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    Andrea A.Z. Kovacs, MD

    TitleProfessor of Pediatrics
    SchoolKeck School of Medicine of USC
    DepartmentPediatrics
    AddressHRA 300 1640 Marengo
    Off Campus
    Los Angeles California 90089-9300
    Phone+1 323 865 1585
    Emailakovacs@usc.edu

       Overview 
       Overview
      Dr. Kovacs is a Professor of Pediatrics and Pathology and the Founder and Director of LAC+USC’s Maternal, Child and Adolescent Center for Infectious Diseases and Virology (MCA). She is Chief of Pediatric Infectious Diseases at the LAC+USC Medical Center/Keck School of Medicine of USC. Dr. Kovacs has dedicated her career to developing new strategies to provide state-of-the-art clinical care to underserved populations using innovative strategies of integrated, multidisciplinary care combined with cutting edge clinical, translational and laboratory-based research at all levels of care to improve the outcomes of these patients, and to educate a new generation of clinicians and researchers to serve them.

      Dr. Kovacs, is the principal investigator of the USC clinical trials unit for the NIH International, Maternal, Pediatric, and Adolescent Clinical Trials (IMPAACT) group and directs the MCA Research Laboratory, which is certified by the NIH, CLIA, CAP and the State of California to perform clinical trials and natural history studies. MCA research projects have included laboratory-based projects, clinical trials design and conduct, epidemiological studies that involve small and large cohorts and translational studies that go from the bench to bedside.

      Dr. Kovacs has many years’ experience, dating to the first cases of acquired immunodeficiency virus (AIDS), in clinical and translational research studies with major emphasis on pathogenesis, transmission, treatment and prevention of human immunodeficiency virus, hepatitis C virus (HCV) and human cytomegalovirus (CMV). Her current research focuses on understanding how viruses act together to alter the immune system and cause disease. Ongoing studies include the impact of "HCV cure" and liver disease on immune activation/dysregulation in reproductive aging HIV and HCV co-infected women and the role of CMV on “immunologic aging” in both children and adults. In infants, she is assessing what effect congenital or perinatal CMV infection has on the developing immune system.


       Biography 
       Clinical Trials
       Awards and Honors
      Los Angeles Magazine, Los Angeles, CA - 1989Trailblazers of Medicine
      Los Angeles County+University of Southern California, Los Angeles, CA - 1990LAC+USC CARES Women in Medicine Award
      Polling & Research Division, Aiken, SC2004 - -The Best Doctors in America
      NIAID, NIH2006 - 2010NIAID, Department of Health & Human Services, AIDS Research Advisory Committee (ARAC)
      Key Professional Media, Inc., Seattle, WA2008 - -Southern California Super Doctors
      American Pediatric Society 2011 - -American Pediatric Society Fellow
      City of Los Angeles, Los Angeles, CA - 2013Certificate of Recognition
      Council of the City of Los Angeles, Los Angeles, CA - 2013Resolution to the Maternal Child & Adolescent Adult Center (MCA) for Excellence
      Infectious Diseases Society of America2014 - -Fellow

