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    David R. Freyer, DO

    TitleProfessor of Clinical Pediatrics
    SchoolKeck School of Medicine of USC
    DepartmentPediatrics
    AddressCHL Mail Stop 54
    Off Campus
    Los Angeles California 90089
    Phone+1 323 361 8953
    vCardDownload vCard

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      Dr. David Freyer joined Children's Hospital Los Angeles in January 2008. As Director of the LIFE Program, he oversees all aspects of its services, which include clinical assessments of more than 350 patients annually, research regarding their long-term outcomes, and training of fellows, residents, and other health care professionals in the care of childhood cancer survivors. His clinical and research activities have focused principally on cancer survivorship and cancer control, including the recognition, management and prevention of short-and long-term morbidity of treatment, as well as health care transition for young adult survivors of childhood cancer, adolescent and young adult (AYA) oncology, palliative care, and decision-making at the end of life. Dr. Freyer is a member of the Children's Oncology Group where he serves as chair of the AYA Committee, on the Steering Committees for the Survivorship & Outcomes and Cancer Control Committees, and on several protocol and administrative committees. Dr. Freyer graduated magna cum laude from DePauw University, obtained his medical degree from the Des Moines University College of Osteopathic Medicine and Surgery, and completed post-graduate medical training at Chicago College of Osteopathic Medicine and Hospitals, Rush University Medical Center and the University of Michigan Medical Center. In 2007, he obtained a MS degree in Clinical Research Design and Statistical Analysis from the University of Michigan School of Public Health.


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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Pinheiro LC, McFatrich M, Lucas N, Walker JS, Withycombe JS, Hinds PS, Sung L, Tomlinson D, Freyer D, Mack JW, Baker JN, Reeve BB. Child and adolescent self-report symptom measurement in pediatric oncology research: a systematic literature review. Qual Life Res. 2017 Sep 06. PMID: 28879501.
        View in: PubMed
      2. Sadak KT, Neglia JP, Freyer D, Harwood E. Identifying metrics of success for transitional care practices in childhood cancer survivorship: A qualitative study of survivorship providers. Pediatr Blood Cancer. 2017 Nov; 64(11). PMID: 28557375.
        View in: PubMed
      3. Cochrane AM, Cheung C, Rangan K, Freyer D, Nahata L, Dhall G, Finlay JL. Long-term follow-up of endocrine function among young children with newly diagnosed malignant central nervous system tumors treated with irradiation-avoiding regimens. Pediatr Blood Cancer. 2017 Nov; 64(11). PMID: 28475292.
        View in: PubMed
      4. Orgel E, Mueske NM, Sposto R, Gilsanz V, Wren TAL, Freyer D, Butturini AM, Mittelman SD. A randomized controlled trial testing an adherence-optimized Vitamin D regimen to mitigate bone change in adolescents being treated for acute lymphoblastic leukemia. Leuk Lymphoma. 2017 Oct; 58(10):2370-2378. PMID: 28278717.
        View in: PubMed
      5. Reeve BB, McFatrich M, Pinheiro LC, Freyer D, Basch EM, Baker JN, Withycombe JS, Sung L, Mack JW, Waldron MK, Mowbray C, Palma D, Hinds PS. Cognitive Interview-Based Validation of the Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events in Adolescents with Cancer. J Pain Symptom Manage. 2017 Apr; 53(4):759-766. PMID: 28062347.
        View in: PubMed
      6. Freyer D, Chen L, Krailo MD, Knight K, Villaluna D, Bliss B, Pollock BH, Ramdas J, Lange B, Van Hoff D, VanSoelen ML, Wiernikowski J, Neuwelt EA, Sung L. Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): a multicentre, randomised, controlled, open-label, phase 3 trial. Lancet Oncol. 2017 Jan; 18(1):63-74. PMID: 27914822.
        View in: PubMed
      7. Bava L, Johns A, Freyer D, Ruccione K. Development of a Culturally Competent Service to Improve Academic Functioning for Latino Survivors of Acute Lymphoblastic Leukemia: Methodological Considerations. J Pediatr Oncol Nurs. 2017 May/Jun; 34(3):222-229. PMID: 27889691.
        View in: PubMed
      8. Reeve BB, McFatrich M, Pinheiro LC, Weaver MS, Sung L, Withycombe JS, Baker JN, Mack JW, Waldron MK, Gibson D, Tomlinson D, Freyer D, Mowbray C, Jacobs S, Palma D, Martens CE, Gold SH, Jackson KD, Hinds PS. Eliciting the child's voice in adverse event reporting in oncology trials: Cognitive interview findings from the Pediatric Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events initiative. Pediatr Blood Cancer. 2017 Mar; 64(3). PMID: 27650708.
