundus reflectance. Ophthalmic Surg Lasers Imaging Retina. 2013 Jul-Aug; 44(4):380-4. PMID: 23883533.
        View in: PubMed
      45. Sreekumar PG, Chothe P, Sharma KK, Baid R, Kompella U, Spee C, Kannan N, Manh C, Ryan SJ, Ganapathy V, Kannan R, Hinton D. Antiapoptotic properties of a-crystallin-derived peptide chaperones and characterization of their uptake transporters in human RPE cells. Invest Ophthalmol Vis Sci. 2013 Apr 17; 54(4):2787-98. PMID: 23532520; PMCID: PMC3632268.
      46. He S, Li X, Chan N, Hinton D. Review: Epigenetic mechanisms in ocular disease. Mol Vis. 2013; 19:665-74. PMID: 23559860; PMCID: PMC3611946.
      47. Phares TW, Stohlman SA, Hinton D, Bergmann CC. Astrocyte-derived CXCL10 drives accumulation of antibody-secreting cells in the central nervous system during viral encephalomyelitis. J Virol. 2013 Mar; 87(6):3382-92. PMID: 23302888; PMCID: PMC3592145.
      48. Phares TW, Stohlman SA, Hinton D, Bergmann CC. Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis. J Neuroinflammation. 2012 Dec 14; 9:269. PMID: 23237504; PMCID: PMC3545890.
      49. Zhu G, Ye R, Jung DY, Barron E, Friedline RH, Benoit VM, Hinton D, Kim JK, Lee AS. GRP78 plays an essential role in adipogenesis and postnatal growth in mice. FASEB J. 2013 Mar; 27(3):955-64. PMID: 23180827; PMCID: PMC3574283.
      50. Sohn EH, He S, Kim LA, Salehi-Had H, Javaheri M, Spee C, Dustin L, Hinton D, Eliott D. Angiofibrotic response to vascular endothelial growth factor inhibition in diabetic retinal detachment: report no. 1. Arch Ophthalmol. 2012 Sep; 130(9):1127-34. PMID: 22965588; PMCID: PMC3984910.
      51. Gundimeda U, McNeill TH, Elhiani AA, Schiffman JE, Hinton D, Gopalakrishna R. Green tea polyphenols precondition against cell death induced by oxygen-glucose deprivation via stimulation of laminin receptor, generation of reactive oxygen species, and activation of protein kinase Ce. J Biol Chem. 2012 Oct 05; 287(41):34694-708. PMID: 22879598; PMCID: PMC3464573.
      52. Dridi S, Hirano Y, Tarallo V, Kim Y, Fowler BJ, Ambati BK, Bogdanovich S, Chiodo VA, Hauswirth WW, Kugel JF, Goodrich JA, Ponicsan SL, Hinton D, Kleinman ME, Baffi JZ, Gelfand BD, Ambati J. ERK1/2 activation is a therapeutic target in age-related macular degeneration. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13781-6. PMID: 22869729; PMCID: PMC3427082.
      53. Hu Y, Liu L, Lu B, Zhu D, Ribeiro R, Diniz B, Thomas PB, Ahuja AK, Hinton D, Tai YC, Hikita ST, Johnson LV, Clegg DO, Thomas BB, Humayun MS. A novel approach for subretinal implantation of ultrathin substrates containing stem cell-derived retinal pigment epithelium monolayer. Ophthalmic Res. 2012; 48(4):186-91. PMID: 22868580.
        View in: PubMed
      54. Lu B, Zhu D, Hinton D, Humayun MS, Tai YC. Mesh-supported submicron parylene-C membranes for culturing retinal pigment epithelial cells. Biomed Microdevices. 2012 Aug; 14(4):659-67. PMID: 22391881.
        View in: PubMed
      55. Hindinger C, Bergmann CC, Hinton D, Phares TW, Parra GI, Hussain S, Savarin C, Atkinson RD, Stohlman SA. IFN-? signaling to astrocytes protects from autoimmune mediated neurological disability. PLoS One. 2012; 7(7):e42088. PMID: 22848713; PMCID: PMC3407093.
      56. Dou G, Sreekumar PG, Spee C, He S, Ryan SJ, Kannan R, Hinton D. Deficiency of aB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction. Free Radic Biol Med. 2012 Sep 01; 53(5):1111-22. PMID: 22781655; PMCID: PMC3454510.
      57. Kannan R, Sreekumar PG, Hinton D. Novel roles for a-crystallins in retinal function and disease. Prog Retin Eye Res. 2012 Nov; 31(6):576-604. PMID: 22721717; PMCID: PMC3472046.
      58. Savarin C, Stohlman SA, Hinton D, Ransohoff RM, Cua DJ, Bergmann CC. IFN-? protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophils. J Neuroinflammation. 2012 May 29; 9:104. PMID: 22642802; PMCID: PMC3419086.
      59. Tarallo V, Hirano Y, Gelfand BD, Dridi S, Kerur N, Kim Y, Cho WG, Kaneko H, Fowler BJ, Bogdanovich S, Albuquerque RJ, Hauswirth WW, Chiodo VA, Kugel JF, Goodrich JA, Ponicsan SL, Chaudhuri G, Murphy MP, Dunaief JL, Ambati BK, Ogura Y, Yoo JW, Lee DK, Provost P, Hinton D, Núñez G, Baffi JZ, Kleinman ME, Ambati J. DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell. 2012 May 11; 149(4):847-59. PMID: 22541070; PMCID: PMC3351582.
      60. Sreekumar PG, Spee C, Ryan SJ, Cole SP, Kannan R, Hinton D. Mechanism of RPE cell death in a-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux. PLoS One. 2012; 7(3):e33420. PMID: 22442691; PMCID: PMC3307734.
      61. Xu J, Zhu D, Sonoda S, He S, Spee C, Ryan SJ, Hinton D. Over-expression of BMP4 inhibits experimental choroidal neovascularization by modulating VEGF and MMP-9. Angiogenesis. 2012 Jun; 15(2):213-27. PMID: 22392094; PMCID: PMC3413482.
      62. Phares TW, Stohlman SA, Hwang M, Min B, Hinton D, Bergmann CC. CD4 T cells promote CD8 T cell immunity at the priming and effector site during viral encephalitis. J Virol. 2012 Mar; 86(5):2416-27. PMID: 22205741; PMCID: PMC3302259.
      63. Amin EM, Oltean S, Hua J, Gammons MV, Hamdollah-Zadeh M, Welsh GI, Cheung MK, Ni L, Kase S, Rennel ES, Symonds KE, Nowak DG, Royer-Pokora B, Saleem MA, Hagiwara M, Schumacher VA, Harper SJ, Hinton D, Bates DO, Ladomery MR. WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing. Cancer Cell. 2011 Dec 13; 20(6):768-80. PMID: 22172722; PMCID: PMC3574979.
      64. Kannan R, Sreekumar PG, Hinton D. VEGF and PEDF secretion in ARPE-19 and fhRPE cells. Invest Ophthalmol Vis Sci. 2011 Nov 21; 52(12):9047. PMID: 22104197; PMCID: PMC3231800.
      65. Sreekumar PG, Hinton D, Kannan R. Methionine sulfoxide reductase A: Structure, function and role in ocular pathology. World J Biol Chem. 2011 Aug 26; 2(8):184-92. PMID: 21909460; PMCID: PMC3163237.
      66. Khankan R, Oliver N, He S, Ryan SJ, Hinton D. Regulation of fibronectin-EDA through CTGF domain-specific interactions with TGFß2 and its receptor TGFßRII. Invest Ophthalmol Vis Sci. 2011 Jul 07; 52(8):5068-78. PMID: 21571675; PMCID: PMC3176038.
      67. Lee NG, Berry JL, Lee TC, Wang AT, Honowitz S, Murphree AL, Varshney N, Hinton D, Fawzi AA. Sonoporation enhances chemotherapeutic efficacy in retinoblastoma cells in vitro. Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3868-73. PMID: 21273549; PMCID: PMC3109062.
      68. Puntambekar SS, Bergmann CC, Savarin C, Karp CL, Phares TW, Parra GI, Hinton D, Stohlman SA. Shifting hierarchies of interleukin-10-producing T cell populations in the central nervous system during acute and persistent viral encephalomyelitis. J Virol. 2011 Jul; 85(13):6702-13. PMID: 21525347; PMCID: PMC3126516.
      69. Marques CP, Kapil P, Hinton D, Hindinger C, Nutt SL, Ransohoff RM, Phares TW, Stohlman SA, Bergmann CC. CXCR3-dependent plasma blast migration to the central nervous system during viral encephalomyelitis. J Virol. 2011 Jul; 85(13):6136-47. PMID: 21507985; PMCID: PMC3126522.
      70. Sadler TR, Nguyen PT, Yang J, Givrad TK, Mayer EA, Maarek JM, Hinton D, Holschneider DP. Antenatal maternal stress alters functional brain responses in adult offspring during conditioned fear. Brain Res. 2011 Apr 18; 1385:163-74. PMID: 21300034; PMCID: PMC3065538.
      71. Couldwell WT, Surnock AA, Tobia AJ, Cabana BE, Stillerman CB, Forsyth PA, Appley AJ, Spence AM, Hinton D, Chen TC. A phase 1/2 study of orally administered synthetic hypericin for treatment of recurrent malignant gliomas. Cancer. 2011 Nov 01; 117(21):4905-15. PMID: 21456013.
