Loading...
Sign in to edit your profile (add interests, mentoring, photo, etc.)

    Chih-Lin Hsieh, PhD

    TitleProfessor of Urology
    SchoolKeck School of Medicine of USC
    DepartmentUrology
    AddressNOR 5420
    Health Sciences Campus
    Los Angeles California 90089-9176
    Phone+1 323 865 0567
    vCardDownload vCard
      Other Positions
      TitleCatherine and Joseph Aresty Chair in Urologic Research


      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Larson NB, McDonnell S, Cannon Albright L, Teerlink C, Stanford J, Ostrander EA, Isaacs WB, Xu J, Cooney KA, Lange E, Schleutker J, Carpten JD, Powell I, Bailey-Wilson JE, Cussenot O, Cancel-Tassin G, Giles GG, MacInnis RJ, Maier C, Whittemore AS, Hsieh C, Wiklund F, Catolona WJ, Foulkes W, Mandal D, Eeles R, Kote-Jarai Z, Ackerman MJ, Olson TM, Klein CJ, Thibodeau SN, Schaid DJ. gsSKAT: Rapid gene set analysis and multiple testing correction for rare-variant association studies using weighted linear kernels. Genet Epidemiol. 2017 May; 41(4):297-308. PMID: 28211093.
        View in: PubMed
      2. Ioannidis NM, Rothstein JH, Pejaver V, Middha S, McDonnell SK, Baheti S, Musolf A, Li Q, Holzinger E, Karyadi D, Cannon-Albright LA, Teerlink CC, Stanford JL, Isaacs WB, Xu J, Cooney KA, Lange EM, Schleutker J, Carpten JD, Powell IJ, Cussenot O, Cancel-Tassin G, Giles GG, MacInnis RJ, Maier C, Hsieh C, Wiklund F, Catalona WJ, Foulkes WD, Mandal D, Eeles RA, Kote-Jarai Z, Bustamante CD, Schaid DJ, Hastie T, Ostrander EA, Bailey-Wilson JE, Radivojac P, Thibodeau SN, Whittemore AS, Sieh W. REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants. Am J Hum Genet. 2016 Oct 06; 99(4):877-885. PMID: 27666373.
        View in: PubMed
      3. Larson NB, McDonnell S, Albright LC, Teerlink C, Stanford J, Ostrander EA, Isaacs WB, Xu J, Cooney KA, Lange E, Schleutker J, Carpten JD, Powell I, Bailey-Wilson J, Cussenot O, Cancel-Tassin G, Giles G, MacInnis R, Maier C, Whittemore AS, Hsieh C, Wiklund F, Catolona WJ, Foulkes W, Mandal D, Eeles R, Kote-Jarai Z, Ackerman MJ, Olson TM, Klein CJ, Thibodeau SN, Schaid DJ. Post hoc Analysis for Detecting Individual Rare Variant Risk Associations Using Probit Regression Bayesian Variable Selection Methods in Case-Control Sequencing Studies. Genet Epidemiol. 2016 09; 40(6):461-9. PMID: 27312771.
        View in: PubMed
      4. Zhang ZZ, Hsieh C, Okitsu CY, Han L, Yu K, Lieber MR. Effect of CpG dinucleotides within IgH switch region repeats on immunoglobulin class switch recombination. Mol Immunol. 2015 Aug; 66(2):284-9. PMID: 25899867; PMCID: PMC4461542.
      5. Zhang ZZ, Pannunzio NR, Hsieh C, Yu K, Lieber MR. Complexities due to single-stranded RNA during antibody detection of genomic rna:dna hybrids. BMC Res Notes. 2015 Apr 08; 8:127. PMID: 25890199; PMCID: PMC4393563.
      6. Okitsu CY, Hsieh C. Sensitivity and specificity of immunoprecipitation of DNA containing 5-Methylcytosine. BMC Res Notes. 2015 Mar 27; 8:102. PMID: 25888776; PMCID: PMC4379710.
