Loading...
Sign in to edit your profile (add interests, mentoring, photo, etc.)

    Curtis Toshio Okamoto, PhD

    TitleAssociate Professor of Pharmacology and Pharmaceutical Sciences
    SchoolSchool of Pharmacy
    DepartmentPharmacology and Pharmaceutical Sciences
    AddressPSC 404A
    Health Sciences Campus
    Los Angeles California 90089-9121
    Phone+1 323 442 3939
    Emailcokamoto@usc.edu
    vCardDownload vCard

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Okamoto C. Regulation of Transporters and Channels by Membrane-Trafficking Complexes in Epithelial Cells. Cold Spring Harb Perspect Biol. 2017 Feb 28. PMID: 28246186.
        View in: PubMed
      2. Zhou L, Wang HY, Tong S, Okamoto C, Shen WC, Zaro JL. Single chain Fc-dimer-human growth hormone fusion protein for improved drug delivery. Biomaterials. 2016 Nov 27; 117:24-31. PMID: 27923197.
        View in: PubMed
      3. Meng Z, Edman MC, Hsueh PY, Chen CY, Klinngam W, Tolmachova T, Okamoto C, Hamm-Alvarez SF. Imbalanced Rab3D versus Rab27 increases cathepsin S secretion from lacrimal acini in a mouse model of Sjögren's Syndrome. Am J Physiol Cell Physiol. 2016 Jun 1; 310(11):C942-54. PMID: 27076615.
        View in: PubMed
      4. Pastuszka MK, Okamoto C, Hamm-Alvarez SF, MacKay JA. Flipping the Switch on Clathrin-Mediated Endocytosis using Thermally Responsive Protein Microdomains. Adv Funct Mater. 2014 Sep 10; 24(34):5340-5347. PMID: 25419208.
        View in: PubMed
      5. Natarajan P, Crothers JM, Rosen JE, Nakada SL, Rakholia M, Okamoto C, Forte JG, Machen TE. Myosin IIB and F-actin control apical vacuolar morphology and histamine-induced trafficking of H-K-ATPase-containing tubulovesicles in gastric parietal cells. Am J Physiol Gastrointest Liver Physiol. 2014 Apr; 306(8):G699-710. PMID: 24578340.
        View in: PubMed
      6. Okamoto C. Don't wanna be Obama (all by my) self: Rab11a is involved in sequestration of fluid-phase cargo from membrane cargo. Focus on "Rab11a-positive compartments in proximal tubule cells sort fluid-phase and membrane cargo". Am J Physiol Cell Physiol. 2014 Mar; 306(5):C428-30. PMID: 24429065.
        View in: PubMed
      7. Gleason BL, Siracuse MV, Moniri NH, Birnie CR, Okamoto C, Crouch MA. Evolution of preprofessional pharmacy curricula. Am J Pharm Educ. 2013 Jun 12; 77(5):95. PMID: 23788806.
        View in: PubMed
      8. Xu S, Ma L, Evans E, Okamoto C, Hamm-Alvarez SF. Polymeric immunoglobulin receptor traffics through two distinct apically targeted pathways in primary lacrimal gland acinar cells. J Cell Sci. 2013 Jun 15; 126(Pt 12):2704-17. PMID: 23606742.
        View in: PubMed
      9. Lacruz RS, Brookes SJ, Wen X, Jimenez JM, Vikman S, Hu P, White SN, Lyngstadaas SP, Okamoto C, Smith CE, Paine ML. Adaptor protein complex 2-mediated, clathrin-dependent endocytosis, and related gene activities, are a prominent feature during maturation stage amelogenesis. J Bone Miner Res. 2013 Mar; 28(3):672-87. PMID: 23044750.
        View in: PubMed
      10. Machen T, Okamoto C, Chew C, Goldenring JR. John Gaetano Forte, PhD. Gastroenterology. 2013 Mar; 144(3):471-3. PMID: 23352594.
        View in: PubMed
      11. Okamoto C. Caring about the other 47% of the water channels. Focus on "Basolateral targeting and microtubule-dependent transcytosis of the aquaporin-2 water channel". Am J Physiol Cell Physiol. 2013 Jan 1; 304(1):C33-5. PMID: 23135701.
