Loading...
Sign in to edit your profile (add interests, mentoring, photo, etc.)

    Abhay Sagare, PhD

    TitleAssistant Professor of Research Physiology & Biophysics
    SchoolKeck School of Medicine of USC
    DepartmentZilkha Neurogenetic Institute
    AddressZNI 301, 1501 San Pablo Street
    Health Sciences Campus
    Los Angeles California 90033
    Phone+1 323 442 1911
    vCardDownload vCard

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Amar AP, Sagare A, Zhao Z, Wang Y, Nelson AR, Griffin JH, Zlokovic BV. Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C. Neuropharmacology. 2017 Sep 18. PMID: 28923278.
        View in: PubMed
      2. Nelson AR, Sagare A, Zlokovic BV. Role of clusterin in the brain vascular clearance of amyloid-ß. Proc Natl Acad Sci U S A. 2017 Aug 15; 114(33):8681-8682. PMID: 28765369.
        View in: PubMed
      3. Nelson AR, Sweeney MD, Sagare A, Zlokovic BV. Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease. Biochim Biophys Acta. 2016 May; 1862(5):887-900. PMID: 26705676; PMCID: PMC4821735 [Available on 05/01/17].
      4. Sagare A, Sweeney MD, Makshanoff J, Zlokovic BV. Shedding of soluble platelet-derived growth factor receptor-ß from human brain pericytes. Neurosci Lett. 2015 Oct 21; 607:97-101. PMID: 26407747; PMCID: PMC4631673 [Available on 10/21/16].
      5. Ramanathan A, Nelson AR, Sagare A, Zlokovic BV. Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer's disease: the role, regulation and restoration of LRP1. Front Aging Neurosci. 2015; 7:136. PMID: 26236233; PMCID: PMC4502358.
      6. Zhao Z, Sagare A, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, Miller CA, Schneider JA, Maeda M, Maeda T, Sugawara T, Ichida JK, Zlokovic BV. Central role for PICALM in amyloid-ß blood-brain barrier transcytosis and clearance. Nat Neurosci. 2015 Jul; 18(7):978-87. PMID: 26005850; PMCID: PMC4482781.
      7. Sweeney MD, Sagare A, Zlokovic BV. Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease. J Cereb Blood Flow Metab. 2015 Jul; 35(7):1055-68. PMID: 25899298; PMCID: PMC4640280.
      8. Winkler EA, Nishida Y, Sagare A, Rege SV, Bell RD, Perlmutter D, Sengillo JD, Hillman S, Kong P, Nelson AR, Sullivan JS, Zhao Z, Meiselman HJ, Wendy RB, Soto J, Abel ED, Makshanoff J, Zuniga E, De Vivo DC, Zlokovic BV. GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration. Nat Neurosci. 2015 Apr; 18(4):521-530. PMID: 25730668; PMCID: PMC4734893.
      9. Montagne A, Barnes SR, Sweeney MD, Halliday MR, Sagare A, Zhao Z, Toga AW, Jacobs RE, Liu CY, Amezcua L, Harrington MG, Chui HC, Law M, Zlokovic BV. Blood-brain barrier breakdown in the aging human hippocampus. Neuron. 2015 Jan 21; 85(2):296-302. PMID: 25611508; PMCID: PMC4350773.
      10. Winkler EA, Sagare A, Zlokovic BV. The pericyte: a forgotten cell type with important implications for Alzheimer's disease? Brain Pathol. 2014 Jul; 24(4):371-86. PMID: 24946075; PMCID: PMC4423607.
      11. Winkler EA, Sengillo JD, Sagare A, Zhao Z, Ma Q, Zuniga E, Wang Y, Zhong Z, Sullivan JS, Griffin JH, Cleveland DW, Zlokovic BV. Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):E1035-42. PMID: 24591593; PMCID: PMC3964055.
      12. Halliday MR, Pomara N, Sagare A, Mack WJ, Frangione B, Zlokovic BV. Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown. JAMA Neurol. 2013 Sep 01; 70(9):1198-200. PMID: 24030206; PMCID: PMC4047029.
      13. Singh I, Sagare A, Coma M, Perlmutter D, Gelein R, Bell RD, Deane RJ, Zhong E, Parisi M, Ciszewski J, Kasper RT, Deane R. Low levels of copper disrupt brain amyloid-ß homeostasis by altering its production and clearance. Proc Natl Acad Sci U S A. 2013 Sep 03; 110(36):14771-6. PMID: 23959870; PMCID: PMC3767519.
      14. Sagare A, Bell RD, Srivastava A, Sengillo JD, Singh I, Nishida Y, Chow N, Zlokovic BV. A lipoprotein receptor cluster IV mutant preferentially binds amyloid-ß and regulates its clearance from the mouse brain. J Biol Chem. 2013 May 24; 288(21):15154-66. PMID: 23580652; PMCID: PMC3663536.