      7. Lu Z, Lieber MR, Tsai AG, Pardo CE, Müschen M, Kladde MP, Hsieh C. Human lymphoid translocation fragile zones are hypomethylated and have accessible chromatin. Mol Cell Biol. 2015 Apr; 35(7):1209-22. PMID: 25624348; PMCID: PMC4355534.
      8. Zhang ZZ, Pannunzio NR, Hsieh C, Yu K, Lieber MR. The role of G-density in switch region repeats for immunoglobulin class switch recombination. Nucleic Acids Res. 2014 Dec 01; 42(21):13186-93. PMID: 25378327; PMCID: PMC4245955.
      9. Zhang ZZ, Pannunzio NR, Han L, Hsieh C, Yu K, Lieber MR. The strength of an Ig switch region is determined by its ability to drive R loop formation and its number of WGCW sites. Cell Rep. 2014 Jul 24; 8(2):557-69. PMID: 25017067; PMCID: PMC4118936.
      10. Okitsu CY, Van Den Berg DJ, Lieber MR, Hsieh C. Reproducibility and reliability of SNP analysis using human cellular DNA at or near nanogram levels. BMC Res Notes. 2013 Dec 06; 6:515. PMID: 24314330; PMCID: PMC4029319.
      11. Teerlink CC, Thibodeau SN, McDonnell SK, Schaid DJ, Rinckleb A, Maier C, Vogel W, Cancel-Tassin G, Egrot C, Cussenot O, Foulkes WD, Giles GG, Hopper JL, Severi G, Eeles R, Easton D, Kote-Jarai Z, Guy M, Cooney KA, Ray AM, Zuhlke KA, Lange EM, Fitzgerald LM, Stanford JL, Ostrander EA, Wiley KE, Isaacs SD, Walsh PC, Isaacs WB, Wahlfors T, Tammela T, Schleutker J, Wiklund F, Grönberg H, Emanuelsson M, Carpten J, Bailey-Wilson J, Whittemore AS, Oakley-Girvan I, Hsieh C, Catalona WJ, Zheng SL, Jin G, Lu L, Xu J. Association analysis of 9,560 prostate cancer cases from the International Consortium of Prostate Cancer Genetics confirms the role of reported prostate cancer associated SNPs for familial disease. Hum Genet. 2014 Mar; 133(3):347-56. PMID: 24162621; PMCID: PMC3945961.
      12. Hong EE, Okitsu CY, Smith AD, Hsieh C. Regionally specific and genome-wide analyses conclusively demonstrate the absence of CpG methylation in human mitochondrial DNA. Mol Cell Biol. 2013 Jul; 33(14):2683-90. PMID: 23671186; PMCID: PMC3700126.
      13. Hsieh JC, Van Den Berg D, Kang H, Hsieh C, Lieber MR. Large chromosome deletions, duplications, and gene conversion events accumulate with age in normal human colon crypts. Aging Cell. 2013 Apr; 12(2):269-79. PMID: 23425690.
        View in: PubMed
      14. Cui X, Lu Z, Kurosawa A, Klemm L, Bagshaw AT, Tsai AG, Gemmell N, Müschen M, Adachi N, Hsieh C, Lieber MR. Both CpG methylation and activation-induced deaminase are required for the fragility of the human bcl-2 major breakpoint region: implications for the timing of the breaks in the t(14;18) translocation. Mol Cell Biol. 2013 Mar; 33(5):947-57. PMID: 23263985; PMCID: PMC3623081.
      15. Xu J, Lange EM, Lu L, Zheng SL, Wang Z, Thibodeau SN, Cannon-Albright LA, Teerlink CC, Camp NJ, Johnson AM, Zuhlke KA, Stanford JL, Ostrander EA, Wiley KE, Isaacs SD, Walsh PC, Maier C, Luedeke M, Vogel W, Schleutker J, Wahlfors T, Tammela T, Schaid D, McDonnell SK, DeRycke MS, Cancel-Tassin G, Cussenot O, Wiklund F, Grönberg H, Eeles R, Easton D, Kote-Jarai Z, Whittemore AS, Hsieh C, Giles GG, Hopper JL, Severi G, Catalona WJ, Mandal D, Ledet E, Foulkes WD, Hamel N, Mahle L, Moller P, Powell I, Bailey-Wilson JE, Carpten JD, Seminara D, Cooney KA, Isaacs WB. HOXB13 is a susceptibility gene for prostate cancer: results from the International Consortium for Prostate Cancer Genetics (ICPCG). Hum Genet. 2013 Jan; 132(1):5-14. PMID: 23064873; PMCID: PMC3535370.