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      72. Xu J, Zhu D, He S, Spee C, Ryan SJ, Hinton D. Transcriptional regulation of bone morphogenetic protein 4 by tumor necrosis factor and its relationship with age-related macular degeneration. FASEB J. 2011 Jul; 25(7):2221-33. PMID: 21411747; PMCID: PMC3114537.
      73. Zhu D, Deng X, Spee C, Sonoda S, Hsieh CL, Barron E, Pera M, Hinton D. Polarized secretion of PEDF from human embryonic stem cell-derived RPE promotes retinal progenitor cell survival. Invest Ophthalmol Vis Sci. 2011 Mar 01; 52(3):1573-85. PMID: 21087957; PMCID: PMC4183377.
      74. Abdallah W, Ameri H, Barron E, Chader GJ, Greenbaum E, Hinton D, Humayun MS. Vitreal oxygenation in retinal ischemia reperfusion. Invest Ophthalmol Vis Sci. 2011 Feb; 52(2):1035-42. PMID: 21051734; PMCID: PMC3053094.
      75. Kaneko H, Dridi S, Tarallo V, Gelfand BD, Fowler BJ, Cho WG, Kleinman ME, Ponicsan SL, Hauswirth WW, Chiodo VA, Karikó K, Yoo JW, Lee DK, Hadziahmetovic M, Song Y, Misra S, Chaudhuri G, Buaas FW, Braun RE, Hinton D, Zhang Q, Grossniklaus HE, Provis JM, Madigan MC, Milam AH, Justice NL, Albuquerque RJ, Blandford AD, Bogdanovich S, Hirano Y, Witta J, Fuchs E, Littman DR, Ambati BK, Rudin CM, Chong MM, Provost P, Kugel JF, Goodrich JA, Dunaief JL, Baffi JZ, Ambati J. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature. 2011 Mar 17; 471(7338):325-30. PMID: 21297615; PMCID: PMC3077055.
      76. Chothe PP, Gnana-Prakasam JP, Ananth S, Martin PM, Kannan R, Hinton D, Smith SB, Ganapathy V. Transport of hepcidin, an iron-regulatory peptide hormone, into retinal pigment epithelial cells via oligopeptide transporters and its relevance to iron homeostasis. Biochem Biophys Res Commun. 2011 Feb 11; 405(2):244-9. PMID: 21219868; PMCID: PMC3060409.
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      81. Lim JI, Spee C, Hinton D. A comparison of hypoxia-inducible factor-a in surgically excised neovascular membranes of patients with diabetes compared with idiopathic epiretinal membranes in nondiabetic patients. Retina. 2010 Oct; 30(9):1472-8. PMID: 20811317; PMCID: PMC3690285.
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      83. Tran ND, Kim S, Vincent HK, Rodriguez A, Hinton D, Bullock MR, Young HF. Aquaporin-1-mediated cerebral edema following traumatic brain injury: effects of acidosis and corticosteroid administration. J Neurosurg. 2010 May; 112(5):1095-104. PMID: 19731985.
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      84. Hua J, Spee C, Kase S, Rennel ES, Magnussen AL, Qiu Y, Varey A, Dhayade S, Churchill AJ, Harper SJ, Bates DO, Hinton D. Recombinant human VEGF165b inhibits experimental choroidal neovascularization. Invest Ophthalmol Vis Sci. 2010 Aug; 51(8):4282-8. PMID: 20237252; PMCID: PMC2910649.
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      86. Parra GI, Bergmann CC, Phares TW, Hinton D, Atkinson R, Stohlman SA. Gamma interferon signaling in oligodendrocytes is critical for protection from neurotropic coronavirus infection. J Virol. 2010 Mar; 84(6):3111-5. PMID: 20042510; PMCID: PMC2826048.
      87. Sonoda S, Sreekumar PG, Kase S, Spee C, Ryan SJ, Kannan R, Hinton D. Attainment of polarity promotes growth factor secretion by retinal pigment epithelial cells: relevance to age-related macular degeneration. Aging (Albany NY). 2009 Dec 27; 2(1):28-42. PMID: 20228934; PMCID: PMC2837203.
      88. Kase S, He S, Sonoda S, Kitamura M, Spee C, Wawrousek E, Ryan SJ, Kannan R, Hinton D. alphaB-crystallin regulation of angiogenesis by modulation of VEGF. Blood. 2010 Apr 22; 115(16):3398-406. PMID: 20023214; PMCID: PMC2858494.
      89. Wang M, Ye R, Barron E, Baumeister P, Mao C, Luo S, Fu Y, Luo B, Dubeau L, Hinton D, Lee AS. Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis. Cell Death Differ. 2010 Mar; 17(3):488-98. PMID: 19816510; PMCID: PMC2822118.
      90. Ireland DD, Stohlman SA, Hinton D, Kapil P, Silverman RH, Atkinson RA, Bergmann CC. RNase L mediated protection from virus induced demyelination. PLoS Pathog. 2009 Oct; 5(10):e1000602. PMID: 19798426; PMCID: PMC2745574.
      91. Zhu D, Sreekumar PG, Hinton D, Kannan R. Expression and regulation of enzymes in the ceramide metabolic pathway in human retinal pigment epithelial cells and their relevance to retinal degeneration. Vision Res. 2010 Mar 31; 50(7):643-51. PMID: 19765607; PMCID: PMC2840213.
      92. He S, Kumar SR, Zhou P, Krasnoperov V, Ryan SJ, Gill PS, Hinton D. Soluble EphB4 inhibition of PDGF-induced RPE migration in vitro. Invest Ophthalmol Vis Sci. 2010 Jan; 51(1):543-52. PMID: 19696168; PMCID: PMC2828363.
      93. Zhu D, Deng X, Xu J, Hinton D. What determines the switch between atrophic and neovascular forms of age related macular degeneration? - the role of BMP4 induced senescence. Aging (Albany NY). 2009 Aug 12; 1(8):740-5. PMID: 20157553; PMCID: PMC2806048.
      94. Chothe PP, Thakkar SV, Gnana-Prakasam JP, Ananth S, Hinton D, Kannan R, Smith SB, Martin PM, Ganapathy V. Identification of a novel sodium-coupled oligopeptide transporter (SOPT2) in mouse and human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2010 Jan; 51(1):413-20. PMID: 19643969; PMCID: PMC3973186.
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      96. Sadler TR, Khodavirdi AC, Hinton D, Holschneider DP. Snap-frozen brain tissue sections stored with desiccant at ambient laboratory conditions without chemical fixation are resistant to degradation for a minimum of 6 months. Appl Immunohistochem Mol Morphol. 2009 Mar; 17(2):165-71. PMID: 19521279; PMCID: PMC2742633.
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      98. Zhu D, Wu J, Spee C, Ryan SJ, Hinton D. BMP4 mediates oxidative stress-induced retinal pigment epithelial cell senescence and is overexpressed in age-related macular degeneration. J Biol Chem. 2009 Apr 03; 284(14):9529-39. PMID: 19158083; PMCID: PMC2666605.
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      102. Savarin C, Bergmann CC, Hinton D, Ransohoff RM, Stohlman SA. Memory CD4+ T-cell-mediated protection from lethal coronavirus encephalomyelitis. J Virol. 2008 Dec; 82(24):12432-40. PMID: 18842712; PMCID: PMC2593339.
      103. Yang Z, Stratton C, Francis PJ, Kleinman ME, Tan PL, Gibbs D, Tong Z, Chen H, Constantine R, Yang X, Chen Y, Zeng J, Davey L, Ma X, Hau VS, Wang C, Harmon J, Buehler J, Pearson E, Patel S, Kaminoh Y, Watkins S, Luo L, Zabriskie NA, Bernstein PS, Cho W, Schwager A, Hinton D, Klein ML, Hamon SC, Simmons E, Yu B, Campochiaro B, Sunness JS, Campochiaro P, Jorde L, Parmigiani G, Zack DJ, Katsanis N, Ambati J, Zhang K. Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. N Engl J Med. 2008 Oct 02; 359(14):1456-63. PMID: 18753640; PMCID: PMC2573951.
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      105. Lundberg P, Ramakrishna C, Brown J, Tyszka JM, Hamamura M, Hinton D, Kovats S, Nalcioglu O, Weinberg K, Openshaw H, Cantin EM. The immune response to herpes simplex virus type 1 infection in susceptible mice is a major cause of central nervous system pathology resulting in fatal encephalitis. J Virol. 2008 Jul; 82(14):7078-88. PMID: 18480436; PMCID: PMC2446972.
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      109. Stohlman SA, Hinton D, Parra B, Atkinson R, Bergmann CC. CD4 T cells contribute to virus control and pathology following central nervous system infection with neurotropic mouse hepatitis virus. J Virol. 2008 Mar; 82(5):2130-9. PMID: 18094171; PMCID: PMC2258904.
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      114. Tedeschi-Blok N, Buckley J, Varma R, Triche TJ, Hinton D. Population-based study of early age-related macular degeneration: role of the complement factor H Y402H polymorphism in bilateral but not unilateral disease. Ophthalmology. 2007 Jan; 114(1):99-103. PMID: 17198853.
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      116. Kannan R, Zhang N, Sreekumar PG, Spee CK, Rodriguez A, Barron E, Hinton D. Stimulation of apical and basolateral VEGF-A and VEGF-C secretion by oxidative stress in polarized retinal pigment epithelial cells. Mol Vis. 2006 Dec 22; 12:1649-59. PMID: 17200665.