        View in: PubMed
      12. Pastuszka MK, Janib SM, Weitzhandler I, Okamoto C, Hamm-Alvarez S, Mackay JA. A tunable and reversible platform for the intracellular formation of genetically engineered protein microdomains. Biomacromolecules. 2012 Nov 12; 13(11):3439-44. PMID: 23088632.
        View in: PubMed
      13. Xu S, Olenyuk BZ, Okamoto C, Hamm-Alvarez SF. Targeting receptor-mediated endocytotic pathways with nanoparticles: Rationale and advances. Adv Drug Deliv Rev. 2012 Sep 29. PMID: 23026636.
        View in: PubMed
      14. Xu S, Edman M, Kothawala MS, Sun G, Chiang L, Mircheff A, Zhu L, Okamoto C, Hamm-Alvarez S. A Rab11a-enriched subapical membrane compartment regulates a cytoskeleton-dependent transcytotic pathway in secretory epithelial cells of the lacrimal gland. J Cell Sci. 2011 Oct 15; 124(Pt 20):3503-14. PMID: 21984810.
        View in: PubMed
      15. Suda J, Zhu L, Okamoto C, Karvar S. Rab27b localizes to the tubulovesicle membranes of gastric parietal cells and regulates acid secretion. Gastroenterology. 2011 Mar; 140(3):868-78. PMID: 20888820.
        View in: PubMed
      16. Okamoto C. Duodenal epithelial cells provide a stimulus package for the recovery from an acid load. J Physiol. 2009 Jul 15; 587(Pt 14):3409. PMID: 19602628.
        View in: PubMed
      17. Evans E, Zhang W, Jerdeva G, Chen CY, Chen X, Hamm-Alvarez SF, Okamoto C. Direct interaction between Rab3D and the polymeric immunoglobulin receptor and trafficking through regulated secretory vesicles in lacrimal gland acinar cells. Am J Physiol Cell Physiol. 2008 Mar; 294(3):C662-74. PMID: 18171724.
        View in: PubMed
      18. Zou Y, Wang H, Shapiro JL, Okamoto C, Brookes SJ, Lyngstadaas SP, Snead ML, Paine ML. Determination of protein regions responsible for interactions of amelogenin with CD63 and LAMP1. Biochem J. 2007 Dec 15; 408(3):347-54. PMID: 17708745.
        View in: PubMed
      19. Shapiro JL, Wen X, Okamoto C, Wang HJ, Lyngstadaas SP, Goldberg M, Snead ML, Paine ML. Cellular uptake of amelogenin, and its localization to CD63, and Lamp1-positive vesicles. Cell Mol Life Sci. 2007 Jan; 64(2):244-56. PMID: 17187173.
        View in: PubMed
      20. Zaro JL, Rajapaksa TE, Okamoto C, Shen WC. Membrane transduction of oligoarginine in HeLa cells is not mediated by macropinocytosis. Mol Pharm. 2006 Mar-Apr; 3(2):181-6. PMID: 16579647.
        View in: PubMed
      21. Zhang N, Kannan R, Okamoto C, Ryan SJ, Lee VH, Hinton DR. Characterization of brimonidine transport in retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2006 Jan; 47(1):287-94. PMID: 16384975.
        View in: PubMed
      22. Jerdeva GV, Yarber FA, Trousdale MD, Rhodes CJ, Okamoto C, Dartt DA, Hamm-Alvarez SF. Dominant-negative PKC-epsilon impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini. Am J Physiol Cell Physiol. 2005 Oct; 289(4):C1052-68. PMID: 15930141.
        View in: PubMed
      23. Wen X, Lei YP, Zhou YL, Okamoto C, Snead ML, Paine ML. Structural organization and cellular localization of tuftelin-interacting protein 11 (TFIP11). Cell Mol Life Sci. 2005 May; 62(9):1038-46. PMID: 15868102.
        View in: PubMed
      24. Chew CS, Okamoto C, Chen X, Thomas R. Drebrin E2 is differentially expressed and phosphorylated in parietal cells in the gastric mucosa. Am J Physiol Gastrointest Liver Physiol. 2005 Aug; 289(2):G320-31. PMID: 15790763.