      16. Bailey-Wilson JE, Childs EJ, Cropp CD, Schaid DJ, Xu J, Camp NJ, Cannon-Albright LA, Farnham JM, George A, Powell I, Carpten JD, Giles GG, Hopper JL, Severi G, English DR, Foulkes WD, Mæhle L, Møller P, Eeles R, Easton D, Guy M, Edwards S, Badzioch MD, Whittemore AS, Oakley-Girvan I, Hsieh C, Dimitrov L, Stanford JL, Karyadi DM, Deutsch K, McIntosh L, Ostrander EA, Wiley KE, Isaacs SD, Walsh PC, Thibodeau SN, McDonnell SK, Hebbring S, Lange EM, Cooney KA, Tammela TL, Schleutker J, Maier C, Bochum S, Hoegel J, Grönberg H, Wiklund F, Emanuelsson M, Cancel-Tassin G, Valeri A, Cussenot O, Isaacs WB. Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families. BMC Med Genet. 2012 Jun 19; 13:46. PMID: 22712434; PMCID: PMC3495053.
      17. Tsai AG, Chen DM, Lin M, Hsieh JC, Okitsu CY, Taghva A, Shibata D, Hsieh C. Heterogeneity and randomness of DNA methylation patterns in human embryonic stem cells. DNA Cell Biol. 2012 Jun; 31(6):893-907. PMID: 22277069.
        View in: PubMed
      18. Jin G, Lu L, Cooney KA, Ray AM, Zuhlke KA, Lange EM, Cannon-Albright LA, Camp NJ, Teerlink CC, Fitzgerald LM, Stanford JL, Wiley KE, Isaacs SD, Walsh PC, Foulkes WD, Giles GG, Hopper JL, Severi G, Eeles R, Easton D, Kote-Jarai Z, Guy M, Rinckleb A, Maier C, Vogel W, Cancel-Tassin G, Egrot C, Cussenot O, Thibodeau SN, McDonnell SK, Schaid DJ, Wiklund F, Grönberg H, Emanuelsson M, Whittemore AS, Oakley-Girvan I, Hsieh C, Wahlfors T, Tammela T, Schleutker J, Catalona WJ, Zheng SL, Ostrander EA, Isaacs WB, Xu J. Validation of prostate cancer risk-related loci identified from genome-wide association studies using family-based association analysis: evidence from the International Consortium for Prostate Cancer Genetics (ICPCG). Hum Genet. 2012 Jul; 131(7):1095-103. PMID: 22198737; PMCID: PMC3535428.
      19. Hasegawa K, Yasuda SY, Teo JL, Nguyen C, McMillan M, Hsieh C, Suemori H, Nakatsuji N, Yamamoto M, Miyabayashi T, Lutzko C, Pera MF, Kahn M. Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion. Stem Cells Transl Med. 2012 Jan; 1(1):18-28. PMID: 23197636; PMCID: PMC3727690.
      20. Lu L, Cancel-Tassin G, Valeri A, Cussenot O, Lange EM, Cooney KA, Farnham JM, Camp NJ, Cannon-Albright LA, Tammela TL, Schleutker J, Hoegel J, Herkommer K, Maier C, Vogel W, Wiklund F, Emanuelsson M, Grönberg H, Wiley KE, Isaacs SD, Walsh PC, Helfand BT, Kan D, Catalona WJ, Stanford JL, FitzGerald LM, Johanneson B, Deutsch K, McIntosh L, Ostrander EA, Thibodeau SN, McDonnell SK, Hebbring S, Schaid DJ, Whittemore AS, Oakley-Girvan I, Hsieh C, Powell I, Bailey-Wilson JE, Cropp CD, Simpson C, Carpten JD, Seminara D, Zheng SL, Xu J, Giles GG, Severi G, Hopper JL, English DR, Foulkes WD, Maehle L, Moller P, Badzioch MD, Edwards S, Guy M, Eeles R, Easton D, Isaacs WB. Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG. Prostate. 2012 Mar; 72(4):410-26. PMID: 21748754; PMCID: PMC3568777.