       ORNG Applications 
       Featured Publications
       Websites

       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Spencer LY, Christiansen S, Wang CH, Mack WJ, Young M, Strickler HD, Anastos K, Minkoff H, Cohen M, Geenblatt RM, Karim R, Operskalski E, Frederick T, Homans JD, Landay A, Kovacs A. Systemic Immune Activation and HIV Shedding in the Female Genital Tract. J Acquir Immune Defic Syndr. 2016 Feb 1; 71(2):155-62..
        View in: PubMed
      2. Kerzerho J, McIlvaine EJ, Anthony P, Mack WJ, Wang CH, Frederick T, Operskalski E, Chen Z, Al-Harthi L, Landay A, Young MA, Tien PC, Augenbraun M, Strickler HD, Akbari O, Golub ET, Sharp GB, Kovacs A. Impact of Hepatitis C Virus on the Circulating Levels of IL-7 in HIV-1 Coinfected Women. J Acquir Immune Defic Syndr. 2016 Feb 1; 71(2):172-80..
        View in: PubMed
      3. Kapetanovic S, Aaron L, Montepiedra G, Anthony P, Thuvamontolrat K, Pahwa S, Burchett S, Weinberg A, Kovacs A. Effect of Cytomegalovirus Co-Infection on Normalization of Selected T-Cell Subsets in Children with Perinatally Acquired HIV Infection Treated with Combination Antiretroviral Therapy. PLoS One. 2015; 10(3):e0120474..
        View in: PubMed
      4. Neely M, Louie S, Xu J, Anthony P, Thuvamontolrat K, Mordwinkin N, Kovacs A. Simultaneous plasma and genital pharmacokinetics and pharmacodynamics of atazanavir and efavirenz in HIV-infected women starting therapy. J Clin Pharmacol. 2015 Feb 12..
        View in: PubMed
      5. Karim R, Mack WJ, Kono N, Tien PC, Anastos K, Lazar J, Young M, Desai S, Golub ET, Kaplan RC, Hodis HN, Kovacs A. T-Cell Activation, Both Pre- and Post-HAART Levels, Correlates With Carotid Artery Stiffness Over 6.5 Years Among HIV-Infected Women in the WIHS. J Acquir Immune Defic Syndr. 2014 Nov 1; 67(3):349-56..
        View in: PubMed
      6. Serrao E, Wang CH, Frederick T, Lee CL, Anthony P, Arribas-Layton D, Baker K, Millstein J, Kovacs A, Neamati N. Alteration of select gene expression patterns in individuals infected with HIV-1. J Med Virol. 2014 Apr; 86(4):678-86..
        View in: PubMed
      7. Karim R, Mack WJ, Stiller T, Operskalski E, Frederick T, Landay A, Young MA, Tien PC, Augenbraun M, Strickler HD, Kovacs A. Association of HIV clinical disease progression with profiles of early immune activation: results from a cluster analysis approach. AIDS. 2013 Jun 1; 27(9):1473-81..
        View in: PubMed
      8. Frederick T, Homans J, Spencer L, Kramer F, Stek A, Operskalski E, Kovacs A. The Effect of Prenatal Highly Active Antiretroviral Therapy on the Transmission of Congenital and Perinatal/Early Postnatal Cytomegalovirus Among HIV-Infected and HIV-Exposed Infants. Clin Infect Dis. 2012 Sep; 55(6):877-84..
        View in: PubMed
      9. Kapetanovic S, Aaron L, Montepiedra G, Burchett SK, Kovacs A. T-cell activation and neurodevelopmental outcomes in perinatally HIV-infected children. AIDS. 2012 May 15; 26(8):959-69..
        View in: PubMed
      10. Homans J, Christensen S, Stiller T, Wang CH, Mack W, Anastos K, Minkoff H, Young M, Greenblatt R, Cohen M, Strickler H, Karim R, Spencer LY, Operskalski E, Frederick T, Kovacs A. Permissive and protective factors associated with presence, level, and longitudinal pattern of cervicovaginal HIV shedding. J Acquir Immune Defic Syndr. 2012 May 1; 60(1):99-110..
        View in: PubMed
      11. Operskalski EA, Kovacs A. HIV/HCV co-infection: pathogenesis, clinical complications, treatment, and new therapeutic technologies. Curr HIV/AIDS Rep. 2011 Mar; 8(1):12-22..
        View in: PubMed
      12. Kovacs A, Karim R, Mack WJ, Xu J, Chen Z, Operskalski E, Frederick T, Landay A, Voris J, Spencer LS, Young MA, Tien PC, Augenbraun M, Strickler HD, Al-Harthi L. Activation of CD8 T cells predicts progression of HIV infection in women coinfected with hepatitis C virus. J Infect Dis. 2010 Mar 15; 201(6):823-34..
