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    Chengyu Liang, MD, PhD

    TitleAssociate Professor of Molecular Microbiology & Immunology
    SchoolKeck School of Medicine of USC
    DepartmentMolecular Microbiology and Immunology
    AddressNRT 5507 1450 Biggy Street
    Health Sciences Campus
    Los Angeles California 90033
    Phone+1 323 442 7840
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      Research in my lab is centered on understanding the basic principle of cellular processes including apoptosis and autophagy, cell cycle regulation and genomic stability, as well as intracellular trafficking matrix in the development of cancer and infectious disease. Being a lysosome-dependent quality control mechanism and house-cleaning activity of the cessll, autophagy (Greek for self-eating) has been increasing recognized being essential for cells to maintain homeostasis and also protect the organism against diverse pathogens and cancerous cells.


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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Yang Y, Quach C, Liang C. Autophagy modulator plays a part in UV protection. Autophagy. 2016 Sep; 12(9):1677-8. PMID: 27439570.
        View in: PubMed
      2. Yang Y, He S, Wang Q, Li F, Kwak MJ, Chen S, O'Connell D, Zhang T, Pirooz SD, Jeon Y, Chimge NO, Frenkel B, Choi Y, Aldrovandi GM, Oh BH, Yuan Z, Liang C. Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase. Mol Cell. 2016 May 19; 62(4):507-19. PMID: 27203177.
        View in: PubMed
      3. O'Connell D, Liang C. Autophagy interaction with herpes simplex virus type-1 infection. Autophagy. 2016 Mar 3; 12(3):451-9. PMID: 26934628.
        View in: PubMed
      4. Chimge NO, Little GH, Baniwal SK, Adisetiyo H, Xie Y, Zhang T, O'Laughlin A, Liu ZY, Ulrich P, Martin A, Mhawech-Fauceglia P, Ellis MJ, Tripathy D, Groshen S, Liang C, Li Z, Schones DE, Frenkel B. RUNX1 prevents oestrogen-mediated AXIN1 suppression and ß-catenin activation in ER-positive breast cancer. Nat Commun. 2016; 7:10751. PMID: 26916619.
        View in: PubMed
      5. He S, Liang C. Frameshift mutation of UVRAG: Switching a tumor suppressor to an oncogene in colorectal cancer. Autophagy. 2015 Oct 3; 11(10):1939-40. PMID: 26327192.
        View in: PubMed
      6. He S, Zhao Z, Yang Y, O'Connell D, Zhang X, Oh S, Ma B, Lee JH, Zhang T, Varghese B, Yip J, Dolatshahi Pirooz S, Li M, Zhang Y, Li GM, Ellen Martin S, Machida K, Liang C. Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers. Nat Commun. 2015; 6:7839. PMID: 26234763.
        View in: PubMed
      7. Minassian A, Zhang J, He S, Zhao J, Zandi E, Saito T, Liang C, Feng P. An Internally Translated MAVS Variant Exposes Its Amino-terminal TRAF-Binding Motifs to Deregulate Interferon Induction. PLoS Pathog. 2015 Jul; 11(7):e1005060. PMID: 26221961.
        View in: PubMed
      8. He S, Zhao J, Song S, He X, Minassian A, Zhou Y, Zhang J, Brulois K, Wang Y, Cabo J, Zandi E, Liang C, Jung JU, Zhang X, Feng P. Viral Pseudo-Enzymes Activate RIG-I via Deamidation to Evade Cytokine Production. Mol Cell. 2015 Apr 2; 58(1):134-46. PMID: 25752576.
        View in: PubMed
      9. Liang Q, Chang B, Lee P, Brulois KF, Ge J, Shi M, Rodgers MA, Feng P, Oh BH, Liang C, Jung JU. Identification of the Essential Role of Viral Bcl-2 for Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication. J Virol. 2015 May 15; 89(10):5308-17. PMID: 25740994.
        View in: PubMed
      10. Yang Y, Liang C. MicroRNAs: an emerging player in autophagy. ScienceOpen Res. 2015; 2015. PMID: 26744638.
        View in: PubMed
      11. Liang C, Oh BH, Jung JU. Novel functions of viral anti-apoptotic factors. Nat Rev Microbiol. 2015 Jan; 13(1):7-12. PMID: 25363821.
        View in: PubMed
      12. Pirooz S, He S, O'Connell D, Khalilzadeh P, Yang Y, Liang C. Viruses customize autophagy protein for efficient viral entry. Autophagy. 2014 Jul; 10(7):1355-6. PMID: 24905575.