      21. Zhu D, Deng X, Spee C, Sonoda S, Hsieh C, Barron E, Pera M, Hinton DR. Polarized secretion of PEDF from human embryonic stem cell-derived RPE promotes retinal progenitor cell survival. Invest Ophthalmol Vis Sci. 2011 Mar 01; 52(3):1573-85. PMID: 21087957; PMCID: PMC4183377.
      22. Christensen GB, Baffoe-Bonnie AB, George A, Powell I, Bailey-Wilson JE, Carpten JD, Giles GG, Hopper JL, Severi G, English DR, Foulkes WD, Maehle L, Moller P, Eeles R, Easton D, Badzioch MD, Whittemore AS, Oakley-Girvan I, Hsieh C, Dimitrov L, Xu J, Stanford JL, Johanneson B, Deutsch K, McIntosh L, Ostrander EA, Wiley KE, Isaacs SD, Walsh PC, Isaacs WB, Thibodeau SN, McDonnell SK, Hebbring S, Schaid DJ, Lange EM, Cooney KA, Tammela TL, Schleutker J, Paiss T, Maier C, Grönberg H, Wiklund F, Emanuelsson M, Farnham JM, Cannon-Albright LA, Camp NJ. Genome-wide linkage analysis of 1,233 prostate cancer pedigrees from the International Consortium for Prostate Cancer Genetics using novel sumLINK and sumLOD analyses. Prostate. 2010 May 15; 70(7):735-44. PMID: 20333727; PMCID: PMC3428045.
      23. Okitsu CY, Hsieh JC, Hsieh C. Transcriptional activity affects the H3K4me3 level and distribution in the coding region. Mol Cell Biol. 2010 Jun; 30(12):2933-46. PMID: 20404096; PMCID: PMC2876678.
      24. Roy D, Zhang Z, Lu Z, Hsieh C, Lieber MR. Competition between the RNA transcript and the nontemplate DNA strand during R-loop formation in vitro: a nick can serve as a strong R-loop initiation site. Mol Cell Biol. 2010 Jan; 30(1):146-59. PMID: 19841062; PMCID: PMC2798282.
      25. Li P, Tong C, Mehrian-Shai R, Jia L, Wu N, Yan Y, Maxson RE, Schulze EN, Song H, Hsieh C, Pera MF, Ying QL. Germline competent embryonic stem cells derived from rat blastocysts. Cell. 2008 Dec 26; 135(7):1299-310. PMID: 19109898; PMCID: PMC2735113.
      26. Tsai AG, Lu H, Raghavan SC, Muschen M, Hsieh C, Lieber MR. Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity. Cell. 2008 Dec 12; 135(6):1130-42. PMID: 19070581; PMCID: PMC2642632.
      27. Wang LC, Okitsu CY, Kochounian H, Rodriguez A, Hsieh C, Zandi E. A simple and inexpensive on-column frit fabrication method for fused-silica capillaries for increased capacity and versatility in LC-MS/MS applications. Proteomics. 2008 May; 8(9):1758-61. PMID: 18384106.
        View in: PubMed
      28. Huang FT, Yu K, Balter BB, Selsing E, Oruc Z, Khamlichi AA, Hsieh C, Lieber MR. Sequence dependence of chromosomal R-loops at the immunoglobulin heavy-chain Smu class switch region. Mol Cell Biol. 2007 Aug; 27(16):5921-32. PMID: 17562862; PMCID: PMC1952116.