        View in: PubMed
      13. Kapetanovic S, Christensen S, Karim R, Lin F, Mack WJ, Operskalski E, Frederick T, Spencer L, Stek A, Kramer F, Kovacs A. Correlates of perinatal depression in HIV-infected women. AIDS Patient Care STDS. 2009 Feb; 23(2):101-8..
        View in: PubMed
      14. Kovacs A. Early immune activation predicts central nervous system disease in HIV-infected infants: implications for early treatment. Clin Infect Dis. 2009 Feb 1; 48(3):347-9..
        View in: PubMed
      15. Kovacs A, Al-Harthi L, Christensen S, Mack W, Cohen M, Landay A. CD8(+) T cell activation in women coinfected with human immunodeficiency virus type 1 and hepatitis C virus. J Infect Dis. 2008 May 15; 197(10):1402-7..
        View in: PubMed
      16. Operskalski EA, Mack WJ, Strickler HD, French AL, Augenbraun M, Tien PC, Villacres MC, Spencer LY, Degiacomo M, Kovacs A. Factors associated with hepatitis C viremia in a large cohort of HIV-infected and -uninfected women. J Clin Virol. 2008 Apr; 41(4):255-63..
        View in: PubMed
      17. Strickler HD, Howard AA, Peters M, Fazzari M, Yu H, Augenbraun M, French AL, Young M, Gange S, Anastos K, Kovacs A. The insulin-like growth factor axis and risk of liver disease in hepatitis C virus/HIV-co-infected women. AIDS. 2008 Feb 19; 22(4):527-31..
        View in: PubMed
      18. French AL, Operskalski E, Peters M, Strickler HD, Tien PC, Sharp GB, Glesby MJ, Young M, Augenbraun M, Seaberg E, Kovacs A. Isolated hepatitis B core antibody is associated with HIV and ongoing but not resolved hepatitis C virus infection in a cohort of US women. J Infect Dis. 2007 May 15; 195(10):1437-42..
        View in: PubMed
      19. Al-Harthi L, Voris J, Du W, Wright D, Nowicki M, Frederick T, Landay A, Kovacs A. Evaluating the impact of hepatitis C virus (HCV) on highly active antiretroviral therapy-mediated immune responses in HCV/HIV-coinfected women: role of HCV on expression of primed/memory T cells. J Infect Dis. 2006 May 1; 193(9):1202-10..
        View in: PubMed
      20. Kovacs A, Villacres MC. The role of race and gender in T cell responses in children perinatally infected with HIV-1. J Infect Dis. 2005 Nov 15; 192(10):1683-5..
        View in: PubMed
      21. Kovacs A, Montepiedra G, Carey V, Pahwa S, Weinberg A, Frenkel L, Capparelli E, Mofenson L, Smith E, McIntosh K, Burchett SK. Immune reconstitution after receipt of highly active antiretroviral therapy in children with advanced or progressive HIV disease and complete or partial viral load response. J Infect Dis. 2005 Jul 15; 192(2):296-302..
        View in: PubMed
      22. Kovacs A, Cowles MK, Britto P, Capparelli E, Fowler MG, Moye J, McIntosh K, Rathore MH, Pitt J, Husson RN. Pharmacokinetics of didanosine and drug resistance mutations in infants exposed to zidovudine during gestation or postnatally and treated with didanosine or zidovudine in the first three months of life. Pediatr Infect Dis J. 2005 Jun; 24(6):503-9..
        View in: PubMed
      23. Nikolopoulou GB, Nowicki MJ, Du W, Homans J, Stek A, Kramer F, Kovacs A. HCV viremia is associated with drug use in young HIV-1 and HCV coinfected pregnant and non-pregnant women. Addiction. 2005 May; 100(5):626-35..
        View in: PubMed
      24. Villacres MC, Literat O, Degiacomo M, Du W, La Rosa C, Diamond DJ, Kovacs A. Reduced type 1 and type 2 cytokines in antiviral memory T helper function among women coinfected with HIV and HCV. J Clin Immunol. 2005 Mar; 25(2):134-41..
        View in: PubMed