        View in: PubMed
      25. Chu C, Okamoto C, Hamm-Alvarez SF, Lee VH. Stable transfection of MDCK cells with epitope-tagged human PepT1. Pharm Res. 2004 Nov; 21(11):1970-3. PMID: 15587917.
        View in: PubMed
      26. Chew CS, Okamoto C, Chen X, Qin HY. IQGAPs are differentially expressed and regulated in polarized gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2005 Feb; 288(2):G376-87. PMID: 15458922.
        View in: PubMed
      27. da Costa SR, Okamoto C, Hamm-Alvarez SF. Actin microfilaments et al.--the many components, effectors and regulators of epithelial cell endocytosis. Adv Drug Deliv Rev. 2003 Nov 14; 55(11):1359-83. PMID: 14597136.
        View in: PubMed
      28. Da Costa SR, Sou E, Xie J, Yarber FA, Okamoto C, Pidgeon M, Kessels MM, Mircheff AK, Schechter JE, Qualmann B, Hamm-Alvarez SF. Impairing actin filament or syndapin functions promotes accumulation of clathrin-coated vesicles at the apical plasma membrane of acinar epithelial cells. Mol Biol Cell. 2003 Nov; 14(11):4397-413. PMID: 12937279.
        View in: PubMed
      29. Chew CS, Chen X, Parente JA, Tarrer S, Okamoto C, Qin HY. Lasp-1 binds to non-muscle F-actin in vitro and is localized within multiple sites of dynamic actin assembly in vivo. J Cell Sci. 2002 Dec 15; 115(Pt 24):4787-99. PMID: 12432067.
        View in: PubMed
      30. Okamoto C. From genetics to cellular physiology. Focus on "Regulation of transferrin-induced endocytosis by wild-type and C282Y-mutant HFE in transfected HeLa cells". Am J Physiol Cell Physiol. 2002 May; 282(5):C971-2. PMID: 11940509.
        View in: PubMed
      31. Schechter J, Stevenson D, Chang D, Chang N, Pidgeon M, Nakamura T, Okamoto C, Trousdale MD, Mircheff AK. Growth of purified lacrimal acinar cells in Matrigel raft cultures. Exp Eye Res. 2002 Mar; 74(3):349-60. PMID: 12014916.
        View in: PubMed
      32. Okamoto C, Li R, Zhang Z, Jeng YY, Chew CS. Regulation of protein and vesicle trafficking at the apical membrane of epithelial cells. J Control Release. 2002 Jan 17; 78(1-3):35-41. PMID: 11772447.
        View in: PubMed
      33. da Costa SR, Andersson S, Arber F, Okamoto C, Hamm-Alvarez S. Cytoskeletal participation in stimulated secretion and compensatory apical plasma membrane retrieval in lacrimal gland acinar cells. Adv Exp Med Biol. 2002; 506(Pt A):199-205. PMID: 12613908.
        View in: PubMed
      34. Okamoto C, Forte JG. Vesicular trafficking machinery, the actin cytoskeleton, and H+-K+-ATPase recycling in the gastric parietal cell. J Physiol. 2001 Apr 15; 532(Pt 2):287-96. PMID: 11306650.
        View in: PubMed
      35. Okamoto C, Duman JG, Tyagarajan K, McDonald KL, Jeng YY, McKinney J, Forte TM, Forte JG. Clathrin in gastric acid secretory (parietal) cells: biochemical characterization and subcellular localization. Am J Physiol Cell Physiol. 2000 Sep; 279(3):C833-51. PMID: 10942733.
        View in: PubMed
      36. Okamoto C, McKinney J, Jeng YY. Clathrin in mitotic spindles. Am J Physiol Cell Physiol. 2000 Aug; 279(2):C369-74. PMID: 10913003.
        View in: PubMed
      37. Paine CT, Paine ML, Luo W, Okamoto C, Lyngstadaas SP, Snead ML. A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts. J Biol Chem. 2000 Jul 21; 275(29):22284-92. PMID: 10806191.