      29. Camp NJ, Cannon-Albright LA, Farnham JM, Baffoe-Bonnie AB, George A, Powell I, Bailey-Wilson JE, Carpten JD, Giles GG, Hopper JL, Severi G, English DR, Foulkes WD, Maehle L, Moller P, Eeles R, Easton D, Badzioch MD, Whittemore AS, Oakley-Girvan I, Hsieh C, Dimitrov L, Xu J, Stanford JL, Johanneson B, Deutsch K, McIntosh L, Ostrander EA, Wiley KE, Isaacs SD, Walsh PC, Thibodeau SN, McDonnell SK, Hebbring S, Schaid DJ, Lange EM, Cooney KA, Tammela TL, Schleutker J, Paiss T, Maier C, Grönberg H, Wiklund F, Emanuelsson M, Isaacs WB. Compelling evidence for a prostate cancer gene at 22q12.3 by the International Consortium for Prostate Cancer Genetics. Hum Mol Genet. 2007 Jun 01; 16(11):1271-8. PMID: 17478474; PMCID: PMC2653215.
      30. Okitsu CY, Hsieh C. DNA methylation dictates histone H3K4 methylation. Mol Cell Biol. 2007 Apr; 27(7):2746-57. PMID: 17242185; PMCID: PMC1899905.
      31. Aoki K, Aoki M, Sugai M, Harada N, Miyoshi H, Tsukamoto T, Mizoshita T, Tatematsu M, Seno H, Chiba T, Oshima M, Hsieh C, Taketo MM. Chromosomal instability by beta-catenin/TCF transcription in APC or beta-catenin mutant cells. Oncogene. 2007 May 24; 26(24):3511-20. PMID: 17160019.
        View in: PubMed
      32. Schaid DJ, McDonnell SK, Zarfas KE, Cunningham JM, Hebbring S, Thibodeau SN, Eeles RA, Easton DF, Foulkes WD, Simard J, Giles GG, Hopper JL, Mahle L, Moller P, Badzioch M, Bishop DT, Evans C, Edwards S, Meitz J, Bullock S, Hope Q, Guy M, Hsieh C, Halpern J, Balise RR, Oakley-Girvan I, Whittemore AS, Xu J, Dimitrov L, Chang BL, Adams TS, Turner AR, Meyers DA, Friedrichsen DM, Deutsch K, Kolb S, Janer M, Hood L, Ostrander EA, Stanford JL, Ewing CM, Gielzak M, Isaacs SD, Walsh PC, Wiley KE, Isaacs WB, Lange EM, Ho LA, Beebe-Dimmer JL, Wood DP, Cooney KA, Seminara D, Ikonen T, Baffoe-Bonnie A, Fredriksson H, Matikainen MP, Tammela TL, Bailey-Wilson J, Schleutker J, Maier C, Herkommer K, Hoegel JJ, Vogel W, Paiss T, Wiklund F, Emanuelsson M, Stenman E, Jonsson BA, Grönberg H, Camp NJ, Farnham J, Cannon-Albright LA, Catalona WJ, Suarez BK, Roehl KA. Pooled genome linkage scan of aggressive prostate cancer: results from the International Consortium for Prostate Cancer Genetics. Hum Genet. 2006 Nov; 120(4):471-85. PMID: 16932970.
        View in: PubMed
      33. Higashimoto T, Panopoulos A, Hsieh C, Zandi E. TNFalpha induces chromosomal abnormalities independent of ROS through IKK, JNK, p38 and caspase pathways. Cytokine. 2006 Apr; 34(1-2):39-50. PMID: 16723255.
        View in: PubMed
      34. Huang FT, Yu K, Hsieh C, Lieber MR. Downstream boundary of chromosomal R-loops at murine switch regions: implications for the mechanism of class switch recombination. Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13):5030-5. PMID: 16547142; PMCID: PMC1458789.
      35. Goll MG, Kirpekar F, Maggert KA, Yoder JA, Hsieh C, Zhang X, Golic KG, Jacobsen SE, Bestor TH. Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2. Science. 2006 Jan 20; 311(5759):395-8. PMID: 16424344.
        View in: PubMed
      36. Raghavan SC, Tsai A, Hsieh C, Lieber MR. Analysis of non-B DNA structure at chromosomal sites in the mammalian genome. Methods Enzymol. 2006; 409:301-16. PMID: 16793408.
