Baruch Frenkel, DMD, PhD
|Title||Professor of Orthopaedic Surgery|
|School||Keck School of Medicine of USC|
|Address||CSC 240 2250 Alcazar Street|
Health Sciences Campus
Los Angeles California 90033
|Phone||+1 323 442 1322|
|Title||J. Harold and Edna L. La Briola Chair in Genetic Orthopaedic Research|
We are a basic science lab, interested in transcriptional control (in particular combinatorial transcriptional control of mammalian gene expression), steroid hormone signaling, and cell biology (including stem cells and cell cycle control). All of our projects have significant clinical implications. Many of them start with high throughput genomic approaches to identify novel pathways in various human diseases, and continue with more traditional cellular and molecular approaches to investigate disease mechanisms in depth. A theme overarching most of the projects in the lab is interactions between steroid hormone receptors and RUNX proteins, for example: 1) Role of RUNX2 in glucocorticoid-induced osteoporosis; 2) Role of RUNX2 in bone-sparing effects of estrogens, androgens and SERMs; 3) Role of RUNX2 in prostate cancer and breast cancer metastasis in general and bone metastasis in particular; and 4) Context-dependent roles of RUNX proteins, in particular RUNX1, in breast cancer suppression and promotion.
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