        View in: PubMed
      38. Okamoto C, Chow DC, Forte AJ. Interaction of alpha- and beta-subunits in native H-K-ATPase and cultured cells transfected with H-K-ATPase beta-subunit. Am J Physiol Cell Physiol. 2000 Apr; 278(4):C727-38. PMID: 10751322.
        View in: PubMed
      39. Okamoto C. HSP27 and signaling to the actin cytoskeleton focus on "HSP27 expression regulates CCK-induced changes of the actin cytoskeleton in CHO-CCK-A cells". Am J Physiol. 1999 Dec; 277(6 Pt 1):C1029-31. PMID: 10600753.
        View in: PubMed
      40. Yang T, Zeng H, Zhang J, Okamoto C, Warren DW, Wood RL, Bachmann M, Mircheff AK. Stimulation with carbachol alters endomembrane distribution and plasma membrane expression of intracellular proteins in lacrimal acinar cells. Exp Eye Res. 1999 Dec; 69(6):651-61. PMID: 10620394.
        View in: PubMed
      41. Yang T, Zeng H, Zhang J, Okamoto C, Warren DW, Wood RL, Bachmann M, Mircheff AK. MHC class II molecules, cathepsins, and La/SSB proteins in lacrimal acinar cell endomembranes. Am J Physiol. 1999 Nov; 277(5 Pt 1):C994-C1007. PMID: 10564093.
        View in: PubMed
      42. Lee VH, Chu C, Mahlin ED, Basu SK, Ann DK, Bolger MB, Haworth IS, Yeung AK, Wu SK, Hamm-Alvarez S, Okamoto C. Biopharmaceutics of transmucosal peptide and protein drug administration: role of transport mechanisms with a focus on the involvement of PepT1. J Control Release. 1999 Nov 1; 62(1-2):129-40. PMID: 10518644.
        View in: PubMed
      43. Orzech E, Schlessinger K, Weiss A, Okamoto C, Aroeti B. Interactions of the AP-1 Golgi adaptor with the polymeric immunoglobulin receptor and their possible role in mediating brefeldin A-sensitive basolateral targeting from the trans-Golgi network. J Biol Chem. 1999 Jan 22; 274(4):2201-15. PMID: 9890983.
        View in: PubMed
      44. Bolger MB, Haworth IS, Yeung AK, Ann D, von Grafenstein H, Hamm-Alvarez S, Okamoto C, Kim KJ, Basu SK, Wu S, Lee VH. Structure, function, and molecular modeling approaches to the study of the intestinal dipeptide transporter PepT1. J Pharm Sci. 1998 Nov; 87(11):1286-91. PMID: 9811478.
        View in: PubMed
      45. Okamoto C, Jeng YY. An immunologically distinct beta-adaptin on tubulovesicles of gastric oxyntic cells. Am J Physiol. 1998 Nov; 275(5 Pt 1):C1323-9. PMID: 9814981.
        View in: PubMed
      46. Yeung AK, Basu SK, Wu SK, Chu C, Okamoto C, Hamm-Alvarez SF, von Grafenstein H, Shen WC, Kim KJ, Bolger MB, Haworth IS, Ann DK, Lee VH. Molecular identification of a role for tyrosine 167 in the function of the human intestinal proton- coupled dipeptide transporter (hPepT1). Biochem Biophys Res Commun. 1998 Sep 8; 250(1):103-7. PMID: 9735340.
        View in: PubMed
      47. Okamoto C, Karam SM, Jeng YY, Forte JG, Goldenring JR. Identification of clathrin and clathrin adaptors on tubulovesicles of gastric acid secretory (oxyntic) cells. Am J Physiol. 1998 Apr; 274(4 Pt 1):C1017-29. PMID: 9575799.
        View in: PubMed
      48. Basu SK, Shen J, Elbert KJ, Okamoto C, Lee VH, von Grafenstein H. Development and utility of anti-PepT1 anti-peptide polyclonal antibodies. Pharm Res. 1998 Feb; 15(2):338-42. PMID: 9523324.
