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    Amir H. Kashani, MD, PhD

    TitleAssistant Professor of Clinical Ophthalmology
    SchoolKeck School of Medicine of USC
    AddressHC4 4900 1450 San Pablo Street
    Off Campus
    Los Angeles California 90033-6103
    Phone+1 323 442 6578
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      Collapse Overview 
      Collapse Overview
      Amir H. Kashani, MD, PhD, attended Johns Hopkins School of Medicine where he obtained both his MD and PhD in Neuroscience in 2006. He completed his ophthalmology residency at the USC Roski Eye Institute and fellowship in vitreoretinal surgery at the top-rated Associated Retinal Consultants in Royal Oak, Michigan. He was awarded both the Heed and Michel’s Fellowships (National Honors) during his training. Dr. Kashani is an NIH funded clinician-scientist who is studying the role of ischemia and hypoxia in the pathophysiology of retinal vascular diseases like diabetic retinopathy. Dr. Kashani also treats patients with medical and surgical retinal diseases including diabetic retinopathy, retinal vein occlusions, age-related macular degeneration and retinal detachments among other common retinal diseases. He also specializes in complex retinal detachment surgeries.

      In the laboratory, Dr. Kashani is developing novel diagnostic and therapeutic methods to diagnose and treat retinal diseases. His investigates the use of advanced imaging spectroscopy and optical coherence tomography methods to improve the early detection of chronic diseases like diabetic retinopathy and retinal venous occlusion. Dr. Kashani is the principal investigator for a clinical trial to test a novel stem cell therapy for severe vision loss from advanced dry age-related macular degeneration. In recognition of his cutting edge research Dr. Kashani has been recognized internatioinally by his peers. In 2016 he was named as one of the top 150 innovators in the field of medical and surgical retina by Ocular Surgery News. In 2017 he was named as one of the top 50 "rising stars" world-wide in the field of ophthalmology by The Ophthalmologist.

      Dr. Kashani has co-authored more than 40 peer reviewed articles in the scientific literature, several subject reviews, and recently co-authored an ophthalmology book entitled "Optical Coherence Tomography and OCT Angiography: Clinical Reference and Case Studies."

      Collapse Biography 
      Collapse Education and Training
      Johns Hopkins School of MedicineMD2006
      Johns Hopkins School of MedicinePhD2006
      USC Roski Eye InstituteOphthalmology Residency2010
      Associated Retinal ConsultantsVitreoretinal Surgery Fellowship2013
      Collapse Awards and Honors
      Johns Hopkins School of Medicine2000Medical Student Research Fellowship
      ARVO2006Retinal Research Foundation Grant
      1999  - 2006Medical Scientist Training Program Fellowship (MSTP)
      2007ARVO Research Travel Grant
      USC Department of Ophthalmology2008Resident Research Award
      Association for Research in Vision and Ophthalmology2009Member
      2009Henry and Lilian Nesburn Award
      2009Heed Resident Research Symposium (Rank #4)
      2012Ron G. Michel's Fellowhship
      Society of Heed Scholars2012Heed Ophthalmic Foundation Fellow
      Ocular Surgery News2016Nominated to 150 leading innovators in medical and surgical retina
      The Ophthalmologist2017Rising Stars Power List

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Zhang Y, Kashani A, Hubbard GB. Diagnostic and Therapeutic Challenges. Retina. 2017 Sep; 37(9):1805-1808. PMID: 28134739.
        View in: PubMed
      2. Kashani A, Chen CL, Gahm JK, Zheng F, Richter GM, Rosenfeld PJ, Shi Y, Wang RK. Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications. Prog Retin Eye Res. 2017 Sep; 60:66-100. PMID: 28760677.
        View in: PubMed
      3. Koulisis N, Kim AY, Chu Z, Shahidzadeh A, Burkemper B, Olmos de Koo LC, Moshfeghi AA, Ameri H, Puliafito CA, Isozaki VL, Wang RK, Kashani A. Quantitative microvascular analysis of retinal venous occlusions by spectral domain optical coherence tomography angiography. PLoS One. 2017; 12(4):e0176404. PMID: 28437483.