      15. Sagare A, Bell RD, Zhao Z, Ma Q, Winkler EA, Ramanathan A, Zlokovic BV. Pericyte loss influences Alzheimer-like neurodegeneration in mice. Nat Commun. 2013; 4:2932. PMID: 24336108; PMCID: PMC3945879.
      16. Sagare A, Bell RD, Zlokovic BV. Neurovascular defects and faulty amyloid-ß vascular clearance in Alzheimer's disease. J Alzheimers Dis. 2013; 33 Suppl 1:S87-100. PMID: 22751174; PMCID: PMC4416477.
      17. Sagare A, Bell RD, Zlokovic BV. Neurovascular dysfunction and faulty amyloid ß-peptide clearance in Alzheimer disease. Cold Spring Harb Perspect Med. 2012 Oct 01; 2(10). PMID: 23028132; PMCID: PMC3475405.
      18. Sagare A, Deane R, Zlokovic BV. Low-density lipoprotein receptor-related protein 1: a physiological Aß homeostatic mechanism with multiple therapeutic opportunities. Pharmacol Ther. 2012 Oct; 136(1):94-105. PMID: 22820095; PMCID: PMC3432694.
      19. Bell RD, Winkler EA, Singh I, Sagare A, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature. 2012 May 16; 485(7399):512-6. PMID: 22622580; PMCID: PMC4047116.
      20. Deane R, Singh I, Sagare A, Bell RD, Ross NT, LaRue B, Love R, Perry S, Paquette N, Deane RJ, Thiyagarajan M, Zarcone T, Fritz G, Friedman AE, Miller BL, Zlokovic BV. A multimodal RAGE-specific inhibitor reduces amyloid ß-mediated brain disorder in a mouse model of Alzheimer disease. J Clin Invest. 2012 Apr; 122(4):1377-92. PMID: 22406537; PMCID: PMC3314449.
      21. Sagare A, Winkler EA, Bell RD, Deane R, Zlokovic BV. From the liver to the blood-brain barrier: an interconnected system regulating brain amyloid-ß levels. J Neurosci Res. 2011 Jul; 89(7):967-8. PMID: 21544850.
        View in: PubMed
      22. Sagare A, Deane R, Zetterberg H, Wallin A, Blennow K, Zlokovic BV. Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-ß is an early biomarker for mild cognitive impairment preceding Alzheimer's disease. J Alzheimers Dis. 2011; 24(1):25-34. PMID: 21157031; PMCID: PMC4096563.
      23. Zhong Z, Wang Y, Guo H, Sagare A, Fernández JA, Bell RD, Barrett TM, Griffin JH, Freeman RS, Zlokovic BV. Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region. J Neurosci. 2010 Nov 17; 30(46):15521-34. PMID: 21084607; PMCID: PMC3012432.
      24. Bell RD, Winkler EA, Sagare A, Singh I, LaRue B, Deane R, Zlokovic BV. Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron. 2010 Nov 04; 68(3):409-27. PMID: 21040844; PMCID: PMC3056408.
      25. Zlokovic BV, Deane R, Sagare A, Bell RD, Winkler EA. Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid ß-peptide elimination from the brain. J Neurochem. 2010 Dec; 115(5):1077-89. PMID: 20854368; PMCID: PMC2972355.
      26. Zhu D, Wang Y, Singh I, Bell RD, Deane R, Zhong Z, Sagare A, Winkler EA, Zlokovic BV. Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor. Blood. 2010 Jun 10; 115(23):4963-72. PMID: 20348395; PMCID: PMC2890172.
      27. Menon P, Deane R, Sagare A, Lane SM, Zarcone TJ, O'Dell MR, Yan C, Zlokovic BV, Berk BC. Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice. Brain Res. 2010 Mar 04; 1317:218-26. PMID: 20043896; PMCID: PMC2861918.
      28. Deane R, Bell RD, Sagare A, Zlokovic BV. Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease. CNS Neurol Disord Drug Targets. 2009 Mar; 8(1):16-30. PMID: 19275634; PMCID: PMC2872930.
      29. Bell RD, Deane R, Chow N, Long X, Sagare A, Singh I, Streb JW, Guo H, Rubio A, Van Nostrand W, Miano JM, Zlokovic BV. SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. Nat Cell Biol. 2009 Feb; 11(2):143-53. PMID: 19098903; PMCID: PMC2654279.
      30. Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest. 2008 Dec; 118(12):4002-13. PMID: 19033669; PMCID: PMC2582453.
      31. Deane R, LaRue B, Sagare A, Castellino FJ, Zhong Z, Zlokovic BV. Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier. J Cereb Blood Flow Metab. 2009 Jan; 29(1):25-33. PMID: 18841163; PMCID: PMC2895315.