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      121. Lutty GA, Chan-Ling T, Phelps DL, Adamis AP, Berns KI, Chan CK, Cole CH, D'Amore PA, Das A, Deng WT, Dobson V, Flynn JT, Friedlander M, Fulton A, Good WV, Grant MB, Hansen R, Hauswirth WW, Hardy RJ, Hinton D, Hughes S, McLeod DS, Palmer EA, Patz A, Penn JS, Raisler BJ, Repka MX, Saint-Geniez M, Shaw LC, Shima DT, Smith BT, Smith LE, Tahija SG, Tasman W, Trese MT. Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California). Mol Vis. 2006 May 23; 12:532-80. PMID: 16735995.
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      122. Kramerov AA, Saghizadeh M, Pan H, Kabosova A, Montenarh M, Ahmed K, Penn JS, Chan CK, Hinton D, Grant MB, Ljubimov AV. Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina. Am J Pathol. 2006 May; 168(5):1722-36. PMID: 16651637; PMCID: PMC1606582.
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      125. Tschen SI, Stohlman SA, Ramakrishna C, Hinton D, Atkinson RD, Bergmann CC. CNS viral infection diverts homing of antibody-secreting cells from lymphoid organs to the CNS. Eur J Immunol. 2006 Mar; 36(3):603-12. PMID: 16437540.
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      126. González JM, Bergmann CC, Ramakrishna C, Hinton D, Atkinson R, Hoskin J, Macklin WB, Stohlman SA. Inhibition of interferon-gamma signaling in oligodendroglia delays coronavirus clearance without altering demyelination. Am J Pathol. 2006 Mar; 168(3):796-804. PMID: 16507895; PMCID: PMC1606538.
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      128. Zhang N, Kannan R, Okamoto CT, Ryan SJ, Lee VH, Hinton D. Characterization of brimonidine transport in retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2006 Jan; 47(1):287-94. PMID: 16384975.
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      129. He S, Ding Y, Zhou J, Krasnoperov V, Zozulya S, Kumar SR, Ryan SJ, Gill PS, Hinton D. Soluble EphB4 regulates choroidal endothelial cell function and inhibits laser-induced choroidal neovascularization. Invest Ophthalmol Vis Sci. 2005 Dec; 46(12):4772-9. PMID: 16303978.
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      130. Lim JI, Spee C, Hangai M, Rocha J, Ying HS, Ryan SJ, Hinton D. Neuropilin-1 expression by endothelial cells and retinal pigment epithelial cells in choroidal neovascular membranes. Am J Ophthalmol. 2005 Dec; 140(6):1044-1050. PMID: 16376649.
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      131. Hangai M, He S, Hoffmann S, Lim JI, Ryan SJ, Hinton D. Sequential induction of angiogenic growth factors by TNF-alpha in choroidal endothelial cells. J Neuroimmunol. 2006 Feb; 171(1-2):45-56. PMID: 16288810.
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      132. Jin M, Yaung J, Kannan R, He S, Ryan SJ, Hinton D. Hepatocyte growth factor protects RPE cells from apoptosis induced by glutathione depletion. Invest Ophthalmol Vis Sci. 2005 Nov; 46(11):4311-9. PMID: 16249513.
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      133. Pan J, Al-Dubaib M, Liao CP, Fujino Y, Hinton D, Hayes KA, Mathes LE, Roy-Burman P. In vivo expression of GFP transgene delivered via a replicating feline leukemia virus. Vet Microbiol. 2005 Oct 31; 110(3-4):181-95. PMID: 16143471.
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      137. Hoffmann S, He S, Jin M, Ehren M, Wiedemann P, Ryan SJ, Hinton D. A selective cyclic integrin antagonist blocks the integrin receptors alphavbeta3 and alphavbeta5 and inhibits retinal pigment epithelium cell attachment, migration and invasion. BMC Ophthalmol. 2005 Jun 29; 5:16. PMID: 15987521; PMCID: PMC1184086.
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      139. Chan CK, Pham LN, Zhou J, Spee C, Ryan SJ, Hinton D. Differential expression of pro- and antiangiogenic factors in mouse strain-dependent hypoxia-induced retinal neovascularization. Lab Invest. 2005 Jun; 85(6):721-33. PMID: 15856049.
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      141. Güven D, Weiland JD, Fujii G, Mech BV, Mahadevappa M, Greenberg R, Roizenblatt R, Qiu G, Labree L, Wang X, Hinton D, Humayun MS. Long-term stimulation by active epiretinal implants in normal and RCD1 dogs. J Neural Eng. 2005 Mar; 2(1):S65-73. PMID: 15876657.
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      144. Kannan R, Jin M, Gamulescu MA, Hinton D. Ceramide-induced apoptosis: role of catalase and hepatocyte growth factor. Free Radic Biol Med. 2004 Jul 15; 37(2):166-75. PMID: 15203188.
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      145. Weiner LP, Louie KA, Atalla LR, Kochounian HH, Du J, Wei W, Hinton D, Gordon EM, Anderson WF, McMillan M. Gene therapy in a murine model for clinical application to multiple sclerosis. Ann Neurol. 2004 Mar; 55(3):390-9. PMID: 14991817.
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      147. Chan CK, Pham LN, Chinn C, Spee C, Ryan SJ, Akhurst RJ, Hinton D. Mouse strain-dependent heterogeneity of resting limbal vasculature. Invest Ophthalmol Vis Sci. 2004 Feb; 45(2):441-7. PMID: 14744883.
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      148. Bergmann CC, Parra B, Hinton D, Ramakrishna C, Dowdell KC, Stohlman SA. Perforin and gamma interferon-mediated control of coronavirus central nervous system infection by CD8 T cells in the absence of CD4 T cells. J Virol. 2004 Feb; 78(4):1739-50. PMID: 14747539; PMCID: PMC369505.
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      154. Bergmann CC, Parra B, Hinton D, Chandran R, Morrison M, Stohlman SA. Perforin-mediated effector function within the central nervous system requires IFN-gamma-mediated MHC up-regulation. J Immunol. 2003 Mar 15; 170(6):3204-13. PMID: 12626579.
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      156. Simard M, Zhang W, Hinton D, Chen TC, Weiss MH, Su YZ, Gopalakrishna R, Law RE, Couldwell WT. Tamoxifen-induced growth arrest and apoptosis in pituitary tumor cells in vitro via a protein kinase C-independent pathway. Cancer Lett. 2002 Nov 28; 185(2):131-8. PMID: 12169386.
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      158. Zhou J, Stohlman SA, Atkinson R, Hinton D, Marten NW. Matrix metalloproteinase expression correlates with virulence following neurotropic mouse hepatitis virus infection. J Virol. 2002 Aug; 76(15):7374-84. PMID: 12097550; PMCID: PMC136378.
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      160. Karanjawala ZE, Murphy N, Hinton D, Hsieh CL, Lieber MR. Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants. Curr Biol. 2002 Mar 05; 12(5):397-402. PMID: 11882291.
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      161. Ryan SJ, Hinton D, Ogden TE, Rao N. Translational research in ophthalmology. Arch Ophthalmol. 2002 Mar; 120(3):389-90. PMID: 11879146.
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      162. Qiao H, Sakamoto T, Hinton D, Gopalakrishna R, Ishibashi T, Ryan SJ, Inomata H. Interferon beta affects retinal pigment epithelial cell proliferation via protein kinase C pathways. Ophthalmologica. 2001 Nov-Dec; 215(6):401-7. PMID: 11741104.
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      163. Masood R, Cai J, Zheng T, Smith DL, Hinton D, Gill PS. Vascular endothelial growth factor (VEGF) is an autocrine growth factor for VEGF receptor-positive human tumors. Blood. 2001 Sep 15; 98(6):1904-13. PMID: 11535528.
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      164. Hangai M, Moon YS, Kitaya N, Chan CK, Wu DY, Peters KG, Ryan SJ, Hinton D. Systemically expressed soluble Tie2 inhibits intraocular neovascularization. Hum Gene Ther. 2001 Jul 01; 12(10):1311-21. PMID: 11440624.
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      167. Gordon EM, Chen ZH, Liu L, Whitley M, Liu L, Wei D, Groshen S, Hinton D, Anderson WF, Beart RW, Hall FL. Systemic administration of a matrix-targeted retroviral vector is efficacious for cancer gene therapy in mice. Hum Gene Ther. 2001 Jan 20; 12(2):193-204. PMID: 11177556.
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      168. Zhou J, Stohlman SA, Marten NW, Hinton D. Regulation of matrix metalloproteinase (MMP) and tissue inhibitor of matrix metalloproteinase (TIMP) genes during JHMV infection of the central nervous system. Adv Exp Med Biol. 2001; 494:329-34. PMID: 11774488.
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      169. Parra B, Bergmann CC, Hinton D, Atkinson R, Stohlman SA. IFN-gamma secreted by virus-specific CD8+ T cells contribute to CNS viral clearance. Adv Exp Med Biol. 2001; 494:335-40. PMID: 11774489.
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      170. Marten NW, Hohman M, Stohlman SA, Atkinson RD, Hinton D, Bergmann CC. Acute CNS infection is insufficient to mediate chronic T cell retention. Adv Exp Med Biol. 2001; 494:349-54. PMID: 11774491.
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      171. Bergmann CC, Marten NW, Hinton D, Parra B, Stohlman SA. CD8 T cell mediated immunity to neurotropic MHV infection. Adv Exp Med Biol. 2001; 494:299-308. PMID: 11774484.
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      172. Stohlman SA, Hinton D. Viral induced demyelination. Brain Pathol. 2001 Jan; 11(1):92-106. PMID: 11145206.