        View in: PubMed
      4. Moysidis SN, Koulisis N, Patel VR, Kashani A, Rao NA, Humayun MS, Rodger DC. THE SECOND BLIND SPOT: SMALL RETINAL VESSEL VASCULOPATHY AFTER VACCINATION AGAINST NEISSERIA MENINGITIDIS AND YELLOW FEVER. Retin Cases Brief Rep. 2017 Winter; 11 Suppl 1:S18-S23. PMID: 27599107.
        View in: PubMed
      5. Kim AY, Rodger DC, Shahidzadeh A, Chu Z, Koulisis N, Burkemper B, Jiang X, Pepple KL, Wang RK, Puliafito CA, Rao NA, Kashani A. Quantifying Retinal Microvascular Changes in Uveitis Using Spectral-Domain Optical Coherence Tomography Angiography. Am J Ophthalmol. 2016 Nov; 171:101-112. PMID: 27594138.
        View in: PubMed
      6. Kim AY, Chu Z, Shahidzadeh A, Wang RK, Puliafito CA, Kashani A. Quantifying Microvascular Density and Morphology in Diabetic Retinopathy Using Spectral-Domain Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci. 2016 Jul 01; 57(9):OCT362-70. PMID: 27409494; PMCID: PMC4968771 [Available on 01/01/17].
      7. Koss MJ, Falabella P, Stefanini FR, Pfister M, Thomas BB, Kashani A, Brant R, Zhu D, Clegg DO, Hinton DR, Humayun MS. Subretinal implantation of a monolayer of human embryonic stem cell-derived retinal pigment epithelium: a feasibility and safety study in Yucatán minipigs. Graefes Arch Clin Exp Ophthalmol. 2016 Aug; 254(8):1553-65. PMID: 27335025.
        View in: PubMed
      8. Kashani A. Stem Cell Therapy in Nonneovascular Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2016 Apr 1; 57(5):ORSFm1-9. PMID: 27116669.
        View in: PubMed
      9. Murali K, Kang D, Nazari H, Scianmarello N, Cadenas E, Tai YC, Kashani A, Humayun M. Spatial Variations in Vitreous Oxygen Consumption. PLoS One. 2016; 11(3):e0149961. PMID: 26930281; PMCID: PMC4773158.
      10. Kashani A, Zhang Y, Capone A, Drenser KA, Puliafito C, Moshfeghi AA, Williams GA, Trese MT. Impaired Retinal Perfusion Resulting From Vitreoretinal Traction: A Mechanism of Retinal Vascular Insufficiency. Ophthalmic Surg Lasers Imaging Retina. 2016 Mar; 47(3):1-11. PMID: 26985791.
        View in: PubMed
      11. Kashani A, Lee SY, Moshfeghi A, Durbin MK, Puliafito CA. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF RETINAL VENOUS OCCLUSION. Retina. 2015 Nov; 35(11):2323-31. PMID: 26457395.
        View in: PubMed
      12. Matsunaga DR, Yi JJ, De Koo LO, Ameri H, Puliafito CA, Kashani A. Optical Coherence Tomography Angiography of Diabetic Retinopathy in Human Subjects. Ophthalmic Surg Lasers Imaging Retina. 2015 Sep; 46(8):796-805. PMID: 26431294.
        View in: PubMed
      13. Nazari H, Zhang L, Zhu D, Chader GJ, Falabella P, Stefanini F, Rowland T, Clegg DO, Kashani A, Hinton DR, Humayun MS. Stem cell based therapies for age-related macular degeneration: The promises and the challenges. Prog Retin Eye Res. 2015 Sep; 48:1-39. PMID: 26113213.
        View in: PubMed
      14. Murali K, Kashani A, Humayun MS. Whole vitreous humor dissection for vitreodynamic analysis. J Vis Exp. 2015 May 24; (99):e52759. PMID: 26065393; PMCID: PMC4532330.
      15. Kashani A, Salehi B, Anghesom D, Kawayeh AM, Rouse GA, Runyon BA. Spleen size in cirrhosis of different etiologies. J Ultrasound Med. 2015 Feb; 34(2):233-8. PMID: 25614396.
        View in: PubMed
      16. Kashani A, Cheung AY, Robinson J, Williams GA. Longitudinal optical density analysis of subretinal fluid after surgical repair of rhegmatogenous retinal detachment. Retina. 2015 Jan; 35(1):149-56. PMID: 25077533.