      25. Tien PC, Kovacs A, Bacchetti P, French AL, Augenbraun M, Cole SR, Hessol N, Justman J. Association between syphilis, antibodies to herpes simplex virus type 2, and recreational drug use and hepatitis B virus infection in the Women's Interagency HIV Study. Clin Infect Dis. 2004 Nov 1; 39(9):1363-70..
        View in: PubMed
      26. Neely M, Kovacs A. Management of antiretroviral therapy in neonates, children, and adolescents. Curr HIV/AIDS Rep. 2004 Jun; 1(2):97-104..
        View in: PubMed
      27. Kovacs A, Connors M. HIV-1 and immune control: can we change the course of HIV-1? Lancet. 2004 Mar 13; 363(9412):833-4..
        View in: PubMed
      28. Neely M, Kovacs A. Management of Antiretroviral Therapy in Neonates, Children, and Adolescents. Curr Infect Dis Rep. 2003 Dec; 5(6):521-530..
        View in: PubMed
      29. Landay A, Benning L, Bremer J, Weiser B, Burger H, Nowicki M, Kovacs A. Correlates of immune activation marker changes in human immunodeficiency virus (HIV)-seropositive and high-risk HIV-seronegative women who use illicit drugs. J Infect Dis. 2003 Jul 15; 188(2):209-18..
        View in: PubMed
      30. Kovacs A, Wasserman SS, Burns D, Wright DJ, Cohn J, Landay A, Weber K, Cohen M, Levine A, Minkoff H, Miotti P, Palefsky J, Young M, Reichelderfer P. Determinants of HIV-1 shedding in the genital tract of women. Lancet. 2001 Nov 10; 358(9293):1593-601..
        View in: PubMed
      31. Coombs RW, Wright DJ, Reichelderfer PS, Burns DN, Cohn J, Cu-Uvin S, Baron PA, Cohen MH, Landay AL, Lewis S, Kovacs A. Variation of human immunodeficiency virus type 1 viral RNA levels in the female genital tract: implications for applying measurements to individual women. J Infect Dis. 2001 Nov 01; 184(9):1187-91..
        View in: PubMed
      32. Reichelderfer PS, Coombs RW, Wright DJ, Cohn J, Burns DN, Cu-Uvin S, Baron PA, Coheng MH, Landay AL, Beckner SK, Lewis SR, Kovacs AA. Effect of menstrual cycle on HIV-1 levels in the peripheral blood and genital tract. WHS 001 Study Team. AIDS. 2000 Sep 29; 14(14):2101-7..
        View in: PubMed
      33. Anastos K, Kalish LA, Hessol N, Weiser B, Melnick S, Burns D, Delapenha R, DeHovitz J, Cohen M, Meyer W, Bremer J, Kovacs A. The relative value of CD4 cell count and quantitative HIV-1 RNA in predicting survival in HIV-1-infected women: results of the women's interagency HIV study. AIDS. 1999 Sep 10; 13(13):1717-26..
        View in: PubMed
      34. Kovacs A, Schluchter M, Easley K, Demmler G, Shearer W, La Russa P, Pitt J, Cooper E, Goldfarb J, Hodes D, Kattan M, McIntosh K. Cytomegalovirus infection and HIV-1 disease progression in infants born to HIV-1-infected women. Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection Study Group. N Engl J Med. 1999 Jul 08; 341(2):77-84.; NIHMSID: NIHMS650558.
        View in: PubMed
      35. The mode of delivery and the risk of vertical transmission of human immunodeficiency virus type 1--a meta-analysis of 15 prospective cohort studies. The International Perinatal HIV Group. N Engl J Med. 1999 Apr 01; 340(13):977-87..
        View in: PubMed
      36. Kovacs A, Hinton DR, Wright D, Xu J, Li XL, Rasheed S, Hofman F. Human immunodeficiency virus type 1 infection of the heart in three infants with acquired immunodeficiency syndrome and sudden death. Pediatr Infect Dis J. 1996 Sep; 15(9):819-24..
        View in: PubMed
      37. Kovacs JA, Kovacs AA. PCP prophylaxis in paediatric HIV infection: time for a change? Lancet. 1994 Jul 2; 344(8914):5-6..
        View in: PubMed
      38. Kovacs A, Frederick T, Church J, Eller A, Oxtoby M, Mascola L. CD4 T-lymphocyte counts and Pneumocystis carinii pneumonia in pediatric HIV infection. JAMA. 1991 Apr 3; 265(13):1698-703..
        View in: PubMed
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