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      173. Jin M, He S, Wörpel V, Ryan SJ, Hinton D. Promotion of adhesion and migration of RPE cells to provisional extracellular matrices by TNF-alpha. Invest Ophthalmol Vis Sci. 2000 Dec; 41(13):4324-32. PMID: 11095634.
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      174. Murata T, He S, Hangai M, Ishibashi T, Xi XP, Kim S, Hsueh WA, Ryan SJ, Law RE, Hinton D. Peroxisome proliferator-activated receptor-gamma ligands inhibit choroidal neovascularization. Invest Ophthalmol Vis Sci. 2000 Jul; 41(8):2309-17. PMID: 10892878.
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      175. Murata T, Cui J, Taba KE, Oh JY, Spee C, Hinton D, Ryan SJ. The possibility of gene therapy for the treatment of choroidal neovascularization. Ophthalmology. 2000 Jul; 107(7):1364-73. PMID: 10889114.
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      176. Hoffmann S, Masood R, Zhang Y, He S, Ryan SJ, Gill P, Hinton D. Selective killing of RPE with a vascular endothelial growth factor chimeric toxin. Invest Ophthalmol Vis Sci. 2000 Jul; 41(8):2389-93. PMID: 10892888.
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      177. Gordon EM, Liu PX, Chen ZH, Liu L, Whitley MD, Gee C, Groshen S, Hinton D, Beart RW, Hall FL. Inhibition of metastatic tumor growth in nude mice by portal vein infusions of matrix-targeted retroviral vectors bearing a cytocidal cyclin G1 construct. Cancer Res. 2000 Jul 01; 60(13):3343-7. PMID: 10910035.
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      178. Marten NW, Stohlman SA, Atkinson RD, Hinton D, Fleming JO, Bergmann CC. Contributions of CD8+ T cells and viral spread to demyelinating disease. J Immunol. 2000 Apr 15; 164(8):4080-8. PMID: 10754301.
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      179. Cui JZ, Kimura H, Spee C, Thumann G, Hinton D, Ryan SJ. Natural history of choroidal neovascularization induced by vascular endothelial growth factor in the primate. Graefes Arch Clin Exp Ophthalmol. 2000 Apr; 238(4):326-33. PMID: 10853932.
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      180. Parra B, Lin MT, Stohlman SA, Bergmann CC, Atkinson R, Hinton D. Contributions of Fas-Fas ligand interactions to the pathogenesis of mouse hepatitis virus in the central nervous system. J Virol. 2000 Mar; 74(5):2447-50. PMID: 10666278; PMCID: PMC111729.
      181. Cai J, Zheng T, Masood R, Smith DL, Hinton D, Kim CN, Fang G, Bhalla K, Gill PS. Paclitaxel Induces Apoptosis in AIDS-Related Kaposi's Sarcoma Cells. Sarcoma. 2000; 4(1-2):37-45. PMID: 18521433; PMCID: PMC2408359.
      182. Stohlman SA, Pei L, Cua DJ, Li Z, Hinton D. Activation of regulatory cells suppresses experimental allergic encephalomyelitis via secretion of IL-10. J Immunol. 1999 Dec 01; 163(11):6338-44. PMID: 10570329.
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      183. Sprando RL, Pestka J, Collins TF, Rorie J, O'Donnell M, Hinton D, Chirtel S. The effect of vomitoxin (Deoxnivalenol) on testicular morphology, testicular spermatid counts and epididymal sperm counts in IL-6KO [B6129-IL6 [TmlKopf] (IL-6 gene deficient)] and WT [B6129F2 (wild type to B6129-IL6 with an intact IL-6 gene)] mice. Food Chem Toxicol. 1999 Nov; 37(11):1073-9. PMID: 10566878.
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      184. Tahara YR, Sakamoto TR, Oshima YR, Ishibashi TR, Inomata HR, Murata TR, Hinton D, Ryan SJ. The antidepressant hypericin inhibits progression of experimental proliferative vitreoretinopathy. Curr Eye Res. 1999 Oct; 19(4):323-9. PMID: 10520228.
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      185. Zhao MW, Jin ML, He S, Spee C, Ryan SJ, Hinton D. A distinct integrin-mediated phagocytic pathway for extracellular matrix remodeling by RPE cells. Invest Ophthalmol Vis Sci. 1999 Oct; 40(11):2713-23. PMID: 10509670.
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      186. Bergmann CC, Altman JD, Hinton D, Stohlman SA. Inverted immunodominance and impaired cytolytic function of CD8+ T cells during viral persistence in the central nervous system. J Immunol. 1999 Sep 15; 163(6):3379-87. PMID: 10477608.
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      187. Amar AP, Hinton D, Krieger MD, Weiss MH. Invasive pituitary adenomas: significance of proliferation parameters. Pituitary. 1999 Aug; 2(2):117-22. PMID: 11081161.
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      188. Thumann G, Bartz-Schmidt KU, El Bakri H, Schraermeyer U, Spee C, Cui JZ, Hinton D, Ryan SJ, Heimann K. Transplantation of autologous iris pigment epithelium to the subretinal space in rabbits. Transplantation. 1999 Jul 27; 68(2):195-201. PMID: 10440387.
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      189. Kundu RK, Sangiorgi F, Wu LY, Pattengale PK, Hinton D, Gill PS, Maxson R. Expression of the human immunodeficiency virus-Tat gene in lymphoid tissues of transgenic mice is associated with B-cell lymphoma. Blood. 1999 Jul 01; 94(1):275-82. PMID: 10381523.
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      190. Lin MT, Hinton D, Marten NW, Bergmann CC, Stohlman SA. Antibody prevents virus reactivation within the central nervous system. J Immunol. 1999 Jun 15; 162(12):7358-68. PMID: 10358187.
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      191. Albuquerque FC, Weiss MH, Kovacs K, Horvath E, Sasano H, Hinton D. A functioning composite 'corticotroph' pituitary adenoma with interspersed adrenocortical cells. Pituitary. 1999 May; 1(3-4):279-84. PMID: 11081209.
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      192. Casella AM, Taba KE, Kimura H, Spee C, Cardillo JA, Ryan SJ, Hinton D. Retinal pigment epithelial cells are heterogeneous in their expression of MHC-II after stimulation with interferon-gamma. Exp Eye Res. 1999 Apr; 68(4):423-30. PMID: 10192799.
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      193. Cua DJ, Groux H, Hinton D, Stohlman SA, Coffman RL. Transgenic interleukin 10 prevents induction of experimental autoimmune encephalomyelitis. J Exp Med. 1999 Mar 15; 189(6):1005-10. PMID: 10075984; PMCID: PMC2193046.
      194. Hinton D, Kovacs K, Chandrasoma PT. Cytologic features of secretory meningioma. Acta Cytol. 1999 Mar-Apr; 43(2):121-5. PMID: 10097697.
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      195. Hofman FM, Chen P, Incardona F, Zidovetzki R, Hinton D. HIV-1 tat protein induces the production of interleukin-8 by human brain-derived endothelial cells. J Neuroimmunol. 1999 Feb 01; 94(1-2):28-39. PMID: 10376933.
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      196. Parra B, Hinton D, Marten NW, Bergmann CC, Lin MT, Yang CS, Stohlman SA. IFN-gamma is required for viral clearance from central nervous system oligodendroglia. J Immunol. 1999 Feb 01; 162(3):1641-7. PMID: 9973424.
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      197. Kimura H, Spee C, Sakamoto T, Hinton D, Ogura Y, Tabata Y, Ikada Y, Ryan SJ. Cellular response in subretinal neovascularization induced by bFGF-impregnated microspheres. Invest Ophthalmol Vis Sci. 1999 Feb; 40(2):524-8. PMID: 9950614.
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      198. Mendel E, Khoo LT, Go JL, Hinton D, Zee CS, Apuzzo ML. Intracerebral Whipple's disease diagnosed by stereotactic biopsy: a case report and review of the literature. Neurosurgery. 1999 Jan; 44(1):203-9. PMID: 9894983.
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      199. Ishibashi T, Murata T, Hangai M, Nagai R, Horiuchi S, Lopez PF, Hinton D, Ryan SJ. Advanced glycation end products in age-related macular degeneration. Arch Ophthalmol. 1998 Dec; 116(12):1629-32. PMID: 9869793.
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      200. Albuquerque FC, Hinton D, Weiss MH. Excessively high prolactin level in a patient with a nonprolactin-secreting adenoma. Case report. J Neurosurg. 1998 Dec; 89(6):1043-6. PMID: 9833836.
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      201. Murata T, Hangai M, Ishibashi T, Spee C, Gordon EM, Anderson WF, Hinton D, Ryan SJ. Retrovirus-mediated gene transfer to photocoagulation-induced choroidal neovascular membranes. Invest Ophthalmol Vis Sci. 1998 Nov; 39(12):2474-8. PMID: 9804157.
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      202. Hoffmann S, Spee C, Murata T, Cui JZ, Ryan SJ, Hinton D. Rapid isolation of choriocapillary endothelial cells by Lycopersicon esculentum-coated Dynabeads. Graefes Arch Clin Exp Ophthalmol. 1998 Oct; 236(10):779-84. PMID: 9801894.
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      203. Commins DL, Hinton D. Cytologic features of hemangioblastoma: comparison with meningioma, anaplastic astrocytoma and renal cell carcinoma. Acta Cytol. 1998 Sep-Oct; 42(5):1104-10. PMID: 9755665.
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      204. He PM, He S, Garner JA, Ryan SJ, Hinton D. Retinal pigment epithelial cells secrete and respond to hepatocyte growth factor. Biochem Biophys Res Commun. 1998 Aug 10; 249(1):253-7. PMID: 9705867.