        View in: PubMed
      17. Moysidis SN, Koulisis N, Ameri H, Matsunaga D, Yi J, Isozaki VL, Kashani A, Olmos de Koo LC. MULTIMODAL IMAGING OF GEOGRAPHIC AREAS OF RETINAL DARKENING. Retin Cases Brief Rep. 2015; 9(4):347-51. PMID: 26421892.
        View in: PubMed
      18. Matsunaga D, Yi J, Puliafito CA, Kashani A. OCT angiography in healthy human subjects. Ophthalmic Surg Lasers Imaging Retina. 2014 Nov-Dec; 45(6):510-5. PMID: 25423629.
        View in: PubMed
      19. Kashani A, Lopez Jaime GR, Saati S, Martin G, Varma R, Humayun MS. Noninvasive assessment of retinal vascular oxygen content among normal and diabetic human subjects: a study using hyperspectral computed tomographic imaging spectroscopy. Retina. 2014 Sep; 34(9):1854-60. PMID: 24732694; PMCID: PMC4145024.
      20. Kashani A, Brown KT, Chang E, Drenser KA, Capone A, Trese MT. Diversity of retinal vascular anomalies in patients with familial exudative vitreoretinopathy. Ophthalmology. 2014 Nov; 121(11):2220-7. PMID: 25005911.
        View in: PubMed
      21. Jamil LH, Kashani A, Scimeca D, Ghabril M, Gross SA, Gill KR, Hasan MK, Woodward TA, Wallace MB, Raimondo M. Can endoscopic ultrasound distinguish between mediastinal benign lymph nodes and those involved by sarcoidosis, lymphoma, or metastasis? Dig Dis Sci. 2014 Sep; 59(9):2191-8. PMID: 24801684.
        View in: PubMed
      22. Stefanini FR, Maia M, Falabella P, Pfister M, Niemeyer M, Kashani A, Humayun MS, Koss MJ. Profile of ocriplasmin and its potential in the treatment of vitreomacular adhesion. Clin Ophthalmol. 2014; 8:847-56. PMID: 24851038; PMCID: PMC4018320.
      23. Cheung AY, Kashani A, Drenser KA. Subretinal peripapillary neovascularization associated with persistent fetal vasculature. Retin Cases Brief Rep. 2014; 8(1):83-6. PMID: 25372216.
        View in: PubMed
      24. Murad-Kejbou S, Kashani A, Capone A, Ruby A. Staphylococcus lugdunensis endophthalmitis after intravitreal injection: a case series. Retin Cases Brief Rep. 2014; 8(1):41-4. PMID: 25372206.
        View in: PubMed
      25. Kashani A, Learned D, Nudleman E, Drenser KA, Capone A, Trese MT. High prevalence of peripheral retinal vascular anomalies in family members of patients with familial exudative vitreoretinopathy. Ophthalmology. 2014 Jan; 121(1):262-8. PMID: 24084499.
        View in: PubMed
      26. Kashani A, Eliott D. The emergence of Klebsiella pneumoniae endogenous endophthalmitis in the USA: basic and clinical advances. J Ophthalmic Inflamm Infect. 2013 Feb 04; 3(1):28. PMID: 23514342; PMCID: PMC3605079.
      27. Alkin Z, Kashani A, López-Jaime GR, Ruiz García H, Humayun MS, Sadda SR. Quantitative analysis of retinal structures using spectral domain optical coherence tomography in normal rabbits. Curr Eye Res. 2013 Feb; 38(2):299-304. PMID: 23373715.
        View in: PubMed
      28. Kashani A, Aaberg TM, Capone A. Vitreomacular traction as a consequence of posterior hyaloidal contraction after transpupillary thermotherapy. Am J Ophthalmol. 2013 May; 155(5):937-45. PMID: 23352339.
        View in: PubMed
      29. Jaime GR, Kashani A, Saati S, Martin G, Chader G, Humayun MS. Acute variations in retinal vascular oxygen content in a rabbit model of retinal venous occlusion. PLoS One. 2012; 7(11):e50179. PMID: 23185567; PMCID: PMC3502464.
      30. Kashani A, Kirkman E, Martin G, Humayun MS. Hyperspectral computed tomographic imaging spectroscopy of vascular oxygen gradients in the rabbit retina in vivo. PLoS One. 2011; 6(9):e24482. PMID: 21931729; PMCID: PMC3172231.