        View in: PubMed
      37. Raghavan SC, Hsieh C, Lieber MR. Both V(D)J coding ends but neither signal end can recombine at the bcl-2 major breakpoint region, and the rejoining is ligase IV dependent. Mol Cell Biol. 2005 Aug; 25(15):6475-84. PMID: 16024785; PMCID: PMC1190333.
      38. Xu J, Dimitrov L, Chang BL, Adams TS, Turner AR, Meyers DA, Eeles RA, Easton DF, Foulkes WD, Simard J, Giles GG, Hopper JL, Mahle L, Moller P, Bishop T, Evans C, Edwards S, Meitz J, Bullock S, Hope Q, Hsieh C, Halpern J, Balise RN, Oakley-Girvan I, Whittemore AS, Ewing CM, Gielzak M, Isaacs SD, Walsh PC, Wiley KE, Isaacs WB, Thibodeau SN, McDonnell SK, Cunningham JM, Zarfas KE, Hebbring S, Schaid DJ, Friedrichsen DM, Deutsch K, Kolb S, Badzioch M, Jarvik GP, Janer M, Hood L, Ostrander EA, Stanford JL, Lange EM, Beebe-Dimmer JL, Mohai CE, Cooney KA, Ikonen T, Baffoe-Bonnie A, Fredriksson H, Matikainen MP, Tammela TLj, Bailey-Wilson J, Schleutker J, Maier C, Herkommer K, Hoegel JJ, Vogel W, Paiss T, Wiklund F, Emanuelsson M, Stenman E, Jonsson BA, Gronberg H, Camp NJ, Farnham J, Cannon-Albright LA, Seminara D. A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer genetics. Am J Hum Genet. 2005 Aug; 77(2):219-29. PMID: 15988677; PMCID: PMC1224525.
      39. Raghavan SC, Chastain P, Lee JS, Hegde BG, Houston S, Langen R, Hsieh C, Haworth IS, Lieber MR. Evidence for a triplex DNA conformation at the bcl-2 major breakpoint region of the t(14;18) translocation. J Biol Chem. 2005 Jun 17; 280(24):22749-60. PMID: 15840562.
        View in: PubMed
      40. Hsieh C. The de novo methylation activity of Dnmt3a is distinctly different than that of Dnmt1. BMC Biochem. 2005 Mar 30; 6:6. PMID: 15799776; PMCID: PMC1084342.
      41. Irvine RA, Adachi N, Shibata DK, Cassell GD, Yu K, Karanjawala ZE, Hsieh C, Lieber MR. Generation and characterization of endonuclease G null mice. Mol Cell Biol. 2005 Jan; 25(1):294-302. PMID: 15601850; PMCID: PMC538798.
      42. Ma Y, Lu H, Tippin B, Goodman MF, Shimazaki N, Koiwai O, Hsieh C, Schwarz K, Lieber MR. A biochemically defined system for mammalian nonhomologous DNA end joining. Mol Cell. 2004 Dec 03; 16(5):701-13. PMID: 15574326.
        View in: PubMed
      43. Veal N, Hsieh C, Xiong S, Mato JM, Lu S, Tsukamoto H. Inhibition of lipopolysaccharide-stimulated TNF-alpha promoter activity by S-adenosylmethionine and 5'-methylthioadenosine. Am J Physiol Gastrointest Liver Physiol. 2004 Aug; 287(2):G352-62. PMID: 15064230.
        View in: PubMed
      44. Raghavan SC, Swanson PC, Wu X, Hsieh C, Lieber MR. A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex. Nature. 2004 Mar 04; 428(6978):88-93. PMID: 14999286.
        View in: PubMed
      45. Karanjawala ZE, Hinton DR, Oh E, Hsieh C, Lieber MR. Developmental retinal apoptosis in Ku86-/- mice. DNA Repair (Amst). 2003 Dec 09; 2(12):1429-34. PMID: 14642570.
        View in: PubMed
      46. Hsieh C, Jones PA. Meddling with methylation. Nat Cell Biol. 2003 Jun; 5(6):502-4. PMID: 12776125.
        View in: PubMed
      47. Yu K, Chedin F, Hsieh C, Wilson TE, Lieber MR. R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells. Nat Immunol. 2003 May; 4(5):442-51. PMID: 12679812.