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      205. Hoffman S, Gopalakrishna R, Gundimeda U, Murata T, Spee C, Ryan SJ, Hinton D. Verapamil inhibits proliferation, migration and protein kinase C activity in human retinal pigment epithelial cells. Exp Eye Res. 1998 Jul; 67(1):45-52. PMID: 9702177.
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      206. Lin MT, Hinton D, Parra B, Stohlman SA, van der Veen RC. The role of IL-10 in mouse hepatitis virus-induced demyelinating encephalomyelitis. Virology. 1998 Jun 05; 245(2):270-80. PMID: 9636366.
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      207. Murata T, Hoffmann S, Ishibashi T, Spee C, Gordon EM, Anderson WF, Hinton D, Ryan SJ. Retrovirus-mediated gene transfer targeted to retinal photocoagulation sites. Diabetologia. 1998 May; 41(5):500-6. PMID: 9628265.
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      208. Takeuchi S, Koeffler HP, Hinton D, Miyoshi I, Melmed S, Shimon I. Mutation and expression analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in pituitary tumors. J Endocrinol. 1998 May; 157(2):337-41. PMID: 9659297.
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      209. Hinton D, Hahn JA, Weiss MH, Couldwell WT. Loss of Rb expression in an ACTH-secreting pituitary carcinoma. Cancer Lett. 1998 Apr 24; 126(2):209-14. PMID: 9585068.
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      210. Stohlman SA, Bergmann CC, Lin MT, Cua DJ, Hinton D. CTL effector function within the central nervous system requires CD4+ T cells. J Immunol. 1998 Mar 15; 160(6):2896-904. PMID: 9510193.
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      211. Sakamoto T, Spee C, Scuric Z, Gordon EM, Hinton D, Anderson WF, Ryan SJ. Ability of retroviral transduction to modify the angiogenic characteristics of RPE cells. Graefes Arch Clin Exp Ophthalmol. 1998 Mar; 236(3):220-9. PMID: 9541827.
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      212. Zhang X, Hinton D, Park S, Parra B, Liao CL, Lai MM, Stohlman SA. Expression of hemagglutinin/esterase by a mouse hepatitis virus coronavirus defective-interfering RNA alters viral pathogenesis. Virology. 1998 Mar 01; 242(1):170-83. PMID: 9501044.
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      213. Hinton D, He S, Graf K, Yang D, Hsueh WA, Ryan SJ, Law RE. Mitogen-activated protein kinase activation mediates PDGF-directed migration of RPE cells. Exp Cell Res. 1998 Feb 25; 239(1):11-5. PMID: 9511719.
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      214. Hinton D, He S, Lopez PF. Apoptosis in surgically excised choroidal neovascular membranes in age-related macular degeneration. Arch Ophthalmol. 1998 Feb; 116(2):203-9. PMID: 9488273.
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      215. Chen TC, Hinton D, Zidovetzki R, Hofman FM. Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas. Lab Invest. 1998 Feb; 78(2):165-74. PMID: 9484714.
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      216. Shimon I, Hinton D, Weiss MH, Melmed S. Prolactinomas express human heparin-binding secretory transforming gene (hst) protein product: marker of tumour invasiveness. Clin Endocrinol (Oxf). 1998 Jan; 48(1):23-9. PMID: 9509064.
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      217. Zhang X, Hinton D, Park S, Liao CL, Lai MM, Stohlman S. Using a defective-interfering RNA system to express the HE protein of mouse hepatitis virus for studying viral pathogenesis. Adv Exp Med Biol. 1998; 440:521-8. PMID: 9782324.
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      218. Stohlman SA, Bergmann CC, Cua DJ, Lin MT, Ho S, Wei W, Hinton D. Apoptosis of JHMV-specific CTL in the CNS in the absence of CD4+ T cells. Adv Exp Med Biol. 1998; 440:425-30. PMID: 9782310.
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      219. Lin MT, Hinton D, Stohlman SA. Mechanisms of viral clearance in perforin-deficient mice. Adv Exp Med Biol. 1998; 440:431-6. PMID: 9782311.
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      220. Zhang W, Law RE, Hinton D, Couldwell WT. Inhibition of human malignant glioma cell motility and invasion in vitro by hypericin, a potent protein kinase C inhibitor. Cancer Lett. 1997 Nov 25; 120(1):31-8. PMID: 9570383.
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      221. Cloughesy TF, Woods RP, Black KL, Couldwell WT, Law RE, Hinton D. Prolonged treatment with biologic agents for malignant glioma: a case study with high dose tamoxifen. J Neurooncol. 1997 Oct; 35(1):39-45. PMID: 9266439.
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      222. Kimura H, Harris MS, Sakamoto T, Gopalakrishna R, Gundimeda U, Cui JZ, Spee C, Hinton D, Ryan SJ. Hypericin inhibits choroidal endothelial cell proliferation and cord formation in vitro. Curr Eye Res. 1997 Oct; 16(10):967-72. PMID: 9330847.
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      223. Chen DS, Zhu NL, Hung G, Skotzko MJ, Hinton D, Tolo V, Hall FL, Anderson WF, Gordon EM. Retroviral vector-mediated transfer of an antisense cyclin G1 construct inhibits osteosarcoma tumor growth in nude mice. Hum Gene Ther. 1997 Sep 20; 8(14):1667-74. PMID: 9322869.
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      224. LeMay DR, Sun JK, Mendel E, Hinton D, Giannotta SL. Chondromyxoid fibroma of the temporal bone. Surg Neurol. 1997 Aug; 48(2):148-52. PMID: 9242240.
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      225. Zhang X, Hinton D, Cua DJ, Stohlman SA, Lai MM. Expression of interferon-gamma by a coronavirus defective-interfering RNA vector and its effect on viral replication, spread, and pathogenicity. Virology. 1997 Jul 07; 233(2):327-38. PMID: 9217056.
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      226. Parra B, Hinton D, Lin MT, Cua DJ, Stohlman SA. Kinetics of cytokine mRNA expression in the central nervous system following lethal and nonlethal coronavirus-induced acute encephalomyelitis. Virology. 1997 Jul 07; 233(2):260-70. PMID: 9217050.
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      227. van der Veen RC, Hinton D, Incardonna F, Hofman FM. Extensive peroxynitrite activity during progressive stages of central nervous system inflammation. J Neuroimmunol. 1997 Jul; 77(1):1-7. PMID: 9209262.
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      228. Schubert CA, Kimura H, Spee C, Hinton D, Gordon EM, Anderson WF, Ryan SJ. Retrovirus-mediated transfer of the suicide gene into retinal pigment epithelial cells in vitro. Curr Eye Res. 1997 Jul; 16(7):656-62. PMID: 9222082.
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      229. Cardillo JA, Stout JT, LaBree L, Azen SP, Omphroy L, Cui JZ, Kimura H, Hinton D, Ryan SJ. Post-traumatic proliferative vitreoretinopathy. The epidemiologic profile, onset, risk factors, and visual outcome. Ophthalmology. 1997 Jul; 104(7):1166-73. PMID: 9224471.
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      230. Chen TC, Hinton D, Sippy BD, Hofman FM. Soluble TNF-alpha receptors are constitutively shed and downregulate adhesion molecule expression in malignant gliomas. J Neuropathol Exp Neurol. 1997 May; 56(5):541-50. PMID: 9143267.
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      231. Lai MM, Zhang X, Hinton D, Stohlman S. Modulation of mouse hepatitis virus infection by defective-interfering RNA-mediated expression of viral proteins and cytokines. J Neurovirol. 1997 May; 3 Suppl 1:S33-4. PMID: 9179788.
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      232. Stohlman SA, Lin M, Parra B, Bergmann CC, Hinton D. Immune regulation of coronavirus-induced demyelinating encephalomyelitis. J Neurovirol. 1997 May; 3 Suppl 1:S56-7. PMID: 9179796.
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      233. Lefkowitz MA, Hinton D, Weiss MH, Giannotta SL, Couldwell WT. Prognostic variables in surgery for skull base meningiomas. Neurosurg Focus. 1997 Apr 15; 2(4):e2. PMID: 15096006.
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      234. Chen TC, Hinton D, Yong VW, Hofman FM. TGF-B2 and soluble p55 TNFR modulate VCAM-1 expression in glioma cells and brain derived endothelial cells. J Neuroimmunol. 1997 Mar; 73(1-2):155-61. PMID: 9058771.
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      235. Yoo JS, Sakamoto T, Spee C, Kimura H, Harris MS, Hinton D, Kay EP, Ryan SJ. cis-Hydroxyproline inhibits proliferation, collagen synthesis, attachment, and migration of cultured bovine retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 1997 Feb; 38(2):520-8. PMID: 9040485.
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      236. Murata T, Kimura H, Sakamoto T, Osusky R, Spee C, Stout TJ, Hinton D, Ryan SJ. Ocular gene therapy: experimental studies and clinical possibilities. Ophthalmic Res. 1997; 29(5):242-51. PMID: 9323715.
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      237. Lin MT, Stohlman SA, Hinton D. Mouse hepatitis virus is cleared from the central nervous systems of mice lacking perforin-mediated cytolysis. J Virol. 1997 Jan; 71(1):383-91. PMID: 8985361; PMCID: PMC191062.
      238. Hinton D, Polk RK, Linse KD, Weiss MH, Kovacs K, Garner JA. Characterization of spherical amyloid protein from a prolactin-producing pituitary adenoma. Acta Neuropathol. 1997 Jan; 93(1):43-9. PMID: 9006656.
