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    Andre J Ouellette, PhD

    TitleProfessor of Pathology
    SchoolKeck School of Medicine of USC
    DepartmentPathology
    AddressNRT 7505
    Health Sciences Campus
    Los Angeles California 90089-9601
    Phone+1 323 442 7959
    vCardDownload vCard

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Patil AA, Ouellette A, Lu W, Zhang G. Rattusin, an intestinal a-defensin-related peptide in rats with a unique cysteine spacing pattern and salt-insensitive antibacterial activities. Antimicrob Agents Chemother. 2013 Apr; 57(4):1823-31. PMID: 23380721; PMCID: PMC3623328.
      2. Anand P, Cermelli S, Li Z, Kassan A, Bosch M, Sigua R, Huang L, Ouellette A, Pol A, Welte MA, Gross SP. A novel role for lipid droplets in the organismal antibacterial response. Elife. 2012 Nov 13; 1:e00003. PMID: 23150794; PMCID: PMC3491588.
      3. Ouellette A, Selsted ME. Immunology. HD6 defensin nanonets. Science. 2012 Jul 27; 337(6093):420-1. PMID: 22837514.
        View in: PubMed
      4. Garcia AE, Tai KP, Puttamadappa SS, Shekhtman A, Ouellette A, Camarero JA. Biosynthesis and antimicrobial evaluation of backbone-cyclized a-defensins. Biochemistry. 2011 Dec 06; 50(48):10508-19. PMID: 22040603; PMCID: PMC3236816.
      5. Ouellette A. Paneth cell a-defensins in enteric innate immunity. Cell Mol Life Sci. 2011 Jul; 68(13):2215-29. PMID: 21560070; PMCID: PMC4073591.
      6. Ouellette A. Paneth cells and innate mucosal immunity. Curr Opin Gastroenterol. 2010 Nov; 26(6):547-53. PMID: 20693892.
        View in: PubMed
      7. Hadjicharalambous C, Sheynis T, Jelinek R, Shanahan MT, Ouellette A, Gizeli E. Mechanisms of alpha-defensin bactericidal action: comparative membrane disruption by Cryptdin-4 and its disulfide-null analogue. Biochemistry. 2008 Nov 25; 47(47):12626-34. PMID: 18973303; PMCID: PMC2645939.
      8. Miszta A, Machán R, Benda A, Ouellette A, Hermens WT, Hof M. Combination of ellipsometry, laser scanning microscopy and Z-scan fluorescence correlation spectroscopy elucidating interaction of cryptdin-4 with supported phospholipid bilayers. J Pept Sci. 2008 Apr; 14(4):503-9. PMID: 17994618.
        View in: PubMed
      9. Tran D, Tran P, Roberts K, Osapay G, Schaal J, Ouellette A, Selsted ME. Microbicidal properties and cytocidal selectivity of rhesus macaque theta defensins. Antimicrob Agents Chemother. 2008 Mar; 52(3):944-53. PMID: 18160518; PMCID: PMC2258523.
      10. Shi J, Aono S, Lu W, Ouellette A, Hu X, Ji Y, Wang L, Lenz S, van Ginkel FW, Liles M, Dykstra C, Morrison EE, Elson CO. A novel role for defensins in intestinal homeostasis: regulation of IL-1beta secretion. J Immunol. 2007 Jul 15; 179(2):1245-53. PMID: 17617617.
        View in: PubMed
      11. Rosengren KJ, Daly NL, Fornander LM, Jönsson LM, Shirafuji Y, Qu X, Vogel HJ, Ouellette A, Craik DJ. Structural and functional characterization of the conserved salt bridge in mammalian paneth cell alpha-defensins: solution structures of mouse CRYPTDIN-4 and (E15D)-CRYPTDIN-4. J Biol Chem. 2006 Sep 22; 281(38):28068-78. PMID: 16857681.
        View in: PubMed
      12. Weeks CS, Tanabe H, Cummings JE, Crampton SP, Sheynis T, Jelinek R, Vanderlick TK, Cocco MJ, Ouellette A. Matrix metalloproteinase-7 activation of mouse paneth cell pro-alpha-defensins: SER43 down arrow ILE44 proteolysis enables membrane-disruptive activity. J Biol Chem. 2006 Sep 29; 281(39):28932-42. PMID: 16822871.
        View in: PubMed
      13. Ouellette A. Paneth cell alpha-defensins: peptide mediators of innate immunity in the small intestine. Springer Semin Immunopathol. 2005 Sep; 27(2):133-46. PMID: 15931529.
        View in: PubMed
      14. Selsted ME, Ouellette A. Mammalian defensins in the antimicrobial immune response. Nat Immunol. 2005 Jun; 6(6):551-7. PMID: 15908936.