        View in: PubMed
      48. Karanjawala ZE, Hsieh C, Lieber MR. Overexpression of Cu/Zn superoxide dismutase is lethal for mice lacking double-strand break repair. DNA Repair (Amst). 2003 Mar 01; 2(3):285-94. PMID: 12547391.
        View in: PubMed
      49. Chedin F, Lieber MR, Hsieh C. The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a. Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26):16916-21. PMID: 12481029; PMCID: PMC139244.
      50. Karanjawala ZE, Adachi N, Irvine RA, Oh EK, Shibata D, Schwarz K, Hsieh C, Lieber MR. The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants. DNA Repair (Amst). 2002 Dec 05; 1(12):1017-26. PMID: 12531011.
        View in: PubMed
      51. Cui H, Onyango P, Brandenburg S, Wu Y, Hsieh C, Feinberg AP. Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2. Cancer Res. 2002 Nov 15; 62(22):6442-6. PMID: 12438232.
        View in: PubMed
      52. Irvine RA, Lin IG, Hsieh C. DNA methylation has a local effect on transcription and histone acetylation. Mol Cell Biol. 2002 Oct; 22(19):6689-96. PMID: 12215526; PMCID: PMC134040.
      53. Karanjawala ZE, Murphy N, Hinton DR, Hsieh C, Lieber MR. Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants. Curr Biol. 2002 Mar 05; 12(5):397-402. PMID: 11882291.
        View in: PubMed
      54. Lin IG, Han L, Taghva A, O'Brien LE, Hsieh C. Murine de novo methyltransferase Dnmt3a demonstrates strand asymmetry and site preference in the methylation of DNA in vitro. Mol Cell Biol. 2002 Feb; 22(3):704-23. PMID: 11784849; PMCID: PMC133553.
      55. Hsieh C, Oakley-Girvan I, Balise RR, Halpern J, Gallagher RP, Wu AH, Kolonel LN, O'Brien LE, Lin IG, Van Den Berg DJ, Teh CZ, West DW, Whittemore AS. A genome screen of families with multiple cases of prostate cancer: evidence of genetic heterogeneity. Am J Hum Genet. 2001 Jul; 69(1):148-58. PMID: 11404817; PMCID: PMC1226029.
      56. Han L, Lin IG, Hsieh C. Protein binding protects sites on stable episomes and in the chromosome from de novo methylation. Mol Cell Biol. 2001 May; 21(10):3416-24. PMID: 11313467; PMCID: PMC100263.
      57. Lin IG, Hsieh C. Chromosomal DNA demethylation specified by protein binding. EMBO Rep. 2001 Feb; 2(2):108-12. PMID: 11258701; PMCID: PMC1083819.
      58. Hsieh C. Dynamics of DNA methylation pattern. Curr Opin Genet Dev. 2000 Apr; 10(2):224-8. PMID: 10753782.
        View in: PubMed
      59. Lin IG, Tomzynski TJ, Ou Q, Hsieh C. Modulation of DNA binding protein affinity directly affects target site demethylation. Mol Cell Biol. 2000 Apr; 20(7):2343-9. PMID: 10713158; PMCID: PMC85401.
      60. Karanjawala ZE, Shi X, Hsieh C, Lieber MR. The mammalian FEN-1 locus: structure and conserved sequence features. Microb Comp Genomics. 2000; 5(3):173-7. PMID: 11252354.
        View in: PubMed
      61. Karanjawala ZE, Grawunder U, Hsieh C, Lieber MR. The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts. Curr Biol. 1999 Dec 16-30; 9(24):1501-4. PMID: 10607596.
        View in: PubMed
      62. Hsieh C. In vivo activity of murine de novo methyltransferases, Dnmt3a and Dnmt3b. Mol Cell Biol. 1999 Dec; 19(12):8211-8. PMID: 10567546; PMCID: PMC84905.