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      9. Miller KA, Wojcik KY, Ramirez CN, Ritt-Olson A, Freyer D, Hamilton AS, Milam JE. Supporting long-term follow-up of young adult survivors of childhood cancer: Correlates of healthcare self-efficacy. Pediatr Blood Cancer. 2017 Feb; 64(2):358-363. PMID: 27567026.
        View in: PubMed
      10. Bava L, Malvar J, Sposto R, Okada M, Gonzalez-Morkos B, Schweers LM, Nuñez C, Ruccione K, Katz ER, Freyer D. A parent-directed intervention for addressing academic risk in Latino survivors of childhood leukemia: results of a pilot study. Psychooncology. 2016 Oct; 25(10):1246-1249. PMID: 27271226.
        View in: PubMed
      11. Ater JL, Xia C, Mazewski CM, Booth TN, Freyer D, Packer RJ, Sposto R, Vezina G, Pollack IF. Nonrandomized comparison of neurofibromatosis type 1 and non-neurofibromatosis type 1 children who received carboplatin and vincristine for progressive low-grade glioma: A report from the Children's Oncology Group. Cancer. 2016 06 15; 122(12):1928-36. PMID: 27061921; PMCID: PMC4892942 [Available on 06/15/17].
      12. Roth ME, O'Mara AM, Seibel NL, Dickens DS, Langevin AM, Pollock BH, Freyer D. Low Enrollment of Adolescents and Young Adults Onto Cancer Trials: Insights From the Community Clinical Oncology Program. J Oncol Pract. 2016 Apr; 12(4):e388-95. PMID: 27026648; PMCID: PMC4960459 [Available on 01/01/17].
      13. Smith AW, Seibel NL, Lewis DR, Albritton KH, Blair DF, Blanke CD, Bleyer WA, Freyer D, Geiger AM, Hayes-Lattin B, Tricoli JV, Wagner LI, Zebrack BJ. Next steps for adolescent and young adult oncology workshop: An update on progress and recommendations for the future. Cancer. 2016 Apr 01; 122(7):988-99. PMID: 26849003.
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      14. Orgel E, Mueske NM, Sposto R, Gilsanz V, Freyer D, Mittelman SD. Limitations of body mass index to assess body composition due to sarcopenic obesity during leukemia therapy. Leuk Lymphoma. 2018 Jan; 59(1):138-145. PMID: 26818609.
        View in: PubMed
      15. Okada M, Hockenberry MJ, Koh CJ, Meeske KA, Rangan KE, Rodgers C, Rosenthal Y, Ruccione KS, Freyer D. Reconsidering Physical Activity Restrictions for Mononephric Survivors of Childhood Cancer: A Report From the Children's Oncology Group. J Pediatr Oncol Nurs. 2016 Jul; 33(4):306-13. PMID: 26589357.
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      16. Orgel E, O'Neil SH, Kayser K, Smith B, Softley TL, Sherman-Bien S, Counts PA, Murphy D, Dhall G, Freyer D. Effect of Sensorineural Hearing Loss on Neurocognitive Functioning in Pediatric Brain Tumor Survivors. Pediatr Blood Cancer. 2016 Mar; 63(3):527-34. PMID: 26529035; PMCID: PMC4724248 [Available on 03/01/17].
      17. Collins CL, Malvar J, Hamilton AS, Deapen DM, Freyer D. Case-linked analysis of clinical trial enrollment among adolescents and young adults at a National Cancer Institute-designated comprehensive cancer center. Cancer. 2015 Dec 15; 121(24):4398-406. PMID: 26393950.
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      18. Milam J, Slaughter R, Meeske K, Ritt-Olson A, Sherman-Bien S, Freyer D, Kuperberg A, Hamilton AS. Substance use among adolescent and young adult cancer survivors. Psychooncology. 2016 Nov; 25(11):1357-1362. PMID: 26315824.
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      19. Reitman AJ, Coates TD, Freyer D. Early Cardiac Iron Overload in a Child on Treatment of Acute Lymphoblastic Leukemia. Pediatrics. 2015 Sep; 136(3):e697-700. PMID: 26283784.
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      20. Meeske KA, Ji L, Freyer D, Gaynon P, Ruccione K, Butturini A, Avramis VI, Siegel S, Matloub Y, Seibel NL, Sposto R. Comparative Toxicity by Sex Among Children Treated for Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group. Pediatr Blood Cancer. 2015 Dec; 62(12):2140-9. PMID: 26173904; PMCID: PMC4624005 [Available on 12/01/16].