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      239. Soong NW, Dang MH, Hinton D, Arnheim N. Mitochondrial DNA deletions are rare in the free radical-rich retinal environment. Neurobiol Aging. 1996 Nov-Dec; 17(6):827-31. PMID: 9363792.
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      240. Openshaw H, Slatkin NE, Stein AS, Hinton D, Forman SJ. Acute polyneuropathy after high dose cytosine arabinoside in patients with leukemia. Cancer. 1996 Nov 01; 78(9):1899-905. PMID: 8909309.
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      241. Kovacs A, Hinton D, Wright D, Xu J, Li XL, Rasheed S, Hofman F. Human immunodeficiency virus type 1 infection of the heart in three infants with acquired immunodeficiency syndrome and sudden death. Pediatr Infect Dis J. 1996 Sep; 15(9):819-24. PMID: 8878228.
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      242. Sippy BD, Hofman FM, Wright AD, He S, Ryan SJ, Hinton D. Soluble tumor necrosis factor receptors are present in human vitreous and shed by retinal pigment epithelial cells. Exp Eye Res. 1996 Sep; 63(3):311-7. PMID: 8943704.
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      243. Hudson HL, Hinton D, Friedman DI, Apuzzo M, Chandrasoma P, Garbut M, Feldon SE. Pseudotumor associated with CNS lymphoma. J Neuroophthalmol. 1996 Sep; 16(3):208-11. PMID: 8865017.
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      244. Hamilton HB, Hinton D, Law RE, Gopalakrishna R, Su YZ, Chen ZH, Weiss MH, Couldwell WT. Inhibition of cellular growth and induction of apoptosis in pituitary adenoma cell lines by the protein kinase C inhibitor hypericin: potential therapeutic application. J Neurosurg. 1996 Aug; 85(2):329-34. PMID: 8755764.
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      245. Blanks JC, Torigoe Y, Hinton D, Blanks RH. Retinal pathology in Alzheimer's disease. I. Ganglion cell loss in foveal/parafoveal retina. Neurobiol Aging. 1996 May-Jun; 17(3):377-84. PMID: 8725899.
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      246. Sadun F, Hinton D, Sadun AA. Rapid growth of an optic nerve ganglioglioma in a patient with neurofibromatosis 1. Ophthalmology. 1996 May; 103(5):794-9. PMID: 8637690.
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      247. Zhang W, Anker L, Law RE, Hinton D, Gopalakrishna R, Pu Q, Gundimeda U, Weiss MH, Couldwell WT. Enhancement of radiosensitivity in human malignant glioma cells by hypericin in vitro. Clin Cancer Res. 1996 May; 2(5):843-6. PMID: 9816239.
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      248. Blanks JC, Schmidt SY, Torigoe Y, Porrello KV, Hinton D, Blanks RH. Retinal pathology in Alzheimer's disease. II. Regional neuron loss and glial changes in GCL. Neurobiol Aging. 1996 May-Jun; 17(3):385-95. PMID: 8725900.
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      249. Kimura H, Sakamoto T, Cardillo JA, Spee C, Hinton D, Gordon EM, Anderson WF, Ryan SJ. Retrovirus-mediated suicide gene transduction in the vitreous cavity of the eye: feasibility in prevention of proliferative vitreoretinopathy. Hum Gene Ther. 1996 May 01; 7(7):799-808. PMID: 8860832.
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      250. Lopez PF, Sippy BD, Lambert HM, Thach AB, Hinton D. Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes. Invest Ophthalmol Vis Sci. 1996 Apr; 37(5):855-68. PMID: 8603870.
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      251. Couldwell WT, Hinton D, Surnock AA, DeGiorgio CM, Weiner LP, Apuzzo ML, Masri L, Law RE, Weiss MH. Treatment of recurrent malignant gliomas with chronic oral high-dose tamoxifen. Clin Cancer Res. 1996 Apr; 2(4):619-22. PMID: 9816211.
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      252. Zhang W, Hinton D, Surnock AA, Couldwell WT. Malignant glioma sensitivity to radiotherapy, high-dose tamoxifen, and hypericin: corroborating clinical response in vitro: case report. Neurosurgery. 1996 Mar; 38(3):587-90; discussion 590-1. PMID: 8837815.
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      253. Harris MS, Sakamoto T, Kimura H, He S, Spee C, Gopalakrishna R, Gundimeda U, Yoo JS, Hinton D, Ryan SJ. Hypericin inhibits cell growth and induces apoptosis in retinal pigment epithelial cells: possible involvement of protein kinase C. Curr Eye Res. 1996 Mar; 15(3):255-62. PMID: 8654105.
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      254. Sippy BD, Hofman FM, Wright AD, Wang JL, Gopalakrishna R, Gundimeda U, He S, Ryan SJ, Hinton D. Induction of intercellular adhesion molecule-1 by tumor necrosis factor-alpha through the 55-kDa receptor is dependent on protein kinase C in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 1996 Mar; 37(4):597-606. PMID: 8595959.
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      255. Sakamoto T, Hinton D, Kimura H, Spee C, Gopalakrishna R, Ryan SJ. Vitamin E succinate inhibits proliferation and migration of retinal pigment epithelial cells in vitro: therapeutic implication for proliferative vitreoretinopathy. Graefes Arch Clin Exp Ophthalmol. 1996 Mar; 234(3):186-92. PMID: 8720718.
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      256. Couldwell WT, Stillerman CB, Rice D, Maceri D, Sherman R, Fukushima T, Hinton D. Malignant clival chordoma with postoperative cutaneous metastases. Skull Base Surg. 1996; 6(1):61-6. PMID: 17170954; PMCID: PMC1656504.
      257. Couldwell WT, Law RE, Hinton D, Gopalakrishna R, Yong VW, Weiss MH. Protein kinase C and growth regulation of pituitary adenomas. Acta Neurochir Suppl. 1996; 65:22-6. PMID: 8738488.
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      258. Sippy BD, Hofman FM, Wallach D, Hinton D. Increased expression of tumor necrosis factor-alpha receptors in the brains of patients with AIDS. J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 15; 10(5):511-21. PMID: 8548330.
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      259. Rabinowicz AL, Abrey LE, Hinton D, Couldwell WT. Cerebral neurocytoma: an unusual cause of refractory epilepsy. Case report and review of the literature. Epilepsia. 1995 Dec; 36(12):1237-40. PMID: 7489702.
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      260. Cua DJ, Hinton D, Stohlman SA. Self-antigen-induced Th2 responses in experimental allergic encephalomyelitis (EAE)-resistant mice. Th2-mediated suppression of autoimmune disease. J Immunol. 1995 Oct 15; 155(8):4052-9. PMID: 7561116.
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      261. Sakamoto T, Kimura H, Scuric Z, Spee C, Gordon EM, Hinton D, Anderson WF, Ryan SJ. Inhibition of experimental proliferative vitreoretinopathy by retroviral vector-mediated transfer of suicide gene. Can proliferative vitreoretinopathy be a target of gene therapy? Ophthalmology. 1995 Oct; 102(10):1417-24. PMID: 9097787.
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      262. Kimura H, Sakamoto T, Hinton D, Spee C, Ogura Y, Tabata Y, Ikada Y, Ryan SJ. A new model of subretinal neovascularization in the rabbit. Invest Ophthalmol Vis Sci. 1995 Sep; 36(10):2110-9. PMID: 7657549.
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      263. Pegolo G, Buckwalter JG, Weiss MH, Hinton D. Pituitary adenomas. Correlation of the cytologic appearance with biologic behavior. Acta Cytol. 1995 Sep-Oct; 39(5):887-92. PMID: 7571965.
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      264. Stohlman SA, Hinton D, Cua D, Dimacali E, Sensintaffar J, Hofman FM, Tahara SM, Yao Q. Tumor necrosis factor expression during mouse hepatitis virus-induced demyelinating encephalomyelitis. J Virol. 1995 Sep; 69(9):5898-903. PMID: 7637037; PMCID: PMC189470.
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      266. Cantin EM, Hinton D, Chen J, Openshaw H. Gamma interferon expression during acute and latent nervous system infection by herpes simplex virus type 1. J Virol. 1995 Aug; 69(8):4898-905. PMID: 7609058; PMCID: PMC189304.
      267. Cua DJ, Hinton D, Kirkman L, Stohlman SA. Macrophages regulate induction of delayed-type hypersensitivity and experimental allergic encephalomyelitis in SJL mice. Eur J Immunol. 1995 Aug; 25(8):2318-24. PMID: 7664794.
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      268. Sippy BD, Hofman FM, He S, Osusky R, Sheu SJ, Walker SM, Ryan SJ, Hinton D. SV40-immortalized and primary cultured human retinal pigment epithelial cells share similar patterns of cytokine-receptor expression and cytokine responsiveness. Curr Eye Res. 1995 Jun; 14(6):495-503. PMID: 7545567.
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      269. Murphy TL, Sakamoto T, Hinton D, Spee C, Gundimeda U, Soriano D, Gopalakrishna R, Ryan SJ. Migration of retinal pigment epithelium cells in vitro is regulated by protein kinase C. Exp Eye Res. 1995 Jun; 60(6):683-95. PMID: 7641851.
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      270. Sakamoto T, Ishibashi T, Kimura H, Yoshikawa H, Spee C, Harris MS, Hinton D, Ryan SJ. Effect of tecogalan sodium on angiogenesis in vitro by choroidal endothelial cells. Invest Ophthalmol Vis Sci. 1995 May; 36(6):1076-83. PMID: 7537258.