        View in: PubMed
      13. Pirooz SD, He S, Zhang T, Zhang X, Zhao Z, Oh S, O'Connell D, Khalilzadeh P, Amini-Bavil-Olyaee S, Farzan M, Liang C. UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2716-21. PMID: 24550300.
        View in: PubMed
      14. He S, O'Connell D, Zhang X, Yang Y, Liang C. The intersection of Golgi-ER retrograde and autophagic trafficking. Autophagy. 2014 Jan; 10(1):180-1. PMID: 24246972.
        View in: PubMed
      15. Zhao Z, Ni D, Ghozalli I, Pirooz SD, Ma B, Liang C. UVRAG: At the crossroad of autophagy and genomic stability. Autophagy. 2012 Sep 1; 8(9):1392-3. PMID: 22885520.
        View in: PubMed
      16. Kim HJ, Zhong Q, Sheng ZH, Yoshimori T, Liang C, Jung JU. Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking. J Cell Sci. 2012 Oct 15; 125(Pt 20):4740-50. PMID: 22797916.
        View in: PubMed
      17. Zhao Z, Oh S, Li D, Ni D, Pirooz SD, Lee JH, Yang S, Lee JY, Ghozalli I, Costanzo V, Stark JM, Liang C. A Dual Role for UVRAG in Maintaining Chromosomal Stability Independent of Autophagy. Dev Cell. 2012 May 15; 22(5):1001-16. PMID: 22542840.
        View in: PubMed
      18. Yang CS, Lee JS, Rodgers M, Min CK, Lee JY, Kim HJ, Lee KH, Kim CJ, Oh B, Zandi E, Yue Z, Kramnik I, Liang C, Jung JU. Autophagy Protein Rubicon Mediates Phagocytic NADPH Oxidase Activation in Response to Microbial Infection or TLR Stimulation. Cell Host Microbe. 2012 Mar 15; 11(3):264-76. PMID: 22423966.
        View in: PubMed
      19. Liang C. Viral FLIPping Autophagy for Longevity. Cell Host Microbe. 2012 Feb 16; 11(2):101-3. PMID: 22341458.
        View in: PubMed
      20. Pirooz SD, Lee JH, Zhao Z, Ni D, Oh S, Liang C. Measurement of γHV68 Infection in Mice. J Vis Exp. 2011; (57). PMID: 22127138.
        View in: PubMed
      21. Oh S, Pirooz SD, Ni D, Zhao Z, Liang C. Anti-autophagic Bcl-2: Not just an innocent bystander. Autophagy. 2011 Feb; 7(2):231-2. PMID: 21099349.
        View in: PubMed
      22. Oh S, E X, Hwang S, Liang C. Autophagy evasion in herpesviral latency. Autophagy. 2010 Jan; 6(1):151-2. PMID: 19923915.
        View in: PubMed
      23. Liang C, Jung JU. Autophagy genes as tumor suppressors. Curr Opin Cell Biol. 2010 Apr; 22(2):226-33. PMID: 19945837.
        View in: PubMed
      24. Lee JS, Li Q, Lee JY, Lee SH, Jeong JH, Lee HR, Chang H, Zhou FC, Gao SJ, Liang C, Jung JU. FLIP-mediated autophagy regulation in cell death control. Nat Cell Biol. 2009 Nov; 11(11):1355-62. PMID: 19838173.
        View in: PubMed
      25. Lee HR, Kim MH, Lee JS, Liang C, Jung JU. Viral interferon regulatory factors. J Interferon Cytokine Res. 2009 Sep; 29(9):621-7. PMID: 19715458.
        View in: PubMed
      26. Gack MU, Kirchhofer A, Shin YC, Inn KS, Liang C, Cui S, Myong S, Ha T, Hopfner KP, Jung JU. Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16743-8. PMID: 18948594.
        View in: PubMed
      27. Liang C, Lee JS, Jung JU. Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis. Semin Cancer Biol. 2008 Dec; 18(6):423-36. PMID: 18948197.
        View in: PubMed
      28. Sir D, Liang C, Chen WL, Jung JU, Ou JH. Perturbation of autophagic pathway by hepatitis C virus. Autophagy. 2008 Aug; 4(6):830-1. PMID: 18635950.
        View in: PubMed
      29. Liang C, Sir D, Lee S, Ou JH, Jung JU. Beyond autophagy: the role of UVRAG in membrane trafficking. Autophagy. 2008 Aug; 4(6):817-20. PMID: 18612260.
        View in: PubMed
      30. Liang C, Lee JS, Inn KS, Gack MU, Li Q, Roberts EA, Vergne I, Deretic V, Feng P, Akazawa C, Jung JU. Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat Cell Biol. 2008 Jul; 10(7):776-87. PMID: 18552835.
        View in: PubMed
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