      21. Weiss AR, Nichols CR, Freyer D. Enhancing Adolescent and Young Adult Oncology Research Within the National Clinical Trials Network: Rationale, Progress, and Emerging Strategies. Semin Oncol. 2015 Oct; 42(5):740-7. PMID: 26433555; PMCID: PMC4604069 [Available on 10/01/16].
      22. Chow EJ, Asselin BL, Schwartz CL, Doody DR, Leisenring WM, Aggarwal S, Baker KS, Bhatia S, Constine LS, Freyer D, Lipshultz SE, Armenian SH. Late Mortality After Dexrazoxane Treatment: A Report From the Children's Oncology Group. J Clin Oncol. 2015 Aug 20; 33(24):2639-45. PMID: 26014292; PMCID: PMC4534526.
      23. Weiss AR, Hayes-Lattin B, Kutny MA, Stock W, Stegenga K, Freyer D. Inclusion of Adolescents and Young Adults in Cancer Clinical Trials. Semin Oncol Nurs. 2015 Aug; 31(3):197-205. PMID: 26210198.
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      24. Lin MH, Wood JR, Mittelman SD, Freyer D. Institutional adherence to cardiovascular risk factor screening guidelines for young survivors of acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 2015 May; 37(4):e253-7. PMID: 25757021.
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      25. Puhalla S, Elmquist W, Freyer D, Kleinberg L, Adkins C, Lockman P, McGregor J, Muldoon L, Nesbit G, Peereboom D, Smith Q, Walker S, Neuwelt E. Unsanctifying the sanctuary: challenges and opportunities with brain metastases. Neuro Oncol. 2015 May; 17(5):639-51. PMID: 25846288; PMCID: PMC4482864.
      26. Orgel E, Tucci J, Alhushki W, Malvar J, Sposto R, Fu CH, Freyer D, Abdel-Azim H, Mittelman SD. Obesity is associated with residual leukemia following induction therapy for childhood B-precursor acute lymphoblastic leukemia. Blood. 2014 Dec 18; 124(26):3932-8. PMID: 25349177.
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      27. Milam JE, Meeske K, Slaughter RI, Sherman-Bien S, Ritt-Olson A, Kuperberg A, Freyer D, Hamilton AS. Cancer-related follow-up care among Hispanic and non-Hispanic childhood cancer survivors: The Project Forward study. Cancer. 2015 Feb 15; 121(4):605-13. PMID: 25345867; PMCID: PMC4319982.
      28. Ruccione KS, Wood JC, Sposto R, Malvar J, Chen C, Freyer D. Characterization of transfusion-derived iron deposition in childhood cancer survivors. Cancer Epidemiol Biomarkers Prev. 2014 Sep; 23(9):1913-9. PMID: 24962841.
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      29. Armenian SH, Gelehrter SK, Vase T, Venkatramani R, Landier W, Wilson KD, Herrera C, Reichman L, Menteer JD, Mascarenhas L, Freyer D, Venkataraman K, Bhatia S. Screening for cardiac dysfunction in anthracycline-exposed childhood cancer survivors. Clin Cancer Res. 2014 Dec 15; 20(24):6314-23. PMID: 24947931; PMCID: PMC4268342.
      30. Armenian SH, Gelehrter SK, Vase T, Venkatramani R, Landier W, Wilson KD, Herrera C, Reichman L, Menteer JD, Mascarenhas L, Freyer D, Venkataraman K, Bhatia S. Carnitine and cardiac dysfunction in childhood cancer survivors treated with anthracyclines. Cancer Epidemiol Biomarkers Prev. 2014 Jun; 23(6):1109-14. PMID: 24718281; PMCID: PMC4053243.
      31. Orgel E, Sposto R, Malvar J, Seibel NL, Ladas E, Gaynon PS, Freyer D. Impact on survival and toxicity by duration of weight extremes during treatment for pediatric acute lymphoblastic leukemia: A report from the Children's Oncology Group. J Clin Oncol. 2014 May 01; 32(13):1331-7. PMID: 24687836; PMCID: PMC3992723.
      32. Goldfarb M, Freyer D. Comparison of secondary and primary thyroid cancer in adolescents and young adults. Cancer. 2014 Apr 15; 120(8):1155-61. PMID: 24615715.
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      33. Venkatramani R, Kamath S, Wong K, Olch AJ, Malvar J, Sposto R, Goodarzian F, Freyer D, Keens TG, Mascarenhas L. Pulmonary outcomes in patients with Hodgkin lymphoma treated with involved field radiation. Pediatr Blood Cancer. 2014 Jul; 61(7):1277-81. PMID: 24482138.