        View in: PubMed
      15. Crouch ML, Becker LA, Bang IS, Tanabe H, Ouellette A, Fang FC. The alternative sigma factor sigma is required for resistance of Salmonella enterica serovar Typhimurium to anti-microbial peptides. Mol Microbiol. 2005 May; 56(3):789-99. PMID: 15819632.
        View in: PubMed
      16. Tanabe H, Ayabe T, Bainbridge B, Guina T, Ernst RK, Darveau RP, Miller SI, Ouellette A. Mouse paneth cell secretory responses to cell surface glycolipids of virulent and attenuated pathogenic bacteria. Infect Immun. 2005 Apr; 73(4):2312-20. PMID: 15784576; PMCID: PMC1087394.
      17. Jing W, Hunter HN, Tanabe H, Ouellette A, Vogel HJ. Solution structure of cryptdin-4, a mouse paneth cell alpha-defensin. Biochemistry. 2004 Dec 21; 43(50):15759-66. PMID: 15595831.
        View in: PubMed
      18. Tanabe H, Ouellette A, Cocco MJ, Robinson WE. Differential effects on human immunodeficiency virus type 1 replication by alpha-defensins with comparable bactericidal activities. J Virol. 2004 Nov; 78(21):11622-31. PMID: 15479803; PMCID: PMC523300.
      19. Maemoto A, Qu X, Rosengren KJ, Tanabe H, Henschen-Edman A, Craik DJ, Ouellette A. Functional analysis of the alpha-defensin disulfide array in mouse cryptdin-4. J Biol Chem. 2004 Oct 15; 279(42):44188-96. PMID: 15297466.
        View in: PubMed
      20. Ouellette A. Defensin-mediated innate immunity in the small intestine. Best Pract Res Clin Gastroenterol. 2004 Apr; 18(2):405-19. PMID: 15123078.
        View in: PubMed
      21. Tanabe H, Yuan J, Zaragoza MM, Dandekar S, Henschen-Edman A, Selsted ME, Ouellette A. Paneth cell alpha-defensins from rhesus macaque small intestine. Infect Immun. 2004 Mar; 72(3):1470-8. PMID: 14977952; PMCID: PMC356057.
      22. Lin PW, Simon PO, Gewirtz AT, Neish AS, Ouellette A, Madara JL, Lencer WI. Paneth cell cryptdins act in vitro as apical paracrine regulators of the innate inflammatory response. J Biol Chem. 2004 May 07; 279(19):19902-7. PMID: 14990585.
        View in: PubMed
      23. Clarke LL, Gawenis LR, Bradford EM, Judd LM, Boyle KT, Simpson JE, Shull GE, Tanabe H, Ouellette A, Franklin CL, Walker NM. Abnormal Paneth cell granule dissolution and compromised resistance to bacterial colonization in the intestine of CF mice. Am J Physiol Gastrointest Liver Physiol. 2004 Jun; 286(6):G1050-8. PMID: 14715526.
        View in: PubMed
      24. Tanabe H, Qu X, Weeks CS, Cummings JE, Kolusheva S, Walsh KB, Jelinek R, Vanderlick TK, Selsted ME, Ouellette A. Structure-activity determinants in paneth cell alpha-defensins: loss-of-function in mouse cryptdin-4 by charge-reversal at arginine residue positions. J Biol Chem. 2004 Mar 19; 279(12):11976-83. PMID: 14702345.
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      25. Satchell DP, Sheynis T, Kolusheva S, Cummings J, Vanderlick TK, Jelinek R, Selsted ME, Ouellette A. Quantitative interactions between cryptdin-4 amino terminal variants and membranes. Peptides. 2003 Nov; 24(11):1795-805. PMID: 15019212.
        View in: PubMed
      26. Satchell DP, Sheynis T, Shirafuji Y, Kolusheva S, Ouellette A, Jelinek R. Interactions of mouse Paneth cell alpha-defensins and alpha-defensin precursors with membranes. Prosegment inhibition of peptide association with biomimetic membranes. J Biol Chem. 2003 Apr 18; 278(16):13838-46. PMID: 12574157.
        View in: PubMed
      27. Shirafuji Y, Tanabe H, Satchell DP, Henschen-Edman A, Wilson CL, Ouellette A. Structural determinants of procryptdin recognition and cleavage by matrix metalloproteinase-7. J Biol Chem. 2003 Mar 07; 278(10):7910-9. PMID: 12482850.
        View in: PubMed
      28. Ayabe T, Satchell DP, Pesendorfer P, Tanabe H, Wilson CL, Hagen SJ, Ouellette A. Activation of Paneth cell alpha-defensins in mouse small intestine. J Biol Chem. 2002 Feb 15; 277(7):5219-28. PMID: 11733520.
        View in: PubMed
      29. Ayabe T, Wulff H, Darmoul D, Cahalan MD, Chandy KG, Ouellette A. Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J Biol Chem. 2002 Feb 01; 277(5):3793-800. PMID: 11724775.
        View in: PubMed
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