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      271. Rabinowicz AL, Hinton D, Dyck P, Couldwell WT. High-dose tamoxifen in treatment of brain tumors: interaction with antiepileptic drugs. Epilepsia. 1995 May; 36(5):513-5. PMID: 7614929.
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      272. Sakamoto T, Sakamoto H, Murphy TL, Spee C, Soriano D, Ishibashi T, Hinton D, Ryan SJ. Vessel formation by choroidal endothelial cells in vitro is modulated by retinal pigment epithelial cells. Arch Ophthalmol. 1995 Apr; 113(4):512-20. PMID: 7536000.
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      273. Ahmadi J, Meyers GS, Segall HD, Sharma OP, Hinton D. Lymphocytic adenohypophysitis: contrast-enhanced MR imaging in five cases. Radiology. 1995 Apr; 195(1):30-4. PMID: 7892490.
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      274. Zee CS, Chen T, Hinton D, Tan M, Segall HD, Apuzzo ML. Magnetic resonance imaging of cystic meningiomas and its surgical implications. Neurosurgery. 1995 Mar; 36(3):482-8. PMID: 7753347.
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      275. Couldwell WT, Weiss MH, Law RE, Hinton D. Paradoxical elevation of Ki-67 labeling with protein kinase inhibition in malignant gliomas. J Neurosurg. 1995 Mar; 82(3):461-8. PMID: 7861225.
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      276. Sakamoto T, Soriano D, Nassaralla J, Murphy TL, Oganesian A, Spee C, Hinton D, Ryan SJ. Effect of intravitreal administration of indomethacin on experimental subretinal neovascularization in the subhuman primate. Arch Ophthalmol. 1995 Feb; 113(2):222-6. PMID: 7864756.
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      277. Stohlman SA, Bergmann CC, van der Veen RC, Hinton D. Mouse hepatitis virus-specific cytotoxic T lymphocytes protect from lethal infection without eliminating virus from the central nervous system. J Virol. 1995 Feb; 69(2):684-94. PMID: 7815531; PMCID: PMC188629.
      278. Sakamoto T, Hinton D, Sakamoto H, Gopalakrishna R, Ryan SJ, McDonnell PJ. Thrombin induced cytoskeletal change in cultured bovine corneal endothelial cells mediated via protein kinase C pathway. Curr Eye Res. 1995 Jan; 14(1):35-45. PMID: 7720404.
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      279. Tishler DM, Weinberg KI, Hinton D, Barbaro N, Annett GM, Raffel C. MDR1 gene expression in brain of patients with medically intractable epilepsy. Epilepsia. 1995 Jan; 36(1):1-6. PMID: 8001500.
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      280. Becker LE, Hinton D. Pathogenesis of craniosynostosis. Pediatr Neurosurg. 1995; 22(2):104-7. PMID: 7710971.
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      281. Stohlman SA, Yao Q, Bergmann CC, Tahara SM, Kyuwa S, Hinton D. Transcription and translation of proinflammatory cytokines following JHMV infection. Adv Exp Med Biol. 1995; 380:173-8. PMID: 8830475.
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      282. Jones KD, Couldwell WT, Hinton D, Su Y, He S, Anker L, Law RE. Lovastatin induces growth inhibition and apoptosis in human malignant glioma cells. Biochem Biophys Res Commun. 1994 Dec 30; 205(3):1681-7. PMID: 7811252.
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      283. Chen TC, Hinton D, Leichman L, Atkinson RD, Apuzzo ML, Couldwell WT. Multifocal inflammatory leukoencephalopathy associated with levamisole and 5-fluorouracil: case report. Neurosurgery. 1994 Dec; 35(6):1138-42; discussion 1142-3. PMID: 7885561.
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      284. Gabrielian K, Osusky R, Sippy BD, Ryan SJ, Hinton D. Effect of TGF-beta on interferon-gamma-induced HLA-DR expression in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 1994 Dec; 35(13):4253-9. PMID: 8002245.
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      285. Couldwell WT, Hinton D, Law RE. Protein kinase C and growth regulation in malignant gliomas. Neurosurgery. 1994 Dec; 35(6):1184-6. PMID: 7885569.
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      286. Kureshi SA, Hofman FM, Schneider JH, Chin LS, Apuzzo ML, Hinton D. Cytokine expression in radiation-induced delayed cerebral injury. Neurosurgery. 1994 Nov; 35(5):822-9; discussion 829-30. PMID: 7838329.
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      287. Sheu SJ, Sakamoto T, Osusky R, Wang HM, Ogden TE, Ryan SJ, Hinton D, Gopalakrishna R. Transforming growth factor-beta regulates human retinal pigment epithelial cell phagocytosis by influencing a protein kinase C-dependent pathway. Graefes Arch Clin Exp Ophthalmol. 1994 Nov; 232(11):695-701. PMID: 7531168.
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      288. Hofman FM, Dohadwala MM, Wright AD, Hinton D, Walker SM. Exogenous tat protein activates central nervous system-derived endothelial cells. J Neuroimmunol. 1994 Oct; 54(1-2):19-28. PMID: 7523444.
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      289. Couldwell WT, Gopalakrishna R, Hinton D, He S, Weiss MH, Law RE, Apuzzo ML, Law RE. Hypericin: a potential antiglioma therapy. Neurosurgery. 1994 Oct; 35(4):705-9; discussion 709-10. PMID: 7808614.
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      290. Ahmadi J, Hinton D, Segall HD, Couldwell WT. Surgical implications of magnetic resonance-enhanced dura. Neurosurgery. 1994 Sep; 35(3):370-7;discussion 377. PMID: 7800128.
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      291. Ahmadi J, Savabi F, Apuzzo ML, Segall HD, Hinton D. Magnetic resonance imaging and quantitative analysis of intracranial cystic lesions: surgical implication. Neurosurgery. 1994 Aug; 35(2):199-207; discussion 207. PMID: 7969826.
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      292. Sakamoto T, Hinton D, Sakamoto H, Oganesian A, Kohen L, Gopalakrishna R, Ryan SJ. Collagen gel contraction induced by retinal pigment epithelial cells and choroidal fibroblasts involves the protein kinase C pathway. Curr Eye Res. 1994 Jun; 13(6):451-9. PMID: 7924409.
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      293. Destian S, Tung H, Gray R, Hinton D, Day J, Fukushima T. Giant infectious intracavernous carotid artery aneurysm presenting as intractable epistaxis. Surg Neurol. 1994 Jun; 41(6):472-6. PMID: 8059325.
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      294. Litofsky NS, Hinton D, Raffel C. The lack of a role for p53 in astrocytomas in pediatric patients. Neurosurgery. 1994 Jun; 34(6):967-72; discussion 972-3. PMID: 8084407.
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      295. Couldwell WT, Hinton D, He S, Chen TC, Sebat I, Weiss MH, Law RE. Protein kinase C inhibitors induce apoptosis in human malignant glioma cell lines. FEBS Lett. 1994 May 23; 345(1):43-6. PMID: 8194597.
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      296. Williams C, Hinton D, Miller CA. Somataglycan-S: a neuronal surface proteoglycan defines the spinocerebellar system. J Neurochem. 1994 Apr; 62(4):1615-30. PMID: 8133288.
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      297. He S, Wang HM, Ye J, Ogden TE, Ryan SJ, Hinton D. Dexamethasone induced proliferation of cultured retinal pigment epithelial cells. Curr Eye Res. 1994 Apr; 13(4):257-61. PMID: 8033587.
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      298. Sakamoto T, Sakamoto H, Sheu SJ, Gabrielian K, Ryan SJ, Hinton D. Intercellular gap formation induced by thrombin in confluent cultured bovine retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 1994 Feb; 35(2):720-9. PMID: 8113023.
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      299. Robinson DL, Destian S, Hinton D. Synovial sarcoma of the neck: radiographic findings with a review of the literature. Am J Otolaryngol. 1994 Jan-Feb; 15(1):46-53. PMID: 8135329.
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      300. Chin LS, Rabb CH, Hinton D, Apuzzo ML. Hemangiopericytoma of the temporal bone presenting as a retroauricular mass. Neurosurgery. 1993 Oct; 33(4):728-31; discussion 731-2. PMID: 8232815.
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      301. Ahmadi J, Hinton D, Segall HD, Couldwell WT, Stanley RB. Dural invasion by craniofacial and calvarial neoplasms: MR imaging and histopathologic evaluation. Radiology. 1993 Sep; 188(3):747-9. PMID: 8351343.
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      302. Couldwell WT, Weiss MH, DeGiorgio CM, Weiner LP, Hinton D, Ehresmann GR, Conti PS, Apuzzo ML. Clinical and radiographic response in a minority of patients with recurrent malignant gliomas treated with high-dose tamoxifen. Neurosurgery. 1993 Mar; 32(3):485-9; discussion 489-90. PMID: 8384328.
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      303. Chen TC, Hinton D, Apuzzo ML, Hofman FM. Differential effects of tumor necrosis factor-alpha on proliferation, cell surface antigen expression, and cytokine interactions in malignant gliomas. Neurosurgery. 1993 Jan; 32(1):85-94. PMID: 8093640.
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      304. Fleming JO, Wang FI, Trousdale MD, Hinton D, Stohlman SA. Interaction of immune and central nervous systems: contribution of anti-viral Thy-1+ cells to demyelination induced by coronavirus JHM. Reg Immunol. 1993 Jan-Feb; 5(1):37-43. PMID: 8102242.
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      305. Soong NW, Hinton D, Cortopassi G, Arnheim N. Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. Nat Genet. 1992 Dec; 2(4):318-23. PMID: 1303287.