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      34. Vanhoff D, Hesser T, Kelly KP, Freyer D, Stork S, Sung L. Facilitating accrual to cancer control and supportive care trials: the clinical research associate perspective. BMC Med Res Methodol. 2013 Dec 31; 13:154. PMID: 24380578; PMCID: PMC3897981.
      35. Canner J, Alonzo TA, Franklin J, Freyer D, Gamis A, Gerbing RB, Lange BJ, Meshinchi S, Woods WG, Perentesis J, Horan J. Differences in outcomes of newly diagnosed acute myeloid leukemia for adolescent/young adult and younger patients: a report from the Children's Oncology Group. Cancer. 2013 Dec 01; 119(23):4162-9. PMID: 24104395; PMCID: PMC4398142.
      36. Isakoff MS, Freyer D, Bleyer A. Young adults with acute lymphoblastic leukemia treated with a pediatric-inspired regimen do not need a bone marrow transplant in first remission. Blood. 2013 Jun 27; 121(26):5253-5. PMID: 23813939.
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      37. Venkatramani R, Kamath S, Wong K, Olch AJ, Malvar J, Sposto R, Goodarzian F, Freyer D, Keens TG, Mascarenhas L. Correlation of clinical and dosimetric factors with adverse pulmonary outcomes in children after lung irradiation. Int J Radiat Oncol Biol Phys. 2013 Aug 01; 86(5):942-8. PMID: 23726005.
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      38. Orgel E, Zung L, Ji L, Finklestein J, Feusner J, Freyer D. Early cardiac outcomes following contemporary treatment for childhood acute myeloid leukemia: a North American perspective. Pediatr Blood Cancer. 2013 Sep; 60(9):1528-33. PMID: 23441080.
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      39. Reeve BB, Withycombe JS, Baker JN, Hooke MC, Lyons JC, Mowbray C, Wang J, Freyer D, Joffe S, Sung L, Tomlinson D, Gold SH, Hinds PS. The first step to integrating the child's voice in adverse event reporting in oncology trials: a content validation study among pediatric oncology clinicians. Pediatr Blood Cancer. 2013 Jul; 60(7):1231-6. PMID: 23335328.
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      40. Freyer D, Felgenhauer J, Perentesis J. Children's Oncology Group's 2013 blueprint for research: adolescent and young adult oncology. Pediatr Blood Cancer. 2013 Jun; 60(6):1055-8. PMID: 23424167; PMCID: PMC4604044.
      41. Okada M, Meeske KA, Menteer J, Freyer D. Exercise recommendations for childhood cancer survivors exposed to cardiotoxic therapies: an institutional clinical practice initiative. J Pediatr Oncol Nurs. 2012 Sep-Oct; 29(5):246-52. PMID: 22907680.
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      42. Ater JL, Zhou T, Holmes E, Mazewski CM, Booth TN, Freyer D, Lazarus KH, Packer RJ, Prados M, Sposto R, Vezina G, Wisoff JH, Pollack IF. Randomized study of two chemotherapy regimens for treatment of low-grade glioma in young children: a report from the Children's Oncology Group. J Clin Oncol. 2012 Jul 20; 30(21):2641-7. PMID: 22665535; PMCID: PMC3413276.
      43. Brock PR, Knight KR, Freyer D, Campbell KC, Steyger PS, Blakley BW, Rassekh SR, Chang KW, Fligor BJ, Rajput K, Sullivan M, Neuwelt EA. Platinum-induced ototoxicity in children: a consensus review on mechanisms, predisposition, and protection, including a new International Society of Pediatric Oncology Boston ototoxicity scale. J Clin Oncol. 2012 Jul 01; 30(19):2408-17. PMID: 22547603; PMCID: PMC3675696.
      44. Ruccione KS, Mudambi K, Sposto R, Fridey J, Ghazarossian S, Freyer D. Association of projected transfusional iron burden with treatment intensity in childhood cancer survivors. Pediatr Blood Cancer. 2012 Oct; 59(4):697-702. PMID: 22190481.
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      45. Eshelman-Kent D, Kinahan KE, Hobbie W, Landier W, Teal S, Friedman D, Nagarajan R, Freyer D. Cancer survivorship practices, services, and delivery: a report from the Children's Oncology Group (COG) nursing discipline, adolescent/young adult, and late effects committees. J Cancer Surviv. 2011 Dec; 5(4):345-57. PMID: 21894490; PMCID: PMC4528909.
      46. Orgel E, Jain S, Ji L, Pollick L, Si S, Finlay J, Freyer D. Hearing loss among survivors of childhood brain tumors treated with an irradiation-sparing approach. Pediatr Blood Cancer. 2012 Jun; 58(6):953-8. PMID: 21796767.