      32. Zhong Z, Deane R, Ali Z, Parisi M, Shapovalov Y, O'Banion MK, Stojanovic K, Sagare A, Boillee S, Cleveland DW, Zlokovic BV. ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nat Neurosci. 2008 Apr; 11(4):420-2. PMID: 18344992; PMCID: PMC2895310.
      33. Deane R, Sagare A, Zlokovic BV. The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease. Curr Pharm Des. 2008; 14(16):1601-5. PMID: 18673201; PMCID: PMC2895311.
      34. Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, Marky A, Lenting PJ, Wu Z, Zarcone T, Goate A, Mayo K, Perlmutter D, Coma M, Zhong Z, Zlokovic BV. Clearance of amyloid-beta by circulating lipoprotein receptors. Nat Med. 2007 Sep; 13(9):1029-31. PMID: 17694066; PMCID: PMC2936449.
      35. Bell RD, Sagare A, Friedman AE, Bedi GS, Holtzman DM, Deane R, Zlokovic BV. Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. J Cereb Blood Flow Metab. 2007 May; 27(5):909-18. PMID: 17077814; PMCID: PMC2853021.
      36. Deane R, Sagare A, Hamm K, Parisi M, LaRue B, Guo H, Wu Z, Holtzman DM, Zlokovic BV. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J Neurosci. 2005 Dec 14; 25(50):11495-503. PMID: 16354907.
        View in: PubMed
      37. Cirrito JR, Deane R, Fagan AM, Spinner ML, Parsadanian M, Finn MB, Jiang H, Prior JL, Sagare A, Bales KR, Paul SM, Zlokovic BV, Piwnica-Worms D, Holtzman DM. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. J Clin Invest. 2005 Nov; 115(11):3285-90. PMID: 16239972; PMCID: PMC1257538.
      38. Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, Brooks AI, Kanagala S, Rubio A, Sagare A, Liu D, Li F, Armstrong D, Gasiewicz T, Zidovetzki R, Song X, Hofman F, Zlokovic BV. Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nat Med. 2005 Sep; 11(9):959-65. PMID: 16116430.
        View in: PubMed
      39. LaRue B, Hogg E, Sagare A, Jovanovic S, Maness L, Maurer C, Deane R, Zlokovic BV. Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice. J Neurosci Methods. 2004 Sep 30; 138(1-2):233-42. PMID: 15325132.
        View in: PubMed
      40. Deane R, Wu Z, Sagare A, Davis J, Du Yan S, Hamm K, Xu F, Parisi M, LaRue B, Hu HW, Spijkers P, Guo H, Song X, Lenting PJ, Van Nostrand WE, Zlokovic BV. LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron. 2004 Aug 05; 43(3):333-44. PMID: 15294142.
        View in: PubMed
      41. Lee YL, Sagare A, Lee CY, Feng HT, Ko YC, Shaw JF, Tsay HS. Formation of protoberberine-type alkaloids by the tubers of somatic embryo-derived plants of Corydalis yanhusuo. Planta Med. 2001 Dec; 67(9):839-42. PMID: 11745021.
        View in: PubMed
      42. Sagare A, Kuo CL, Chueh FS, Tsay HS. De novo regeneration of Scrophularia yoshimurae Yamazaki (Scrophulariaceae) and quantitative analysis of harpagoside, an iridoid glucoside, formed in aerial and underground parts of in vitro propagated and wild plants by HPLC. Biol Pharm Bull. 2001 Nov; 24(11):1311-5. PMID: 11725970.
        View in: PubMed
      43. Chueh FS, Chen CC, Sagare A, Tsay HS. Quantitative determination of secoiridoid glucosides in in vitro propagated plants of Gentiana davidii var. formosana by high performance liquid chromatography. Planta Med. 2001 Feb; 67(1):70-3. PMID: 11270726.
        View in: PubMed
      44. Sagare A, Lee YL, Lin TC, Chen CC, Tsay HS. Cytokinin-induced somatic embryogenesis and plant regeneration in Corydalis yanhusuo (Fumariaceae) - a medicinal plant. Plant Sci. 2000 Dec 07; 160(1):139-147. PMID: 11164586.
        View in: PubMed
      45. Sagare A, Suhasini K, Krishnamurthy KV. Plant regeneration via somatic embryogenesis in chick pea (Cicer arietinum L.). Plant Cell Rep. 1993 Sep; 12(11):652-5. PMID: 24201882.
        View in: PubMed
      Abhay's Networks
      Concepts
      Derived automatically from this person's publications.
      _
      Co-Authors
      People in Profiles who have published with this person.
      _
      Similar People
      People who share similar concepts with this person.
      _
      Same Department