        View in: PubMed
      49. Mircheff AK, Gierow JP, Yang T, Zhang J, Wood RL, Azzarolo AM, Warren DW, Zeng H, Guo Z, Kaslow HR, Hamm-Alvarez SF, Okamoto C, Bachmann M. Sjögren's autoimmunity: how perturbation of recognition in endomembrane traffic may provoke pathological recognition at the cell surface. J Mol Recognit. 1998; 11(1-6):40-8. PMID: 10076804.
        View in: PubMed
      50. Gierow JP, Yang T, Bekmezian A, Liu N, Norian JM, Kim SA, Rafisolyman S, Zeng H, Okamoto C, Wood RL, Mircheff AK. Na-K-ATPase in lacrimal gland acinar cell endosomal system: correcting a case of mistaken identity. Am J Physiol. 1996 Nov; 271(5 Pt 1):C1685-98. PMID: 8944653.
        View in: PubMed
      51. Okamoto C, Song W, Bomsel M, Mostov KE. Rapid internalization of the polymeric immunoglobulin receptor requires phosphorylated serine 726. J Biol Chem. 1994 Jun 3; 269(22):15676-82. PMID: 8195218.
        View in: PubMed
      52. Okamoto C, Shia SP, Bird C, Mostov KE, Roth MG. The cytoplasmic domain of the polymeric immunoglobulin receptor contains two internalization signals that are distinct from its basolateral sorting signal. J Biol Chem. 1992 May 15; 267(14):9925-32. PMID: 1577823.
        View in: PubMed
      53. Mostov K, Apodaca G, Aroeti B, Okamoto C. Plasma membrane protein sorting in polarized epithelial cells. J Cell Biol. 1992 Feb; 116(3):577-83. PMID: 1730769.
        View in: PubMed
      54. Aroeti B, Casanova J, Okamoto C, Cardone M, Pollack A, Tang K, Mostov K. Polymeric immunoglobulin receptor. Int Rev Cytol. 1992; 137B:157-68. PMID: 1478818.
        View in: PubMed
      55. Canfield VA, Okamoto C, Chow D, Dorfman J, Gros P, Forte JG, Levenson R. Cloning of the H,K-ATPase beta subunit. Tissue-specific expression, chromosomal assignment, and relationship to Na,K-ATPase beta subunits. J Biol Chem. 1990 Nov 15; 265(32):19878-84. PMID: 1978834.
        View in: PubMed
      56. Okamoto C, Karpilow JM, Smolka A, Forte JG. Isolation and characterization of gastric microsomal glycoproteins. Evidence for a glycosylated beta-subunit of the H+/K(+)-ATPase. Biochim Biophys Acta. 1990 Mar 1; 1037(3):360-72. PMID: 1690026.
        View in: PubMed
      57. Forte JG, Hanzel DK, Okamoto C, Chow D, Urushidani T. Membrane and protein recycling associated with gastric HCl secretion. J Intern Med Suppl. 1990; 732:17-26. PMID: 2166524.
        View in: PubMed
      58. Okamoto C, Forte JG. Distribution of lectin-binding sites in oxyntic and chief cells of isolated rabbit gastric glands. Gastroenterology. 1988 Aug; 95(2):334-42. PMID: 3134267.
        View in: PubMed
      59. Reichstein BJ, Okamoto C, Forte JG. Effect of ethanol on acid secretion by isolated gastric glands from rabbit. Gastroenterology. 1986 Aug; 91(2):439-47. PMID: 3013711.
        View in: PubMed
      60. Nagle BW, Okamoto C, Taggart B, Burnside B. The teleost cone cytoskeleton. Localization of actin, microtubules, and intermediate filaments. Invest Ophthalmol Vis Sci. 1986 May; 27(5):689-701. PMID: 3700018.
        View in: PubMed
      61. Wolosin JM, Okamoto C, Forte TM, Forte JG. Actin and associated proteins in gastric epithelial cells. Biochim Biophys Acta. 1983 Dec 13; 761(2):171-82. PMID: 6228258.
        View in: PubMed
      62. Forte JG, Forte TM, Black JA, Okamoto C, Wolosin JM. Correlation of parietal cell structure and function. J Clin Gastroenterol. 1983; 5 Suppl 1:17-27. PMID: 6228573.
        View in: PubMed