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      306. Schneider J, Hofman FM, Apuzzo ML, Hinton D. Cytokines and immunoregulatory molecules in malignant glial neoplasms. J Neurosurg. 1992 Aug; 77(2):265-73. PMID: 1625016.
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      307. Liu X, Zwiebel LJ, Hinton D, Benzer S, Hall JC, Rosbash M. The period gene encodes a predominantly nuclear protein in adult Drosophila. J Neurosci. 1992 Jul; 12(7):2735-44. PMID: 1613555.
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      308. Wang FI, Hinton D, Gilmore W, Trousdale MD, Fleming JO. Sequential infection of glial cells by the murine hepatitis virus JHM strain (MHV-4) leads to a characteristic distribution of demyelination. Lab Invest. 1992 Jun; 66(6):744-54. PMID: 1318460.
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      309. Hofman FM, Hinton D. Tumor necrosis factor-alpha in the retina in acquired immune deficiency syndrome. Invest Ophthalmol Vis Sci. 1992 May; 33(6):1829-35. PMID: 1582785.
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      310. Gee MS, Kliewer KE, Hinton D. Nucleolar organizer regions in paragangliomas of the head and neck. Arch Otolaryngol Head Neck Surg. 1992 Apr; 118(4):380-3. PMID: 1554466.
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      311. Merrill JE, Kono DH, Clayton J, Ando DG, Hinton D, Hofman FM. Inflammatory leukocytes and cytokines in the peptide-induced disease of experimental allergic encephalomyelitis in SJL and B10.PL mice. Proc Natl Acad Sci U S A. 1992 Jan 15; 89(2):574-8. PMID: 1370583; PMCID: PMC48281.
      312. Levy ML, Tung H, Couldwell WT, Hinton D, Apuzzo ML. Neurosurgery, molecular medicine, and the Pandora-Panacea continuum: future implications for glioma therapy? Clin Neurosurg. 1992; 39:421-62. PMID: 1360886.
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      313. Openshaw H, Hinton D, Slatkin NE, Bierman PJ, Hoffman FM, Snyder DS. Exacerbation of inflammatory demyelinating polyneuropathy after bone marrow transplantation. Bone Marrow Transplant. 1991 May; 7(5):411-4. PMID: 1906357.
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      314. Chin LS, Hinton D. The standardized assessment of argyrophilic nucleolar organizer regions in meningeal tumors. J Neurosurg. 1991 Apr; 74(4):590-6. PMID: 1705973.
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      315. Hofman FM, Hinton D, Baemayr J, Weil M, Merrill JE. Lymphokines and immunoregulatory molecules in subacute sclerosing panencephalitis. Clin Immunol Immunopathol. 1991 Mar; 58(3):331-42. PMID: 1900461.
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      316. Blanks JC, Torigoe Y, Hinton D, Blanks RH. Retinal degeneration in the macula of patients with Alzheimer's disease. Ann N Y Acad Sci. 1991; 640:44-6. PMID: 1776758.
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      317. Boelter WD, Burt BA, Spector EB, Hinton D, Pavlova Z, Fujimoto A. Dystrophin protein and RFLP analysis for fetal diagnosis and carrier confirmation of Duchenne muscular dystrophy. Prenat Diagn. 1990 Nov; 10(11):703-15. PMID: 1980950.
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      318. Hinton D, Blanks JC, Fong HK, Casey PJ, Hildebrandt E, Simons MI. Novel localization of a G protein, Gz-alpha, in neurons of brain and retina. J Neurosci. 1990 Aug; 10(8):2763-70. PMID: 2117645.
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      319. Appley AJ, Fitzgibbons PL, Chandrasoma PT, Hinton D, Apuzzo ML. Multiparameter flow cytometric analysis of neoplasms of the central nervous system: correlation of nuclear antigen p105 and DNA content with clinical behavior. Neurosurgery. 1990 Jul; 27(1):83-96. PMID: 2377285.
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      320. Gallie BL, Squire JA, Goddard A, Dunn JM, Canton M, Hinton D, Zhu XP, Phillips RA. Mechanism of oncogenesis in retinoblastoma. Lab Invest. 1990 Apr; 62(4):394-408. PMID: 2185376.
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      321. Williams C, Kozlowski MA, Hinton D, Miller CA. Degeneration of spinocerebellar neurons in amyotrophic lateral sclerosis. Ann Neurol. 1990 Mar; 27(3):215-25. PMID: 2327732.
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      322. Hofman FM, Hinton D. Cytokine interactions in the central nervous system. Reg Immunol. 1990-1991; 3(5):268-78. PMID: 1716950.
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      323. Fleming JO, Wang FI, Trousdale MD, Hinton D, Stohlman SA. Immunopathogenesis of demyelination induced by MHV-4. Adv Exp Med Biol. 1990; 276:565-72. PMID: 1966450.
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      324. Blanks JC, Hinton D, Sadun AA, Miller CA. Retinal ganglion cell degeneration in Alzheimer's disease. Brain Res. 1989 Nov 06; 501(2):364-72. PMID: 2819446.
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      325. Hofman FM, Hinton D, Johnson K, Merrill JE. Tumor necrosis factor identified in multiple sclerosis brain. J Exp Med. 1989 Aug 01; 170(2):607-12. PMID: 2754393; PMCID: PMC2189402.
      326. Kozlowski MA, Williams C, Hinton D, Miller CA. Heterotopic neurons in spinal cord of patients with ALS. Neurology. 1989 May; 39(5):644-8. PMID: 2710354.
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      327. Hinton D, Henderson VW, Blanks JC, Rudnicka M, Miller CA. Monoclonal antibodies react with neuronal subpopulations in the human nervous system. J Comp Neurol. 1988 Jan 15; 267(3):398-408. PMID: 3343408.
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      328. Jagadha V, Halliday WC, Becker LE, Hinton D. The association of infantile osteopetrosis and neuronal storage disease in two brothers. Acta Neuropathol. 1988; 75(3):233-40. PMID: 3348081.
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      329. Miller CA, Rudnicka M, Hinton D, Blanks JC, Kozlowski M. Monoclonal antibody identification of subpopulations of cerebral cortical neurons affected in Alzheimer disease. Proc Natl Acad Sci U S A. 1987 Dec; 84(23):8657-61. PMID: 3120196; PMCID: PMC299605.
      330. Banerjee U, Renfranz PJ, Hinton D, Rabin BA, Benzer S. The sevenless+ protein is expressed apically in cell membranes of developing Drosophila retina; it is not restricted to cell R7. Cell. 1987 Oct 09; 51(1):151-8. PMID: 3115594.
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      331. Sadun AA, Borchert M, DeVita E, Hinton D, Bassi CJ. Assessment of visual impairment in patients with Alzheimer's disease. Am J Ophthalmol. 1987 Aug 15; 104(2):113-20. PMID: 3618708.
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      332. Hinton D, Coope PA, Malpress WA, Janus ED. Trends in blood lead levels in Christchurch (NZ) and environs 1978-85. J Epidemiol Community Health. 1986 Sep; 40(3):244-8. PMID: 3772282; PMCID: PMC1052532.
      333. Hinton D, Sadun AA, Blanks JC, Miller CA. Optic-nerve degeneration in Alzheimer's disease. N Engl J Med. 1986 Aug 21; 315(8):485-7. PMID: 3736630.
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      334. Hofman FM, von Hanwehr RI, Dinarello CA, Mizel SB, Hinton D, Merrill JE. Immunoregulatory molecules and IL 2 receptors identified in multiple sclerosis brain. J Immunol. 1986 May 01; 136(9):3239-45. PMID: 3082983.
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      335. Malpress WA, Janus ED, Hinton D. Blood lead levels in the New Zealand population: preliminary communication. N Z Med J. 1984 Dec 12; 97(769):868-9. PMID: 6595572.
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      336. Muakkassa KF, Hoffman HJ, Hinton D, Hendrick EB, Humphreys RP, Ash J. Lambdoid synostosis. Part 2: Review of cases managed at The Hospital for Sick Children, 1972-1982. J Neurosurg. 1984 Aug; 61(2):340-7. PMID: 6737059.
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      337. Hinton D, Becker LE, Muakkassa KF, Hoffman HJ. Lambdoid synostosis. Part 1. The lambdoid suture: normal development and pathology of "synostosis". J Neurosurg. 1984 Aug; 61(2):333-9. PMID: 6737058.
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      338. Hinton D, Halliday WC. Primary rhabdomyosarcoma of the cerebellum--a light, electron microscopic, and immunohistochemical study. J Neuropathol Exp Neurol. 1984 Jul; 43(4):439-49. PMID: 6737010.
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      339. Hinton D, Dolan E, Sima AA. The value of histopathological examination of surgically removed blood clot in determining the etiology of spontaneous intracerebral hemorrhage. Stroke. 1984 May-Jun; 15(3):517-20. PMID: 6729882.
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      340. Perry TL, Kish SJ, Hinton D, Hansen S, Becker LE, Gelfand EW. Neurochemical abnormalities in a patient with ataxia-telangiectasia. Neurology. 1984 Feb; 34(2):187-91. PMID: 6320055.
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      341. Sima AA, Hinton D. Hirano-bodies in the distal symmetric polyneuropathy of the spontaneously diabetic BB-Wistar rat. Acta Neurol Scand. 1983 Aug; 68(2):107-12. PMID: 6314728.
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      342. Hinton D, Mobbs EG, Sima AA, Hanna W. Steroid receptors in meningiomas. A histochemical and biochemical study. Acta Neuropathol. 1983; 62(1-2):134-40. PMID: 6659871.
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