      31. Kashani A, Eliott D. Bilateral Klebsiella pneumoniae (K1 serotype) endogenous endophthalmitis as the presenting sign of disseminated infection. Ophthalmic Surg Lasers Imaging. 2011 Feb 10; 42 Online:e12-4. PMID: 21323188.
        View in: PubMed
      32. Kashani A, Zimmer-Galler IE, Shah SM, Dustin L, Do DV, Eliott D, Haller JA, Nguyen QD. Retinal thickness analysis by race, gender, and age using Stratus OCT. Am J Ophthalmol. 2010 Mar; 149(3):496-502.e1. PMID: 20042179; PMCID: PMC2826608.
      33. Kashani A, Keane PA, Dustin L, Walsh AC, Sadda SR. Quantitative subanalysis of cystoid spaces and outer nuclear layer using optical coherence tomography in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3366-73. PMID: 19168893; PMCID: PMC2908154.
      34. Kabir A, Keshvari M, Kashani A, Alavian SM. Predicting response to HBV vaccination in people with positive anti-HBc but negative HBsAg and anti-HBs. Hum Vaccin. 2008 Sep-Oct; 4(5):379-83. PMID: 18398305.
        View in: PubMed
      35. Kashani A, Landaverde C, Medici V, Rossaro L. Fluid retention in cirrhosis: pathophysiology and management. QJM. 2008 Feb; 101(2):71-85. PMID: 18184668.
        View in: PubMed
      36. Kashani A, Qiu Z, Jurata L, Lee SK, Pfaff S, Goebbels S, Nave KA, Ghosh A. Calcium activation of the LMO4 transcription complex and its role in the patterning of thalamocortical connections. J Neurosci. 2006 Aug 09; 26(32):8398-408. PMID: 16899735.
        View in: PubMed
      37. Kim PM, Aizawa H, Kim PS, Huang AS, Wickramasinghe SR, Kashani A, Barrow RK, Huganir RL, Ghosh A, Snyder SH. Serine racemase: activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration. Proc Natl Acad Sci U S A. 2005 Feb 08; 102(6):2105-10. PMID: 15684087; PMCID: PMC548584.
      38. Grinnell AD, Chen BM, Kashani A, Lin J, Suzuki K, Kidokoro Y. The role of integrins in the modulation of neurotransmitter release from motor nerve terminals by stretch and hypertonicity. J Neurocytol. 2003 Jun-Sep; 32(5-8):489-503. PMID: 15034249.
        View in: PubMed
      39. Redmond L, Kashani A, Ghosh A. Calcium regulation of dendritic growth via CaM kinase IV and CREB-mediated transcription. Neuron. 2002 Jun 13; 34(6):999-1010. PMID: 12086646.
        View in: PubMed
      40. Yaghmai R, Kashani A, Geraghty MT, Okoh J, Pomper M, Tangerman A, Wagner C, Stabler SP, Allen RH, Mudd SH, Braverman N. Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient with cystathionine beta-synthase (CBS) deficiency. Am J Med Genet. 2002 Feb 15; 108(1):57-63. PMID: 11857551.
        View in: PubMed
      41. Kashani A, Hutchins GM. Meningeal-cutaneous relationships in anencephaly: evidence for a primary mesenchymal abnormality. Hum Pathol. 2001 May; 32(5):553-8. PMID: 11381375.
        View in: PubMed
      42. Kashani A, Chen BM, Grinnell AD. Hypertonic enhancement of transmitter release from frog motor nerve terminals: Ca2+ independence and role of integrins. J Physiol. 2001 Jan 15; 530(Pt 2):243-52. PMID: 11208972; PMCID: PMC2278411.
      43. Yoshizumi MO, Kashani A, Palmer J, Lee G, Mondino B. High dose intramuscular methylprednisolone in experimental Staphylococcus aureus endophthalmitis. J Ocul Pharmacol Ther. 1999 Feb; 15(1):91-6. PMID: 10048352.
        View in: PubMed
      44. Yoshizumi MO, Bhavsar AR, Dessouki A, Kashani A. Safety of repeated intravitreous injections of antibiotics and dexamethasone. Retina. 1999; 19(5):437-41. PMID: 10546941.
        View in: PubMed