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      47. Freyer D, Devidas M, La M, Carroll WL, Gaynon PS, Hunger SP, Seibel NL. Postrelapse survival in childhood acute lymphoblastic leukemia is independent of initial treatment intensity: a report from the Children's Oncology Group. Blood. 2011 Mar 17; 117(11):3010-5. PMID: 21193696; PMCID: PMC3062307.
      48. Freyer D. Transition of care for young adult survivors of childhood and adolescent cancer: rationale and approaches. J Clin Oncol. 2010 Nov 10; 28(32):4810-8. PMID: 20351333; PMCID: PMC3018346.
      49. Nachman JB, La MK, Hunger SP, Heerema NA, Gaynon PS, Hastings C, Mattano LA, Sather H, Devidas M, Freyer D, Steinherz PG, Seibel NL. Young adults with acute lymphoblastic leukemia have an excellent outcome with chemotherapy alone and benefit from intensive postinduction treatment: a report from the children's oncology group. J Clin Oncol. 2009 Nov 01; 27(31):5189-94. PMID: 19805689; PMCID: PMC3053149.
      50. Nicolino M, Byrne B, Wraith JE, Leslie N, Mandel H, Freyer D, Arnold GL, Pivnick EK, Ottinger CJ, Robinson PH, Loo JC, Smitka M, Jardine P, Tatò L, Chabrol B, McCandless S, Kimura S, Mehta L, Bali D, Skrinar A, Morgan C, Rangachari L, Corzo D, Kishnani PS. Clinical outcomes after long-term treatment with alglucosidase alfa in infants and children with advanced Pompe disease. Genet Med. 2009 Mar; 11(3):210-9. PMID: 19287243.
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      51. Freyer D, Sung L, Reaman GH. Prevention of hearing loss in children receiving cisplatin chemotherapy. J Clin Oncol. 2009 Jan 10; 27(2):317-8; author reply 318-9. PMID: 19064953.
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      52. Couluris M, Mayer JL, Freyer D, Sandler E, Xu P, Krischer JP. The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia. J Pediatr Hematol Oncol. 2008 Nov; 30(11):791-7. PMID: 18989154; PMCID: PMC2917791.
      53. Freyer D, Brugieres L. Adolescent and young adult oncology: transition of care. Pediatr Blood Cancer. 2008 May; 50(5 Suppl):1116-9. PMID: 18360840.
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      54. Seibel NL, Steinherz PG, Sather HN, Nachman JB, Delaat C, Ettinger LJ, Freyer D, Mattano LA, Hastings CA, Rubin CM, Bertolone K, Franklin JL, Heerema NA, Mitchell TL, Pyesmany AF, La MK, Edens C, Gaynon PS. Early postinduction intensification therapy improves survival for children and adolescents with high-risk acute lymphoblastic leukemia: a report from the Children's Oncology Group. Blood. 2008 Mar 01; 111(5):2548-55. PMID: 18039957; PMCID: PMC2254538.
      55. Freyer D. Measuring the impact of dexrazoxane cardioprotection. Pediatr Blood Cancer. 2007 Apr; 48(4):483-4; author reply 485. PMID: 16767713.
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      56. Freyer D, Kibrick-Lazear R. In sickness and in health: transition of cancer-related care for older adolescents and young adults. Cancer. 2006 Oct 01; 107(7 Suppl):1702-9. PMID: 16921480.
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      57. Freyer D, Kuperberg A, Sterken DJ, Pastyrnak SL, Hudson D, Richards T. Multidisciplinary care of the dying adolescent. Child Adolesc Psychiatr Clin N Am. 2006 Jul; 15(3):693-715. PMID: 16797445.
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      58. Friedman DL, Freyer D, Levitt GA. Models of care for survivors of childhood cancer. Pediatr Blood Cancer. 2006 Feb; 46(2):159-68. PMID: 16369920.
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      59. Freyer D, Gowans LK, Warzynski M, Lee WI. Flow cytometric diagnosis of X-linked hyper-IgM syndrome: application of an accurate and convenient procedure. J Pediatr Hematol Oncol. 2004 Jun; 26(6):363-70. PMID: 15167349.
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      60. Freyer D. Care of the dying adolescent: special considerations. Pediatrics. 2004 Feb; 113(2):381-8. PMID: 14754953.
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      61. Schlatter M, Snyder K, Freyer D. Successful nonoperative management of typhlitis in pediatric oncology patients. J Pediatr Surg. 2002 Aug; 37(8):1151-5. PMID: 12149691.
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