      63. Xu GL, Bestor TH, Bourc'his D, Hsieh C, Tommerup N, Bugge M, Hulten M, Qu X, Russo JJ, Viegas-Péquignot E. Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature. 1999 Nov 11; 402(6758):187-91. PMID: 10647011.
        View in: PubMed
      64. Whittemore AS, Lin IG, Oakley-Girvan I, Gallagher RP, Halpern J, Kolonel LN, Wu AH, Hsieh C. No evidence of linkage for chromosome 1q42.2-43 in prostate cancer. Am J Hum Genet. 1999 Jul; 65(1):254-6. PMID: 10364541; PMCID: PMC1378099.
      65. Hsieh C. Evidence that protein binding specifies sites of DNA demethylation. Mol Cell Biol. 1999 Jan; 19(1):46-56. PMID: 9858530; PMCID: PMC83864.
      66. Gauss GH, Domain I, Hsieh C, Lieber MR. V(D)J recombination activity in human hematopoietic cells: correlation with developmental stage and genome stability. Eur J Immunol. 1998 Jan; 28(1):351-8. PMID: 9485214.
        View in: PubMed
      67. Hsieh C, Oakley-Girvan I, Gallagher RP, Wu AH, Kolonel LN, Teh CZ, Halpern J, West DW, Paffenbarger RS, Whittemore AS. Re: prostate cancer susceptibility locus on chromosome 1q: a confirmatory study. J Natl Cancer Inst. 1997 Dec 17; 89(24):1893-4. PMID: 9414179.
        View in: PubMed
      68. Hsieh C. Stability of patch methylation and its impact in regions of transcriptional initiation and elongation. Mol Cell Biol. 1997 Oct; 17(10):5897-904. PMID: 9315647; PMCID: PMC232437.
      69. Wu X, Li J, Li X, Hsieh C, Burgers PM, Lieber MR. Processing of branched DNA intermediates by a complex of human FEN-1 and PCNA. Nucleic Acids Res. 1996 Jun 01; 24(11):2036-43. PMID: 8668533; PMCID: PMC145902.
      70. Hiraoka LR, Harrington JJ, Gerhard DS, Lieber MR, Hsieh C. Sequence of human FEN-1, a structure-specific endonuclease, and chromosomal localization of the gene (FEN1) in mouse and human. Genomics. 1995 Jan 01; 25(1):220-5. PMID: 7774922.
        View in: PubMed
      71. Hsieh C. Dependence of transcriptional repression on CpG methylation density. Mol Cell Biol. 1994 Aug; 14(8):5487-94. PMID: 7518564; PMCID: PMC359068.
      72. Hsieh C, Arlett CF, Lieber MR. V(D)J recombination in ataxia telangiectasia, Bloom's syndrome, and a DNA ligase I-associated immunodeficiency disorder. J Biol Chem. 1993 Sep 25; 268(27):20105-9. PMID: 8397200.
        View in: PubMed
      73. Harrington J, Hsieh C, Gerton J, Bosma G, Lieber MR. Analysis of the defect in DNA end joining in the murine scid mutation. Mol Cell Biol. 1992 Oct; 12(10):4758-68. PMID: 1406659; PMCID: PMC360403.
      74. Hsieh C, McCloskey RP, Lieber MR. V(D)J recombination on minichromosomes is not affected by transcription. J Biol Chem. 1992 Aug 05; 267(22):15613-9. PMID: 1639801.
        View in: PubMed
      75. Hsieh C, Gauss G, Lieber MR. Replication, transcription, CpG methylation and DNA topology in V(D)J recombination. Curr Top Microbiol Immunol. 1992; 182:125-35. PMID: 1490346.
        View in: PubMed
      76. Hsieh C, Lieber MR. CpG methylated minichromosomes become inaccessible for V(D)J recombination after undergoing replication. EMBO J. 1992 Jan; 11(1):315-25. PMID: 1371250; PMCID: PMC556452.
      77. Hsieh C, McCloskey RP, Radany E, Lieber MR. V(D)J recombination: evidence that a replicative mechanism is not required. Mol Cell Biol. 1991 Aug; 11(8):3972-7. PMID: 2072902; PMCID: PMC361195.